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First results of a Phase 1 study evaluating safety, PK, PD and clinical activity of STC-15, aMETTL3 inhibitor, in patients with advanced malignancies Rodon, J.; Moser, J. C.; Papadopoulos, K. P.; Ofir-Rosenfeld, Y.; Weisser, H.; Snyder, M.; Schmalbach, T.; Barker, T.; Deshpande, D.; Skead, B.; Hester, D.; Sheth, N.; Leon, P. Saldana; Blanco-Cepeda, E.; Rausch, O.; Holz, J. B. Share Save
First-in-class inhibitors of the tRNA methyltransferase METTL1 for the treatment of cancer Sapetschnig, Alexandra; Thomas, Beth; Yankova, Eliza; Fischl, Harry; Azevedo, Aleksandra; Bucknell, Sarah; Fosbeary, Richard; Sawyer, Sapphire; Evans, Sian; Livi, Carmen; Andrews, Byron; Rogan, Jack; Webster, Natalie; Fyfe, Matthew; Tzelepis, Konstantinos; Rausch, Oliver Share Save
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Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity Guirguis, Andrew A.; Ofir-Rosenfeld, Yaara; Knezevic, Kathy; Blackaby, Wesley; Hardick, David; Chan, Yih-Chih; Motazedian, Ali; Gillespie, Andrea; Vassiliadis, Dane; Lam, Enid Y. N.; Tran, Kevin; Andrews, Byron; Harbour, Michael E.; Vasiliauskaite, Lina; Saunders, Claire J.; Tsagkogeorga, Georgia; Azevedo, Aleksandra; Obacz, Joanna; Pilka, Ewa S.; Carkill, Marie; Macpherson, Laura; Wainwright, Elanor N.; Liddicoat, Brian; Blyth, Benjamin J.; Albertella, Mark R.; Rausch, Oliver; Dawson, Mark A. Share Save
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages Sturgess, Katherine; Yankova, Eliza; Vijayabaskar, M. S.; Isobe, Tomoya; Rak, Justyna; Kucinski, Iwo; Barile, Melania; Webster, Natalie A.; Eleftheriou, Maria; Hannah, Rebecca; Gozdecka, Malgorzata; Vassiliou, George; Rausch, Oliver; Wilson, Nicola K.; Gottgens, Berthold; Tzelepis, Konstantinos Share Save
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals (May, 10.1038/s41594-023-00997-7, 2023) Rueckle, Cornelia; Koertel, Nadine; Basilicata, M. Felicia; Busch, Anke; Zhou, You; Hoch-Kraft, Peter; Tretow, Kerstin; Kielisch, Fridolin; Bertin, Marco; Pradhan, Mihika; Musheev, Michael; Schweiger, Susann; Niehrs, Christof; Rausch, Oliver; Zarnack, Kathi; Keller Valsecchi, Claudia Isabelle; Koenig, Julian Share Save
RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals Rueckle, Cornelia; Koertel, Nadine; Basilicata, M. Felicia; Busch, Anke; Zhou, You; Hoch-Kraft, Peter; Tretow, Kerstin; Kielisch, Fridolin; Bertin, Marco; Pradhan, Mihika; Musheev, Michael; Schweiger, Susann; Niehrs, Christof; Rausch, Oliver; Zarnack, Kathi; Valsecchi, Claudia Isabelle Keller; Koenig, Julian Share Save
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STC-15, AN ORAL SMALL MOLECULE INHIBITOR OF THE RNA METHYLTRANSFERASE METTL3, INHIBITS TUMOUR GROWTH THROUGH ACTIVATION OF ANTI-CANCER IMMUNE RESPONSES AND SYNERGISES WITH IMMUNE CHECKPOINT BLOCKADE Ofir-Rosenfeld, Yaara; Rausch, Oliver; McMahon, Jerry; Vasiliauskaite, Lina; Saunders, Claire; Sapetschnig, Alexandra; Tsagkogeorga, Georgia; Albertella, Mark; Carkill, Marie; Self-Fordham, Jezrom; Holz, Josefin-Beate Share Save
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Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning Koertel, Nadine; Rueckle, Cornelia; Zhou, You; Busch, Anke; Hoch-Kraft, Peter; Sutandy, F. X. Reymond; Haase, Jacob; Pradhan, Mihika; Musheev, Michael; Ostareck, Dirk; Ostareck-Lederer, Antje; Dieterich, Christoph; Huettelmaier, Stefan; Niehrs, Christof; Rausch, Oliver; Dominissini, Dan; Koenig, Julian; Zarnack, Kathi Share Save
A small molecule inhibitor of the RNA m6A writer METTL3 inhibits the development of acute myeloid leukemia (AML) in vivo Albertella, Mark; Blackaby, Wesley; Fosbeary, Richard; Hendrick, Alan; Leggate, Dan; Ofir-Rosenfeld, Yaara; Sapetschnig, Alexandra; Tzelepis, Konstantinos; Yankova, Eliza; Kouzarides, Tony; Rausch, Oliver Share Save
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CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model Cansfield, Andrew D.; Ladduwahetty, Tammy; Sunose, Mihiro; Ellard, Katie; Lynch, Rosemary; Newton, Anthea L.; Lewis, Ann; Bennett, Gavin; Zinn, Nico; Thomson, Douglas W.; Rueger, Anne J.; Feutrill, John T.; Rausch, Oliver; Watt, Alan P.; Bergamini, Giovanna Share Save
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation (vol 8, pg 576, 2012) Bergamini, Giovanna; Bell, Kathryn; Shimamura, Satoko; Werner, Thilo; Cansfield, Andrew; Mueller, Katrin; Perrin, Jessica; Rau, Christina; Ellard, Katie; Hopf, Carsten; Doce, Carola; Leggate, Daniel; Mangano, Raffaella; Mathieson, Toby; O'Mahony, Alison; Plavec, Ivan; Rharbaoui, Faiza; Reinhard, Friedrich; Savitski, Mikhail M.; Ramsden, Nigel; Hirsch, Emilio; Drewes, Gerard; Rausch, Oliver; Bantscheff, Marcus; Neubauer, Gitte Share Save
A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation Bergamini, Giovanna; Bell, Kathryn; Shimamura, Satoko; Werner, Thilo; Cansfield, Andrew; Mueller, Katrin; Perrin, Jessica; Rau, Christina; Ellard, Katie; Hopf, Carsten; Doce, Carola; Leggate, Daniel; Mangano, Raffaella; Mathieson, Toby; O'Mahony, Alison; Plavec, Ivan; Rharbaoui, Faiza; Reinhard, Friedrich; Savitski, Mikhail M.; Ramsden, Nigel; Hirsch, Emilio; Drewes, Gerard; Rausch, Oliver; Bantscheff, Marcus; Neubauer, Gitte Share Save
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