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SaveRobust activation and clonal expansion of early, non-exhausted, stem-like endogenous T cells induced by chemo-immunotherapy treatment in patients with pediatric brain tumors is predictive of clinical outcome
Johnson, Theodore S.; Pacholczyk, Rafal; Satpathy, Sarthak; Berrong, Zuzana; Chien, Franklin; Huang, Chenbin; Thomas, Beena E.; Chi, Susan N.; Baird, Lissa; Sadek, Ramses F.; Friedman, Gregory; Hummel, Trent R.; Yeo, Kee Kiat; Macdonald, Tobey J.; Bhasin, Manoj K.; Munn, David H. Share Save β-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapyKyritsi, Konstantina; Pacholczyk, Rafal; Douglass, Eugene; Yu, Miao; Fang, Hui; Zhou, Gang; Kaur, Balveen; Wang, Qin; Munn, David H.; Hong, Bangxing Share Save UFL1 promotes survival and function of virtual memory CD8 T cellsBhatt, Brinda; Kumar, Kunal; Shi, Huidong; Ganesan, Dhasarathan; Anazodo, Francis; Rathakrishnan, Aravind; Zhu, Huabin; Wanna, Andrew; Jiang, Chen; Jayavelu, Tamilselvan; Lokeshwar, Vinata Bal; Pacholczyk, Rafal; Munn, David H.; Sheridan, Brian S.; Moskophidis, Demetrius; Li, Honglin; Singh, Nagendra Share Save Blocking Feedback Immunosuppression of Antigen Presentation in Brain Tumor During Oncolytic Virotherapy with oHSV-mshPKRTsuboi, Nobushige; Rivera-Caraballo, Kimberly A.; Sahu, Upasana; Pacholczyk, Rafal; Douglass, Eugene; Johnson, Theodore S.; Wang, Qin; Kolhe, Ravindra; Hedrick, Catherine C.; Munn, David H.; Hong, Bangxing Share Save Brain CD73 modulates interferon signaling to regulate glioblastoma invasionKyritsi, Konstantina; Ye, Jishi; Douglass, Eugene; Pacholczyk, Rafal; Tsuboi, Nobushige; Otani, Yoshihiro; Wang, Qin; Munn, David H.; Kaur, Balveen; Hong, Bangxing Share Save PHASE 2 TRIAL USING INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH CHILDHOOD BRAIN CANCER: INTERIM ANALYSIS OF THE GCC1949 STUDY (NCT04049669)Johnson, Theodore S.; Pacholczyk, Rafal; Ring, Eric K.; Aguilera, Dolly; Castellino, Robert C.; Fangusaro, Jason R.; Eaton, Bree R.; Chi, Susan; Yeo, Kee Kiat; Hummel, Trent R.; Berrong, Zuzana; Creager, Julianne; Ingerski, Lisa; Schniederjan, Matthew; Huang, Chenbin; Satpathy, Sarthak; Thomas, Beena E.; Sadek, Ramses F.; Kennedy, Eugene P.; Bhasin, Manoj K.; Macdonald, Tobey J.; Munn, David H. Share Save Share Save The Simple prEservatioN of Single cElls method for cryopreservation enables the generation of single-cell immune profiles from whole bloodSatpathy, Sarthak; Thomas, Beena E.; Pilcher, William J.; Bakhtiari, Mojtaba; Ponder, Lori A.; Pacholczyk, Rafal; Prahalad, Sampath; Bhasin, Swati S.; Munn, David H.; Bhasin, Manoj K. Share Save Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trialJohnson, Theodore S.; MacDonald, Tobey J.; Pacholczyk, Rafal; Aguilera, Dolly; Al-Basheer, Ahmad; Bajaj, Manish; Bandopadhayay, Pratiti; Berrong, Zuzana; Bouffet, Eric; Castellino, Robert C.; Dorris, Kathleen; Eaton, Bree R.; Esiashvili, Natia; Fangusaro, Jason R.; Foreman, Nicholas; Fridlyand, Diana; Giller, Cole; Heger, Ian M.; Huang, Chenbin; Kadom, Nadja; Kennedy, Eugene P.; Manoharan, Neevika; Martin, William; McDonough, Colleen; Parker, Rebecca S.; Ramaswamy, Vijay; Ring, Eric; Rojiani, Amyn; Sadek, Ramses F.; Satpathy, Sarthak; Schniederjan, Matthew; Smith, Amy; Smith, Christopher; Thomas, Beena E.; Vaizer, Rachel; Yeo, Kee Kiat; Bhasin, Manoj K.; Munn, David H. Share Save INTERIM ANALYSIS OF THE GCC1949 PHASE 2 TRIAL USING INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORSJohnson, Theodore S.; Pacholczyk, Rafal; Aguilera, Dolly; Berrong, Zuzana; Castellino, Robert C.; Chi, Susan; Creager, Julianne; Eaton, Bree R.; Fangusaro, Jason R.; Huang, Chenbin; Hummel, Trent; Ingerski, Lisa; Kennedy, Eugene P.; Ring, Eric; Sadek, Ramses F.; Satpathy, Sarthak; Schniederjan, Matthew; Thomas, Beena E.; Yeo, Kee Kiat; Bhasin, Manoj; MacDonald, Tobey J.; Munn, David H. Share Save Medullary sinus macrophages limit cancer therapy efficacy by an efferocytosis-induced IL-33/ST2 axis in the tumor-draining lymph nodeLamorte, Sara; Neufeld, Luke; Quevedo, Rene; Zhang, Xin; Ciudad, M. Teresa; Jin, Robbie; Saeed, Zaid Kamil; Karlsson, Mikael C. I.; Mak, Tak W.; Munn, David; Brooks, David; McGaha, Tracy Share Save Indoximod or ibrutinib/indoximod based clinical chemo-immunotherapy drives conversion of extra-tumoral circulating stem-like precursor CD8+T cells into clonally expanded, rejuvenated effector cellsJohnson, Theodore S.; Pacholczyk, Rafal; Berrong, Zuzana; Huang, Chenbin; Kennedy, Eugene P.; Ring, Eric; Sadek, Ramses F.; Satpathy, Sarthak; Thomas, Beena E.; MacDonald, Tobey J.; Bhasin, Manoj; Munn, David H. Share Save Share Save Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapyAboelella, Nada S.; Brandle, Caitlin; Okoko, Ogacheko; Gazi, Md Yeashin; Ding, Zhi-Chun; Xu, Hongyan; Gorman, Gregory; Bollag, Roni; Davila, Marco L.; Bryan, Locke J.; Munn, David H.; Piazza, Gary A.; Zhou, Gang Share Save Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunitySharma, Madhav D.; Pacholczyk, Rafal; Shi, Huidong; Berrong, Zuzana J.; Zakharia, Yousef; Greco, Austin; Chang, Chang-Sheng S.; Eathiraj, Sudharshan; Kennedy, Eugene; Cash, Thomas; Bollag, Roni J.; Kolhe, Ravindra; Sadek, Ramses; McGaha, Tracy L.; Rodriguez, Paulo; Mandula, Jessica; Blazar, Bruce R.; Johnson, Theodore S.; Munn, David H. Share Save Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanomaZakharia, Yousef; McWilliams, Robert R.; Rixe, Olivier; Drabick, Joseph; Shaheen, Montaser F.; Grossmann, Kenneth F.; Kolhe, Ravindra; Pacholczyk, Rafal; Sadek, Ramses; Tennant, Lucinda L.; Smith, Christopher M.; Kennedy, Eugene P.; Link, Charles J., Jr.; Vahanian, Nicholas N.; Yu, Jiayi; Shen, Steven S.; Brincks, Erik L.; Rossi, Gabriela R.; Munn, David; Milhem, Mohammed Share Save FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105)Johnson, Theodore S.; Pacholczyk, Rafal; Aguilera, Dolly; Al-Basheer, Ahmad; Bajaj, Manish; Berrong, Zuzana; Castellino, Robert C.; Eaton, Bree R.; Esiashvili, Natia; Foreman, Nicholas; Heger, Ian M.; Kennedy, Eugene P.; Martin, William; Ring, Eric; Sadek, Ramses F.; Smith, Amy; Smith, Chris; Vaizer, Rachel; MacDonald, Tobey J.; Munn, David H. Share Save Share Save Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunityDing, Zhi-Chun; Shi, Huidong; Aboelella, Nada S.; Fesenkova, Kateryna; Park, Eun-Jeong; Liu, Zhuoqi; Pei, Lirong; Li, Jiaqi; McIndoe, Richard A.; Xu, Hongyan; Piazza, Gary A.; Blazar, Bruce R.; Munn, David H.; Zhou, Gang Share Save 
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