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R

Ronald L. Wange

food and drug administration

37H-index
65Paper Count
5.5KCitation Count
Published Papers 40
Publication Date
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Safety considerations for cereblon-recruiting targeted protein degraders
errNature Reviews Drug Discovery
IF101.8
err2026-04-20
err0
PREAI
errHelen Garside; Amy Aslamkhan; Danette L. Daniels; Kaushik Datta; Mikael Egebjerg; Renee R. Hukkanen; Lyn H. Jones; Natalie Ketter; Tejas S. Lahoti; Lise I. Loberg; Davorka Messmer; Raegan O’Lone; Timothy Pastoor; Mira Pavkovic; Lucilia Pereira Mouriès; Zoran Rankovic; Aishwarya Rengarajan; Neil Vargesson; Axel Vicart; Ronald L. Wange; Gina Yanochko-Hoffman; Ruth Roberts; James Sidaway
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Corrigendum to “Hypothesis-driven approach to developmental toxicity assessment: Using mechanistic information to inform testing” [Reprod. Toxicol. 140 (2026) 109119]
errReproductive Toxicology
IF2.8
err2025-12-26
err0
errOAAI
errGeorge Daston; Matthew Burbank; Florian Gautier; Barbara F. Hales; Amer Jamalpoor; Yasunari Kanda; Susan Makris; Aldert H. Piersma; Nicola Powles-Glover; Sonya Sobrian; Vicki Sutherland; Steven Van Cruchten; Ronald L. Wange; Connie L. Chen
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errSave
Hypothesis-driven approach to developmental toxicity assessment: using mechanistic information to inform testing
errReproductive Toxicology
IF2.8
err2025-11-29
err0
PREAI
errGeorge Daston; Matthew Burbank; Florian Gautier; Barbara F. Hales; Amer Jamelpoor; Yasunari Kanda; Susan Makris; Aldert H. Piersma; Nicola Powles-Glover; Sonya Sobrian; Vicki Sutherland; Steven Van Cruchten; Ronald L. Wange; Connie L. Chen
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errSave
Minimizing Use of Nonhuman Primates to Inform Risk to Fertility and of Adverse Pregnancy Outcomes with Pharmaceuticals
errRegulatory Toxicology and Pharmacology
IF3.5
err2025-10-24
err0
PREAI
errChristopher J. Bowman; Ann Baker; Diann L. Blanset; Kimberly C. Brannen; Gary J. Chellman; Brian Enright; Wendy Halpern; Bethany R. Hannas; Kazushige Maki; Fumito Mikashima; Shermaine Mitchell-Ryan; Eve Mylchreest; Manjunatha K. Nanjappa; Helen Prior; Puck Roos; Dinesh Stanislaus; Angela R. Stermer; Jane Stewart; Katie Turner; Steven van Cruchten; Peter J.K. van Meer; Justin D. Vidal; Ronald L. Wange; Connie Chen; Peter Theunissen
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errSave
Retrospective evaluation of the use of non-human primates for fertility assessment of pharmaceuticals submitted for marketing approval in the EU
errRegulatory Toxicology and Pharmacology
IF3.5
err2025-10-23
err0
PREAI
errPuck Roos; Diann L. Blanset; Peter J.K. van Meer; Shermaine Mitchell-Ryan; Peter T. Theunissen; Katie J. Turner; Ronald L. Wange; Christopher J. Bowman
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errSave
Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development
errINTERNATIONAL JOURNAL OF TOXICOLOGY
IF1
err2025-09-01
err0
errOAAI
errPierson, Jennifer Beck; Bahinski, Anthony; Berridge, Brian; Bramham, Daniel; Bourcier, Todd; Chaudhary, Khuram W.; Eldridge, Sandy; Kanda, Yasunari; Mattes, William B.; Oliphant, Jessica; Pang, Li; Savtchenko, Alex; Siegel, Jeffery; Simpson, Natalie; Tu, Chengyi; Wange, Ronald; Wu, Joseph C.; Yang, Xi
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errSave
New approach methodologies for assessing developmental toxicity of pharmaceuticals: Case Examples and Future Directions
errReproductive Toxicology
IF2.8
err2025-08-28
err0
errOAAI
errNicola Powles-Glover; Allen R. Kaczor; Steven Van Cruchten; Christopher J. Bowman; Kimberly C. Brannen; Claudia Demarta-Gatsi; Isabelle LeConte; Amer Jamalpoor; Fumito Mikashima; Shermaine Mitchell-Ryan; Dinesh Stanislaus; Peter Theunissen; Belen Tornesi; Ronald L. Wange; Connie L. Chen
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errSave
Developmental and Reproductive Toxicity Testing Strategies for Oligonucleotides: A Workshop Proceedings
errnucleic acid therapeutics
IF4.7
err2025-06-05
err0
PREAI
errBethany R. Hannas; Sara M. Bender; Eileen Blasi; Christopher J. Bowman; Joy A. Cavagnaro; Connie L. Chen; Pragati S. Coder; Britt Duijndam; Alan Hoberman; Tae-Won Kim; Isabelle Leconte; Kazushige Maki; Mineo Matsumoto; Fumito Mikashima; Dinah L. Misner; Lutz Mueller; Nicola Powles-Glover; Stephanie Rayhon; Camelia Saffarini; Christine Siezen; Jennifer Sisler; Ronald L. Wange; Tacey White; Michael V. Templin
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errSave
An Evaluation of First-in-Human Studies for RNA Oligonucleotides
errNUCLEIC ACID THERAPEUTICS
IF4.7
err2024-12-01
err1
PREAI
errStern, Sydney; Wange, Ronald L.; Rogers, Hobart
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errSave
Exploring rabbit as a nonrodent species for general toxicology studies
errTOXICOLOGICAL SCIENCES
IF4.1
err2024-02-19
err1
PREAI
errSokolowski, Katie; Turner, Patricia, V; Lewis, Elise; Wange, Ronald L.; Fortin, Marie C.
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errSave
Considerations regarding the use of nonhuman primates in assessing safety endpoints for pharmaceuticals
errREGULATORY TOXICOLOGY AND PHARMACOLOGY
IF3.5
err2023-09-01
err12
PREAI
errBrown, Paul C.; Wange, Ronald L.
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errSave
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: Reconstitution studies in a ZAP-70-deficient jurkat T-Cell line
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err259
errOAAI
errWilliams, BL; Schreiber, KL; Zhang, WG; Wange, RL; Samelson, LE; Leibson, PJ; Abraham, RT
errShare
errSave
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err337
errOAAI
errShan, XC; Czar, MJ; Bunnell, SC; Liu, PH; Liu, YS; Schwartzberg, PL; Wange, RL
errShare
errSave
Membrane raft-dependent regulation of phospholipase Cγ-1 activation in T lymphocytes
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err64
errOAAI
errVerí, MC; DeBell, KE; Seminario, MC; DiBaldassarre, A; Reischl, I; Rawat, R; Graham, L; Noviello, C; Rellahan, BL; Miscia, S; Wange, RL; Bonvini, E
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errSave
ZAP-70-independent Ca2+ mobilization and Erk activation in Jurkat T cells in response to T-Cell antigen receptor ligation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err52
errOAAI
errShan, XC; Balakir, R; Criado, G; Wood, JS; Seminario, MC; Madrenas, J; Wange, RL
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errSave
FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations
errREGULATORY TOXICOLOGY AND PHARMACOLOGY
IF3.5
err2023-02-01
err20
errOAAI
errAckley, David; Birkebak, Joanne; Blumel, Jorg; Bourcier, Todd; de Zafra, Christina; Goodwin, Andrew; Halpern, Wendy; Herzyk, Danuta; Kronenberg, Sven; Mauthe, Robert; Shenton, Jacintha; Shuey, Dana; Wange, Ronald L.
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errSave
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
errTOXICS
IF4.1
err2022-05-01
err65
errOAAI
errChang, Xiaoqing; Tan, Yu-Mei; Allen, David G.; Bell, Shannon; Brown, Paul C.; Browning, Lauren; Ceger, Patricia; Gearhart, Jeffery; Hakkinen, Pertti J.; Kabadi, Shruti V.; Kleinstreuer, Nicole C.; Lumen, Annie; Matheson, Joanna; Paini, Alicia; Pangburn, Heather A.; Petersen, Elijah J.; Reinke, Emily N.; Ribeiro, Alexandre J. S.; Sipes, Nisha; Sweeney, Lisa M.; Wambaugh, John F.; Wange, Ronald; Wetmore, Barbara A.; Mumtaz, Moiz
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errSave
Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future
errREGULATORY TOXICOLOGY AND PHARMACOLOGY
IF3.5
err2021-07-01
err23
PREAI
errWange, Ronald L.; Brown, Paul C.; Davis-Bruno, Karen L.
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errSave
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
errCTS-CLINICAL AND TRANSLATIONAL SCIENCE
IF2.8
err2021-06-16
err120
errOAAI
errWang, Hongbing; Brown, Paul C.; Chow, Edwin C. Y.; Ewart, Lorna; Ferguson, Stephen S.; Fitzpatrick, Suzanne; Freedman, Benjamin S.; Guo, Grace L.; Hedrich, William; Heyward, Scott; Hickman, James; Isoherranen, Nina; Li, Albert P.; Liu, Qi; Mumenthaler, Shannon M.; Polli, James; Proctor, William R.; Ribeiro, Alexandre; Wang, Jian-Ying; Wange, Ronald L.; Huang, Shiew-Mei
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errSave
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
errREGULATORY TOXICOLOGY AND PHARMACOLOGY
IF3.5
err2020-07-01
err103
PREAI
errAvila, Amy M.; Bebenek, Ilona; Bonzo, Jessica A.; Bourcier, Todd; Bruno, Karen L. Davis; Carlson, David B.; Dubinion, John; Elayan, Ikram; Harrouk, Wafa; Lee, Shwu-Luan; Mendrick, Donna L.; Merrill, Jill C.; Peretz, Jackye; Place, Emily; Saulnier, Muriel; Wange, Ronald L.; Yao, Jia; Zhao, Dong; Brown, Paul C.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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H-index: 181 · Papers: 1.6K
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Joseph C. Wu
H-index: 139 · Papers: 1.2K
J
John J. O’Shea
H-index: 131 · Papers: 476
M
Myriam Gorospe
H-index: 114 · Papers: 649
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