Not logged in Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. Share Save
Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication Colombo, Eloic; Desilets, Antoine; Hassanzadeh, Malihe; Lemieux, Gabriel; Marois, Isabelle; Cliche, Dominic; Delbrouck, Julien A.; Murza, Alexandre; Jean, Francois; Marsault, Eric; Richter, Martin V.; Leduc, Richard; Boudreault, Pierre-Luc Share Save
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants Perez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save
Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells Blagojevic, Polina; Perez-Vargas, Jimena; Jian, Kunzhong; Williams, David E.; Villanueva, Ivan; Thompson, Connor A. H.; Ennis, Siobhan; Niikura, Masahiro; Tietjen, Ian; Jean, Francois; Andersen, Raymond J. Share Save
Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade Cloherty, Alexandra P. M.; Rader, Anusca G.; Patel, Kharishma S.; Perez-Vargas, Jimena; Thompson, Connor A. H.; Ennis, Siobhan; Niikura, Masahiro; Wildenberg, Manon E.; Muncan, Vanesa; Schreurs, Renee R. C. E.; Jean, Francois; Ribeiro, Carla M. S. Share Save
Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication Shapira, Tirosh; Vimalanathan, Selvarani; Rens, Celine; Pichler, Virginia; Pena-Diaz, Sandra; Jordana, Grace; Rees, William; Winkler, Dirk F. H.; Sarai, Iqbal; Steiner, Theodore; Jean, Francois; Pelech, Steven; Av-Gay, Yossef Share Save
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Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules Gentile, Francesco; Fernandez, Michael; Ban, Fuqiang; Ton, Anh-Tien; Mslati, Hazem; Perez, Carl F.; Leblanc, Eric; Yaacoub, Jean Charle; Gleave, James; Stern, Abraham; Wong, Bill; Jean, Francois; Strynadka, Natalie; Cherkasov, Artem Share Save
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Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem Thomson, C. A.; Wang, Y.; Jackson, L. M.; Olson, M.; Wang, W.; Liavonchanka, A.; Keleta, L.; Silva, V.; Diederich, S.; Jones, R. B.; Gubbay, J.; Pasick, J.; Petric, M.; Jean, Francois; Allen, V. G.; Brown, E. G.; Rini, J. M.; Schrader, J. W. Share Save
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