Not logged in A Phase 1B Trial in GBA1-Associated Parkinson's Disease of BIA-28-6156, a Glucocerebrosidase Activator den Heijer, Jonas M.; Kruithof, Annelieke C.; Moerland, Matthijs; Walker, Mike; Dudgeon, Lindsay; Justman, Craig; Solomini, Imelda; Splitalny, Leslie; Leymarie, Nancy; Khatri, Kshitij; Cullen, Valerie C.; Hilt, Dana C.; Groeneveld, Geert Jan; Lansbury, Peter Share Save
A Biomarker Study in Patients with GBA1-Parkinson's Disease and Healthy Controls den Heijer, Jonas M.; Cullen, Valerie C.; Pereira, Diana R.; Yavuz, Yalcin; de Kam, Marieke L.; Grievink, Hendrika W.; Moerland, Matthijs; Leymarie, Nancy; Khatri, Kshitij; Sollomoni, Imelda; Spitalny, Leslie; Dungeon, Lindsay; Hilt, Dana C.; Justman, Craig; Lansbury, Peter; Groeneveld, Geert Jan Share Save
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Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A.; Sulzer, David; Vekrellis, Kostas; Halliday, Glenda M.; Tomlinson, Julianna J.; Schlossmacher, Michael; Jensen, Poul Henning; Schulze-Hentrich, Julia; Riess, Olaf; Hirst, Warren D.; El-Agnaf, Omar; Mollenhauer, Brit; Lansbury, Peter; Outeiro, Tiago F. Share Save
A randomized single and multiple ascending dose study in healthy volunteers of LTI-291, a centrally penetrant glucocerebrosidase activator den Heijer, Jonas M.; Kruithof, Annelieke C.; van Amerongen, Guido; de Kam, Marieke L.; Thijssen, Eva; Grievink, Hendrika W.; Moerland, Matthijs; Walker, Mike; Been, Kees; Skerlj, Renato; Justman, Craig; Dudgeon, Lindsay; Lansbury, Peter; Cullen, Valerie C.; Hilt, Dana C.; Groeneveld, Geert Jan Share Save
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Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors Caputo, Samantha; Di Martino, Simona; Cilibrasi, Vincenzo; Tardia, Piero; Mazzonna, Marco; Russo, Debora; Penna, Ilaria; Summa, Maria; Bertozzi, Sine Mandrup; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Ottonello, Giuliana; Liu, Min; Lansbury, Peter; Armirotti, Andrea; Bertorelli, Rosalia; Ray, Soumya S.; Skerlj, Renato; Scarpelli, Rita Share Save
A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands. den Heijer, Jonas M.; Cullen, Valerie C.; Quadri, Marialuisa; Schmitz, Arnoud; Hilt, Dana C.; Lansbury, Peter; Berendse, Henk W.; van de Berg, Wilma D. J.; de Bie, Rob M. A.; Boertien, Jeffrey M.; Boon, Agnita J. W.; Contarino, M. Fiorella; van Hilten, Jacobus J.; Hoff, Jorrit, I; van Mierlo, Tom; Munts, Alex G.; van der Plas, Anne A.; Ponsen, Mirthe M.; Baas, Frank; Majoor-Krakauer, Danielle; Bonifati, Vincenzo; van Laar, Teus; Groeneveld, Geert J. Share Save
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors Di Martino, Simona; Tardia, Piero; Cilibrasi, Vincenzo; Caputo, Samantha; Mazzonna, Marco; Russo, Debora; Penna, Ilaria; Realini, Natalia; Margaroli, Natasha; Migliore, Marco; Pizzirani, Daniela; Ottonello, Giuliana; Bertozzi, Sine Mandrup; Armirotti, Andrea; Duc Nguyen; Sun, Ying; Bongarzone, Ernesto R.; Lansbury, Peter; Liu, Min; Skerlj, Renato; Scarpelli, Rita Share Save
Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein Cuddy, Leah K.; Wani, Willayat Y.; Morella, Martino L.; Pitcairn, Caleb; Tsutsumi, Kotaro; Fredriksen, Kristina; Justman, Craig J.; Grammatopoulos, Tom N.; Belur, Nandkishore R.; Zunke, Friederike; Subramanian, Aarthi; Affaneh, Amira; Lansbury, Peter T., Jr.; Mazzulli, Joseph R. Share Save
β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site Zheng, Jianbin; Chen, Long; Skinner, Owen S.; Ysselstein, Daniel; Remis, Jonathan; Lansbury, Peter; Skerlj, Renato; Mrosek, Michael; Heunisch, Ursula; Krapp, Stephan; Charrow, Joel; Schwake, Michael; Kelleher, Neil L.; Silverman, Richard B.; Krainc, Dimitri Share Save
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form Collier, Timothy J.; Srivastava, Kinshuk R.; Justman, Craig; Grammatopoulous, Tom; Hutter-Paier, Birgit; Prokesch, Manuela; Havas, Daniel; Rochet, Jean-Christophe; Liu, Fang; Jock, Kevin; de Oliveira, Patricia; Stirtz, Georgia L.; Dettmer, Ulf; Sortwell, Caryl E.; Feany, Mel B.; Lansbury, Peter; Lapidus, Lisa; Paumier, Katrina L. Share Save
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An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments Fezoui, Y; Hartley, DM; Harper, JD; Khurana, R; Walsh, DM; Condron, MM; Selkoe, DJ; Lansbury, PT; Fink, AL; Teplow, DB Share Save
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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein Paleologou, Katerina E.; Schmid, Adrian W.; Rospigliosi, Carla C.; Kim, Hai-Young; Lamberto, Gonzalo R.; Fredenburg, Ross A.; Lansbury, Peter T., Jr.; Fernandez, Claudio O.; Eliezer, David; Zweckstetter, Markus; Lashuel, Hilal A. Share Save
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy Martinez-Vicente, Marta; Talloczy, Zsolt; Kaushik, Susmita; Massey, Ashish C.; Mazzulli, Joseph; Mosharov, Eugene V.; Hodara, Roberto; Fredenburg, Ross; Wu, Du-Chu; Follenzi, Antonia; Dauer, William; Przedborski, Serge; Lschiropoulos, Harry; Lansbury, Peter T.; Sulzer, David; Cuervo, Ana Maria Share Save
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