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AI-driven discovery of synergistic drug combinations against pancreatic cancer Pourmousa, Mohsen; Jain, Sankalp; Barnaeva, Elena; Jin, Wengong; Hochuli, Joshua; Itkin, Zina; Maxfield, Travis; Melo-Filho, Cleber; Thieme, Andrew; Wilson, Kelli; Klumpp-Thomas, Carleen; Michael, Sam; Southall, Noel; Jaakkola, Tommi; Muratov, Eugene N.; Barzilay, Regina; Tropsha, Alexander; Ferrer, Marc Share Save
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice Chandia-Cristi, America; Gutierrez, Daniela A.; Dulcey, Andres E.; Lara, Marcelo; Vargas, Lina; Lin, Yi-Han; Jimenez-Munoz, Pablo; Larenas, Gabriela; Xu, Xin; Wang, Amy; Owens, Ashley; Dextras, Christopher; Chen, Yuchi; Pinto, Claudio; Marin, Tamara; Almarza-Salazar, Hugo; Acevedo, Keryma; Cancino, Gonzalo I.; Hu, Xin; Rojas, Patricio; Ferrer, Marc; Southall, Noel; Henderson, Mark J.; Zanlungo, Silvana; Marugan, Juan J.; Alvarez, R. Alejandra Share Save
An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers Sarkar, Rhitajit; Bolel, Priyanka; Kapoor, Abhijeet; Eliseeva, Elena; Dulcey, Andres E.; Templin, Jay S.; Wang, Amy Q.; Xu, Xin; Southall, Noel; Klubo-Gwiezdzinska, Joanna; Neumann, Susanne; Marugan, Juan J.; Gershengorn, Marvin C. Share Save
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Structure-Activity Relationships of a Brain-Penetrant D3 Dopamine Receptor Negative Allosteric Modulator and Investigation of its Binding Site Moritz, Amy E.; Madaras, Nora S.; Inbody, Laura R.; Kelley, Amber M.; Gandhi, Disha M.; Akano, Emmanuel O.; Lee, Kuo H.; Free, R. Benjamin; Hu, Xin; Southall, Noel T.; Ferrer, Marc; Shi, Lei; Frankowski, Kevin J.; Sibley, David R. Share Save
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2 Esteban-Lopez, Maria; Wilson, Kenneth J.; Myhr, Courtney; Kaftanovskaya, Elena M.; Henderson, Mark J.; Southall, Noel T.; Xu, Xin; Wang, Amy; Hu, Xin; Barnaeva, Elena; Ye, Wenjuan; George, Emmett R.; Sherrill, John T.; Ferrer, Marc; Morello, Roy; Agoulnik, Irina U.; Marugan, Juan J.; Agoulnik, Alexander, I Share Save
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Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells Sayedyahossein, Samar; Smith, Jessica; Barnaeva, Elena; Li, Zhigang; Choe, Jun; Ronzetti, Michael; Dextras, Christopher; Hu, Xin; Marugan, Juan; Southall, Noel; Baljinnyam, Bolormaa; Thines, Louise; Tran, Andy D.; Ferrer, Marc; Sacks, David B. Share Save
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement Sanchez, Tino W.; Ronzetti, Michael H.; Owens, Ashley E.; Antony, Maria; Voss, Ty; Wallgren, Eric; Talley, Daniel; Balakrishnan, Krishna; Porello, Sebastian E. Leyes; Rai, Ganesha; Marugan, Juan J.; Michael, Samuel G.; Baljinnyam, Bolormaa; Southall, Noel; Simeonov, Anton; Henderson, Mark J. Share Save
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis Frankowski, Kevin J.; Patnaik, Samarjit; Wang, Chen; Southall, Noel; Dutta, Dipannita; De, Soumitta; Li, Dandan; Dextras, Christopher; Lin, Yi-Han; Bryant-Connah, Marthe; Davis, Danielle; Wang, Feijun; Wachsmuth, Leah M.; Shah, Pranav; Williams, Jordan; Kabir, Md; Zhu, Edward; Baljinnyam, Bolormaa; Wang, Amy; Xu, Xin; Norton, John; Ferrer, Marc; Titus, Steve; Simeonov, Anton; Zheng, Wei; Griner, Lesley A. Mathews; Jadhav, Ajit; Aube, Jeffrey; Henderson, Mark J.; Rudloff, Udo; Schoenen, Frank J.; Huang, Sui; Marugan, Juan J. Share Save
Progress toward a universal biomedical data translator Fecho, Karamarie; Thessen, Anne E.; Baranzini, Sergio E.; Bizon, Chris; Hadlock, Jennifer J.; Huang, Sui; Roper, Ryan T.; Southall, Noel; Ta, Casey; Watkins, Paul B.; Williams, Mark D.; Xu, Hao; Byrd, William; Dancik, Vlado; Duby, Marc P.; Dumontier, Michel; Glusman, Gustavo; Harris, Nomi L.; Hinderer, Eugene W.; Hyde, Greg; Johs, Adam; Su, Andrew, I; Qin, Guangrong; Zhu, Qian Share Save
Defining clinical outcome pathways Korn, Daniel; Thieme, Andrew J.; Alves, Vinicius M.; Yeakey, Michael; Borba, Joyce V. V. B.; Capuzzi, Stephen J.; Fecho, Karamarie; Bizon, Chris; Edwards, Stephen W.; Chirkova, Rada; Colvis, Christine M.; Southall, Noel T.; Austin, Christopher P.; Muratov, Eugene N.; Tropsha, Alexander Share Save
Structure-Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site Moritz, Amy E.; Madaras, Nora S.; Inbody, Laura R.; Kelley, Amber M.; Gandhi, Disha M.; Akano, Emmanuel; Lee, Kuo H.; Free, R. B.; Hu, Xin; Southall, Noel T.; Ferrer, Mare; Shi, Lei; Frankowski, Kevin J.; Sibley, David R. Share Save
RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis Esteban-Lopez, Maria; Wilson, Kenneth; Myhr, Courtney; Kaftanovskaya, Elena; Henderson, Mark; Southall, Noel; Hu, Xin; Barnaeva, Elena; Ferrer, Mare; Kim, David Share Save
Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine Gross, J. D.; Kim, D. W.; Zhou, Y.; Jansen, D.; Slosky, L. M.; Clark, N. B.; Ray, C. R.; Hu, X.; Southall, N.; Wang, A.; Xu, X.; Barnaeva, E.; Wetsel, W. C.; Ferrer, M.; Marugan, J. J.; Caron, M. G.; Barak, L. S.; Toth, K. Share Save
High-Throughput Cellular Thermal Shift Assay Using Acoustic Transfer of Protein Lysates Owens, Ashley E.; Iannotti, Michael J.; Sanchez, Tino W.; Voss, Ty; Kapoor, Abhijeet; Hall, Matthew D.; Marugan, Juan J.; Michael, Sam; Southall, Noel; Henderson, Mark J. Share Save
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NCATS Inxight Drugs: a comprehensive and curated portal for translational research Siramshetty, Vishal B.; Grishagin, Ivan; Dac-Trung Nguyen; Peryea, Tyler; Skovpen, Yulia; Stroganov, Oleg; Katzel, Daniel; Sheils, Timothy; Jadhav, Ajit; Mathe, Ewy A.; Southall, Noel T. Share Save
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