Not logged in Highly potent quinoxalinediones inhibit a-hemolysin and ameliorate Staphylococcus aureus lung infections Shekhar, Aditya; Di Lucrezia, Raffaella; Jerye, Karoline; Korotkov, Vadim S.; Harmrolfs, Kirsten; Rox, Katharina; Weich, Herbert A.; Ghai, Ishan; Delhommel, Florent; Becher, Isabelle; Degenhart, Carsten; Fansa, Eyad; Unger, Anke; Habenberger, Peter; Klebl, Bert; Lukat, Peer; Schmelz, Stefan; Henke, Steffi; Borgert, Sebastian; Lang, Julia C.; Sasse, Florenz; Diestel, Randi; Richter, Clementine; Schneider-Daum, Nicole; Hinkelmann, Bettina; Niemz, Jana; Lehr, Claus-Michael; Jaensch, Lothar; Huehn, Jochen; Alm, Richard; Savitski, Mikhail; Welte, Tobias; Hesterkamp, Thomas; Sattler, Michael; Winterhalter, Mathias; Blankenfeldt, Wulf; Medina, Eva; Bilitewski, Ursula; Dinkel, Klaus; Broenstrup, Mark Share Save
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Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity Abdelsamie, Ahmed S.; Hamed, Mostafa M.; Schuetz, Christian; Roehrig, Teresa; Kany, Andreas M.; Schmelz, Stefan; Blankenfeldt, Wulf; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
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The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes Schwanke, Hella; Goncalves Magalhaes, Vladimir; Schmelz, Stefan; Wyler, Emanuel; Hennig, Thomas; Guenther, Thomas; Grundhoff, Adam; Doelken, Lars; Landthaler, Markus; van Ham, Marco; Jaensch, Lothar; Buessow, Konrad; van den Heuvel, Joop; Blankenfeldt, Wulf; Friedel, Caroline C.; Erhard, Florian; Brinkmann, Melanie M. Share Save
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle Hamed, Mostafa M.; Abdelsamie, Ahmed S.; Rox, Katharina; Schuetz, Christian; Kany, Andreas M.; Roehrig, Teresa; Schmelz, Stefan; Blankenfeldt, Wulf; Arce-Rodriguez, Alejandro; Borrero-de Acuna, Jose Manuel; Jahn, Dieter; Rademacher, Jessica; Ringshausen, Felix C.; Cramer, Nina; Tuemmler, Burkhard; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin Share Save
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa Borgert, Sebastian Roman; Henke, Steffi; Witzgall, Florian; Schmelz, Stefan; Lage, Susanne zur; Hotop, Sven-Kevin; Stephen, Steffi; Luebken, Dennis; Krueger, Jonas; Gomez, Nicolas Oswaldo; van Ham, Marco; Jaensch, Lothar; Kalesse, Markus; Pich, Andreas; Broenstrup, Mark; Haeussler, Susanne; Blankenfeldt, Wulf Share Save
Divergent synthesis and biological evaluation of 2-(trifluoromethyl) pyridines as virulence-attenuating inverse agonists targeting PqsR Schutz, Christian; Hodzic, Amir; Hamed, Mostafa; Abdelsamie, Ahmed S.; Kany, Andreas M.; Bauer, Maximilian; Rohrig, Teresa; Schmelz, Stefan; Scrima, Andrea; Blankenfeldt, Wulf; Empting, Martin Share Save
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms Schuetz, Christian; Ho, Duy-Khiet; Hamed, Mostafa Mohamed; Abdelsamie, Ahmed Saad; Roehrig, Teresa; Herr, Christian; Kany, Andreas Martin; Rox, Katharina; Schmelz, Stefan; Siebenbuerger, Lorenz; Wirth, Marius; Boerger, Carsten; Yahiaoui, Samir; Bals, Robert; Scrima, Andrea; Blankenfeldt, Wulf; Horstmann, Justus Constantin; Christmann, Rebekka; Murgia, Xabier; Koch, Marcus; Berwanger, Aylin; Loretz, Brigitta; Hirsch, Anna Katharina Herta; Hartmann, Rolf Wolfgang; Lehr, Claus-Michael; Empting, Martin Share Save
Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence Zender, Michael; Witzgall, Florian; Kiefer, Alexander; Kirsch, Benjamin; Maurer, Christine K.; Kany, Andreas M.; Xu, Ningna; Schmelz, Stefan; Boerger, Carsten; Blankenfeldt, Wulf; Empting, Martin Share Save
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Structure of the Dispase Autolysis-inducing Protein from Streptomyces mobaraensis and Glutamine Cross-linking Sites for Transglutaminase Fiebig, David; Schmelz, Stefan; Zindel, Stephan; Ehret, Vera; Beck, Jan; Ebenig, Aileen; Ehret, Marina; Froels, Sabrina; Pfeifer, Felicitas; Kolmar, Harald; Fuchsbauer, Hans-Lothar; Scrima, Andrea Share Save
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Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation Siegmund, Vanessa; Schmelz, Stefan; Dickgiesser, Stephan; Beck, Jan; Ebenig, Aileen; Fittler, Heiko; Frauendorf, Holm; Piater, Birgit; Betz, Ulrich A. K.; Avrutina, Olga; Scrima, Andrea; Fuchsbauer, Hans-Lothar; Kolmar, Harald Share Save
In situ structural analysis of the Yersinia enterocolitica injectisome Kudryashev, Mikhail; Stenta, Marco; Schmelz, Stefan; Amstutz, Marlise; Wiesand, Ulrich; Castano-Diez, Daniel; Degiacomi, Matteo T.; Muennich, Stefan; Bleck, Christopher K. E.; Kowal, Julia; Diepold, Andreas; Heinz, Dirk W.; Dal Peraro, Matteo; Cornelis, Guy R.; Stahlberg, Henning Share Save
High Affinity Peptide Inhibitors of the Hepatitis C Virus NS3-4A Protease Refractory to Common Resistant Mutants Kuegler, Jonas; Schmelz, Stefan; Gentzsch, Juliane; Haid, Sibylle; Pollmann, Erik; van den Heuvel, Joop; Franke, Raimo; Pietschmann, Thomas; Heinz, Dirk W.; Collins, John Share Save
Braces for the Peptide Backbone: Insights into Structure-Activity Relationships of Protease Inhibitor Mimics with Locked Amide Conformations Tischler, Marco; Nasu, Daichi; Empting, Martin; Schmelz, Stefan; Heinz, Dirk W.; Rottmann, Philipp; Kolmar, Harald; Buntkowsky, Gerd; Tietze, Daniel; Avrutina, Olga Share Save
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