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A Phase 2a, Double-blind, Placebo-controlled Study of ORX750 in Patients with Narcolepsy (type 1 and 2) and Idiopathic Hypersomnia: Study Design Dauvilliers, Yves; Plazzi, Guiseppe; Plante, David; Mignot, Emmanuel; Roth, Thomas; Sterkel, Amanda; Hartman, Deborah; Kong, Jennifer; Accardi, Mario; Saha, Saurabh; Im, Ellie Share Save
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Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment Szabo, Peter M.; Vajdi, Amir; Kumar, Namit; Tolstorukov, Michael Y.; Chen, Benjamin J. J.; Edwards, Robin; Ligon, Keith L.; Chasalow, Scott D.; Chow, Kin-Hoe; Shetty, Aniket; Bolisetty, Mohan; Holloway, James L.; Golhar, Ryan; Kidd, Brian A.; Hull, Philip Ansumana; Houser, Jeff; Vlach, Logan; Siemers, Nathan O.; Saha, Saurabh Share Save
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Cancer cell survival depends on collagen uptake into tumor-associated stroma Hsu, Kuo-Sheng; Dunleavey, James M.; Szot, Christopher; Yang, Liping; Hilton, Mary Beth; Morris, Karen; Seaman, Steven; Feng, Yang; Lutz, Emily M.; Koogle, Robert; Tomassoni-Ardori, Francesco; Saha, Saurabh; Zhang, Xiaoyan M.; Zudaire, Enrique; Bajgain, Pradip; Rose, Joshua; Zhu, Zhongyu; Dimitrov, Dimiter S.; Cuttitta, Frank; Emenaker, Nancy J.; Tessarollo, Lino; St Croix, Brad Share Save
The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis Li, Ying; Belt, Katharina; Alqahtani, Saad F.; Saha, Saurabh; Fenske, Ricarda; Van Aken, Olivier; Whelan, James; Millar, A. Harvey; Murcha, Monika W.; Huang, Shaobai Share Save
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Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release Szot, Christopher; Saha, Saurabh; Zhang, Xiaoyan M.; Zhu, Zhongyu; Hilton, Mary Beth; Morris, Karen; Seaman, Steven; Dunleavey, James M.; Hsu, Kuo-Sheng; Yu, Guo-Jun; Morris, Holly; Swing, Deborah A.; Haines, Diana C.; Wang, Yanping; Hwang, Jennifer; Feng, Yang; Welsch, Dean; DeCrescenzo, Gary; Chaudhary, Amit; Zudaire, Enrique; Dimitrov, Dimiter S.; St Croix, Brad Share Save
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First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study Sullivan, Ryan J.; Infante, Jeffrey R.; Janku, Filip; Wong, Deborah Jean Lee; Sosman, Jeffrey A.; Keedy, Vicki; Patel, Manish R.; Shapiro, Geoffrey I.; Mier, James W.; Tolcher, Anthony W.; Wang-Gillam, Andrea; Sznol, Mario; Flaherty, Keith; Buchbinder, Elizabeth; Carvajal, Richard D.; Varghese, Anna M.; Lacouture, Mario E.; Ribas, Antoni; Patel, Sapna P.; DeCrescenzo, Gary A.; Emery, Caroline M.; Groover, Anna L.; Saha, Saurabh; Varterasian, Mary; Welsch, Dean J.; Hyman, David M.; Li, Bob T. Share Save
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Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) Germann, Ursula A.; Furey, Brinley F.; Markland, William; Hoover, Russell R.; Aronov, Alex M.; Roix, Jeffrey J.; Hale, Michael; Boucher, Diane M.; Sorrell, David A.; Martinez-Botella, Gabriel; Fitzgibbon, Matthew; Shapiro, Paul; Wick, Michael J.; Samadani, Ramin; Meshaw, Kathryn; Groover, Anna; DeCrescenzo, Gary; Namchuk, Mark; Emery, Caroline M.; Saha, Saurabh; Welsch, Dean J. Share Save
US immigration order strikes against biotech Levin, Jeremy M.; Holtzman, Steven H.; Maraganore, John; Hastings, Paul J.; Cohen, Ron; Dahiyat, Bassil; Adams, Julian; Adams, Chris; Ahrens, Brett; Albers, Jeff; Aspinall, Mara G.; Audia, James E.; Babler, Martin; Barrett, Peter; Barry, Zoe; Bermingham, Nessan; Blocha, Stephen; Blum, Robert I.; Bolno, Paul B.; Bonney, Michael W.; Booth, Bruce; Bradbury, Daniel M.; Brauer, Steven K.; Byers, Brook; Cagnoni, Pablo J.; Cali, Brian M.; Ciechanover, Isaac; Clark, Chip; Clayman, Michael D.; Cleland, Jeff L.; Cobb, Paula; Cooper, Ron; Currie, Mark G.; Diekman, John; Dobmeier, Eric L.; Doerfler, Doug; Donley, Elizabeth L. R.; Dunsire, Deborah; During, Matthew; Eckstein, Jens W.; Elenko, Eric; Exter, Neil A.; Fleming, Jonathan J.; Flesher, Gregory J.; Formela, Jean-Francois; Forrester, Robert; Francois, Cedric; Franklin, Heather; Freemana, Mason W.; Furst, Howard; Gage, Leonard Patrick; Galakatos, Nicholas; Gallagher, Brian M.; Geraghty, James A.; Gill, Simba; Goeddel, David V.; Goldsmith, Mark A.; Gowen, Maxine; Goyal, Vikas; Graney, Tom; Grayzel, David; Greene, Barry; Grint, Paul; Gutierrez-Ramos, J. C.; Haney, Bill; Tuan Ha-Ngoc; Harris, Tim; Hasnain, Faheem; Hata, Yujiro Steve; Hecht, Peter; Henshaw, Leslie; Heyman, Rich; Hoppenot, Herve; Horvitz, H. Robert; Hughes, Thomas E.; Hutton, Wende S.; Isaacs, Stephen T.; Jenkins, Annalisa; Jonker, Jeff; Kaplan, Jeff; Karsen, Perry; Keiper, Jeb; Kim, Jean; Kindler, Jeff; King, Rachel; King, Vanessa; Kjellson, Nina; Koenig, Scott; Koenig, Gerhard; Kolchinsky, Peter; Laikind, Paul; Langer, Robert (Bob); Lee, John J.; Leff, Jonathan S.; Leicher, Bruce A.; Leschly, Nick; Levin, Andrew; Levin, Mark; Levine, Arnold J.; Levy, Alan; Liu, David R.; Lodish, Harvey F.; Lopatin, Uri; Love, Ted W.; Macdonald, Guy; Maderis, Gail J.; Mahadevia, Ankit; Mahanthappa, Nagesh K.; Martin, Joel F.; Martin, Alex; Martucci, W. Eddie; McArthur, James G.; McCann, Corey M.; McCarthy, Sean A.; McDonough, C. Geoffrey; Mendlein, John; Miller, Larry; Miralles, Diego; Moch, Kenneth I.; More, Bob; Myers, Andrew G.; Narachi, Michael A.; Nashat, Amir; Nelson, Wendy; Newell, William J.; Olle, Bernat; Osborn, John E.; Owens, Julia C.; Pande, Atul; Papadopoulos, Stelios; Parker, H. Stewart; Parmara, Kush M.; Patterson, Matthew R.; Paul, Steve M.; Perez, Rob; Perry, Matthew; Pfeffer, Cary G.; Powell, Mike; Pruzanski, Mark; Purcell, Dennis J.; Rakhit, Amit; Ramamoorthi, Kartik; Rastetter, William; Rawcliffe, Adrian (Ad); Reid, Laurence E.; Renaud, Ron C.; Rhodes, Jason P.; Rieflin, William J.; Robins, Chad; Rocklageb, Scott M.; Rosenblatt, Michael; Rosin, Jonathan G.; Rutter, William J.; Saha, Saurabh; Samuels, Camille; Sato, Vicki L.; Scangos, George; Scarlett, John A.; Schenkein, David; Schreiber, Stuart L.; Schwabb, Andrew; Sekhri, Paul; Shah, Rajeev; Shenk, Thomas; Siegall, Clay B.; Simon, Nick J.; Simonian, Nancy; Stein, Jeff; Su, Michael; Szela, Mary T.; Taglietti, Marco; Tandon, Nina; Termeer, Henri; Thornberry, Nancy A.; Tolar, Martin; Ulevitchc, Richard; Vaishnaw, Akshay K.; VanLent, Anne; Varsavsky, Martin; Vlasuk, George P.; Vounatsos, Michel; Waksal, Samuel G.; Warma, Neil; Watts, Ryan J.; Werber, Yaron; Westphal, Christoph; Wierenga, Wendell; Williams, Doug E.; Williams, Lewis (Rusty); Xanthopoulos, Kleanthis G.; Zohar, Daphne; Zweifach, Sandford (Sandy) Share Save
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[124I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection Zhang, Xiaoyan M.; Zhang, Halle H.; McLeroth, Patrick; Berkowitz, Richard D.; Mont, Michael A.; Stabin, Michael G.; Siegel, Barry A.; Alavi, Abass; Barnett, T. Marc; Gelb, Jeffrey; Petit, Chantal; Spaltro, John; Cho, Steve Y.; Pomper, Martin G.; Conklin, James J.; Bettegowda, Chetan; Saha, Saurabh Share Save
The selective ERK inhibitor BVD-523 is active in models of MAPK pathway-dependent cancers, including those with intrinsic and acquired drug resistance Germann, Ursula; Furey, Brinley; Roix, Jeff; Markland, William; Hoover, Russell; Aronov, Alex; Hale, Michael; Chen, Guanjing; Martinez-Botella, Gabriel; Alargova, Rossitza; Fan, Bin; Sorrell, David; Meshaw, Kay; Shapiro, Paul; Wick, Michael J.; Benes, Cyril; Garnett, Mathew; DeCrescenzo, Gary; Namchuk, Mark; Saha, Saurabh; Welsch, Dean J. Share Save
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