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C

Charles A. Gersbach

Duke University

65H-index
242Paper Count
2.3WCitation Count
Published Papers 139
Publication Date
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dHyperCas12a enables multiplexed CRISPRi screens
errNature Communications
IF15.7
err2026-02-12
err0
errOAAI
errSchuyler M. Melore; Christian D. McRoberts Amador; Marisa C. Hamilton; Charles A. Gersbach; Timothy E. Reddy
errShare
errSave
Monitoring biological effects of somatic cell genome editing
errNature Reviews Genetics
IF52
err2026-01-13
err0
PREAI
errBenjamin S. Freedman; Jeff W. M. Bulte; Bruce R. Conklin; Luke M. Judge; Melinda R. Dwinell; Aron M. Geurts; Madeleine J. Sitton; Vineet Mahajan; Samira Kiani; Charles A. Gersbach; Mo R. Ebrahimkhani; John J. Kelly; John A. Ronald; Ryuji Morizane; Navin Gupta; Ali Shakeri-Zadeh; Nicole Vo; Krishanu Saha; Shivani Saxena; David M. Gamm; Divya Sinha; Alice F. Tarantal; Moriel Vandsburger; Azusa Matsubara; Hongxia Fu; Shengdar Q. Tsai
errShare
errSave
The IGVF catalog-from genetic variation to function
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-12-01
err1
PREAI
errLi, Daofeng; Liu, Shane; Assis, Pedro R.; Li, Mingjie; Dong, Shengcheng; Whaling, Ian; Jolanki, Otto; Kagda, Meenakshi; Zhang, Wenjin; Macias-Velasco, Juan F.; Liu, Tianjie; Cody, Sarah; Antonacci-Fulton, Lucinda; Huang, Yuanhao; Liu, Jie; Montgomery, Michael T.; Zeiberg, Daniel; Jain, Shantanu; Pejaver, Vikas; Bergquist, Timothy; Chen, Yile; Radivojac, Predrag; Gersbach, Charles A.; Sherpa, Rintsen N.; Castro, Christopher P.; Boyle, Alan P.; Starita, Lea M.; Fowler, Douglas M.; Ahituv, Nadav; Dey, Kushal K.; Majoros, William H.; Reddy, Timothy E.; Craven, Mark; Sinha, Riya; Sverchkov, Yuriy; Cai, Xiangmeng; Nzima, Mpathi Z.; Calderwood, Michael A.; Rozowsky, Joel; Gerstein, Mark; Ma, Jian; Yue, Feng; Cherry, J. Michael; Love, Michael, I; Engreitz, Jesse M.; Hitz, Benjamin C.; Wang, Ting
errShare
errSave
A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress
errGENOME RESEARCH
IF5.5
err2025-11-01
err0
PREAI
errAnglen, Taylor; Kaplow, Irene M.; Choi, Baekgyu; Dewars, Enya; Perelli, Robin M.; Hagy, Kevin T.; Tran, Duc; Ramaker, Megan E.; Shah, Svati H.; Jung, Inkyung; Landstrom, Andrew P.; Karra, Ravi; Diao, Yarui; Gersbach, Charles A.
errShare
errSave
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
errScience
IF45.8
err2025-09-25
err0
PREAI
errBrian D. Cosgrove; Lexi R. Bounds; Carson Key Taylor; Alan L. Su; Anthony J. Rizzo; Alejandro Barrera; Tongyu Sun; Alexias Safi; Lingyun Song; Thomas Whitlow; Aleksandra Tata; Nahid Iglesias; Yarui Diao; Purushothama Rao Tata; Brenton D. Hoffman; Gregory E. Crawford; Charles A. Gersbach
errShare
errSave
Characterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using
errCELL GENOMICS
IF9
err2025-02-01
err0
errOAAI
errLiu, Siyan; Hamilton, Marisa C.; Cowart, Thomas; Barrera, Alejandro; Bounds, Lexi R.; Nelson, Alexander C.; Dornbaum, Sophie F.; Riley, Julia W.; Doty, Richard W.; Allen, Andrew S.; Crawford, Gregory E.; Majoros, William H.; Gersbach, Charles A.
errShare
errSave
Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing
errCELL GENOMICS
IF9
err2025-02-01
err0
errOAAI
errRohm, Dahlia; Black, Joshua B.; Mccutcheon, Sean R.; Barrera, Alejandro; Berry, Shante S.; Morone, Daniel J.; Nuttle, Xander; de Esch, Celine E.; Tai, Derek J. C.; Talkowski, Michael E.; Iglesias, Nahid; Gersbach, Charles A.
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errSave
Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
errNATURE COMMUNICATIONS
IF15.7
err2024-08-09
err0
errOAAI
errGao, Yudong; Shonai, Daichi; Trn, Matthew; Zhao, Jieqing; Soderblom, Erik J.; Garcia-Moreno, S. Alexandra; Gersbach, Charles A.; Wetsel, William C.; Dawson, Geraldine; Velmeshev, Dmitry; Jiang, Yong-hui; Sloofman, Laura G.; Buxbaum, Joseph D.; Soderling, Scott H.
errShare
errSave
Epigenome editing technologies for discovery and medicine
errNATURE BIOTECHNOLOGY
IF41.7
err2024-07-29
err2
PREAI
errMcCutcheon, Sean R.; Rohm, Dahlia; Iglesias, Nahid; Gersbach, Charles A.
errShare
errSave
Multicenter integrated analysis of noncoding CRISPRi screens
errNATURE METHODS
IF32.1
err2024-03-19
err10
errOAAI
errYao, David; Tycko, Josh; Oh, Jin Woo; Bounds, Lexi R.; Gosai, Sager J.; Lataniotis, Lazaros; Mackay-Smith, Ava; Doughty, Benjamin R.; Gabdank, Idan; Schmidt, Henri; Guerrero-Altamirano, Tania; Siklenka, Keith; Guo, Katherine; White, Alexander D.; Youngworth, Ingrid; Andreeva, Kalina; Ren, Xingjie; Barrera, Alejandro; Luo, Yunhai; Yardimci, Galip Gurkan; Tewhey, Ryan; Kundaje, Anshul; Greenleaf, William J.; Sabeti, Pardis C.; Leslie, Christina; Pritykin, Yuri; Moore, Jill E.; Beer, Michael A.; Gersbach, Charles A.; Reddy, Timothy E.; Shen, Yin; Engreitz, Jesse M.; Bassik, Michael C.; Reilly, Steven K.
errShare
errSave
A humanized mouse model for adeno-associated viral gene therapy
errNATURE COMMUNICATIONS
IF15.7
err2024-03-04
err2
errOAAI
errBarzi, Mercedes; Chen, Tong; Gonzalez, Trevor J.; Pankowicz, Francis P.; Oh, Seh Hoon; Streff, Helen L.; Rosales, Alan; Ma, Yunhan; Collias, Sabrina; Woodfield, Sarah E.; Diehl, Anna Mae; Vasudevan, Sanjeev A.; Galvan, Thao N.; Goss, John; Gersbach, Charles A.; Bissig-Choisat, Beatrice; Asokan, Aravind; Bissig, Karl-Dimiter
errShare
errSave
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
errNATURE GENETICS
IF31.8
err2023-11-09
err17
errOAAI
errMcCutcheon, Sean R.; Swartz, Adam M.; Brown, Michael C.; Barrera, Alejandro; Amador, Christian McRoberts; Siklenka, Keith; Humayun, Lucas; ter Weele, Maria A.; Isaacs, James M.; Reddy, Timothy E.; Allen, Andrew S.; Nair, Smita K.; Antonia, Scott J.; Gersbach, Charles A.
errShare
errSave
PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system
errAPL BIOENGINEERING
IF4.1
err2023-10-16
err3
errOAAI
errLee, Jounghyun H.; Shores, Kevin L.; Breithaupt, Jason J.; Lee, Caleb S.; Fodera, Daniella M.; Kwon, Jennifer B.; Ettyreddy, Adarsh R.; Myers, Kristin M.; Evison, Benny J.; Suchowerska, Alexandra K.; Gersbach, Charles A.; Leong, Kam W.; Truskey, George A.
errShare
errSave
Nonviral In Vivo Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles
errACS NANO
IF16
err2023-08-15
err6
PREAI
errFletcher, R. Brock; Stokes, Larry D.; Kelly, Isom B., III; Henderson, Katelyn M.; Vallecillo-Viejo, Isabel C.; Colazo, Juan M.; Wong, Benjamin V.; Yu, Fang; d'Arcy, Richard; Struthers, Morgan N.; Evans, Brian C.; Ayers, Jacob; Castanon, Matthew; Weirich, Michael J.; Reilly, Sarah K.; Patel, Shrusti S.; Ivanova, Yoanna I.; Batista, Carlos A. Silvera; Weiss, Sharon M.; Gersbach, Charles A.; Brunger, Jonathan M.; Duvall, Craig L.
errShare
errSave
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair
errCELL STEM CELL
IF20.4
err2023-01-01
err27
errOAAI
errYan, Ruorong; Cigliola, Valentina; Oonk, Kelsey A.; Petrover, Zachary; DeLuca, Sophia; Wolfson, David W.; Vekstein, Andrew; Mendiola, Michelle A.; Devlin, Garth; Bishawi, Muath; Gemberling, Matthew P.; Sinha, Tanvi; Sargent, Michelle A.; York, Allen J.; Shakked, Avraham; DeBenedittis, Paige; Wendell, David C.; Ou, Jianhong; Kang, Junsu; Goldman, Joseph A.; Baht, Gurpreet S.; Karra, Ravi; Williams, Adam R.; Bowles, Dawn E.; Asokan, Aravind; Tzahor, Eldad; Gersbach, Charles A.; Molkentin, Jeffery D.; Bursac, Nenad; Black, Brian L.; Poss, Kenneth D.
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errSave
Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing
errNATURE COMMUNICATIONS
IF15.7
err2022-10-10
err33
errOAAI
errGonzalez, Trevor J.; Simon, Katherine E.; Blondel, Leo O.; Fanous, Marco M.; Roger, Angela L.; Maysonet, Maribel Santiago; Devlin, Garth W.; Smith, Timothy J.; Oh, Daniel K.; Havlik, L. Patrick; Castellanos Rivera, Ruth M.; Piedrahita, Jorge A.; ElMallah, Mai K.; Gersbach, Charles A.; Asokan, Aravind
errShare
errSave
Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators
errACS NANO
IF16
err2022-03-31
err16
errOAAI
errBeyersdorf, Jared P.; Bawage, Swapnil; Iglesias, Nahid; Peck, Hannah E.; Hobbs, Ryan A.; Wroe, Jay A.; Zurla, Chiara; Gersbach, Charles A.; Santangelo, Philip J.
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errSave
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models
errNATURE COMMUNICATIONS
IF15.7
err2021-11-24
err98
errOAAI
errHakim, Chady H.; Kumar, Sandeep R. P.; Perez-Lopez, Dennis O.; Wasala, Nalinda B.; Zhang, Dong; Yue, Yongping; Teixeira, James; Pan, Xiufang; Zhang, Keqing; Million, Emily D.; Nelson, Christopher E.; Metzger, Samantha; Han, Jin; Louderman, Jacqueline A.; Schmidt, Florian; Feng, Feng; Grimm, Dirk; Smith, Bruce F.; Yao, Gang; Yang, N. Nora; Gersbach, Charles A.; Chen, Shi-jie; Herzog, Roland W.; Duan, Dongsheng
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errSave
Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy
errMOLECULAR THERAPY
IF12
err2021-11-01
err38
errOAAI
errPickar-Oliver, Adrian; Gough, Veronica; Bohning, Joel D.; Liu, Siyan; Robinson-Hamm, Jacqueline N.; Daniels, Heather; Majoros, William H.; Devlin, Garth; Asokan, Aravind; Gersbach, Charles A.
errShare
errSave
Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis
errADVANCED SCIENCE
IF14.1
err2021-08-10
err18
errOAAI
errWang, Lihua; Wang, Ergang; Prado Balcazar, Jorge; Wu, Zhenzhen; Xiang, Kun; Wang, Yi; Huang, Qiang; Negrete, Marcos; Chen, Kai-Yuan; Li, Wei; Fu, Yujie; Dohlman, Anders; Mines, Robert; Zhang, Liwen; Kobayashi, Yoshihiko; Chen, Tianyi; Shi, Guizhi; Shen, John Paul; Kopetz, Scott; Tata, Purushothama Rao; Moreno, Victor; Gersbach, Charles; Crawford, Gregory; Hsu, David; Huang, Emina; Bu, Pengcheng; Shen, Xiling
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errSave

Research Directions

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Co-authors
Cooperation Journals
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Norbert Perrimon
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Jennifer A. Doudna
H-index: 149 · Papers: 672
J
Jeffery D. Molkentin
H-index: 141 · Papers: 642
J
Joseph D. Buxbaum
H-index: 140 · Papers: 791
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