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K

Klaus Okkenhaug

University of Cambridge

66H-index
185Paper Count
2.1WCitation Count
Published Papers 98
Publication Date
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Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy
errNature Immunology
IF27.6
err2026-01-16
err0
errOAAI
errAlberto G. Conti; Alexander C. Evans; Teresa von Linde; Christian Deo T. Deguit; Sarah K. Whiteside; Alexander J. Wesolowski; Charlotte J. Imianowski; Yumi Yamashita-Kanemaru; Layla Dahmani; Jack Chapman; Ardon M. Pillay; Aws Al-Deka; Randy Greaves; Oliver Burton; Panagiota Vardaka; Shienny Sampurno; Iván Pérez-Núñez; Nicole Y. L. Saw; Jie Yang; Andrew J. M. Howden; Klaus Okkenhaug; Suman Mitra; Bartlomiej Swiatczak; Ian A. Parish; Rahul Roychoudhuri
errShare
errSave
Perturbing local steroidogenesis to improve breast cancer immunity
errNATURE COMMUNICATIONS
IF15.7
err2025-04-26
err0
errOAAI
errZhao, Qiuchen; Pramanik, Jhuma; Lu, Yongjin; Homer, Natalie Z. M.; Imianowski, Charlotte J.; Zhang, Baojie; Iqbal, Muhammad; Shaji, Sanu Korumadathil; Morris, Andrew Conway; Roychoudhuri, Rahul; Okkenhaug, Klaus; Qiu, Pengfei; Mahata, Bidesh
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errSave
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
errNATURE MICROBIOLOGY
IF19.4
err2025-02-10
err2
errOAAI
errSardar, Puspendu; Beresford-Jones, Benjamin S.; Xia, Wangmingyu; Shabana, Omar; Suyama, Satoshi; Ramos, Ruben J. F.; Soderholm, Amelia T.; Tourlomousis, Panagiotis; Kuo, Paula; Evans, Alexander C.; Imianowski, Charlotte J.; Conti, Alberto G.; Wesolowski, Alexander J.; Baker, Natalie M.; Mccord, Emily A. L.; Okkenhaug, Klaus; Whiteside, Sarah K.; Bryant, Clare E.; Cross, Justin R.
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errSave
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-11-27
err0
errOAAI
errCourreges, Christina J. F.; Davenport, Elizabeth C. M.; Bilanges, Benoit; Rebollo-Gomez, Elena; Hukelmann, Jens; Schoenfelder, Priya; Edgar, James R.; Sansom, David; Scudamore, Cheryl L.; Roychoudhuri, Rahul; Garden, Oliver A.; Vanhaesebroeck, Bart; Okkenhaug, Klaus
errShare
errSave
PI3K Inhibitors in Hematology: When One Door Closes…
errCLINICAL CANCER RESEARCH
IF10.2
err2024-07-05
err1
PREAI
errSkanland, Sigrid S.; Okkenhaug, Klaus; Davids, Matthew S.
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errSave
Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site
errSCIENCE IMMUNOLOGY
IF16.3
err2024-05-24
err3
errOAAI
errTakahashi, Munetomo; So, Tsz Y.; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J.; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y. F.; Lyons, Paul A.; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J.; Smith, Ken G. C.; Jodrell, Duncan I.; Chapman, Michael A.; Thaventhiran, James E. D.
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errSave
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion
errSCIENCE IMMUNOLOGY
IF16.3
err2023-12-15
err8
errOAAI
errWhiteside, Sarah K.; Grant, Francis M.; Alvisi, Giorgia; Clarke, James; Tang, Leqi; Imianowski, Charlotte J.; Zhang, Baojie; Evans, Alexander C.; Wesolowski, Alexander J.; Conti, Alberto G.; Yang, Jie; Lauder, Sarah N.; Clement, Mathew; Humphreys, Ian R.; Dooley, James; Burton, Oliver; Liston, Adrian; Alloisio, Marco; Voulaz, Emanuele; Langhorne, Jean; Okkenhaug, Klaus; Lugli, Enrico; Roychoudhuri, Rahul
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errSave
Tissue-resident B cells orchestrate macrophage polarisation and function
errNATURE COMMUNICATIONS
IF15.7
err2023-11-04
err16
errOAAI
errSuchanek, Ondrej; Ferdinand, John R.; Tuong, Zewen K.; Wijeyesinghe, Sathi; Chandra, Anita; Clauder, Ann-Katrin; Almeida, Larissa N.; Clare, Simon; Harcourt, Katherine; Ward, Christopher J.; Bashford-Rogers, Rachael; Lawley, Trevor; Manz, Rudolf A.; Okkenhaug, Klaus; Masopust, David; Clatworthy, Menna R.
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errSave
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion
errTRENDS IN IMMUNOLOGY
IF13.9
err2023-11-01
err5
errOAAI
errJohansen, Kristoffer H.; Golec, Dominic P.; Okkenhaug, Klaus; Schwartzberg, Pamela L.
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errSave
Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release
errEMBO REPORTS
IF6.2
err2023-10-11
err10
errOAAI
errStewart, Hazel; Palmulli, Roberta; Johansen, Kristoffer H.; Mcgovern, Naomi; Shehata, Ola M.; Carnell, George W.; Jackson, Hannah K.; Lee, Jin S.; Brown, Jonathan C.; Burgoyne, Thomas; Heeney, Jonathan L.; Okkenhaug, Klaus; Firth, Andrew E.; Peden, Andrew A.; Edgar, James R.
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errSave
An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome
errPULMONARY PHARMACOLOGY & THERAPEUTICS
IF2.8
err2023-04-01
err14
errOAAI
errBegg, Malcolm; Amour, Augustin; Jarvis, Emily; Tang, Teresa; Franco, Sara Santos; Want, Andrew; Beerahee, Misba; Fernando, Disala; Karkera, Yakshitha; Sander, Clare; Southworth, Thomas; Singh, Dave; Clark, Jonathan; Nejentsev, Sergey; Okkenhaug, Klaus; Condliffe, Alison; Chandra, Anita; Cahn, Anthony; Hall, Edward Banham
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errSave
Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err62
errOAAI
errBjorgo, Elisa; Solheim, Silje A.; Abrahamsen, Hilde; Baillie, George S.; Brown, Kim M.; Berge, Torunn; Okkenhaug, Klaus; Houslay, Miles D.; Tasken, Kjetil
errShare
errSave
Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/b-Arrestin/cAMP Phosphodiesterase 4 Complex (vol 30, pg 1660, 2010)
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-02-27
err0
errOAAI
errBjorgo, Elisa; Solheim, Silje A.; Abrahamsen, Hilde; Baillie, George S.; Brown, Kim M.; Berge, Torunn; Okkenhaug, Klaus; Houslay, Miles D.; Tasken, Kjetil
errShare
errSave
BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2022-09-30
err10
errOAAI
errImianowski, Charlotte J.; Whiteside, Sarah K.; Lozano, Teresa; Evans, Alexander C.; Benson, Jayme D.; Courreges, Christina J. F.; Sadiyah, Firas; Lau, Colleen M.; Zandhuis, Nordin D.; Grant, Francis M.; Schuijs, Martijn J.; Vardaka, Panagiota; Kuo, Paula; Soilleux, Elizabeth J.; Yang, Jie; Sun, Joseph C.; Kurosaki, Tomohiro; Okkenhaug, Klaus; Halim, Timotheus Y. F.; Roychoudhuri, Rahul
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errSave
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells
errSCIENCE SIGNALING
IF6.6
err2022-07-19
err16
errOAAI
errJohansen, Kristoffer H.; Golec, Dominic P.; Huang, Bonnie; Park, Chung; Thomsen, Julie H.; Preite, Silvia; Cannons, Jennifer L.; Garcon, Fabien; Schrom, Edward C.; Courreges, Christina J. F.; Veres, Tibor Z.; Harrison, James; Nus, Meritxell; Phelan, James D.; Bergmeier, Wolfgang; Kehrl, John H.; Okkenhaug, Klaus; Schwartzberg, Pamela L.
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errSave
Activated PI3K6 syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model
errbrain behavior and immunity
IF3.5
err2021-12-01
err4
errOAAI
errSerra, Ines; Manusama, Olivia R.; Kaiser, Fabian M. P.; Floriano, Izi Izumi; Wahl, Lucas; van der Zalm, Christian; IJspeert, Hanna; van Hagen, P. Martin; van Beveren, Nico J. M.; Arend, Sandra M.; Okkenhaug, Klaus; Pel, Johan J. M.; Dalm, Virgil A. S. H.; Badura, Aleksandra
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errSave
PI3K inhibitors are finally coming of age (Jun, 10.1038/s41573-021-00209-1, 2021)
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2021-09-01
err6
errOAAI
errVanhaesebroeck, Bart; Perry, Matthew W. D.; Brown, Jennifer R.; Andre, Fabrice; Okkenhaug, Klaus
errShare
errSave
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
errBLOOD ADVANCES
IF7.1
err2021-08-17
err10
errOAAI
errPantarelli, Chiara; Pan, Dingxin; Chetwynd, Stephen; Stark, Anne-Katrien; Hornigold, Kirsti; Machin, Polly; Crossland, Laraine; Cleary, Simon J.; Baker, Martin J.; Hampson, Elizabeth; Mandel, Anna; Segonds-Pichon, Anne; Walker, Rachael; Veer, Cornelis van 't; Riffo-Vasquez, Yanira; Okkenhaug, Klaus; Pitchford, Simon; Welch, Heidi C. E.
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errSave
PI3K in T Cell Adhesion and Trafficking
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2021-08-06
err17
errOAAI
errJohansen, Kristoffer H.; Golec, Dominic P.; Thomsen, Julie H.; Schwartzberg, Pamela L.; Okkenhaug, Klaus
errShare
errSave
PI3K inhibitors are finally coming of age
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2021-06-14
err266
errOAAI
errVanhaesebroeck, Bart; Perry, Matthew W. D.; Brown, Jennifer R.; Andre, Fabrice; Okkenhaug, Klaus
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Jean‐Laurent Casanova
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Alain Fischer
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A
Arlene H. Sharpe
H-index: 154 · Papers: 737
N
Nicholas P. Restifo
H-index: 150 · Papers: 890
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