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D

Denis Wirtz

johns hopkins university

94H-index
541Paper Count
3.2WCitation Count
Published Papers 218
Publication Date
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3D multi-omics tumour atlases: from technology to biology and clinical translation
errNature Reviews Cancer
IF66.8
err2026-06-15
err0
PREAI
errMiao Liu; Jorge Villazon; André Forjaz; Xiaolong Tian; Rong Fan; Siyuan Wang; Lingyan Shi; Denis Wirtz; Ashley L. Kiemen
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errSave
iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining
errNature Communications
IF15.7
err2026-02-24
err0
errOAAI
errFan Wu; Shuyuan Zheng; Yani Chen; Peijia Ye; Moo Joong Kim; Seojin Lee; Geroge Kuo; Shriya Pillan; Ruihan Yuan; Kyu Sang Han; Bofei Yu; Qingfeng Zhu; Sarah M. Shin; Courtney D. Cannon; Gabriele Pierre; Kanako Iwasaki; Cristina Aguayo-Mazzucato; Nicolas Musi; George A. Kuchel; Birgit Schilling; Laura D. Wood; Won Jin Ho; Robert A. Anders; Denis Wirtz; Pei-Hsun Wu
errShare
errSave
Methods to analyze cell migration data: fundamentals and practical guidelines
errNature Methods
IF32.1
err2025-12-18
err0
PREAI
errPei-Hsun Wu; Jude M. Phillip; Wenxuan Du; Andre Forjaz; Praful R. Nair; Denis Wirtz
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errSave
Selecting the optimal cell migration assay: fundamentals and practical guidelines
errNature Methods
IF32.1
err2025-12-18
err0
PREAI
errWenxuan Du; Praful R. Nair; Andre Forjaz; Jude M. Phillip; Pei-Hsun Wu; Denis Wirtz
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errSave
Mechano-induced patterned domain formation by monocytes
errNature Materials
IF38.5
err2025-11-05
err0
PREAI
errWenxuan Du; Jingyi Zhu; Yufei Wu; Hongyi Liu; Ashley L. Kiemen; Zeqi Wan; Eban Andrew Hanna; Hui Zhang; Sean X. Sun; Denis Wirtz
errShare
errSave
Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories
errCell
IF42.5
err2025-07-26
err0
errOAAI
errJeanette A.I. Johnson; Daniel R. Bergman; Heber L. Rocha; David L. Zhou; Eric Cramer; Ian C. Mclean; Yoseph W. Dance; Max Booth; Zachary Nicholas; Tamara Lopez-Vidal; Atul Deshpande; Randy Heiland; Elmar Bucher; Fatemeh Shojaeian; Matthew Dunworth; André Forjaz; Michael Getz; Inês Godet; Furkan Kurtoglu; Melissa Lyman; John Metzcar; Jacob T. Mitchell; Andrew Raddatz; Jacobo Solorzano; Aneequa Sundus; Yafei Wang; David G. DeNardo; Andrew J. Ewald; Daniele M. Gilkes; Luciane T. Kagohara; Ashley L. Kiemen; Elizabeth D. Thompson; Denis Wirtz; Laura D. Wood; Pei-Hsun Wu; Neeha Zaidi; Lei Zheng; Jacquelyn W. Zimmerman; Jude M. Phillip; Elizabeth M. Jaffee; Joe W. Gray; Lisa M. Coussens; Young Hwan Chang; Laura M. Heiser; Genevieve L. Stein-O’Brien; Elana J. Fertig; Paul Macklin
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errSave
Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues
errCell Reports Methods
IF4.5
err2025-06-09
err0
errOAAI
errAndré Forjaz; Eduarda Vaz; Valentina Matos Romero; Saurabh Joshi; Vasco Queiroga; Alicia M. Braxton; Ann C. Jiang; Kohei Fujikura; Toby Cornish; Seung-Mo Hong; Ralph H. Hruban; Pei-Hsun Wu; Laura D. Wood; Ashley L. Kiemen; Denis Wirtz
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errSave
Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube
errSCIENCE ADVANCES
IF12.5
err2024-09-27
err1
errOAAI
errCrawford, Ashleigh J.; Forjaz, Andre; Bons, Joanna; Bhorkar, Isha; Roy, Triya; Schell, David; Queiroga, Vasco; Ren, Kehan; Kramer, Donald; Huang, Wilson; Russo, Gabriella C.; Lee, Meng-Horng; Wu, Pei-Hsun; Shih, Ie-Ming; Wang, Tian-Li; Atkinson, Mark A.; Schilling, Birgit; Kiemen, Ashley L.; Wirtz, Denis
errShare
errSave
RETRACTION: Retraction: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
errCANCER RESEARCH
IF16.6
err2024-09-04
err0
PREAI
errGilkes, Daniele M.; Chaturvedi, Pallavi; Bajpai, Saumendra; Wong, Carmen C.; Wei, Hong; Pitcairn, Stephen; Hubbi, Maimon E.; Wirtz, Denis; Semenza, Gregg L.
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errSave
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
errCELL SYSTEMS
IF7.7
err2024-08-01
err2
PREAI
errBell, Alexander T. F.; Mitchell, Jacob T.; Kiemen, Ashley L.; Lyman, Melissa; Fujikura, Kohei; Lee, Jae W.; Coyne, Erin; Shin, Sarah M.; Nagaraj, Sushma; Deshpande, Atul; Wu, Pei-Hsun; Sidiropoulos, Dimitrios N.; Erbe, Rossin; Stern, Jacob; Chan, Rena; Williams, Stephen; Chell, James M.; Ciotti, Lauren; Zimmerman, Jacquelyn W.; Wirtz, Denis; Ho, Won Jin; Zaidi, Neeha; Thompson, Elizabeth; Jaffee, Elizabeth M.; Wood, Laura D.; Fertig, Elana J.; Kagohara, Luciane T.
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errSave
Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings
errSCIENCE ADVANCES
IF12.5
err2024-07-26
err0
errOAAI
errKiemen, Ashley L.; Wu, Pei-Hsun; Braxton, Alicia M.; Cornish, Toby C.; Hruban, Ralph H.; Wood, Laura D.; Wirtz, Denis; Zwicker, David
errShare
errSave
Local, Sustained, and Targeted Co-Delivery of MEK Inhibitor and Doxorubicin Inhibits Tumor Progression in E-Cadherin-Positive Breast Cancer
errPHARMACEUTICS
IF5.5
err2024-07-25
err1
errOAAI
errKuhn, Paul M.; Russo, Gabriella C.; Crawford, Ashleigh J.; Venkatraman, Aditya; Yang, Nanlan; Starich, Bartholomew A.; Schneiderman, Zachary; Wu, Pei-Hsun; Vo, Thi; Wirtz, Denis; Kokkoli, Efrosini
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errSave
E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer
errCANCER RESEARCH
IF16.6
err2024-07-02
err2
PREAI
errLee, Geonhui; Wong, Claudia; Cho, Anna; West, Junior J.; Crawford, Ashleigh J.; Russo, Gabriella C.; Si, Bishwa R.; Kim, Jungwoo; Hoffner, Lauren; Jang, Cholsoon; Jung, Moonjung; Leone, Robert D.; Konstantopoulos, Konstantinos; Ewald, Andrew J.; Wirtz, Denis; Jeong, Sangmoo
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errSave
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer (mar,10.1038/s41388-024-03007-2, 2023)
errONCOGENE
IF7.3
err2024-04-05
err0
errOAAI
errRusso, Gabriella C.; Crawford, Ashleigh J.; Clark, David; Cui, Julie; Carney, Ryan; Karl, Michelle N.; Su, Boyang; Starich, Bartholomew; Lih, Tung-Shing; Kamat, Pratik; Zhang, Qiming; Nair, Praful R.; Wu, Pei-Hsun; Lee, Meng-Horng; Leong, Hon S.; Zhang, Hui; Rebecca, Vito W.; Wirtz, Denis
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errSave
The unique metabolite landscape of the aged microenvironment dictates melanoma migratory and invasive capacity
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errAlicea, Gretchen Marie; Patel, Payal; Wei, Meihan; Rebecca, Vito; Wirtz, Denis
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errSave
Three-dimensional immune atlas of pancreatic cancer precursor lesions reveals large inter- and intra-lesion heterogeneity
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errKiemen, Ashley L.; Almagro-Perez, Cristina; Matos-Romero, Valentina; Braxton, Alicia M.; Mahesh-Babu, Jaanvi; Thompson, Elizabeth D.; Cornish, Toby C.; Wu, PeiHsun; Wood, Laura D.; Munoz-Barrutia, Arrate; Hruban, Ralph H.; Wirtz, Denis
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errSave
Three-dimensional multi-omic analysis of early invasion of human pancreatic ductal adenocarcinoma from IPMN
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errDatta, Shalini; Shin, Sarah M.; Kanacharoen, Jessie; Pfluger, Michael Johannes; Hirose, Katsuya; Forjaz, Andre; Graham, Sarah; Wu, Pei-Hsun; Hruban, Ralph H.; Wirtz, Denis; Ho, Won Jin; Kiemen, Ashley L.; Wood, Laura D.
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errSave
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
errONCOGENE
IF7.3
err2024-03-20
err7
errOAAI
errRusso, Gabriella C.; Crawford, Ashleigh J.; Clark, David; Cui, Julie; Carney, Ryan; Karl, Michelle N.; Su, Boyang; Starich, Bartholomew; Lih, Tung-Shing; Kamat, Pratik; Zhang, Qiming; Nair, Praful R.; Wu, Pei-Hsun; Lee, Meng-Horng; Leong, Hon S.; Zhang, Hui; Rebecca, Vito W.; Wirtz, Denis
errShare
errSave
MLL1 regulates cytokine-driven cell migration and metastasis
errSCIENCE ADVANCES
IF12.5
err2024-03-15
err4
errOAAI
errNair, Praful R.; Danilova, Ludmila; Gomez-de-Mariscal, Estibaliz; Kim, Dongjoo; Fan, Rong; Munoz-Barrutia, Arrate; Fertig, Elana J.; Wirtz, Denis
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errSave
Tumor proliferation and invasion are intrinsically coupled and unraveled through tunable spheroid and physics-based models
errACTA BIOMATERIALIA
IF9.6
err2024-02-01
err2
errOAAI
errCrawford, Ashleigh J.; Gomez-Cruz, Clara; Russo, Gabriella C.; Huang, Wilson; Bhorkar, Isha; Roy, Triya; Munoz-Barrutia, Arrate; Wirtz, Denis; Garcia-Gonzalez, Daniel
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
G
Gordon B. Mills
H-index: 231 · Papers: 3.5K
R
Ralph H. Hruban
H-index: 209 · Papers: 2.0K
G
Gregg L. Semenza
H-index: 185 · Papers: 682
K
Kun‐Liang Guan
H-index: 168 · Papers: 621
T
Tyler Jacks
H-index: 158 · Papers: 817
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