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Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation Coassolo, Sebastien; Michaelian, Nairie; Maculins, Timurs; Azumaya, Caleigh M.; Cheung, Tommy K.; Yin, Jianping; Zilberleyb, Inna; Pahuja, Kanika Bajaj; Garner, Thomas; Lau, Ted; Mau, Davis; Grimmer, Matthew; Fortin, Jean-Philippe; Costa, Mike; Dimitrova, Yoana N.; Rose, Christopher M.; Hsu, Peter L.; Yauch, Robert L. Share Save
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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models (vol 67, pg 1262, 2024) Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Crew, Andrew P.; Davenport, Kim; Dinicola, Dean; Dong, Hanqing; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Gan; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S. Share Save
Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs Zhang, Donglu; Ma, Bin; Dragovich, Peter S.; Ma, Li; Chen, Shu; Chen, Eugene C.; Ye, Xiaofen; Liu, Joyce; Pizzano, Jennifer; Bortolon, Elizabeth; Chan, Emily; Zhang, Xing; Chen, Yi-Chen; Levy, Elizabeth S.; Yauch, Robert L.; Khojasteh, S. Cyrus; Hop, Cornelis E. C. A. Share Save
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Davenport, Kim; DiNicola, Dean; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S. Share Save
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats Maher, Jonathan; Stagg, Nicola; Cain, Gary; Andaya, Roxanne; Katavolos, Paula; Gallardo-Chang, Fermin; Pham, Anna; Ye, Xiaofen; Januario, Tom; Alcantar, Tuija; Caothien, Roger; Roose-Girma, Merone; Zhang, Donglu; Li, Ruina; Chen, Shu; Yauch, Robert L. Share Save
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma Yao, Xiaosai; Hong, Jing Han; Nargund, Amrita M.; Ng, Michelle Shu Wen; Heng, Hong Lee; Li, Zhimei; Guan, Peiyong; Sugiura, Masahiro; Chu, Pek Lim; Wang, Loo Chien; Ye, Xiaofen; Qu, James; Kwek, Xiu Yi; Lim, Jeffrey Chun Tatt; Ooi, Wen Fong; Koh, Joanna; Wang, Zhenxun; Pan, You-Fu; Ong, Yan Shan; Tan, Kiat-Yi; Goh, Jian Yuan; Ng, Sheng Rong; Pignata, Luca; Huang, Dachuan; Lezhava, Alexander; Tay, Su Ting; Lee, Minghui; Yeo, Xun Hui; Tam, Wai Leong; Rha, Sun Young; Li, Shang; Guccione, Ernesto; Futreal, Andrew; Tan, Jing; Yeong, Joe Poh Sheng; Hong, Wanjin; Yauch, Robert; Chang, Kenneth Tou-En; Sobota, Radoslaw M.; Tan, Patrick; Teh, Bin Tean Share Save
PBRM1-deficient PBAF complexes target de novo genomic loci to activate NF-κB pathway in clear cell renal cell carcinoma Yao, Xiaosai; Hong, Jing Han; Nargund, Amrita; Ng, Michelle Shu Wen; Heng, Hong Lee; Li, Zhimei; Guan, Peiyong; Sugiura, Masahiro; Chu, Pek Lim; Wang, Loo Chien; Ye, Xiaofen; Yauch, Robert; Chang, Kenneth Tou-En; Sobota, Radoslaw M.; Tan, Patrick; Teh, Bin Tean Share Save
Exploratory analysis of hormone receptor-positive (HR plus ), human epidermal growth factor receptor 2-negative (HER-2) PIK3CA mutated (mut) advanced breast cancer (aBC) treated with taselisib (TAS) and/or fulvestrant (FUL) reveals increased CCNE2 expression with poor outcome to placebo (PBO) plus FUL but not TAS plus FUL in SANDPIPER Johnson, Radia M.; Liu, Bonnie; Cortes, Javier; Dent, Susan; Harbeck, Nadia; Krop, Ian E.; Jacot, William; Yauch, Robert L.; Stout, Thomas J.; Schimmoller, Frauke; Gendreau, Steven; Wilson, Timothy R. Share Save
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L. Share Save
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients Fernando, Tharu M.; Piskol, Robert; Bainer, Russell; Sokol, Ethan S.; Trabucco, Sally E.; Zhang, Qing; Trinh, Huong; Maund, Sophia; Kschonsak, Marc; Chaudhuri, Subhra; Modrusan, Zora; Januario, Thomas; Yauch, Robert L. Share Save
Characterization and therapeutic implications of SMARCA4 mutations in cancer Fernando, Tharu M.; Piskol, Robert; Bainer, Russell; Sokol, Ethan; Trabucco, Sally; Zhang, Qing; Huong Trinh; Maund, Sophia; Kschonsak, Marc; Chaudhuri, Subhra; Januario, Tom; Modrusan, Zora; Yauch, Robert L. Share Save
Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models Berlin, Michael; Cantley, Jennifer; Wang, Jing; Bookbinder, Mark; Cadelina, Gregory; Chan, Emily; Chen, Huifen; Chen, Xin; Davenport, Kim; Fernando, Tharu; Gordon, Debbie; Hamman, Brian; Haskell, Roy; Ishchenko, Alexey; Kirkpatrick, Donald S.; Maher, Jonathan; Merchant, Mark; Moffat, John; Morgan, Alicia; Nguyen, An; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Sethuraman, Vijay; Staben, Leanna; Wilson, Catherine; Ye, Xiaofen; Broccatelli, Fabio; Yauch, Robert; Dragovich, Peter S. Share Save
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types Wagle, Marie-Claire; Kirouac, Daniel; Klijn, Christiaan; Liu, Bonnie; Mahajan, Shilpi; Junttila, Melissa; Moffat, John; Merchant, Mark; Huw, Ling; Wongchenko, Matthew; Okrah, Kwame; Srinivasan, Shrividhya; Mounir, Zineb; Sumiyoshi, Teiko; Haverty, Peter M.; Yauch, Robert L.; Yan, Yibing; Kabbarah, Omar; Hampton, Garret; Amler, Lukas; Ramanujan, Saroja; Lackner, Mark R.; Huang, Shih-Min A. Share Save
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PRC2 mediated repression of SMARCA2 predicts for EZH2 inhibitor activity in tumors with SWI/SNF mutations Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Solon, Margaret; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Koeppen, Hartmut; Yauch, Robert L. Share Save
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice Lau, Janet; Cheung, Jeanne; Navarro, Armando; Lianoglou, Steve; Haley, Benjamin; Totpal, Klara; Sanders, Laura; Koeppen, Hartmut; Caplazi, Patrick; McBride, Jacqueline; Chiu, Henry; Hong, Rebecca; Grogan, Jane; Javinal, Vincent; Yauch, Robert; Irving, Bryan; Belvin, Marcia; Mellman, Ira; Kim, Jeong M.; Schmidt, Maike Share Save
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