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SaveNeuropilin Antagonists (NRPas) Block the Phosphorylation of the Cancer Therapeutic Key Factor p38α Kinase Triggering Cell Death
Borriello, Lucia; Jarray, Rafika; Rignault-Bricard, Rachel; Montes, Matthieu; Lopez, Nicolas; Maciel, Thiago Trovati; Hermine, Olivier; Raynaud, Francoise; Demange, Luc; Lepelletier, Yves Share Save Share Save Computationally driven discovery of SARS-CoV-2 Mpro inhibitors: from design to experimental validationEl Khoury, Lea; Jing, Zhifeng; Cuzzolin, Alberto; Deplano, Alessandro; Loco, Daniele; Sattarov, Boris; Hedin, Florent; Wendeborn, Sebastian; Ho, Chris; El Ahdab, Dina; Inizan, Theo Jaffrelot; Sturlese, Mattia; Sosic, Alice; Volpiana, Martina; Lugato, Angela; Barone, Marco; Gatto, Barbara; Macchia, Maria Ludovica; Bellanda, Massimo; Battistutta, Roberto; Salata, Cristiano; Kondratov, Ivan; Iminov, Rustam; Khairulin, Andrii; Mykhalonok, Yaroslav; Pochepko, Anton; Chashka-Ratushnyi, Volodymyr; Kos, Iaroslava; Moro, Stefano; Montes, Matthieu; Ren, Pengyu; Ponder, Jay W.; Lagardere, Louis; Piquemal, Jean-Philip; Sabbadin, Davide Share Save Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinomaDumond, Aurore; Brachet, Etienne; Durivault, Jerome; Vial, Valerie; Puszko, Anna K.; Lepelletier, Yves; Montemagno, Christopher; Pagnuzzi-Boncompagni, Marina; Hermine, Olivier; Garbay, Christiane; Lagarde, Nathalie; Montes, Matthieu; Demange, Luc; Grepin, Renaud; Pages, Gilles Share Save High-resolution mining of the SARS-CoV-2 main protease conformational space: supercomputer-driven unsupervised adaptive samplingInizan, Theo Jaffrelot; Celerse, Frederic; Adjoua, Olivier; El Ahdab, Dina; Jolly, Luc-Henri; Liu, Chengwen; Ren, Pengyu; Montes, Matthieu; Lagarde, Nathalie; Lagardere, Louis; Monmarche, Pierre; Piquemal, Jean-Philip Share Save Share Save New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatmentsDufies, Maeva; Grytsai, Oleksandr; Ronco, Cyril; Camara, Oumar; Ambrosetti, Damien; Hagege, Anais; Parola, Julien; Mateo, Lou; Ayrault, Marion; Giuliano, Sandy; Grepin, Renaud; Lagarde, Nathalie; Montes, Matthieu; Auberger, Patrick; Demange, Luc; Benhida, Rachid; Pages, Gilles Share Save Share Save NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft modelLiu, Wang-Qing; Lepelletier, Yves; Montes, Matthieu; Borriello, Lucia; Jarray, Rafika; Grepin, Renaud; Leforban, Bertrand; Loukaci, Ali; Benhida, Rachid; Hermine, Olivier; Dufour, Sylvie; Pages, Gilles; Garbay, Christiane; Raynaud, Francoise; Hadj-Slimane, Reda; Demange, Luc Share Save New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modelingRayar, Anita Marie; Lagarde, Nathalie; Martin, Frederique; Blanchard, Florent; Liagre, Bertrand; Ferroud, Clotilde; Zagury, Jean-Francois; Montes, Matthieu; Veitia, Maite Sylla-Iyarreta Share Save Share Save Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screeningMouhsine, Hadley; Guillemain, Helene; Moreau, Gabriel; Fourati, Najla; Zerrouki, Chouki; Baron, Bruno; Desallais, Lucille; Gizzi, Patrick; Ben Nasr, Nesrine; Perrier, Julie; Ratsimandresy, Rojo; Spadoni, Jean-Louis; Do, Herve; England, Patrick; Montes, Matthieu; Zagury, Jean-Francois Share Save Share Save Share Save Share Save Share Save Share Save Share Save 
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