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Fabrizio Chiti

university of florence

63H-index
240Paper Count
2.8WCitation Count
Published Papers 116
Publication Date
Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations
err2026-05-02
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errFlavia Catalano; Alessandra Bigi; Francesca Troilo; Federica Gabriele; Gianluca Pistoia; Italia A. Asteriti; Francesco Angelucci; Giorgio Giardina; Fabrizio Chiti; Carlo Travaglini-Allocatelli; Adele Di Matteo
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Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates
err2025-12-09
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errAlessandra Bigi; Andrea Carlotta Conti; Liliana Napolitano; Giuliana Fusco; Alfonso De Simone; Fabrizio Chiti; Roberta Cascella; Cristina Cecchi
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Natural aminosterols inhibit NMDA receptors with low nanomolar potency
err2025-03-24
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errGiulia Fani; Elisabetta Coppi; Silvia Errico; Federica Cherchi; Martina Gennari; Denise Barbut; Michele Vendruscolo; Michael Zasloff; Anna Maria Pugliese; Fabrizio Chiti
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Detection of an Intermediate in the Unfolding Process of the N-Terminal Domain of TDP-43
err2025-02-05
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errMarzi, Isabella; Pieraccini, Giuseppe; Bemporad, Francesco; Chiti, Fabrizio
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Evolving concepts of the protein universe
err2025-02-01
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errKulkarni, Prakash; Porter, Lauren; Chou, Tsui-Fen; Chong, Shasha; Chiti, Fabrizio; Schafer, Joseph W.; Mohanty, Atish; Ramisetty, Sravani; Onuchic, Jose N.; Tuite, Mick; Weninger, Keith R.; Koonin, Eugene, V; Salgia, Ravi
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Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins
err2025-01-22
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errErrico, Silvia; Fani, Giulia; Ventura, Salvador; Schymkowitz, Joost; Rousseau, Frederic; Trovato, Antonio; Vendruscolo, Michele; Bemporad, Francesco; Chiti, Fabrizio
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Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain
err2024-07-13
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errStaderini, Tommaso; Bigi, Alessandra; Lagreve, Clement; Marzi, Isabella; Bemporad, Francesco; Chiti, Fabrizio
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Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates
err2024-04-03
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errChen, Serene W.; Barritt, Joseph D.; Cascella, Roberta; Bigi, Alessandra; Cecchi, Cristina; Banchelli, Martina; Gallo, Angelo; Jarvis, James A.; Chiti, Fabrizio; Dobson, Christopher M.; Fusco, Giuliana; De Simone, Alfonso
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Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
err2024-03-08
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errBigi, Alessandra; Fani, Giulia; Bessi, Valentina; Napolitano, Liliana; Bagnoli, Silvia; Ingannato, Assunta; Neri, Lorenzo; Cascella, Roberta; Matteini, Paolo; Sorbi, Sandro; Nacmias, Benedetta; Cecchi, Cristina; Chiti, Fabrizio
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A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF
err2024-01-18
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errBigi, Alessandra; Napolitano, Liliana; Vadukul, Devkee M.; Chiti, Fabrizio; Cecchi, Cristina; Aprile, Francesco A.; Cascella, Roberta
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Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes
err2023-07-11
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errErrico, Silvia; Lucchesi, Giacomo; Odino, Davide; Osman, Enass Youssef; Cascella, Roberta; Neri, Lorenzo; Capitini, Claudia; Calamai, Martino; Bemporad, Francesco; Cecchi, Cristina; Kinney, William A.; Barbut, Denise; Relini, Annalisa; Canale, Claudio; Caminati, Gabriella; Limbocker, Ryan; Vendruscolo, Michele; Zasloff, Michael; Chiti, Fabrizio
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Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
err2023-04-18
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errLimbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M.; Vendruscolo, Michele; Chiti, Fabrizio
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Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol
err2023-02-01
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PREAI
errBarletti, Beatrice; Lucchesi, Giacomo; Muscat, Stefano; Errico, Silvia; Barbut, Denise; Danani, Andrea; Zasloff, Michael; Grasso, Gianvito; Chiti, Fabrizio; Caminati, Gabriella
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An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
err2022-12-10
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errCascella, Roberta; Banchelli, Martina; Abolghasem Ghadami, Seyyed; Ami, Diletta; Gagliani, Maria Cristina; Bigi, Alessandra; Staderini, Tommaso; Tampellini, Davide; Cortese, Katia; Cecchi, Cristina; Natalello, Antonino; Adibi, Hadi; Matteini, Paolo; Chiti, Fabrizio
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Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy
err2022-11-24
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errCapitini, Claudia; Pesce, Luca; Fani, Giulia; Mazzamuto, Giacomo; Genovese, Massimo; Franceschini, Alessandra; Paoli, Paolo; Pieraccini, Giuseppe; Zasloff, Michael; Chiti, Fabrizio; Pavone, Francesco S.; Calamai, Martino
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Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
err2022-09-14
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errBigi, Alessandra; Cascella, Roberta; Chiti, Fabrizio; Cecchi, Cristina
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The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes
err2022-09-07
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errFusco, Giuliana; Bemporad, Francesco; Chiti, Fabrizio; Dobson, Christopher M. M.; De Simone, Alfonso
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Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species
err2022-08-27
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errFani, Giulia; La Torre, Chiara Ester; Cascella, Roberta; Cecchi, Cristina; Vendruscolo, Michele; Chiti, Fabrizio
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