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Guy G. Poirier

Children's Hospital of Philadelphia

97H-index
434Paper Count
4.1WCitation Count
Published Papers 142
Publication Date
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
err2025-11-29
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errVeronica Cherdyntseva; Joanna Paulson; Daniel González-Acosta; Patricia Ubieto-Capella; Melani Rodrigues; Moses Aouami; Selin Adakli; Jean-Philippe Gagné; Collin Bakker; Guy G. Poirier; Nitika Taneja; Massimo Lopes
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Codon specific readthrough as a mechanism of BRCA2 restoration in acquired PARP inhibitor and chemotherapy resistance
err2025-10-28
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errMcgehee, Cordelia D.; Meng, X. Wei; Wu, Xinyan; Correia, Cristina; Venkatachalam, Annapoorna; Flatten, Karen S.; Peterson, Kevin L.; Patel, Anand G.; Rossman, Olivia K.; Wong, Clara; Hurley, Rachel M.; Wagner, Jill M.; Schneider, Paula A.; Dai, Haiming; Poirier, Guy G.; Hendrickson, Andrea E. Wahner; Swisher, Elizabeth M.; Pandey, Akhilesh; Li, Hu; Kaufmann, Scott H.
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Proteome-wide microarray-based screening of PAR-binding proteins
err2025-04-16
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PREAI
errKang, Bong Gu; Kang, Sung-Ung; Kim, Jae Jin; Kwon, Ji-Sun; Gagne, Jean-Philippe; Lee, Seo Yun; Kim, Soyeon; Lee, Karl S.; Ha, Shinwon; Jeong, Jun Seop; Lee, Yun-Il; Zhu, Heng; Kim, Dongsan; Poirier, Guy G.; Kang, Ho Chul; Dawson, Valina L.
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CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair
err2025-01-25
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errProvencher, Luc; Nartey, Wilson; Brownlee, Peter M.; Atkins, Austin W.; Gagne, Jean-Philippe; Baudrier, Lou; Ting, Nicholas S. Y.; Piett, Cortt G.; Fang, Shujuan; Pearson, Dustin D.; Moore, Shaun; Billon, Pierre; Nagel, Zachary D.; Poirier, Guy G.; Williams, Gareth J.; Goodarzi, Aaron A.
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Proteomic study identifies Aurora-A-mediated regulation of alternative splicing through multiple splicing factors
err2025-01-01
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errDamodaran, Arun Prasath; Gavard, Olivia; Gagne, Jean-Philippe; Rogalska, Malgorzata Ewa; Behera, Amit K.; Mancini, Estefania; Bertolin, Giulia; Courtheoux, Thibault; Kumari, Bandana; Cailloce, Justine; Mereau, Agnes; Poirier, Guy G.; Valcarcel, Juan; Gonatopoulos-Pournatzis, Thomas; Watrin, Erwan; Prigent, Claude
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A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
err2024-12-16
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errFan, Angela T.; Gadbois, Gillian E.; Huang, Hai-Tsang; Chaudhry, Charu; Jiang, Jiewei; Sigua, Logan H.; Smith, Emily R.; Wu, Sitong; Poirier, Grace J.; Dunne-Dombrink, Kara; Goyal, Pavitra; Tao, Andrew J.; Sellers, William R.; Fischer, Eric S.; Donovan, Katherine A.; Ferguson, Fleur M.
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pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
err2024-03-27
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errOAAI
errAshour, Kholoud; Sali, Sujitha; Aldoukhi, Ali H.; Hall, Derek; Mubaid, Souad; Busque, Sandrine; Lian, Xian Jin; Gagne, Jean-Philippe; Khattak, Shahryar; Di Marco, Sergio; Poirier, Guy G.; Gallouzi, Imed-Eddine
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Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation
err2024-03-18
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errOAAI
errHossain, M. Iqbal; Lee, Jun Hee; Gagne, Jean-Philippe; Khan, Junaid; Poirier, Guy G.; King, Peter H.; Dawson, Valina L.; Dawson, Ted M.; Andrabi, Shaida A.
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Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation
err2024-02-07
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errOAAI
errMubaid, Souad; Sanchez, Brenda Janice; Algehani, Rinad A.; Skopenkova, Viktoriia; Adjibade, Pauline; Hall, Derek T.; Busque, Sandrine; Lian, Xian Jin; Ashour, Kholoud; Tremblay, Anne-Marie K.; Carlile, Graeme; Gagne, Jean-Philippe; Diaz-Gaxiola, Andrea; Khattak, Shahryar; Di Marco, Sergio; Thomas, David Y.; Poirier, Guy G.; Gallouzi, Imed-Eddine
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ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
err2023-10-12
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errO'Sullivan, Julia; Kothari, Charu; Caron, Marie-Christine; Gagne, Jean-Philippe; Jin, Zhigang; Nonfoux, Louis; Beneyton, Adele; Coulombe, Yan; Thomas, Melissa; Atalay, Nurgul; Meng, X. Wei; Milano, Larissa; Jean, Dominique; Boisvert, Francois-Michel; Kaufmann, Scott H.; Hendzel, Michael J.; Masson, Jean-Yves; Poirier, Guy G.
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The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors
err2023-08-21
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errBeneyton, Adele; Nonfoux, Louis; Gagne, Jean-Philippe; Rodrigue, Amelie; Kothari, Charu; Atalay, Nurgul; Hendzel, Michael J.; Poirier, Guy G.; Masson, Jean-Yves
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PARP1 associates with R-loops to promote their resolution and genome stability
err2023-02-16
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errLaspata, Natalie; Kaur, Parminder; Mersaoui, Sofiane Yacine; Muoio, Daniela; Liu, Zhiyan Silvia; Bannister, Maxwell Henry; Nguyen, Hai Dang; Curry, Caroline; Pascal, John M.; Poirier, Guy G.; Wang, Hong; Masson, Jean-Yves; Fouquerel, Elise
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Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus
err2022-06-06
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errBecker, Yann L. C.; Gagne, Jean-Philippe; Julien, Anne-Sophie; Levesque, Tania; Allaeys, Isabelle; Gougeard, Nadine; Rubio, Vicente; Boisvert, Francois-Michel; Jean, Dominique; Wagner, Eric; Poirier, Guy G.; Fortin, Paul R.; Boilard, Eric
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Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer's Disease
errCELLS
IF5.2
err2022-04-09
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errMaggiore, Anna; Casale, Assunta Maria; Toscanelli, Walter; Cappucci, Ugo; Rotili, Dante; Grieco, Maddalena; Gagne, Jean-Philippe; Poirier, Guy G.; D'Erme, Maria; Piacentini, Lucia
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ADP-ribosyltransferases, an update on function and nomenclature
err2021-09-13
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errLuscher, Bernhard; Ahel, Ivan; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael; Corda, Daniela; Dantzer, Francoise; Daugherty, Matthew D.; Dawson, Ted M.; Dawson, Valina L.; Deindl, Sebastian; Fehr, Anthony R.; Feijs, Karla L. H.; Filippov, Dmitri V.; Gagne, Jean-Philippe; Grimaldi, Giovanna; Guettler, Sebastian; Hoch, Nicolas C.; Hottiger, Michael O.; Korn, Patricia; Kraus, W. Lee; Ladurner, Andreas; Lehtio, Lari; Leung, Anthony K. L.; Lord, Christopher J.; Mangerich, Aswin; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L.; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M.; Pawlowski, Krzysztof; Poirier, Guy G.; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yelamos, Jose; Yu, Xiaochun; Zaja, Roko; Ziegler, Mathias
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PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons
err2021-09-01
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PREAI
errMarcus, Joshua M.; Hossain, Mohammed I.; Gagne, Jean-Philippe; Poirier, Guy G.; McMahon, Lori L.; Cowell, Rita M.; Andrabi, Shaida A.
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Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair
err2021-03-10
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errMoison, Celine; Chagraoui, Jalila; Caron, Marie-Christine; Gagne, Jean-Philippe; Coulombe, Yan; Poirier, Guy G.; Masson, Jean-Yves; Sauvageau, Guy
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Platelets release mitochondrial antigens in systemic lupus erythematosus
err2021-02-17
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PREAI
errMelki, Imene; Allaeys, Isabelle; Tessandier, Nicolas; Levesque, Tania; Cloutier, Nathalie; Laroche, Audree; Vernoux, Nathalie; Becker, Yann; Benk-Fortin, Hadrien; Zufferey, Anne; Rollet-Labelle, Emmanuelle; Pouliot, Marc; Poirier, Guy; Patey, Natacha; Belleannee, Clemence; Soulet, Denis; McKenzie, Steven E.; Brisson, Alain; Tremblay, Marie-Eve; Lood, Christian; Fortin, Paul R.; Boilard, Eric
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CARM1 regulates replication fork speed and stress response by stimulating PARP1
err2021-02-01
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errGenois, Marie-Michelle; Gagne, Jean-Philippe; Yasuhara, Takaaki; Jackson, Jessica; Saxena, Sneha; Langelier, Marie-France; Ahel, Ivan; Bedford, Mark T.; Pascal, John M.; Vindigni, Alessandro; Poirier, Guy G.; Zou, Lee
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