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CX-5461 sensitizes DNA damage repair-proficient castrate-resistant prostate cancer to PARP inhibition Lawrence, Mitchell G.; Porter, Laura H.; Choo, Nicholas; Sanij, Elaine; Taylor, Renea; Pearson, Richard; Simpson, Kaylene J.; Hannan, Ross D.; Sandhu, Shahneen; Furic, Luc Share Save
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ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia Behrens, Kira; Brajanovski, Natalie; Xu, Zhen; Viney, Elizabeth M.; Dirago, Ladina; Hediyeh-Zadeh, Soroor; Davis, Melissa J.; Pearson, Richard B.; Sanij, Elaine; Alexander, Warren S.; Ng, Ashley P. Share Save
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mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF Hannan, KM; Brandenburger, Y; Jenkins, A; Sharkey, K; Cavanaugh, A; Rothblum, L; Moss, T; Poortinga, G; McArthur, GA; Pearson, RB; Hannan, RD Share Save
SPEN is a biomarker for CDK4/6 inhibitor resistance in patients with metastatic hormone receptor positive (HR+)/HER2-breast cancer Van Geelen, Courtney T.; Teo, Zhi Ling; Savas, Peter; Luen, Stephen J.; Clarke, Kylie A.; Sant, Sneha; Cowley, Karla J.; Caramia, Franco; Simpson, Kaylene J.; Andre, Fabrice; Dawson, Sarah-Jane; Pearson, Richard; Loi, Sherene Share Save
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway Hannan, Katherine M.; Soo, Priscilla; Wong, Mei S.; Lee, Justine K.; Hein, Nadine; Poh, Perlita; Wysoke, Kira D.; Williams, Tobias D.; Montellese, Christian; Smith, Lorey K.; Al-Obaidi, Sheren J.; Nunez-Villacis, Lorena; Pavy, Megan; He, Jin-Shu; Parsons, Kate M.; Loring, Karagh E.; Morrison, Tess; Diesch, Jeannine; Burgio, Gaetan; Ferreira, Rita; Feng, Zhi-Ping; Gould, Cathryn M.; Madhamshettiwar, Piyush B.; Flygare, Johan; Gonda, Thomas J.; Simpson, Kaylene J.; Kutay, Ulrike; Pearson, Richard B.; Engel, Christoph; Watkins, Nicholas J.; Hannan, Ross D.; George, Amee J. Share Save
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation Zhu, Haoran; Chan, Keefe T.; Huang, Xinran; Cerra, Carmelo; Blake, Shaun; Trigos, Anna S.; Anderson, Dovile; Creek, Darren J.; De Souza, David P.; Wang, Xi; Fu, Caiyun; Jana, Metta; Sanij, Elaine; Pearson, Richard B.; Kang, Jian Share Save
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma Smith, Lorey K.; Parmenter, Tiffany; Kleinschmidt, Margarete; Kusnadi, Eric P.; Kang, Jian; Martin, Claire A.; Lau, Peter; Patel, Riyaben; Lorent, Julie; Papadopoli, David; Trigos, Anna; Ward, Teresa; Rao, Aparna D.; Lelliott, Emily J.; Sheppard, Karen E.; Goode, David; Hicks, Rodney J.; Tiganis, Tony; Simpson, Kaylene J.; Larsson, Ola; Blythe, Benjamin; Cullinane, Carleen; Wickramasinghe, Vihandha O.; Pearson, Richard B.; McArthur, Grant A. Share Save
The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function Koltowska, Katarzyna; Okuda, Kazuhide S.; Gloger, Marleen; Rondon-Galeano, Maria; Mason, Elizabeth; Xuan, Jiachen; Dudczig, Stefanie; Chen, Huijun; Arnold, Hannah; Skoczylas, Renae; Bower, Neil, I; Paterson, Scott; Lagendijk, Anne Karine; Baillie, Gregory J.; Leshchiner, Ignaty; Simons, Cas; Smith, Kelly A.; Goessling, Wolfram; Heath, Joan K.; Pearson, Richard B.; Sanij, Elaine; Schulte-Merker, Stefan; Hogan, Benjamin M. Share Save
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CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition Lawrence, Mitchell G.; Porter, Laura H.; Choo, Nicholas; Pook, David; Grummet, Jeremy P.; Pezaro, Carmel J.; Sandhu, Shahneen; Ramm, Susanne; Luu, Jennii; Bakshi, Andrew; Goode, David L.; Sanij, Elaine; Pearson, Richard B.; Hannan, Ross D.; Simpson, Kaylene J.; Taylor, Renea A.; Risbridger, Gail P.; Furic, Luc Share Save
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer Yan, Shunfei; Xuan, Jiachen; Brajanovski, Natalie; Tancock, Madeleine R. C.; Madhamshettiwar, Piyush B.; Simpson, Kaylene J.; Ellis, Sarah; Kang, Jian; Cullinane, Carleen; Sheppard, Karen E.; Hannan, Katherine M.; Hannan, Ross D.; Sanij, Elaine; Pearson, Richard B.; Chan, Keefe T. Share Save
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis Kusnadi, Eric P.; Trigos, Anna S.; Cullinane, Carleen; Goode, David L.; Larsson, Ola; Devlin, Jennifer R.; Chan, Keefe T.; De Souza, David P.; McConville, Malcolm J.; McArthur, Grant A.; Thomas, George; Sanij, Elaine; Poortinga, Gretchen; Hannan, Ross D.; Hannan, Katherine M.; Kang, Jian; Pearson, Richard B. Share Save
Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression Gao, Jixuan; Jung, MoonSun; Mayoh, Chelsea; Venkat, Pooja; Hannan, Katherine M.; Fletcher, Jamie, I; Kamili, Alvin; Gifford, Andrew J.; Kusnadi, Eric P.; Pearson, Richard B.; Hannan, Ross D.; Haber, Michelle; Norris, Murray D.; Somers, Klaartje; Henderson, Michelle J. Share Save
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer Sanij, Elaine; Hannan, Katherine M.; Xuan, Jiachen; Yan, Shunfei; Ahern, Jessica E.; Trigos, Anna S.; Brajanovski, Natalie; Son, Jinbae; Chan, Keefe T.; Kondrashova, Olga; Lieschke, Elizabeth; Wakefield, Matthew J.; Frank, Daniel; Ellis, Sarah; Cullinane, Carleen; Kang, Jian; Poortinga, Gretchen; Nag, Purba; Deans, Andrew J.; Khanna, Kum Kum; Mileshkin, Linda; McArthur, Grant A.; Soong, John; Berns, Els M. J. J.; Hannan, Ross D.; Scott, Clare L.; Sheppard, Karen E.; Pearson, Richard B. Share Save
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