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SaveCovalent targeting of splicing in T cells
Scott, Kevin A.; Kojima, Hiroyuki; Ropek, Nathalie; Warren, Charles D.; Zhang, Tiffany L.; Hogg, Simon J.; Sanford, Henry; Webster, Caroline; Zhang, Xiaoyu; Rahman, Jahan; Melillo, Bruno; Cravatt, Benjamin F.; Lyu, Jiankun; Abdel-Wahab, Omar; Vinogradova, Ekaterina V. Share Save GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignanciesBenbarche, Salima; Pineda, Jose Mario Bello; Galvis, Laura Baquero; Biswas, Jeetayu; Liu, Bo; Wang, Eric; Zhang, Qian; Hogg, Simon J.; Lyttle, Kadeen; Dahi, Ariana; Lewis, Alexander M.; Saechi, Martina; Rahman, Jahan; Fox, Nina; Ai, Yuxi; Mehta, Sanjoy; Garippa, Ralph; Ortiz-Pacheco, Juliana; Li, Zhuoning; Monetti, Mara; Stanley, Robert F.; Doulatov, Sergei; Bradley, Robert K.; Abdel-Wahab, Omar Share Save PRMT1 acts as a suppressor of MHC-I and anti-tumor immunityDjajawi, Tirta M.; Pijpers, Lizzy; Srivaths, Akash; Chisanga, David; Chan, Kok Fei; Hogg, Simon J.; Neil, Liam; Rivera, Sarahi Mendoza; Bartonicek, Nenad; Ellis, Sarah L.; Sian, Terry C. C. Lim Kam; Faridi, Pouya; Liao, Yang; Pal, Bhupinder; Behren, Andreas; Shi, Wei; Vervoort, Stephin J.; Johnstone, Ricky W.; Kearney, Conor J. Share Save CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity (vol 42, 113014, 2023)House, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma V.; Tong, Junming; Nguyen, Datminh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A. Share Save Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemiaKnorr, Katherine; Rahman, Jahan; Erickson, Caroline; Wang, Eric; Monetti, Mara; Li, Zhuoning; Ortiz-Pacheco, Juliana; Jones, Andrew; Lu, Sydney X.; Stanley, Robert F.; Baez, Maria; Fox, Nina; Castro, Cynthia; Marino, Alessandra E.; Jiang, Caroline; Penson, Alex; Hogg, Simon J.; Mi, Xiaoli; Nakajima, Hideaki; Kunimoto, Hiroyoshi; Nishimura, Koutarou; Inoue, Daichi; Greenbaum, Benjamin; Knorr, David; Ravetch, Jeffrey; Abdel-Wahab, Omar Share Save E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trialBewersdorf, Jan Philipp; Stahl, Maximilian; Taylor, Justin; Mi, Xiaoli; Chandhok, Namrata Sonia; Watts, Justin; Derkach, Andriy; Wysocki, Mateusz; Lu, Sydney X.; Bourcier, Jessie; Hogg, Simon J.; Rahman, Jahan; Chaudhry, Sana; Totiger, Tulasigeri M.; Abdel-Wahab, Omar; Stein, Eytan M. Share Save Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphomaOh, Danielle H.; Ma, Xiao; Hogg, Simon J.; He, Jackson; Kearney, Conor; Brasacchio, Daniella; Susanto, Olivia; Maher, Belinda; Jennings, Ian G.; Newbold, Andrea; Fraser, Peter; Gruber, Emily; Kats, Lev M.; Gregory, Gareth P.; Johnstone, Ricky W.; Thompson, Philip E.; Shortt, Jake Share Save CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunityHouse, Imran G.; Derrick, Emily B.; Sek, Kevin; Chen, Amanda X. Y.; Li, Jasmine; Lai, Junyun; Todd, Kirsten L.; Munoz, Isabelle; Michie, Jessica; Chan, Cheok Weng; Huang, Yu-Kuan; Chan, Jack D.; Petley, Emma, V; Tong, Junming; Nguyen, DatMinh; Engel, Sven; Savas, Peter; Hogg, Simon J.; Vervoort, Stephin J.; Kearney, Conor J.; Burr, Marian L.; Lam, Enid Y. N.; Gilan, Omer; Bedoui, Sammy; Johnstone, Ricky W.; Dawson, Mark A.; Loi, Sherene; Darcy, Phillip K.; Beavis, Paul A. Share Save Proteomic discovery of chemical probes that perturb protein complexes in human cellsLazear, Michael R.; Remsberg, Jarrett R.; Jaeger, Martin G.; Rothamel, Katherine; Her, Hsuan-lin; DeMeester, Kristen E.; Njomen, Evert; Hogg, Simon J.; Rahman, Jahan; Whitby, Landon R.; Won, Sang Joon; Schafroth, Michael A.; Ogasawara, Daisuke; Yokoyama, Minoru; Lindsey, Garrett L.; Li, Haoxin; Germain, Jason; Barbas, Sabrina; Vaughan, Joan; Hanigan, Thomas W.; Vartabedian, Vincent F.; Reinhardt, Christopher J.; Dix, Melissa M.; Koo, Seong Joo; Heo, Inha; Teijaro, John R.; Simon, Gabriel M.; Ghosh, Brahma; Abdel-Wahab, Omar; Ahn, Kay; Saghatelian, Alan; Melillo, Bruno; Schreiber, Stuart L.; Yeo, Gene W.; Cravatt, Benjamin F. Share Save Pharmacologic modulation of RNA splicing enhances anti-tumor immunityThomas, James D.; Lu, Sydney X.; De Neef, Emma; Sabio, Erich; Rousseau, Benoit; Gigoux, Mathieu; Knorr, David A.; Greenbaum, Benjamin; Elhanati, Yuval; Hogg, Simon J.; Chow, Andrew; Ghosh, Arnab; Xie, Abigail; Zamarin, Dmitriy; Cui, Daniel; Erickson, Caroline; Singer, Michael; Cho, Hana; Wang, Eric; Lu, Bin; Durham, Benjamin H.; Shah, Harshal; Chowell, Diego; Gabel, Austin M.; Shen, Yudao; Liu, Jing; Jin, Jian; Rhodes, Matthew C.; Taylor, Richard E.; Molina, Henrik; Wolchok, Jedd D.; Merghoub, Taha; Diaz, Luis A., Jr.; Abdel-Wahab, Omar; Bradley, Robert K. Share Save NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemiaWitkowski, Matthew T.; Lee, Soobeom; Wang, Eric; Lee, Anna K.; Talbot, Alexis; Ma, Chao; Tsopoulidis, Nikolaos; Brumbaugh, Justin; Zhao, Yaqi; Roberts, Kathryn G.; Hogg, Simon J.; Nomikou, Sofia; Ghebrechristos, Yohana E.; Thandapani, Palaniraja; Mullighan, Charles G.; Hochedlinger, Konrad; Chen, Weiqiang; Abdel-Wahab, Omar; Eyquem, Justin; Aifantis, Iannis Share Save Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restrictionFujihara, Kenji M.; Zhang, Bonnie Z.; Jackson, Thomas D.; Ogunkola, Moses O.; Nijagal, Brunda; Milne, Julia, V; Sallman, David A.; Ang, Ching-Seng; Nikolic, Iva; Kearney, Conor J.; Hogg, Simon J.; Cabalag, Carlos S.; Sutton, Vivien R.; Watt, Sally; Fujihara, Asuka T.; Trapani, Joseph A.; Simpson, Kaylene J.; Stojanovski, Diana; Leimkuhler, Silke; Haupt, Sue; Phillips, Wayne A.; Clemons, Nicholas J. Share Save Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic TransformationChen, Sisi; Vedula, Rahul S.; Cuevas-Navarro, Antonio; Lu, Bin; Hogg, Simon J.; Wang, Eric; Benbarche, Salima; Knorr, Katherine; Kim, Won Jun; Stanley, Robert F.; Cho, Hana; Erickson, Caroline; Singer, Michael; Cui, Dan; Tittley, Steven; Durham, Benjamin H.; Pavletich, Tatiana S.; Fiala, Elise; Walsh, Michael F.; Inoue, Daichi; Monette, Sebastien; Taylor, Justin; Rosen, Neal; McCormick, Frank; Lindsley, R. Coleman; Castel, Pau; Abdel-Wahab, Omar Share Save Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancerHogg, Simon J.; Motorna, Olga; Kearney, Conor J.; Derrick, Emily B.; House, Imran G.; Todorovski, Izabela; Kelly, Madison J.; Zethoven, Magnus; Bromberg, Kenneth D.; Lai, Albert; Beavis, Paul A.; Shortt, Jake; Johnstone, Ricky W.; Vervoort, Stephin J. Share Save Share Save Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemiaSo, Joan; Lewis, Alexander C.; Smith, Lorey K.; Stanley, Kym; Franich, Rheana; Yoannidis, David; Pijpers, Lizzy; Dominguez, Pilar; Hogg, Simon J.; Vervoort, Stephin J.; Brown, Fiona C.; Johnstone, Ricky W.; McDonald, Gabrielle; Ulanet, Danielle B.; Murtie, Josh; Gruber, Emily; Kats, Lev M. Share Save Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphomaWong, Jonathan; Gruber, Emily; Maher, Belinda; Waltham, Mark; Sabouri-Thompson, Zahra; Jong, Ian; Luong, Quinton; Levy, Sidney; Kumar, Beena; Brasacchio, Daniella; Jia, Wendy; So, Joan; Skinner, Hugh; Lewis, Alexander; Hogg, Simon J.; Vervoort, Stephin; DiCorleto, Carmen; Uhe, Micheleine; Gamgee, Jeanette; Opat, Stephen; Gregory, Gareth P.; Polekhina, Galina; Reynolds, John; Hawkes, Eliza A.; Kailainathan, Gajan; Gasiorowski, Robin; Kats, Lev M.; Shortt, Jake Share Save Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AMLSalmon, Jessica M.; Todorovski, Izabela; Stanley, Kym L.; Bruedigam, Claudia; Kearney, Conor J.; Martelotto, Luciano G.; Rossello, Fernando; Semple, Timothy; Arnau, Gisela Mir; Zethoven, Magnus; Bots, Michael; Bjelosevic, Stefan; Cluse, Leonie A.; Fraser, Peter J.; Litalien, Veronique; Vidacs, Eva; McArthur, Kate; Matthews, Antony Y.; Gressier, Elise; de Weerd, Nicole A.; Lichte, Jens; Kelly, Madison J.; Hogg, Simon J.; Hertzog, Paul J.; Kats, Lev M.; Vervoort, Stephin J.; De Carvalho, Daniel D.; Scheu, Stefanie; Bedoui, Sammy; Kile, Benjamin T.; Lane, Steven W.; Perkins, Andrew C.; Wei, Andrew H.; Dominguez, Pilar M.; Johnstone, Ricky W. Share Save Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibitionHogg, Simon J.; Motorna, Olga; Cluse, Leonie A.; Johanson, Timothy M.; Coughlan, Hannah D.; Raviram, Ramya; Myers, Robert M.; Costacurta, Matteo; Todorovski, Izabela; Pijpers, Lizzy; Bjelosevic, Stefan; Williams, Tobias; Huskins, Shannon N.; Kearney, Conor J.; Devlin, Jennifer R.; Fan, Zheng; Jabbari, Jafar S.; Martin, Ben P.; Fareh, Mohamed; Kelly, Madison J.; Dupere-Richer, Daphne; Sandow, Jarrod J.; Feran, Breon; Knight, Deborah; Khong, Tiffany; Spencer, Andrew; Harrison, Simon J.; Gregory, Gareth; Wickramasinghe, Vihandha O.; Webb, Andrew, I; Taberlay, Phillippa C.; Bromberg, Kenneth D.; Lai, Albert; Papenfuss, Anthony T.; Smyth, Gordon K.; Allan, Rhys S.; Licht, Jonathan D.; Landau, Dan A.; Abdel-Wahab, Omar; Shortt, Jake; Vervoort, Stephin J.; Johnstone, Ricky W. Share Save 
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