Guideng Li - Publications, H-index & Citations

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Guideng Li

California Institute of Technology

26H-index

71Paper Count

3.0KCitation Count

Published Papers 40

Publication Date

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer

Nature Communications

IF15.7

2026-04-15

OAAI

Yapeng Su; Chunmei Liu; Xiang Lu; Hui-Yu Chuang; Guideng Li; Shiqun Shao; Yan Kong; Jihoon W. Lee; Rachel H. Ng; Stephanie Wong; Lidia Robert; Charles Warden; Victoria Liu; Jie Chen; Zhuo Wang; Guangrong Qin; Yin Tang; Hanjun Cheng; Alphonsus H. C. Ng; Daniel Chen; Songming Peng; Min Xue; Dazy Johnson; Yu Xu; Jinhui Wang; Xiwei Wu; Ilya Shmulevich; Qihui Shi; Raphael Levine; Antoni Ribas; David Baltimore; Jun Guo; James R. Heath; Wei Wei

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Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer

Nature Metabolism

IF20.8

2026-03-04

PREAI

Yun Yang; Yong Wu; Xin Guo; Wen-Juan Gan; Wen-Xin Wu; Wei-Yi Shi; Xiao-Shun He; Yi-Xuan Liu; Shan Wan; Zhi Jiang; Yue Liu; Xiu-Ming Li; Zu-Da Pan; Xue Zhang; You Xu; Xiao-Jiao Gao; Ling-Chuan Guo; Guideng Li; Hua Wu

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The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

Nature

IF48.5

2026-01-14

OAAI

Hongcheng Cheng; Yapeng Su; Xiaoli Pan; Yue Xu; Ermei Xie; Jing Du; Daniel G. Chen; Xiaomeng Dai; Raphael Gottardo; Philip D. Greenberg; Guideng Li

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Dual gains from targeting MondoA in T cells

Nature Metabolism

IF20.8

2025-08-22

PREAI

Ermei Xie; Guideng Li

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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

Immunity

IF26.3

2025-08-14

PREAI

Kaili Ma; Hongcheng Cheng; Lin Wang; Han Xiao; Fenghua Liu; Yu Yang; Zhen Xiao; Kun Tang; Shicheng Li; Gang Wang; Minmin Ge; Jiajia Wang; Xiaowei Liu; Hai-Xi Sun; Ziyi Luo; Zhimin Gu; Ping-Chih Ho; Guideng Li; Lianjun Zhang

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Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma

Cancer Cell

IF44.5

2025-05-08

OAAI

Shanshan Zhang; Yan Zhou; Zhonghua Liu; Yuqian Wang; Xiang Zhou; Haiwen Chen; Xinyu Zhang; Yanhong Chen; Qisheng Feng; Xiaoping Ye; Shanghang Xie; Mu-Sheng Zeng; Weiwei Zhai; Yi-Xin Zeng; Sumei Cao; Guideng Li; Miao Xu

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Metabolic plasticity of T cell fate decision

CHINESE MEDICAL JOURNAL

IF7.3

2024-03-26

OAAI

Pan, Xiaoli; Wang, Jiajia; Zhang, Lianjun; Li, Guideng; Huang, Bo

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Deciphering Membrane-Protein Interactions and High-Throughput Antigen Identification with Cell Doublets

ADVANCED SCIENCE

IF14.1

2024-02-11

OAAI

Wang, Yuqian; Wang, Zhe; Yang, Juan; Lei, Xiaobo; Liu, Yisu; Frankiw, Luke; Wang, Jianwei; Li, Guideng

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Suppression of the METTL3-m6A-integrin 01 axis by extracellular acidification impairs T cell infiltration and antitumor activity

CELL REPORTS

IF6.9

2024-02-01

OAAI

Wang, Zhe; Shang, Jingzhe; Qiu, Yajing; Cheng, Hongcheng; Tao, Mengyuan; Xie, Ermei; Pei, Xin; Li, Wenhui; Zhang, Lianjun; Wu, Aiping; Li, Guideng

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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+T cell discovery and analysis

COMMUNICATIONS BIOLOGY

IF5.1

2023-05-16

OAAI

Chour, William; Choi, Jongchan; Xie, Jingyi; Chaffee, Mary E. E.; Schmitt, Thomas M. M.; Finton, Kathryn; DeLucia, Diana C. C.; Xu, Alexander M. M.; Su, Yapeng; Chen, Daniel G. G.; Zhang, Rongyu; Yuan, Dan; Hong, Sunga; Ng, Alphonsus H. C.; Butler, Jonah Z. Z.; Edmark, Rick A. A.; Jones, Lesley C. C.; Murray, Kim M. K. M.; Peng, Songming; Li, Guideng; Strong, Roland K. K.; Lee, John K. K.; Goldman, Jason D. D.; Greenberg, Philip D. D.; Heath, James R. R.

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Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness

NATURE METABOLISM

IF20.8

2023-01-30

OAAI

Cheng, Hongcheng; Qiu, Yajing; Xu, Yue; Chen, Li; Ma, Kaili; Tao, Mengyuan; Frankiw, Luke; Yin, Hongli; Xie, Ermei; Pan, Xiaoli; Du, Jing; Wang, Zhe; Zhu, Wenjie; Chen, Lu; Zhang, Lianjun; Li, Guideng

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Special issue on the tumor microenvironment: Featuring the special issue Guest Editor

CANCER LETTERS

IF10.1

2022-11-01

PREAI

Li, Guideng

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The tumor microenvironment's role in malignant progression and treatment response

CANCER LETTERS

IF10.1

2022-11-01

PREAI

Frankiw, Luke; Li, Guideng

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Engineered retroviruses map ligand-receptor interactions

NATURE METHODS

IF32.1

2022-04-08

OAAI

Wang, Yuqian; Wang, Zhe; Li, Guideng

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Cross-dressing of dendritic cells strengthens antitumor immunity

TRENDS IN CANCER

IF17.5

2022-03-01

PREAI

Yin, Hongli; Cheng, Hongcheng; Wang, Yuqian; Li, Guideng

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The tumor microenvironment shapes the molecular characteristics of exhausted CD8+ T cells

CANCER LETTERS

IF10.1

2021-05-01

PREAI

Cheng, Hongcheng; Ma, Kaili; Zhang, Lianjun; Li, Guideng

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Mitochondrial Damage and the Road to Exhaustion

CELL METABOLISM

IF30.9

2020-12-01

OAAI

Li, Wenhui; Cheng, Hongcheng; Li, Guideng; Zhang, Lianjun

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Systems biology for investigating drug resistance mechanism of melanoma

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Su, Yapeng; Li, Guideng; Ko, Melissa; Cheng, Hanjun; Zhu, Ronghui; Xue, Min; Robert, Lidia; Levine, Raphael; Ribas, Antoni; Nolan, Garry; Wei, Wei; Plevritis, Sylvia; Baltimore, David; Heath, James R.

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T cell antigen discovery

NATURE METHODS

IF32.1

2020-07-06

PREAI

Joglekar, Alok V.; Li, Guideng

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Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

NATURE COMMUNICATIONS

IF15.7

2020-05-11

OAAI

Su, Yapeng; Ko, Melissa E.; Cheng, Hanjun; Zhu, Ronghui; Xue, Min; Wang, Jessica; Lee, Jihoon W.; Frankiw, Luke; Xu, Alexander; Wong, Stephanie; Robert, Lidia; Takata, Kaitlyn; Yuan, Dan; Lu, Yue; Huang, Sui; Ribas, Antoni; Levine, Raphael; Nolan, Garry P.; Wei, Wei; Plevritis, Sylvia K.; Li, Guideng; Baltimore, David; Heath, James R.

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Research Directions