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Xandra O. Breakefield

Harvard University

99H-index
387Paper Count
6.3WCitation Count
Published Papers 143
Publication Date
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Targeting the adenosine A2A receptor enhances the efficacy of low dose temozolomide in a murine glioma model
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errRepiton, Pierre; Xiao, Tianhe; Gurevich, Mia; Shah, Sia; Ianni, Emilio Di; Breyne, Koen; Scapozza, Leonardo; Breakefield, Xandra
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errSave
AAV Hamartin Gene Therapy in a Stochastic, Cerebral Mouse Model of Tuberous Sclerosis Type 1
errMolecular Therapy Methods & Clinical Development
IF4.7
err2025-08-13
err0
errOAAI
errEdwina Abou Haidar; Shilpa Prabhakar; Alexandra L. Geffrey; Mohammed Mahamdeh; Tomeh Tomeh; Koen Breyne; Elie Roumieh; Mia Gurevich; Roy J. Soberman; Gregory R. Wojtkiewicz; John W. Chen; Justin Seungkyu Han; Anat Stemmer-Rachamimov; Xandra O. Breakefield
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errSave
Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve
errGene Therapy
IF4.5
err2025-06-10
err0
PREAI
errEdwina Abou Haidar; Shilpa Prabhakar; Pike See Cheah; Killian S. Hanlon; Paula Espinoza; Adam V. Crain; Nikita Patel; Greta W. Radcliff; Ming Cheng; Iván Coto Hernández; Steven Minderler; Demitri de la Cruz; Carrie Ng; Cintia Carla da Hora; Alain Charest; Anat Stemmer-Rachamimov; Nate Jowett; Xandra O. Breakefield; Casey A. Maguire
errShare
errSave
Probing the glioma micro-environment: Analysis using biopsy in combination with ultra-fast cyclic immunolabeling
errNEOPLASIA
IF7.7
err2024-11-01
err0
errOAAI
errvan Solinge, Thomas S.; Oh, Juhyun; Abels, Erik; Koch, Peter; Breakefield, Xandra O.; Weissleder, Ralph; Broekman, Marike L. D.
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errSave
Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
errADVANCED DRUG DELIVERY REVIEWS
IF17.6
err2024-08-01
err0
errOAAI
errLeandro, Kevin; Rufino-Ramos, David; Breyne, Koen; Di Ianni, Emilio; Lopes, Sara M.; Nobre, Rui Jorge; Kleinstiver, Benjamin P.; Perdiga, Pedro R. L.; Breakefield, Xandra O.; de Almeida, Luis Pereira
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errSave
Opportunities and challenges for innovative and equitable healthcare
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2024-02-26
err2
PREAI
errEcker, David J.; Aiello, Clarice D.; Arron, Joseph R.; Bennett, C. Frank; Bernard, Amy; Breakefield, Xandra O.; Broderick, Timothy J.; Callier, Shawneequa L.; Canton, Barry; Chen, Janice S.; Fishburn, C. Simone; Garrett, Banning; Hecht, Sidney M.; Janowitz, Tobias; Kliegman, Melinda; Krainer, Adrian; Louis, Chrystal U.; Lowe, Christopher; Sehgal, Alfica; Tozan, Yesim; Tracey, Kevin J.; Urnov, Fyodor; Wattendorf, Daniel; Williams, Thomas W.; Zhao, Xuanhe; Hayden, Michael R.
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errSave
Heparin interferes with the uptake of liposomes in glioma
errinternational journal of pharmaceutics
IF6.4
err2023-12-01
err2
errOAAI
errSolinge, Thomas S. van; Friis, Kristina Pagh; O'Brien, Killian; Verschoor, Romy L.; van Aarle, Jeroen; Koekman, Arnold; Breakefield, Xandra O.; Vader, Pieter; Schiffelers, Raymond; Broekman, Marike
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errSave
Roles of extracellular vesicles in glioblastoma: foes, friends and informers
errFRONTIERS IN ONCOLOGY
IF3.3
err2023-11-24
err6
errOAAI
errLunavat, Taral R.; Nieland, Lisa; Vrijmoet, Anne B.; Zargani-Piccardi, Ayrton; Samaha, Youssef; Breyne, Koen; Breakefield, Xandra O.
errShare
errSave
Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients
errNEURO-ONCOLOGY ADVANCES
IF4.1
err2023-09-04
err0
errOAAI
errYekula, Anudeep; Hsia, Tiffaney; Kitchen, Robert R.; Chakrabortty, Sudipto K.; Yu, Wei; Batool, Syeda M.; Lewis, Brian; Szeglowski, Antoni J.; Weissleder, Ralph; Lee, Hakho; Chi, Andrew S.; Batchelor, Tracy; Carter, Bob S.; Breakefield, Xandra O.; Skog, Johan; Balaj, Leonora
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errSave
Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles
errMOLECULAR THERAPY
IF12
err2023-07-01
err3
errOAAI
errRufino-Ramos, David; Leandro, Kevin; Perdigao, Pedro R. L.; O'Brien, Killian; Pinto, Maria Manuel; Santana, Magda M.; van Solinge, Thomas S.; Mahjoum, Shadi; Breakefield, Xandra O.; Breyne, Koen; de Almeida, Luis Pereira
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errSave
Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers
errMOLECULAR THERAPY
IF12
err2023-07-01
err1
errOAAI
errMaalouf, Katia E.; Vaine, Christine A.; Frederick, Dawn M.; Yoshinaga, Akiko; Obuchi, Wataru; Mahjoum, Shadi; Nieland, Lisa; Al Ali, Jamal; Bragg, D. Cristopher; Breakefield, Xandra O.; Breyne, Koen
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errSave
Engineered EVs designed to target diseases of the CNS
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2023-04-01
err21
errOAAI
errNieland, Lisa; Mahjoum, Shadi; Grandell, Emily; Breyne, Koen; Breakefield, Xandra O.
errShare
errSave
Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-21
err257
errOAAI
errSaydam, Okay; Shen, Yiping; Wuerdinger, Thomas; Senol, Ozlem; Boke, Elvan; James, Marianne F.; Tannous, Bakhos A.; Stemmer-Rachamimov, Anat O.; Yi, Ming; Stephens, Robert M.; Fraefel, Cornel; Gusella, James F.; Krichevsky, Anna M.; Breakefield, Xandra O.
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errSave
Illuminating cellular and extracellular vesicle-mediated communication via a split-Nanoluc reporter in vitro and in vivo
errCELL REPORTS METHODS
IF4.5
err2023-02-01
err1
errOAAI
errvan Solinge, Thomas S.; Mahjoum, Shadi; Ughetto, Stefano; Sammarco, Alessandro; Broekman, Marike L. D.; Breakefield, Xandra O.; O'Brien, Killian P.
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errSave
Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma
errADVANCED MATERIALS
IF26.8
err2022-12-18
err19
errOAAI
errLugani, Sophie; Halabi, Elias A. A.; Oh, Juhyun; Kohler, Rainer H. H.; Peterson, Hannah M. M.; Breakefield, Xandra O. O.; Chiocca, E. Antonio A.; Miller, Miles A. A.; Garris, Christopher S. S.; Weissleder, Ralph
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errSave
CRISPR-Cas knockout of miR21 reduces glioma growth
errMOLECULAR THERAPY-ONCOLYTICS
IF0
err2022-06-01
err20
errOAAI
errNieland, Lisa; van Solinge, Thomas S.; Cheah, Pike See; Morsett, Liza M.; El Khoury, Joseph; Rissman, Joseph, I; Kleinstiver, Benjamin P.; Broekman, Marike L. D.; Breakefield, Xandra O.; Abels, Erik R.
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errSave
Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-05-19
err15
errOAAI
errBreyne, Koen; Ughetto, Stefano; Rufino-Ramos, David; Mahjoum, Shadi; Grandell, Emily A.; de Almeida, Luis P.; Breakefield, Xandra O.
errShare
errSave
Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo
errCELL REPORTS
IF6.9
err2022-04-01
err109
errOAAI
errO'Brien, Killian; Ughetto, Stefano; Mahjoum, Shadi; Nair, V. Anil; Breakefield, Xandra O.
errShare
errSave
Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo
errBIOMATERIALS
IF12.9
err2022-02-01
err20
errOAAI
errRufino-Ramos, David; Lule, Sevda; Mahjoum, Shadi; Ughetto, Stefano; Bragg, D. Cristopher; de Almeida, Luis Pereira; Breakefield, Xandra O.; Breyne, Koen
errShare
errSave
Exosome-based liquid biopsies in cancer: opportunities and challenges
errANNALS OF ONCOLOGY
IF65.4
err2021-04-01
err520
errOAAI
errYu, W.; Hurley, J.; Roberts, D.; Chakrabortty, S. K.; Enderle, D.; Noerholm, M.; Breakefield, X. O.; Skog, J. K.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
R
Ralph Weissleder
H-index: 200 · Papers: 1.6K
B
Bradley T. Hyman
H-index: 187 · Papers: 1.1K
G
Gordon J. Freeman
H-index: 174 · Papers: 1.1K
A
Anthony E. Lang
H-index: 166 · Papers: 1.5K
M
Mark Hallett
H-index: 161 · Papers: 1.5K
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