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Walter Becker

RWTH Aachen University

50H-index
258Paper Count
8.7KCitation Count
Published Papers 43
Publication Date
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The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7
errCell Death & Disease
IF9.6
err2026-03-26
err0
errOAAI
errGerrit Wilms; Katharina Schwandt; Stefan Düsterhöft; Philip Helmich; Justyna Wozniak; Florian Kraft; Sebastian Kallabis; Felix Meissner; Walter Becker
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Elevated expression levels of the protein kinase DYRK1B induce mesenchymal features in A549 lung cancer cells
errBMC CANCER
IF3.4
err2024-10-31
err0
errOAAI
errSester, Soraya; Wilms, Gerrit; Ahlburg, Joana; Babendreyer, Aaron; Becker, Walter
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errSave
Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells
errSCIENTIFIC REPORTS
IF3.9
err2024-10-13
err0
errOAAI
errVorwerk, Vincent Andreas; Wilms, Gerrit; Babendreyer, Aaron; Becker, Walter
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Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-30
err0
PREAI
errWilms, Gerrit; Schofield, Kevin; Maddern, Shayna; Foley, Christopher; Shaw, Yeng; Smith, Breland; Basantes, L. Emilia; Schwandt, Katharina; Babendreyer, Aaron; Chavez, Timothy; McKee, Nicholas; Gokhale, Vijay; Kallabis, Sebastian; Meissner, Felix; Rokey, Samantha N.; Dunckley, Travis; Montfort, William R.; Becker, Walter; Hulme, Christopher
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Functional characterization of two DYRK1B variants causative of AOMS3
errORPHANET JOURNAL OF RARE DISEASES
IF3.5
err2024-06-12
err0
errOAAI
errDetro-Dassen, Silvia; Sternberg, Anna; Lehmann, Sonja Maria; Schwandt, Katharina; Duesterhoeft, Stefan; Becker, Walter
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Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
errSCIENTIFIC REPORTS
IF3.9
err2022-02-14
err5
errOAAI
errPapenfuss, Marco; Luetzow, Svenja; Wilms, Gerrit; Babendreyer, Aaron; Flasshoff, Maren; Kunick, Conrad; Becker, Walter
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Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2022-01-01
err18
PREAI
errAlNajjar, Yasmeen T.; Gabr, Moustafa; ElHady, Ahmed K.; Salah, Mohamed; Wilms, Gerrit; Abadi, Ashraf H.; Becker, Walter; Abdel-Halim, Mohammad; Engel, Matthias
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Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2021-11-02
err5
PREAI
errAboushady, Youssef; Gabr, Moustafa; ElHady, Ahmed K.; Salah, Mohamed; Abadi, Ashraf H.; Wilms, Gerrit; Becker, Walter; Abdel-Halim, Mohammad; Engel, Matthias
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errSave
How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine
errMOLECULES
IF4.6
err2020-12-16
err12
errOAAI
errWurzlbauer, Anne; Rueben, Katharina; Guerdal, Ece; Chaikuad, Apirat; Knapp, Stefan; Sippl, Wolfgang; Becker, Walter; Bracher, Franz
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errSave
Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2018-10-01
err17
PREAI
errDarwish, Sarah S.; Abdel-Halim, Mohammad; ElHady, Ahmed K.; Salah, Mohamed; Abadi, Ashraf H.; Becker, Walter; Engel, Matthias
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errSave
Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2018-09-01
err20
PREAI
errDarwish, Sarah S.; Abdel-Halim, Mohammad; Salah, Mohamed; Abadi, Ashraf H.; Becker, Walter; Engel, Matthias
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errSave
Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
errMOLECULES
IF4.6
err2018-01-24
err24
errOAAI
errMeine, Rosanna; Becker, Walter; Falke, Hannes; Preu, Lutz; Loaec, Nadege; Meijer, Laurent; Kunick, Conrad
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errSave
A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy
errFEBS JOURNAL
IF4.2
err2017-12-12
err54
errOAAI
errBecker, Walter
errShare
errSave
DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain
errSCIENTIFIC REPORTS
IF3.9
err2017-07-25
err28
errOAAI
errAbu Jhaisha, Samira; Widowati, Esti W.; Kii, Isao; Sonamoto, Rie; Knapp, Stefan; Papadopoulos, Chrisovalantis; Becker, Walter
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errSave
The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2
errSCIENTIFIC REPORTS
IF3.9
err2016-06-16
err46
errOAAI
errGlenewinkel, Florian; Cohen, Michael J.; King, Cason R.; Kaspar, Sophie; Bamberg-Lemper, Simone; Mymryk, Joe S.; Becker, Walter
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errSave
DYRK protein kinases
errCURRENT BIOLOGY
IF7.5
err2015-06-01
err55
errOAAI
errSoppa, Ulf; Becker, Walter
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errSave
10-lodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2015-03-23
err91
errOAAI
errFalke, Hannes; Chaikuad, Apirat; Becker, Anja; Loaec, Nadege; Lozach, Olivier; Abu Jhaisha, Samira; Becker, Walter; Jones, Peter G.; Preu, Lutz; Baumann, Knut; Knapp, Stefan; Meijer, Laurent; Kunick, Conrad
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Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK)
errCELL COMMUNICATION AND SIGNALING
IF8.9
err2015-01-29
err35
errOAAI
errvan der Laden, Jan; Soppa, Ulf; Becker, Walter
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The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation
errCELL CYCLE
IF3.4
err2014-05-07
err141
errOAAI
errSoppa, Ulf; Schumacher, Julian; Florencio Ortiz, Victoria; Pasqualon, Tobias; Tejedor, Francisco J.; Becker, Walter
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Mechanism of dual specificity kinase activity of DYRK1A
errFEBS JOURNAL
IF4.2
err2013-07-22
err63
PREAI
errWalte, Agnes; Rueben, Katharina; Birner-Gruenberger, Ruth; Preisinger, Christian; Bamberg-Lemper, Simone; Hilz, Nikolaus; Bracher, Franz; Becker, Walter
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Research Directions

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Co-authors
Cooperation Journals
P
Philip Cohen
H-index: 156 · Papers: 581
N
Neal G. Copeland
H-index: 150 · Papers: 1.0K
M
Michel Goedert
H-index: 146 · Papers: 565
N
Nancy A. Jenkins
H-index: 135 · Papers: 867
T
Tom L. Blundell
H-index: 112 · Papers: 736
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