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J

Jason R. Spence

University of Michigan Medical School

72H-index
314Paper Count
2.2WCitation Count
Published Papers 129
Publication Date
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Mapping mesenchymal diversity in the human small intestine and organoids
errNature Cell Biology
IF19.1
err2026-07-22
err0
errOAAI
errKelli F. Johnson; Xiangning Dong; Yu-Hwai Tsai; Angeline Wu; Sydney G. Clark; Abigail Vallie; Sha Huang; Charlie J. Childs; Rachel K. Zwick; Ian Glass; Katherine D. Walton; Ophir D. Klein; Jason R. Spence
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Publisher Correction: Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut
errNature Microbiology
IF19.4
err2025-12-23
err0
errOAAI
errShaobo Yang; Zongqi Wang; Chengyuan Fang; Mengdi Yang; Saleh Khawaled; Shanna Bonanno; Neel S. Joshi; Yun Wei; Ke Zhang; Valeria Márquez-Pellegrin; Ming Guan; Songqi Zhang; Anna Clara Bader; Ningyuan Ye; Amber E. Haley; Michael K. Dame; Jason R. Spence; Xuesong He; James G. Fox; Ömer H. Yilmaz; Yatrik M. Shah; Rizwan Romee; Jiahe Li
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errSave
Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut
errNature Microbiology
IF19.4
err2025-12-08
err0
PREAI
errShaobo Yang; Zongqi Wang; Chengyuan Fang; Mengdi Yang; Saleh Khawaled; Shanna Bonanno; Neel S. Joshi; Yun Wei; Ke Zhang; Valeria Márquez-Pellegrin; Ming Guan; Songqi Zhang; Anna Clara Bader; Ningyuan Ye; Amber E. Haley; Michael K. Dame; Jason R. Spence; Xuesong He; James G. Fox; Ömer H. Yilmaz; Yatrik M. Shah; Rizwan Romee; Jiahe Li
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Dynamics of YAP localization and transcript activity in human oocytes and granulosa cells across early-stage folliculogenesis: an exploratory investigation
errJournal of Assisted Reproduction and Genetics
IF2.7
err2025-09-26
err0
errOAAI
errJordan H. Machlin; Kate Potocsky; Robin E. Kruger; Jason Spence; Vasantha Padmanabhan; Ariella Shikanov
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errSave
Recent evolution of the developing human intestine affects metabolic and barrier functions
errScience
IF45.8
err2025-07-17
err0
PREAI
errQianhui Yu; Umut Kilik; Stefano Secchia; Lukas Adam; Yu-Hwai Tsai; Christiana Fauci; Jasper Janssens; Charlie J. Childs; Katherine D. Walton; Rubén López-Sandoval; Angeline Wu; Marina Almató Bellavista; Sha Huang; Calen A. Steiner; Yannick Throm; Michael James Boyle; Zhisong He; Joep Beumer; Barbara Treutlein; Craig B. Lowe; Jason R. Spence; J. Gray Camp
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errSave
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD
errNature Metabolism
IF20.8
err2025-06-26
err0
PREAI
errWesley Huang; Yuezhong Zhang; Nupur K. Das; Sumeet Solanki; Chesta Jain; Marwa O. El-Derany; Imhoi Koo; Hannah N. Bell; Noora Aabed; Rashi Singhal; Cristina Castillo; Kathryn Buscher; Yinzhi Ying; James Dimitroff; Ankit Sharma; Jiaqi Shi; Simon P. Hogan; Michael K. Dame; Peter D. R. Higgins; Justin A. Colacino; Tae Gyu Oh; Jason R. Spence; Andrew D. Patterson; Andrew S. Greenberg; Joel K. Greenson; Asma Nusrat; Yatrik M. Shah
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errSave
An integrated transcriptomic cell atlas of human endoderm-derived organoids
errNATURE GENETICS
IF0
err2025-05-12
err0
errOAAI
errXu, Quan; Halle, Lennard; Hediyeh-zadeh, Soroor; Kuijs, Merel; Riedweg, Rya; Kilik, Umut; Recaldin, Timothy; Yu, Qianhui; Rall, Isabell; Frum, Tristan; Adam, Lukas; Parikh, Shrey; Kfuri-Rubens, Raphael; Gander, Manuel; Klein, Dominik; Curion, Fabiola; He, Zhisong; Fleck, Jonas Simon; Oost, Koen; Kahnwald, Maurice; Barbiero, Silvia; Mitrofanova, Olga; Maciag, Grzegorz Jerzy; Jensen, Kim B.; Lutolf, Matthias; Liberali, Prisca; Spence, Jason R.; Gjorevski, Nikolche; Beumer, Joep; Treutlein, Barbara; Theis, Fabian J.; Camp, J. Gray
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errSave
Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature
errCELL STEM CELL
IF20.4
err2025-04-01
err1
errOAAI
errChilds, Charlie J.; Poling, Holly M.; Chen, Kevin; Tsai, Yu-Hwai; Wu, Angeline; Vallie, Abigail; Eiken, Madeline K.; Huang, Sha; Sweet, Caden W.; Schreiner, Ryan; Xiao, Zhiwei; Spencer, Ryan C.; Paris, Samantha A.; Conchola, Ansley S.; Villanueva, Jonathan W.; Anderman, Meghan F.; Holloway, Emily M.; Singh, Akaljot; Giger, Roman J.; Mahe, Maxime M.; Loebel, Claudia; Helmrath, Michael A.; Walton, Katherine D.; Rafii, Shahin; Spence, Jason R.
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Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels
errSTEM CELL REPORTS
IF5.1
err2025-01-01
err0
errOAAI
errEiken, Madeline K.; Childs, Charlie J.; Brastrom, Lindy K.; Frum, Tristan; Plaster, Eleanor M.; Ahmed, Donia W.; Spencer, Ryan C.; Shachaf, Orren; Pfeiffer, Suzanne; Levine, Justin E.; Alysandratos, Konstantinos-Dionysios; Kotton, Darrell N.; Spence, Jason R.; Loebel, Claudia
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errSave
Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal Salmonella enterica serovars
errMSPHERE
IF3.1
err2024-12-19
err0
PREAI
errLawrence, Anna-Lisa E.; Berger, Ryan P.; Hill, David R.; Huang, Sha; Yadagiri, Veda K.; Bons, Brooke; Fields, Courtney; Knight, Jason S.; Wobus, Christiane E.; Spence, Jason R.; Young, Vincent B.; Abuaita, Basel H.; O'Riordan, Mary X.
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Polymer Design of Microwell Hydrogels Influences Epithelial-Mesenchymal Interactions During Human Bronchosphere Formation
errADVANCED NANOBIOMED RESEARCH
IF4.4
err2024-11-21
err0
errOAAI
errEiken, Madeline K.; Levine, Justin E.; Lee, Shinyeong; Lukpat, Samantha; Plaster, Eleanor M.; Bala, Vikram; Spence, Jason R.; Loebel, Claudia
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errSave
APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling
errcardiovascular research
IF10.8
err2024-07-24
err3
PREAI
errLiu, Ziyi; Liu, Yu; Yu, Zhiyun; Tan, Cheng; Pek, Nicole; O'Donnell, Anna; Wu, Angeline; Glass, Ian; Winlaw, David S.; Guo, Minzhe; Spence, Jason R.; Chen, Ya-Wen; Yutzey, Katherine E.; Miao, Yifei; Gu, Mingxia
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GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function
errMOLECULAR CANCER RESEARCH
IF4.7
err2024-07-17
err0
PREAI
errRay, Paramita; Jaiswal, Sangeeta; Ferrer-Torres, Daysha; Wang, Zhuwen; Nancarrow, Derek; Curtin, Meghan; Martinho, May San; Lacy, Shannon M.; Kasturirangan, Srimathi; Thomas, Dafydd; Spence, Jason R.; Truttmann, Matthias C.; Lagisetty, Kiran H.; Lawrence, Theodore S.; Wang, Thomas D.; Beer, David G.; Ray, Dipankar
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Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-05-01
err0
PREAI
errLi, Jiapeng; Jorge, Daniel Macedo de Melo; Wang, Weiwen; Sun, Shuxin; Frum, Tristan; Hang, Yu-An; Liu, Yueting; Zhou, Xingwu; Xiao, Jingcheng; Wang, Xinwen; Spence, Jason R.; Wobus, Christiane E.; Zhu, Hao-Jie
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errSave
Near-Infrared In Vivo Imaging of Claudin-1 Expression by Orthotopically Implanted Patient-Derived Colonic Adenoma Organoids
errDIAGNOSTICS
IF3.3
err2024-01-26
err0
errOAAI
errJaiswal, Sangeeta; Wang, Fa; Wu, Xiaoli; Chang, Tse-Shao; Shirazi, Ahmad; Lee, Miki; Dame, Michael K.; Spence, Jason R.; Wang, Thomas D.
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errSave
Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection
errJOURNAL OF VIROLOGY
IF3.8
err2023-12-21
err1
errOAAI
errCunha, Juliana Bragazzi; Leix, Kyle; Sherman, Emily J.; Mirabelli, Carmen; Frum, Tristan; Zhang, Charles J.; Kennedy, Andrew A.; Lauring, Adam S.; Tai, Andrew W.; Sexton, Jonathan Z.; Spence, Jason R.; Wobus, Christiane E.; Emmer, Brian T.
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errSave
IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis
errJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
IF11.2
err2023-12-01
err12
PREAI
errMarella, Sahiti; Sharma, Ankit; Ganesan, Varsha; Ferrer-Torres, Daysha; Krempski, James W.; Idelman, Gila; Clark, Sydney; Nasiri, Zena; Vanoni, Simone; Zeng, Chang; Dlugosz, Andrej A.; Zhou, Haibin; Wang, Shaomeng; Doyle, Alfred D.; Wright, Benjamin L.; Spence, Jason R.; Chehade, Mirna; Hogan, Simon P.
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Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
errCELL STEM CELL
IF20.4
err2023-11-01
err14
errOAAI
errMunera, Jorge O.; Kechele, Daniel O.; Bouffi, Carine; Qu, Na; Jing, Ran; Maity, Pritiprasanna; Enriquez, Jacob R.; Han, Lu; Campbell, Ian; Mahe, Maxime M.; Mccauley, Heather A.; Zhang, Xinghao; Sundaram, Nambirajan; Hudson, Jonathan R.; Zarsozo-Lacoste, Adrian; Pradhan, Suman; Tominaga, Kentaro; Sanchez, J. Guillermo; Weiss, Alison A.; Chatuvedi, Praneet; Spence, Jason R.; Hachimi, Mariam; North, Trista; Daley, George Q.; Mayhew, Christopher N.; Hu, Yueh-Chiang; Takebe, Takanori; Helmrath, Michael A.; Wells, James M.
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errSave
Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model
errBMC GENOMICS
IF3.7
err2023-10-26
err2
errOAAI
errHung, Yu-Han; Capeling, Meghan; Villanueva, Jonathan W.; Kanke, Matt; Shanahan, Michael T.; Huang, Sha; Cubitt, Rebecca; Rinaldi, Vera D.; Schimenti, John C.; Spence, Jason R.; Sethupathy, Praveen
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errSave
Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung
errNPJ REGENERATIVE MEDICINE
IF6.5
err2023-09-09
err5
errOAAI
errFrum, Tristan; Hsu, Peggy P.; Hein, Renee F. C.; Conchola, Ansley S.; Zhang, Charles J.; Utter, Olivia R.; Anand, Abhinav; Zhang, Yi; Clark, Sydney G.; Glass, Ian; Sexton, Jonathan Z.; Spence, Jason R.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Gabriel Núñez
H-index: 152 · Papers: 519
B
Brian G. Feagan
H-index: 136 · Papers: 1.3K
G
George Q. Daley
H-index: 128 · Papers: 640
K
Klaus H. Kaestner
H-index: 126 · Papers: 602
K
Kristian Helin
H-index: 119 · Papers: 447
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