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Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors Nicolle, Simon; Barker, Mike; Barrett, John; Campbell, Matthew; Wojno-Picon, Justyna; Atkinson, Stephen J.; Aylott, Helen; Kessedjian, Hripsimee; He, Yanan; Messenger, Cassie; Roberts, Emma; Spitzfaden, Claus; Le, Joelle; Zinn, Nico; Werner, Thilo; Dumpelfeld, Birgit; Bantscheff, Marcus; Somers, Don O.; Reid, Heather; Thang, Kevin; Gobbetti, Thomas; Lewis, Huw D. Share Save
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety Pero, Joseph E.; Mueller, Elizabeth A.; Adams, Ashley M.; Adolph, Ramona S.; Bagchi, Parikshit; Balce, Dale; Bantscheff, Marcus; Barauskas, Ona; Bartha, Istvan; Bohan, Dana; Cai, Haiying; Carabajal, Esteban; Cassidy, James; Cato, Matthew; Chaudhary, Khuram W.; Chen, Dingjun; Chen, Yi-Pei; Colas, Christophe; Darwech, Isra; Eberl, H. Christian; Fernandez, Beth; Gordon, Earl; Grosse, Johannes; Hansen, Justin; Hetzler, Belinda; Hwang, Seungmin; Jeyasingh, Sam; Kowalski, Beatriz; Lehmann, Stephanie; Lo, Gary; McAllaster, Michael; McHugh, Charles; Momont, Corey; Newby, Zachary; Nigro, Maria; Oladunni, Fatai; Pannirselvam, Malar; Park, Arnold; Pearson, Neil; Peat, Andrew J.; Plastridge, Bob; Ranjan, Rohit; Safabakhsh, Pegah; Shapiro, Nathan D.; Soriaga, Leah; Stokes, Neil; Sweeney, David; Talecki, Lindsey; Telenti, Amalio; Terrell, Ashley; Tse, Winston; Wang, Lisha; Wang, Shuya; Wedel, Laura; Werner, Thilo; Wilk, Deidre Dalmas; Yim, Samantha; Zhou, Jiayi Share Save
Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells Picco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Lee, Yang; Vieira, Sara F.; Bhosle, Shriram; May, Kieron; Herranz-Ors, Carmen; Walker, Samantha J.; Shenje, Raynold; Dincer, Cansu; Gibson, Freddy; Banerjee, Ruby; Hewitson, Zoe; Werner, Thilo; Cottom, Joshua E.; Peng, Yang; Deng, Nanhua; Zhang, Youyou; Nartey, Eldridge N.; Nickels, Leng; Landis, Philip; Conticelli, Daniela; McCarten, Katrina; Bush, Jacob; Sharma, Mamta; Lightfoot, Howard; House, David; Milford, Emma; Grant, Emma K.; Glogowski, Michal P.; Wagner, Craig D.; Bantscheff, Marcus; Rutkowska-Klute, Anna; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, H. Christian; Jones, Brian T.; Schneck, Jessica L.; Murphy, Dennis J.; Voest, Emile E.; Taygerly, Joshua P.; DeMartino, Michael P.; Coelho, Matthew A.; Houseley, Jonathan; Sharma, Geeta; Schwartz, Benjamin; Garnett, Mathew J. Share Save
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition Burtscher, Mira L.; Gade, Stephan; Garrido-Rodriguez, Martin; Rutkowska, Anna; Werner, Thilo; Eberl, H. Christian; Petretich, Massimo; Knopf, Natascha; Zirngibl, Katharina; Grandi, Paola; Bergamini, Giovanna; Bantscheff, Marcus; Faelth-Savitski, Maria; Saez-Rodriguez, Julio Share Save
Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90 Jin, Jing; Tian, Ruijun; Pasculescu, Adrian; Dai, Anna Yue; Williton, Kelly; Taylor, Lorne; Savitski, Mikhail M.; Bantscheff, Marcus; Woodgett, James R.; Pawson, Tony; Colwill, Karen Share Save
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis Singh, Vinayak; Grzegorzewicz, Anna E.; Fienberg, Stephen; Muller, Rudolf; Khonde, Lutete Peguy; Sanz, Olalla; Alfonso, Salvatore; Urones, Beatriz; Drewes, Gerard; Bantscheff, Marcus; Ghidelli-Disse, Sonja; Ioerger, Thomas R.; Angala, Bhanupriya; Liu, Jiuyu; Lee, Richard E.; Sacchettini, James C.; Krieger, Inna, V; Jackson, Mary; Chibale, Kelly; Ghorpade, Sandeep R. Share Save
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages Arendse, Lauren B.; Murithi, James M.; Qahash, Tarrick; Pasaje, Charisse Flerida A.; Godoy, Luiz C.; Dey, Sumanta; Gibhard, Liezl; Ghidelli-Disse, Sonja; Drewes, Gerard; Bantscheff, Marcus; Lafuente-Monasterio, Maria J.; Fienberg, Stephen; Wambua, Lynn; Gachuhi, Samuel; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Aswat, Ayesha S.; Erlank, Erica; Venter, Nelius; Mittal, Nimisha; Luth, Madeline R.; Ottilie, Sabine; Winzeler, Elizabeth A.; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Niles, Jacquin C.; Llinas, Manuel; Fidock, David A.; Chibale, Kelly Share Save
Systematic discovery of biomolecular condensate-specific protein phosphorylation Sridharan, Sindhuja; Hernandez-Armendariz, Alberto; Kurzawa, Nils; Potel, Clement M.; Memon, Danish; Beltrao, Pedro; Bantscheff, Marcus; Huber, Wolfgang; Cuylen-Haering, Sara; Savitski, Mikhail M. Share Save
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A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles (Nov, 10.1038/s41467-020-19529-8, 2020) Kurzawa, Nils; Becher, Isabelle; Sridharan, Sindhuja; Franken, Holger; Mateus, Andre; Anders, Simon; Bantscheff, Marcus; Huber, Wolfgang; Savitski, Mikhail M. Share Save
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia Pappalardi, Melissa B.; Keenan, Kathryn; Cockerill, Mark; Kellner, Wendy A.; Stowell, Alexandra; Sherk, Christian; Wong, Kristen; Pathuri, Sarath; Briand, Jacques; Steidel, Michael; Chapman, Philip; Groy, Arthur; Wiseman, Ashley K.; McHugh, Charles F.; Campobasso, Nino; Graves, Alan P.; Fairweather, Emma; Werner, Thilo; Raoof, Ali; Butlin, Roger J.; Rueda, Lourdes; Horton, John R.; Fosbenner, David T.; Zhang, Cunyu; Handler, Jessica L.; Muliaditan, Morris; Mebrahtu, Makda; Jaworski, Jon-Paul; McNulty, Dean E.; Burt, Charlotte; Eberl, H. Christian; Taylor, Amy N.; Ho, Thau; Merrihew, Susan; Foley, Shawn W.; Rutkowska, Anna; Li, Mei; Romeril, Stuart P.; Goldberg, Kristin; Zhang, Xing; Kershaw, Christopher S.; Bantscheff, Marcus; Jurewicz, Anthony J.; Minthorn, Elisabeth; Grandi, Paola; Patel, Mehul; Benowitz, Andrew B.; Mohammad, Helai P.; Gilmartin, Aidan G.; Prinjha, Rab K.; Ogilvie, Donald; Carpenter, Christopher; Heerding, Dirk; Baylin, Stephen B.; Jones, Peter A.; Cheng, Xiaodong; King, Bryan W.; Luengo, Juan, I; Jordan, Allan M.; Waddell, Ian; Kruger, Ryan G.; McCabe, Michael T. Share Save
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs Law, Robert P.; Nunes, Joao; Chung, Chun-wa; Bantscheff, Marcus; Buda, Karol; Dai, Han; Evans, John P.; Flinders, Adam; Klimaszewska, Diana; Lewis, Antonia J.; Muelbaier, Marcel; Scott-Stevens, Paul; Stacey, Peter; Tame, Christopher J.; Watt, Gillian F.; Zinn, Nico; Queisser, Markus A.; Harling, John D.; Benowitz, Andrew B. Share Save
One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics Fallon, David J.; Lehmann, Stephanie; Chung, Chun-wa; Phillipou, Alex; Eberl, Christian; Fantom, Ken G. M.; Zappacosta, Francesca; Patel, Vipulkumar K.; Bantscheff, Marcus; Schofield, Christopher J.; Tomkinson, Nicholas C. O.; Bush, Jacob T. Share Save
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