Not logged in Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia Pappalardi, Melissa B.; Keenan, Kathryn; Cockerill, Mark; Kellner, Wendy A.; Stowell, Alexandra; Sherk, Christian; Wong, Kristen; Pathuri, Sarath; Briand, Jacques; Steidel, Michael; Chapman, Philip; Groy, Arthur; Wiseman, Ashley K.; McHugh, Charles F.; Campobasso, Nino; Graves, Alan P.; Fairweather, Emma; Werner, Thilo; Raoof, Ali; Butlin, Roger J.; Rueda, Lourdes; Horton, John R.; Fosbenner, David T.; Zhang, Cunyu; Handler, Jessica L.; Muliaditan, Morris; Mebrahtu, Makda; Jaworski, Jon-Paul; McNulty, Dean E.; Burt, Charlotte; Eberl, H. Christian; Taylor, Amy N.; Ho, Thau; Merrihew, Susan; Foley, Shawn W.; Rutkowska, Anna; Li, Mei; Romeril, Stuart P.; Goldberg, Kristin; Zhang, Xing; Kershaw, Christopher S.; Bantscheff, Marcus; Jurewicz, Anthony J.; Minthorn, Elisabeth; Grandi, Paola; Patel, Mehul; Benowitz, Andrew B.; Mohammad, Helai P.; Gilmartin, Aidan G.; Prinjha, Rab K.; Ogilvie, Donald; Carpenter, Christopher; Heerding, Dirk; Baylin, Stephen B.; Jones, Peter A.; Cheng, Xiaodong; King, Bryan W.; Luengo, Juan, I; Jordan, Allan M.; Waddell, Ian; Kruger, Ryan G.; McCabe, Michael T. Share Save
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs Law, Robert P.; Nunes, Joao; Chung, Chun-wa; Bantscheff, Marcus; Buda, Karol; Dai, Han; Evans, John P.; Flinders, Adam; Klimaszewska, Diana; Lewis, Antonia J.; Muelbaier, Marcel; Scott-Stevens, Paul; Stacey, Peter; Tame, Christopher J.; Watt, Gillian F.; Zinn, Nico; Queisser, Markus A.; Harling, John D.; Benowitz, Andrew B. Share Save
Share Save
The PROTACtable genome Schneider, Melanie; Radoux, Chris J.; Hercules, Andrew; Ochoa, David; Dunham, Ian; Zalmas, Lykourgos-Panagiotis; Hessler, Gerhard; Ruf, Sven; Shanmugasundaram, Veerabahu; Hann, Michael M.; Thomas, Pam J.; Queisser, Markus A.; Benowitz, Andrew B.; Brown, Kris; Leach, Andrew R. Share Save
Share Save
Structural Insights into PROTAC-Mediated Degradation of BcI-xL Chung, Chun-wa; Dai, Han; Fernandez, Esther; Tinworth, Christopher P.; Churcher, Ian; Cryan, Jenni; Denyer, Jane; Harling, John D.; Konopacka, Agnieszka; Queisser, Markus A.; Tame, Christopher J.; Watt, Gillian; Jiang, Fan; Qian, Dongming; Benowitz, Andrew B. Share Save
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor Gilmartin, Aidan G.; Groy, Arthur; Gore, Elizabeth R.; Atkins, Charity; Long, Edward R.; Montoute, Monica N.; Wu, Zining; Halsey, Wendy; McNulty, Dean E.; Ennulat, Daniela; Rueda, Lourdes; Pappalardi, Melissa B.; Kruger, Ryan G.; McCabe, Michael T.; Raoof, Ali; Butlin, Roger; Stowell, Alexandra; Cockerill, Mark; Waddell, Ian; Ogilvie, Donald; Luengo, Juan; Jordan, Allan; Benowitz, Andrew B. Share Save
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2 Mares, Alina; Miah, Afjal H.; Smith, Ian E. D.; Rackham, Mark; Thawani, Aditya R.; Cryan, Jenni; Haile, Pamela A.; Votta, Bartholomew J.; Beal, Allison M.; Capriotti, Carol; Reilly, Michael A.; Fisher, Don T.; Zinn, Nico; Bantscheff, Marcus; MacDonald, Thomas T.; Vossenkamper, Anna; Dace, Phoebe; Churcher, Ian; Benowitz, Andrew B.; Watt, Gillian; Denyer, Jane; Scott-Stevens, Paul; Harling, John D. Share Save
Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents Pappalardi, Melissa B.; Cockerill, Mark; Handler, Jessica L.; Stowell, Alexandra; Keenan, Kathryn; Sherk, Christian S.; Minthorn, Elisabeth A.; McHugh, Charles F.; Burt, Charlotte; Wong, Kristen; Fosbenner, David T.; Patel, Mehul; Briand, Jacques; Mohammad, Helai; Rueda, Lourdes; Benowitz, Andrew; Prinjha, Rab; Heerding, Dirk; Kruger, Ryan G.; Raoof, Ali; Jordan, Allan; King, Bryan W.; McCabe, Michael T. Share Save
Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions Ariazi, Jennifer; Benowitz, Andrew; De Biasi, Vern; Den Boer, Monique L.; Cherqui, Stephanie; Cui, Haifeng; Douillet, Nathalie; Eugenin, Eliseo A.; Favre, David; Goodman, Spencer; Gousset, Karine; Hanein, Dorit; Israel, David I.; Kimura, Shunsuke; Kirkpatrick, Robert B.; Kuhn, Nastaran; Jeong, Claire; Lou, Emil; Mailliard, Robbie; Maio, Stephen; Okafo, George; Osswald, Matthias; Pasquier, Jennifer; Polak, Roel; Pradel, Gabriele; de Rooij, Bob; Schaeffer, Peter; Skeberdis, Vytenis A.; Smith, Ian F.; Tanveer, Ahmad; Volkmann, Niels; Wu, Zhenhua; Zurzolo, Chiara Share Save
Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase Concha, Nestor; Huang, Jianzhong; Bai, Xiaopeng; Benowitz, Andrew; Brady, Pat; Grady, LaShadric C.; Kryn, Luz Helena; Holmes, David; Ingraham, Karen; Jin, Qi; Kaushansky, Laura Pothier; McCloskey, Lynn; Messer, Jeffrey A.; O'Keefe, Heather; Patel, Amish; Satz, Alexander L.; Sinnamon, Robert H.; Schneck, Jessica; Skinner, Steve R.; Summerfield, Jennifer; Taylor, Amy; Taylor, J. David; Evindar, Ghotas; Stavenger, Robert A. Share Save
Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA Ligase Howard, Steven; Amin, Nader; Benowitz, Andrew B.; Chiarparin, Elisabetta; Cui, Haifeng; Deng, Xiaodong; Heightman, Tom D.; Holmes, David J.; Hopkins, Anna; Huang, Jianzhong; Jin, Qi; Kreatsoulas, Constantine; Martin, Agnes C. L.; Massey, Frances; McCloskey, Lynn; Mortenson, Paul N.; Pathuri, Puja; Tisi, Dominic; Williams, Pamela A. Share Save
Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics Smith, AB; Charnley, AK; Mesaros, EF; Kikuchi, O; Wang, WY; Benowitz, A; Chu, CL; Feng, JJ; Chen, KH; Lin, A; Cheng, FC; Taylor, L; Hirschmann, R Share Save
Share Save
Share Save
Share Save
Design and synthesis of a competent pyrrolinone-peptide hybrid ligand for the class II major histocompatibility complex protein HLA-DR1 Smith, AB; Benowitz, AB; Sprengeler, PA; Barbosa, J; Guzman, MC; Hirschmann, R; Schweiger, EJ; Bolin, DR; Nagy, Z; Campbell, RM; Cox, DC; Olson, GL Share Save
Design, synthesis, and evaluation of a pyrrolinone-peptide hybrid ligand for the class II MHC protein HLA-DR1 Smith, AB; Benowitz, AB; Guzman, MC; Sprengeler, PA; Hirschmann, R; Schweiger, EJ; Bolin, DR; Nagy, Z; Campbell, RM; Cox, DC; Olson, GL Share Save
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
