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J

James L. Riley

university of pennsylvania

76H-index
277Paper Count
2.7WCitation Count
Published Papers 112
Publication Date
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Antigen-boosted CD4CAR-T cells fail to expand or control viremia in multiple nonhuman primate models of HIV
errBlood
IF23.1
err2026-02-26
err0
PREAI
errLucy H. Maynard; Carly E. Starke; Nikhita H. Poole; Blake J. Rust; Haiying Zhu; Laurence Stensland; Meei-Li Huang; Ailyn C. Pérez-Osorio; Jesenia I. Atherley; Teresa Einhaus; Jason Murray; M. Betina Pampena; Michael R. Betts; Keith R. Jerome; James L. Riley; Hans-Peter Kiem; Christopher W. Peterson
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errSave
Cell-derived nanoparticles generated from cell-based artificial antigen presenting cells allow for the robust and rapid manufacturing of patient T cells
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errDeng, Mosha Z.; Lai, Meizan; Jiang, Shuguang; Kong, Hong; Cooper, Vincent; Carvalho, Edmund; Gu, Meidi; Padron, David Nardo; Zhang, Caimei; Hanindya, Chiquita; Arturo, Jesus; Barranco, Junco; Jain, Ankita; Gerique, Laura Garcia; Davis, Megan; Riley, James L.
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errSave
p:Hishing for T cells: Using 'chimeric antigen-presenting' (CAP) T cells to target and eliminate antigen-specific T cell populations
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errRead, Kaitlin A.; Shu, Jiayi; Christopher, Cole W.; McCabe, Caitlin R.; Riley, James L.
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errSave
CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy
errNature Biomedical Engineering
IF26.6
err2025-10-21
err0
PREAI
errÁngel Ramírez-Fernández; Alexander J. Dimitri; Fang Chen; Robert Bartoszek; Gregory M. Chen; Laura Córdoba-Espejo; Yuqi Zhou; Yun-hsin Tang; Chien-Ting Lin; Reyes Acosta; John Scholler; Guido Ghilardi; Patrizia Porazzi; Mireia Pellicer; Núria Profitós-Pelejà; Stefan K. Barta; Anne Chew; Julie K. Jadlowsky; Vanessa E. Gonzalez; Donald L. Siegel; Bruce L. Levine; Gaël Roué; Marco Ruella; Michael T. Lotze; Carl H. June; James L. Riley; Joseph A. Fraietta
errShare
errSave
Optimal Pairing of Binder and Costimulatory Domains Improves Dual CAR T Cell Efficacy
errMolecular Therapy
IF12
err2025-08-05
err0
PREAI
errDivanshu Shukla; Sasikanth Manne; Shuguang Jiang; Marco Ruella; E. John Wherry; James L. Riley
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errSave
Gene-modified NK cells expressing CD64 and preloaded with HIV-specific BNAbs target autologous HIV-1-infected CD4+ T cells by ADCC
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-02-17
err0
PREAI
errTomescu, Costin; Ochoa-Ortiz, Adiana; Lu, Lily D.; Kong, Hong; Riley, James L.; Montaner, Luis J.
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errSave
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication (vol 131, e144486, 2021)
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-05-01
err1
errOAAI
errTebas, Pablo; Jadlowsky, Julie K.; Shaw, Pamela A.; Tian, Lifeng; Esparza, Erin; Brennan, Andrea L.; Kim, Sukyung; Naing, Soe Yu; Richardson, Max W.; Vogel, Ashley N.; Maldini, Colby R.; Kong, Hong; Liu, Xiaojun; Lacey, Simon F.; Bauer, Anya M.; Mampe, Felicity; Richman, Lee P.; Lee, Gary; Ando, Dale; Levine, Bruce L.; Porter, David L.; Zhao, Yangbing; Siegel, Don L.; Bar, Katharine J.; June, Carl H.; Riley, James L.
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errSave
Crosstalk between histone and DNA methylation in the development and progression of ALK plus ALCL
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLobello, Cosimo; Wang, Shengchun; Rao, Shilpa; Pawlicki, Jan; Mansoor, Nashwa; Riley, James L.; Nejati, Reza; Mariusz, Wasik A.
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errSave
Aberrant expression of GOLM1 protects ALK+ anaplastic large cell lymphoma from apoptosis by enhancing BCL-XL stability
errBLOOD ADVANCES
IF7.1
err2023-07-28
err5
errOAAI
errZi, Zhenguo; Du, Shujuan; Zhang, Liming; Wang, Yuebo; Ding, Ling; Zhang, Chongqi; Wang, Huanyu; Pawlicki, Jan; Cai, Yuan; Yao, Yazhou; Zhou, Feng; Tong, Yin; Riley, James L.; Cai, Qiliang; Ma, Xiaojing; Wei, Fang
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errSave
Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells
errMOLECULAR THERAPY
IF12
err2023-07-01
err7
errOAAI
errWyatt, Megan M.; Huff, Logan W.; Nelson, Michelle H.; Neal, Lillian R.; Medvec, Andrew R.; Rivera, Guillermo O. Rangel; Smith, Aubrey S.; Reyes, Amalia M. Rivera; Knochelmann, Hannah M.; Riley, James L.; Lesinski, Gregory B.; Paulos, Chrystal M.
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errSave
Mitochondrial cristae disruption enables optimal T cell activation and expansion
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-05-01
err0
errOAAI
errCarvalho, Edmund; Su, Irene; Ecker, Christopher; Srivatsa, Sriram; Riley, James
errShare
errSave
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err1.9K
errOAAI
errParry, RV; Chemnitz, JM; Frauwirth, KA; Lanfranco, AR; Braunstein, I; Kobayashi, SV; Linsley, PS; Thompson, CB; Riley, JL
errShare
errSave
Quantitative immunopeptidomics reveals a tumor stroma-specific target for T cell therapy
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2022-08-31
err21
errOAAI
errKim, Gloria B.; Fritsche, Jens; Bunk, Sebastian; Mahr, Andrea; Unverdorben, Felix; Tosh, Kevin; Kong, Hong; Maldini, Colby R.; Lau, Chui; Srivatsa, Sriram; Jiang, Shuguang; Glover, Joshua; Dopkin, Derek; Zhang, Carolyn X.; Schuster, Heiko; Kowalewski, Daniel J.; Goldfinger, Valentina; Ott, Martina; Fuhrmann, David; Baues, Maike; Boesmueller, Hans; Schraeder, Christoph; Schimmack, Gisela; Song, Colette; Hoffgaard, Franziska; Roemer, Michael; Tsou, Chih-Chiang; Hofmann, Martin; Treiber, Thomas; Hutt, Meike; Alten, Leonie; Jaworski, Maike; Alpert, Amir; Missel, Sarah; Reinhardt, Carsten; Singh, Harpreet; Schoor, Oliver; Walter, Steffen; Wagner, Claudia; Maurer, Dominik; Weinschenk, Toni; Riley, James L.
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errSave
Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque
errCELL REPORTS MEDICINE
IF10.6
err2022-05-01
err16
errOAAI
errEllis, Gavin I.; Coker, Kimberly E.; Winn, Delaine W.; Deng, Mosha Z.; Shukla, Divanshu; Bhoj, Vijay; Milone, Michael C.; Wang, Wei; Liu, Chengyang; Naji, Ali; Duran-Struuck, Raimon; Riley, James L.
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errSave
Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation
errJOURNAL OF IMMUNOLOGY
IF3.4
err2022-05-01
err0
PREAI
errEllis, Gavin I.; Coker, Kimberly E.; Winn, Delaine W.; Deng, Mosha Z.; Shukla, Divanshu; Bhoj, Vijay; Milone, Michael C.; Wang, Wei; Liu, Chengyang; Naji, Ali; Duran-Struuck, Raimon; Riley, James L.
errShare
errSave
Ultrasensitive antigen density discrimination by synNotch
errCELL RESEARCH
IF25.9
err2021-05-04
err1
errOAAI
errShukla, Divanshu; Riley, James L.
errShare
errSave
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2021-04-01
err60
errOAAI
errTebas, Pablo; Jadlowsky, Julie K.; Shaw, Pamela A.; Tian, Lifeng; Esparza, Erin; Brennan, Andrea L.; Kim, Sukyung; Naing, Soe Yu; Richardson, Max W.; Vogel, Ashley N.; Maldini, Colby R.; Kong, Hong; Liu, Xiaojun; Lacey, Simon F.; Bauer, Anya M.; Mampe, Felicity; Richman, Lee P.; Lee, Gary; Ando, Dale; Levine, Bruce L.; Porter, David L.; Zhao, Yangbing; Siegel, Don L.; Bar, Katharine J.; June, Carl H.; Riley, James L.
errShare
errSave
NPM-ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation
errCANCER RESEARCH
IF16.6
err2021-02-22
err14
errOAAI
errPawlicki, Jan M.; Cookmeyer, David L.; Maseda, Damian; Everett, John K.; Wei, Fang; Kong, Hong; Zhang, Qian; Wang, Hong Y.; Tobias, John W.; Walter, David M.; Zullo, Kelly M.; Javaid, Sarah; Watkins, Amanda; Wasik, Mariusz A.; Bushman, Frederic D.; Riley, James L.
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errSave
Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation
errBLOOD ADVANCES
IF7.1
err2021-02-18
err21
errOAAI
errDavis, Zachary; Felices, Martin; Lenvik, Todd; Badal, Sujan; Walker, Joshua T.; Hinderlie, Peter; Riley, James L.; Vallera, Daniel A.; Blazar, Bruce R.; Miller, Jeffrey S.
errShare
errSave
Genetic engineering of T cells for immunotherapy
errNATURE REVIEWS GENETICS
IF52
err2021-02-18
err87
errOAAI
errEllis, Gavin I.; Sheppard, Neil C.; Riley, James L.
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
C
Craig B. Thompson
H-index: 206 · Papers: 767
M
Michel C. Nussenzweig
H-index: 183 · Papers: 617
C
Carl H. June
H-index: 177 · Papers: 1.4K
G
Gordon J. Freeman
H-index: 174 · Papers: 1.1K
I
Ira Pastan
H-index: 164 · Papers: 1.6K
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