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I

Isaac B. Hilton

rice university

21H-index
68Paper Count
4.8KCitation Count
Published Papers 28
Publication Date
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Clinical Translation of Epigenome Editing Technologies
errCurrent Opinion in Biomedical Engineering
IF4.2
err2026-04-17
err0
PREAI
errAlex J. Ma; Blake H. Brown; Sunghwan Kim; Isaac B. Hilton
errShare
errSave
CRISPR-Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function after myocardial infarction
errMolecular Therapy
IF12
err2026-03-09
err0
errOAAI
errMario Escobar; Saad A. Malik; Mira A. Srinivasa; Miguel A. Mendez-Sosa; Jessica M. Miller; Samantha L. Lydon; Sandy N. Luong; Pretty R. Mathew; Riham R.E. Abouleisa; Suridh Chakravarty; Saliha Pathan; Tamer M.A. Mohamed; Ravi K. Ghanta; Isaac B. Hilton
errShare
errSave
Integrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems
errCell Systems
IF7.7
err2025-12-17
err0
PREAI
errElliot L. Chaikof; Jichao Chen; Martha U. Gillette; Laurie A. Boyer; Tara L. Deans; Pulin Li; Isaac B. Hilton; Kyle Daniels; Yogesh Goyal; Ying Mei; Changyang Linghu; Theresa B. Loveless; David M. Truong; Michael R. Blatchley; Mingxia Gu; Caleb J. Bashor; Jason H. Yang; Ritu Raman; Akhilesh B. Reddy; Krishanu Saha
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errSave
Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells
errACS SYNTHETIC BIOLOGY
IF3.9
err2025-02-03
err0
PREAI
errGuerra-Resendez, Rosa Selenia; Lydon, Samantha LeGoff; Ma, Alex J.; Bedford, Guy C.; Reed, Daniel R.; Kim, Sunghwan; Teran, Erik R.; Nishiguchi, Tomoki; Escobar, Mario; Dinardo, Andrew R.; Hilton, Isaac B.
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errSave
Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control
errNATURE METHODS
IF32.1
err2023-10-09
err7
errOAAI
errMahata, Barun; Cabrera, Alan; Brenner, Daniel A.; Guerra-Resendez, Rosa Selenia; Li, Jing; Goell, Jacob; Wang, Kaiyuan; Guo, Yannie; Escobar, Mario; Parthasarathy, Abinand Krishna; Szadowski, Hailey; Bedford, Guy; Reed, Daniel R.; Kim, Sunghwan; Hilton, Isaac B.
errShare
errSave
Lipid Deposition Profiles Influence Foreign Body Responses
errADVANCED MATERIALS
IF26.8
err2023-03-31
err9
errOAAI
errSchreib, Christian C.; Jarvis, Maria I.; Terlier, Tanguy; Goell, Jacob; Mukherjee, Sudip; Doerfert, Michael D.; Wilson, Taylor Anne; Beauregard, Michael; Martins, Kevin N.; Lee, Jared; Solis, Leonardo Sanchez D.; Vazquez, Esperanza; Oberli, Matthias A.; Hanak, Brian W.; Diehl, Michael; Hilton, Isaac; Veiseh, Omid
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errSave
Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2022-12-21
err16
errOAAI
errZhao, Fanglong; Sun, Chunxiao; Liu, Zhiwen; Cabrera, Alan; Escobar, Mario; Huang, Shunyu; Yuan, Qichen; Nie, Qiuyue; Luo, Kevin Lee; Lin, Angela; Vanegas, Jeffrey A.; Zhu, Tong; Hilton, Isaac B.; Gao, Xue
errShare
errSave
Tuning neurodegeneration-linked gene expression, one (edited) base at a time
errMOLECULAR THERAPY
IF12
err2022-12-01
err0
errOAAI
errGuerra-Resendez, Rosa Selenia; Brenner, Daniel; Hilton, Isaac B.
errShare
errSave
The sound of silence: Transgene silencing in mammalian cell engineering
errCELL SYSTEMS
IF7.7
err2022-12-01
err48
errOAAI
errCabrera, Alan; Edelstein, Hailey I.; Glykofrydis, Fokion; Love, Kasey S.; Palacios, Sebastian; Tycko, Josh; Zhang, Meng; Lensch, Sarah; Shields, Cara E.; Livingston, Mark; Weiss, Ron; Zhao, Huimin; Haynes, Karmella A.; Morsut, Leonardo; Chen, Yvonne Y.; Khalil, Ahmad S.; Wong, Wilson W.; Collins, James J.; Rosser, Susan J.; Polizzi, Karen; Elowitz, Michael B.; Fussenegger, Martin; Hilton, Isaac B.; Leonard, Joshua N.; Bintu, Lacramioara; Galloway, Kate E.; Deans, Tara L.
errShare
errSave
Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription
errCELL REPORTS
IF6.9
err2022-11-01
err19
errOAAI
errReed, Kathleen S. M.; Davis, Eric S.; Bond, Marielle L.; Cabrera, Alan; Thulson, Eliza; Quiroga, Ivana Yoseli; Cassel, Shannon; Woolery, Kamisha T.; Hilton, Isaac; Won, Hyejung; Love, Michael I.; Phanstiel, Douglas H.
errShare
errSave
Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells
errACS SYNTHETIC BIOLOGY
IF3.9
err2022-09-26
err14
errOAAI
errEscobar, Mario; Li, Jing; Patel, Aditi; Liu, Shizhe; Xu, Qi; Hilton, Isaac B.
errShare
errSave
Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-07-18
err21
errOAAI
errWang, Kaiyuan; Escobar, Mario; Li, Jing; Mahata, Barun; Goell, Jacob; Shah, Spencer; Cluck, Madeleine; Hilton, Isaac B.
errShare
errSave
Engineering the next generation of cell-based therapeutics
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2022-05-30
err167
errOAAI
errBashor, Caleb J.; Hilton, Isaac B.; Bandukwala, Hozefa; Smith, Devyn M.; Veiseh, Omid
errShare
errSave
Transgenic mice for in vivo epigenome editing with CRISPR-based systems
errNATURE METHODS
IF32.1
err2021-08-02
err73
errOAAI
errGemberling, Matthew; Siklenka, Keith; Rodriguez, Erica; Tonn-Eisinger, Katherine R.; Barrera, Alejandro; Liu, Fang; Kantor, Ariel; Li, Liqing; Cigliola, Valentina; Hazlett, Mariah F.; Williams, Courtney; Bartelt, Luke C.; Madigan, Victoria J.; Bodle, Josephine; Daniels, Heather; Rouse, Douglas C.; Hilton, Isaac B.; Asokan, Aravind; Ciofani, Maria; Poss, Kenneth D.; Reddy, Timothy E.; West, Anne E.; Gersbach, Charles A.
errShare
errSave
CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility
errTRENDS IN BIOTECHNOLOGY
IF14.9
err2021-07-01
err55
PREAI
errGoell, Jacob H.; Hilton, Isaac B.
errShare
errSave
Reversing Post-Infectious Epigenetic-Mediated Immune Suppression
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2021-06-07
err18
errOAAI
errAbhimanyu; Ontiveros, Carlos O.; Guerra-Resendez, Rosa S.; Nishiguchi, Tomoki; Ladki, Malik; Hilton, Isaac B.; Schlesinger, Larry S.; DiNardo, Andrew R.
errShare
errSave
Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
errNATURE COMMUNICATIONS
IF15.7
err2021-02-09
err47
errOAAI
errLi, Jing; Mahata, Barun; Escobar, Mario; Goell, Jacob; Wang, Kaiyuan; Khemka, Pranav; Hilton, Isaac B.
errShare
errSave
Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects
errSCIENCE ADVANCES
IF12.5
err2020-07-17
err70
errOAAI
errLee, Sangsin; Ding, Ning; Sun, Yidi; Yuan, Tanglong; Li, Jing; Yuan, Qichen; Liu, Lizhong; Yang, Jie; Wang, Qian; Kolomeisky, Anatoly B.; Hilton, Isaac B.; Zuo, Erwei; Gao, Xue
errShare
errSave
CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome
errNATURE BIOTECHNOLOGY
IF41.7
err2017-04-03
err364
errOAAI
errKlann, Tyler S.; Black, Joshua B.; Chellappan, Malathi; Safi, Alexias; Song, Lingyun; Hilton, Isaac B.; Crawford, Gregory E.; Reddy, Timothy E.; Gersbach, Charles A.
errShare
errSave
GENETIC ENGINEERING Chemical control for CRISPR editing
errNATURE CHEMICAL BIOLOGY
IF13.7
err2016-11-07
err5
PREAI
errHilton, Isaac B.; Gersbach, Charles A.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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James J. Collins
H-index: 162 · Papers: 589
J
J. Jack Lee
H-index: 146 · Papers: 2.8K
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赵慧敏 (Huimin Zhao)
H-index: 98 · Papers: 721
G
Gregory E. Crawford
H-index: 91 · Papers: 293
E
Elliot L. Chaikof
H-index: 81 · Papers: 449
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