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Frank Sicheri

Lunenfeld-Tanenbaum Research Institute

72H-index
280Paper Count
2.1WCitation Count
Published Papers 111
Publication Date
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Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c
errCommunications Chemistry
IF6.2
err2026-06-27
err0
errOAAI
errPavel Mader; Linshan Liu; Frédéric Vallée; Francois Denis; Victor Pau; Daniel Mao; Lauren Caldwell; Kin Chan; Igor Kurinov; Yael Mamane; Paranjay Parikh; Zemin Zhang; Michel Gallant; Mike Tyers; W. Cameron Black; Michael Zinda; Daniel Durocher; Jeff Wrana; Michal Zimmermann; Frank Sicheri
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The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4
errNature Chemical Biology
IF13.7
err2026-04-09
err0
PREAI
errChetan K. Chana; Ines Ben Makhlouf; Jaeyoun Kim; April J. Y. Yu; Nathalie Moatti; Stephen Orlicky; Cassandra J. Wong; Leon Baronijan; XiaoJing Tang; Daniel Mao; Brett Larsen; Laura McGary; Brendon Seale; Pavel Mader; Derek F. Ceccarelli; Philip Barbulescu; Alberto Martin; Daniel Durocher; Laurence Pelletier; Anne-Claude Gingras; Frank Sicheri
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Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-03-31
err0
PREAI
errDavid Smil; Yong Liu; Tao Xin; Taira Kiyota; Ahmed Aman; Julie Grouleff; Laurent Hoffer; Dhananjay C. Joshi; Mohammad R. Inanlou; Siyuan Song; Daniel Y.L. Mao; Abiodun A. Ogunjimi; Victor Pau; Fiona D. Chini; Igor Kurinov; Ying Zhang; Anh Thu Nguyen; Jeffrey L. Wrana; Frank Sicheri; Liliana Attisano
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WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
errNature Communications
IF15.7
err2025-11-24
err0
errOAAI
errRinskje B. Tjeerdsma; Timothy F. Ng; Maurits Roorda; Daniëlle Bianchi; Sora Yang; Clara Bonnet; Michael VanInsberghe; Marieke Everts; Femke J. Bakker; H. Rudolf de Boer; Nathalie Moatti; Nicole Hustedt; Jay Z Yin; Lisa Hoeg; Matthew Leibovitch; Frank Sicheri; Alexander van Oudenaarden; Steven de Jong; Jeroen van den Berg; Marvin E. Tanenbaum; Thijn R. Brummelkamp; Daniel Durocher; Marcel A.T.M. van Vugt
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Phosphorylation as a candidate regulatory mechanism for effector recruitment to tankyrase
errROYAL SOCIETY OPEN SCIENCE
IF2.9
err2025-10-15
err0
PREAI
errBroadway, Benjamin J.; Pollock, Katie; Cronin, Nora; Rottapel, Robert; Sicheri, Frank; Guettler, Sebastian
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Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates
errComputational and Structural Biotechnology Journal
IF4.1
err2025-09-11
err0
errOAAI
errElliot Sicheri; Daniel Mao; Michael Tyers; Frank Sicheri
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Author Correction: Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32
errNature Communications
IF15.7
err2025-07-24
err0
errOAAI
errSamara Mishelle Ona Chuquimarca; Jonah Beenstock; Salima Daou; Jennifer Porat; Alexander F. A. Keszei; Jay Z. Yin; Tobias Beschauner; Mark A. Bayfield; Mohammad T. Mazhab-Jafari; Frank Sicheri
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Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-05-16
err0
PREAI
errVallee, Frederic; Casas-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar; Suarez, Catalina; Sangiorgi, Bruno; Li, Li; Hyer, Marc; Papp, Robert; Leclaire, Marie-Eve; Perryman, Alexander L.; Liu, Bingcan; Surprenant, Simon; Mochirian, Philippe; Pau, Victor; Maderova, Zdenka; Mader, Pavel; Yin, Shou Yun; Goodfellow, Elliot; Roulston, Anne; Stocco, Rino; Godbout, Claude; Baruah, Prasamit; Bonneau-Fortin, Alexanne; Schonhoft, Joseph D.; Nejad, Parham; Norman, David; Truong, Vouy Linh; Crane, Sheldon; Attia, Mohamed A.; Mao, Daniel; Sicheri, Frank; Marshall, C. Gary; Zimmermann, Michal; Bendahan, David; Gallant, Michel; Black, W. Cameron
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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark (Expression of Concern of 10.1038/NATURE12318)
errNATURE
IF48.5
err2025-01-29
err0
PREAI
errFradet-Turcotte, Amelie; Canny, Marella D.; Escribano-Diaz, Cristina; Orthwein, Alexandre; Leung, Charles C. Y.; Huang, Hao; Landry, Marie-Claude; Kitevski-LeBlanc, Julianne; Noordermeer, Sylvie M.; Sicheri, Frank; Durocher, Daniel
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Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32
errNATURE COMMUNICATIONS
IF15.7
err2024-12-05
err0
errOAAI
errChuquimarca, Samara Mishelle Ona; Beenstock, Jonah; Daou, Salima; Porat, Jennifer; Keszei, Alexander F. A.; Yin, Jay Z.; Beschauner, Tobias; Bayfield, Mark A.; Mazhab-Jafari, Mohammad T.; Sicheri, Frank
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A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin
errBIOCONJUGATE CHEMISTRY
IF3.9
err2024-08-21
err0
errOAAI
errKoszela, Joanna; Pham, Nhan T.; Shave, Steven; St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Steven; Marinier, Anne; Sicheri, Frank; Tyers, Mike; Auer, Manfred
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The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-02-22
err0
errOAAI
errMaisonneuve, Pierre; Sahmi, Malha; Bergeron-Labrecque, Fanny; Ma, Xianjie Iris; Queguiner, Juliette; Arseneault, Genevieve; Lefrancois, Martin; Kurinov, Igor; Fronzes, Remi; Sicheri, Frank; Therrien, Marc
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Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of eph receptors
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err198
errOAAI
errBinns, KL; Taylor, PP; Sicheri, F; Pawson, T; Holland, SJ
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PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2α
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err78
errOAAI
errDey, M; Trieselmann, B; Locke, EG; Lu, JF; Cao, C; Dar, AC; Krishnamoorthy, T; Dong, JS; Sicheri, F; Dever, TE
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High Accuracy Prediction of PROTAC Complex Structures
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-03-24
err17
PREAI
errIgnatov, Mikhail; Jindal, Akhil; Kotelnikov, Sergei; Beglov, Dmitri; Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Poda, Gennady; Batey, Robert A.; Sicheri, Frank; Whitty, Adrian; Tonge, Peter J.; Vajda, Sandor; Kozakov, Dima
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SCFCdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-21
err18
errOAAI
errLiu, Qingquan; Larsen, Brett; Ricicova, Marketa; Orlicky, Stephen; Tekotte, Hille; Tang, Xiaojing; Craig, Karen; Quiring, Adam; Le Bihan, Thierry; Hansen, Carl; Sicheri, Frank; Tyers, Mike
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Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err84
errOAAI
errKeszei, Alexander F. A.; Tang, Xiaojing; McCormick, Craig; Zeqiraj, Elton; Rohde, John R.; Tyers, Mike; Sicheri, Frank
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A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay
errSCIENTIFIC REPORTS
IF3.9
err2023-03-08
err1
errOAAI
errAlexander-Howden, Beatrice; Zhang, Li; van der Sloot, Almer M.; Tollis, Sylvain; St-Cyr, Daniel J.; Sicheri, Frank; Bird, Adrian P.; Tyers, Mike; Lyst, Matthew J.
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SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination
errEMBO REPORTS
IF6.2
err2022-10-24
err7
errOAAI
errO'Brien, Siobhan; Kelso, Susan; Steinhart, Zachary; Orlicky, Stephen; Mis, Monika; Kim, Yunhye; Lin, Sichun; Sicheri, Frank; Angers, Stephane
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Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-09-20
err34
errOAAI
errBubenik, Monica; Mader, Pavel; Mochirian, Philippe; Vallee, Frederic; Clark, Jillian; Truchon, Jean-Francois; Perryman, Alexander L.; Pau, Victor; Kurinov, Igor; Zahn, Karl E.; Leclaire, Marie-Eve; Papp, Robert; Mathieu, Marie-Claude; Hamel, Martine; Duffy, Nicole M.; Godbout, Claude; Casas-Selves, Matias; Falgueyret, Jean-Pierre; Baruah, Prasamit S.; Nicolas, Olivier; Stocco, Rino; Poirier, Hugo; Martino, Giovanni; Fortin, Alexanne Bonneau; Roulston, Anne; Chefson, Amandine; Dorich, Stephane; St-Onge, Miguel; Patel, Purvish; Pellerin, Charles; Ciblat, Stephane; Pinter, Thomas; Barabe, Francis; El Bakkouri, Majida; Parikh, Paranjay; Gervais, Christian; Sfeir, Agnel; Mamane, Yael; Morris, Stephen J.; Black, W. Cameron; Sicheri, Frank; Gallant, Michel
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Research Directions

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Co-authors
Cooperation Journals
H
Hans Clevers
H-index: 236 · Papers: 1.3K
A
Alain Fischer
H-index: 157 · Papers: 1.2K
T
Tony Pawson
H-index: 157 · Papers: 751
A
Albert J. R. Heck
H-index: 132 · Papers: 1.2K
D
David Ron
H-index: 130 · Papers: 421
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