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Laurence Fayadat‐Dilman

Merck & Co., Inc.

14H-index
41Paper Count
1.0KCitation Count
Published Papers 26
Publication Date
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Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable; Low-Aggregating; and Highly Efficacious Antibody-Drug Conjugates
errJournal of Medicinal Chemistry
IF6.8
err2026-04-30
err0
PREAI
errRyan V. Quiroz; Simon B. Lang; Rebecca E. Johnson; Nancy Zepeda; Vlad Bacauanu; Christian L. Morales; Manoj Charati; John A. Flygare; Olivia R. Chastain; Zhong L. Hua; Edward P. Bowman; Bernhard H. Geierstanger; Alycia K. Uyeoka; Fan Zhang; Huimin Zhong; Esther Kofman; Daniela M. Tomazela; Laurence Fayadat-Dilman; Mengxuan Jia; Michael Judo; Ian Knemeyer; Peyman Akbari; Qingyun Yan; Evan R. Barry; Alan B. Northrup; W. Michael Seganish
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Discovery of Novel N-Linked Camptothecin Linker-Payloads to Access Antibody–Drug Conjugates with High Target-Mediated In Vivo Efficacy
errJournal of Medicinal Chemistry
IF6.8
err2026-04-30
err0
PREAI
errVlad Bacauanu; Si-Jie Chen; Simon B. Lang; Christian L. Morales; Nancy Zepeda; Manoj Charati; John A. Flygare; Rebecca E. Johnson; Ryan V. Quiroz; Song Yang; Olivia R. Chastain; Zhong L. Hua; Edward P. Bowman; Bernhard H. Geierstanger; Daniela M. Tomazela; Esther Kofman; Alycia K. Uyeoka; Fan Zhang; Laurence Fayadat-Dilman; Mengxuan Jia; Michael Judo; Ian Knemeyer; Peyman Akbari; Qingyun Yan; Evan R. Barry; Alan B. Northrup; W. Michael Seganish
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Harnessing Design of Experiments and Automation Significantly Improves Transient Protein Production in Chinese Hamster Ovary Cells and Accelerates Drug Discovery
errNew Biotechnology
IF4.9
err2026-01-20
err0
errOAAI
errJing Ke; Mandy Li; Sultan Yilmaz; Yan Liu; Hang Thi Thu Nguyen; Pamela Zhang; Laurence Fayadat-Dilman; Jeanne E. Baker
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Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates
errPharmaceutics 2025, Vol. 17, Page 1568
IF5.5
err2025-12-05
err0
errOAAI
errMaru Jaime-Garza; Andrew Waight; Manish Hudlikar; Michael J. Eddins; Elnaz S. Rasti; Jan Paulo T. Zaragoza; Laurence Fayadat-Dilman; Jill E. Chrencik; Sandra B. Gabelli; Yun-Ting Chen; Cameron L. Noland
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Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening
errmAbs
IF7.3
err2025-05-10
err0
errOAAI
errKevin James Metcalf; Galen Wo; Jan Paulo Zaragoza; Fahimeh Raoufi; Jeanne Baker; Daoyang Chen; Mehabaw Derebe; Jason Hogan; Amy Hsu; Esther Kofman; David Leigh; Mandy Li; Dan Malashock; Cate Mann; Soha Motlagh; Jihea Park; Karthik Sathiyamoorthy; Madhura Shidhore; Yinyan Tang; Kevin Teng; Katharine Williams; Andrew Waight; Sultan Yilmaz; Fan Zhang; Huimin Zhong; Laurence Fayadat-Dilman; Marc Bailly
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Novel Native Reversed-Phase Liquid Chromatography (nRPLC)/MS for Antibody-Drug Conjugates (ADCs) Characterization and Drug-Antibody Ratio (DAR) Assessment
errANALYTICAL CHEMISTRY
IF6.7
err2025-03-31
err0
PREAI
errMa, Fengfei; Sanchez, A. Carl; Song, James; Kofman, Esther; Tomazela, Daniela; Fayadat-Dilman, Laurence; Hettiarachchi, Kanaka; Al-Sayah, Mohammad Ahmed
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Characterizing Monoclonal Antibody Aggregation Using Charge Detection Mass Spectrometry and Industry Standard Methods
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2025-03-01
err0
PREAI
errJordan, Jacob S.; Harper, Conner C.; Zhang, Fan; Kofman, Esther; Sam, Miranda; Zaragoza, Jan Paulo; Bhagwat, Bhagyashree; Fayadat-Dilman, Laurence; Williams, Evan R.
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An Integrated Strategy to Identify Tyrosine Sulfation from the Therapeutic Proteins
errJOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
IF2.7
err2024-09-26
err0
PREAI
errJang, Eunju; Ma, Fengfei; Tomazela, Daniela; Fayadat-Dilman, Laurence; Al-Sayah, Mohammad Ahmed
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Charge Detection Mass Spectrometry Reveals Conformational Heterogeneity in Megadalton-Sized Monoclonal Antibody Aggregates
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-08-07
err2
PREAI
errJordan, Jacob S.; Harper, Conner C.; Zhang, Fan; Kofman, Esther; Li, Mandy; Sathiyamoorthy, Karthik; Zaragoza, Jan Paulo; Fayadat-Dilman, Laurence; Williams, Evan R.
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A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties
errMABS
IF7.3
err2023-08-23
err9
errOAAI
errWaight, Andrew B.; Prihoda, David; Shrestha, Rojan; Metcalf, Kevin; Bailly, Marc; Ancona, Marco; Widatalla, Talal; Rollins, Zachary; Cheng, Alan C.; Bitton, Danny A.; Fayadat-Dilman, Laurence
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Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry
errMABS
IF7.3
err2023-06-28
err6
errOAAI
errXu, Tian; Zhang, Fan; Chen, Daoyang; Sun, Liangliang; Tomazela, Daniela; Fayadat-Dilman, Laurence
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Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-05-04
err4
errOAAI
errPande, Kalyan; Hollingsworth, Scott A.; Sam, Miranda; Gao, Qinshan; Singh, Sujata; Saha, Anasuya; Vroom, Karin; Ma, Xiaohong Shirley; Brazell, Tres; Gorman, Dan; Chen, Shi-Juan; Raoufi, Fahimeh; Bailly, Marc; Grandy, David; Sathiyamoorthy, Karthik; Zhang, Lan; Thompson, Rob; Cheng, Alan C.; Fayadat-Dilman, Laurence; Geierstanger, Bernhard H.; Kingsley, Laura J.
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BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning
errMABS
IF7.3
err2022-02-08
err71
errOAAI
errPrihoda, David; Maamary, Jad; Waight, Andrew; Juan, Veronica; Fayadat-Dilman, Laurence; Svozil, Daniel; Bitton, Danny A.
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Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action (vol 4, 927, 2021)
errCOMMUNICATIONS BIOLOGY
IF5.1
err2021-11-15
err0
errOAAI
errPalte, Rachel L.; Juan, Veronica; Gomez-Llorente, Yacob; Bailly, Marc Andre; Chakravarthy, Kalyan; Chen, Xun; Cipriano, Daniel; Fayad, Ghassan N.; Fayadat-Dilman, Laurence; Gathiaka, Symon; Greb, Heiko; Hall, Brian; Handa, Mas; Hsieh, Mark; Kofman, Esther; Lin, Heping; Miller, J. Richard; Nguyen, Nhung; O'Neil, Jennifer; Shaheen, Hussam; Sterner, Eric; Strickland, Corey; Sun, Angie; Taremi, Shane; Scapin, Giovanna
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Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
errMABS
IF7.3
err2021-11-08
err17
errOAAI
errLai, Pin-Kuang; Ghag, Gaurav; Yu, Yao; Juan, Veronica; Fayadat-Dilman, Laurence; Trout, Bernhardt L.
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Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction
errANTIBODIES
IF2.7
err2021-02-15
err12
errOAAI
errMieczkowski, Carl; Cheng, Alan; Fischmann, Thierry; Hsieh, Mark; Baker, Jeanne; Uchida, Makiko; Raghunathan, Gopalan; Strickland, Corey; Fayadat-Dilman, Laurence
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Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies
errANTIBODIES
IF2.7
err2020-11-22
err4
errOAAI
errMieczkowski, Carl; Bahmanjah, Soheila; Yu, Yao; Baker, Jeanne; Raghunathan, Gopalan; Tomazela, Daniela; Hsieh, Mark; McCoy, Mark; Strickland, Corey; Fayadat-Dilman, Laurence
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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2020-06-02
err16
errOAAI
errHutchins, Beth; Starling, Gary C.; McCoy, Mark A.; Herzyk, Danuta; Poulet, Frederique M.; Dulos, John; Liu, Liming; Kang, Soonmo Peter; Fayadat-Dilman, Laurence; Hsieh, Mark; Andrews, Christine L.; Ayanoglu, Gulesi; Cullen, Constance; Malefyt, Rene de Waal; Kastelein, Robert A.; Le Saux, Sabine; Lee, Julie; Li, Sophie; Malashock, Dan; Sadekova, Svetlana; Soder, George; van Eenennaam, Hans; Willingham, Aarron; Yu, Ying; Streuli, Michel; Carven, Gregory J.; van Elsas, Andrea
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Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
errMABS
IF7.3
err2020-05-20
err30
errOAAI
errMa, Fengfei; Raoufi, Fahimeh; Bailly, Marc Andre; Fayadat-Dilman, Laurence; Tomazela, Daniela
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Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
errMABS
IF7.3
err2020-04-05
err148
errOAAI
errBailly, Marc; Mieczkowski, Carl; Juan, Veronica; Metwally, Essam; Tomazela, Daniela; Baker, Jeanne; Uchida, Makiko; Kofman, Ester; Raoufi, Fahimeh; Motlagh, Soha; Yu, Yao; Park, Jihea; Raghava, Smita; Welsh, John; Rauscher, Michael; Raghunathan, Gopalan; Hsieh, Mark; Chen, Yi-Ling; Nguyen, Hang Thu; Nguyen, Nhung; Cipriano, Dan; Fayadat-Dilman, Laurence
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Research Directions

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Co-authors
Cooperation Journals
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王巍 (Wei Wang)
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Evan R. Williams
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René de Waal Malefyt
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David K. Grandy
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