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Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid Bravo-Hernandez, Mariana; Mazur, Curt; Chen, Hao; Fradkin, Linda; Searcy, Justin; Burel, Sebastien; Kelly, Mackenzie; Bruening, Dona; O'Rourke, Jacqueline G.; Cai, Yuhang; Nguyen, Jonathon; Berman-Booty, Lisa; Cummins, Lendell; Gaus, Hans; Powers, Berit; Zhao, Hien T.; Jafar-Nejad, Paymaan; Henry, Scott; Swayze, Eric E.; Kordasiewicz, Holly B. Share Save
Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system O'Rourke, Jacqueline G.; Bachmann, Gemma; Mazur, Curt; Zhou, Keming; Platoshyn, Oleksandr; Bravo Hernandez, Mariana; Klein, Stephanie K.; Nguyen, Jonathon; Burel, Sebastien; Hoffmaster, Christine; Zanardi, Thomas; Jafar-nejad, Paymaan; Marsala, Martin; Henry, Scott P.; Swayze, Eric E.; Powers, Berit; Kordasiewicz, Holly B. Share Save
Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia Prakash, Thazha P.; Mullick, Adam E.; Riney, Stan; Yu, Jinghua; Nikan, Mehran; Quirk, Clare; Crutchfield, Amanda; Damle, Sagar S.; Klein, Stephanie; Swayze, Eric E. Share Save
Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W. Brad; Watt, Andrew T.; Migawa, Michael T.; Swayze, Eric E.; Prakash, Thazha P. Share Save
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial (vol 29, pg 1437, 2023) Mummery, Catherine J.; Borjesson-Hanson, Anne; Blackburn, Daniel J.; Vijverberg, Everard G. B.; De Deyn, Peter Paul; Ducharme, Simon; Jonsson, Michael; Schneider, Anja; Rinne, Juha O.; Ludolph, Albert C.; Bodenschatz, Ralf; Kordasiewicz, Holly; Swayze, Eric E.; Fitzsimmons, Bethany; Mignon, Laurence; Moore, Katrina M.; Yun, Chris; Baumann, Tiffany; Li, Dan; Norris, Daniel A.; Crean, Rebecca; Graham, Danielle L.; Huang, Ellen; Ratti, Elena; Bennett, C. Frank; Junge, Candice; Lane, Roger M. Share Save
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial Mummery, Catherine J.; Borjesson-Hanson, Anne; Blackburn, Daniel J.; Vijverberg, Everard G. B.; De Deyn, Peter Paul; Ducharme, Simon; Jonsson, Michael; Schneider, Anja; Rinne, Juha O.; Ludolph, Albert C.; Bodenschatz, Ralf; Kordasiewicz, Holly; Swayze, Eric E.; Fitzsimmons, Bethany; Mignon, Laurence; Moore, Katrina M.; Yun, Chris; Baumann, Tiffany; Li, Dan; Norris, Daniel A.; Crean, Rebecca; Graham, Danielle L.; Huang, Ellen; Ratti, Elena; Bennett, C. Frank; Junge, Candice; Lane, Roger M. Share Save
Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA Rajasekaran, Tamilselvan; Freestone, Graeme C.; Galindo-Murillo, Rodrigo; Lugato, Barbara; Gaus, Hans; Migawa, Michael T.; Swayze, Eric. E.; Cheatham III, Thomas E.; Seth, Punit P.; Hanessian, Stephen Share Save
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Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA Rajasekaran, Tamilselvan; Freestone, Graeme C.; Galindo-Murillo, Rodrigo; Lugato, Barbara; Rico, Lorena; Salinas, Juan C.; Gaus, Hans; Migawa, Michael T.; Swayze, Eric E.; Cheatham, Thomas E., III; Hanessian, Stephen; Seth, Punit P. Share Save
LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model (vol 8, pg 508, 2017) Zhao, Hien Tran; John, Neena; Delic, Vedad; Ikeda-Lee, Karli; Kim, Aneeza; Weihofen, Andreas; Swayze, Eric E.; Kordasiewicz, Holly B.; West, Andrew B.; Volpicelli-Daley, Laura A. Share Save
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides Anderson, Brooke A.; Freestone, Graeme C.; Low, Audrey; De-Hoyos, Cheryl L.; Drury, William J., III; Ostergaard, Michael E.; Migawa, Michael T.; Fazio, Michael; Wan, W. Brad; Berdeja, Andres; Scandalis, Eli; Burel, Sebastien A.; Vickers, Timothy A.; Crooke, Stanley T.; Swayze, Eric E.; Liang, Xuehai; Seth, Punit P. Share Save
LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model (vol 8, pg 508, 2017) Zhao, Hien Tran; John, Neena; Delic, Vedad; Ikeda-Lee, Karli; Kim, Aneeza; Weihofen, Andreas; Swayze, Eric E.; Kordasiewicz, Holly B.; West, Andrew B.; Volpicelli-Daley, Laura A. Share Save
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease Cole, Tracy A.; Zhao, Hien; Collier, Timothy J.; Sandoval, Ivette; Sortwell, Caryl E.; Steece-Collier, Kathy; Daley, Brian F.; Booms, Alix; Lipton, Jack; Welch, Mackenzie; Berman, Melissa; Jandreski, Luke; Graham, Danielle; Weihofen, Andreas; Celano, Stephanie; Schulz, Emily; Cole-Strauss, Allyson; Luna, Esteban; Quach, Duc; Mohan, Apoorva; Bennett, C. Frank; Swayze, Eric E.; Kordasiewicz, Holly B.; Luk, Kelvin C.; Paumier, Katrina L. Share Save
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs Vasquez, Guillermo; Freestone, Graeme C.; Wan, W. Brad; Low, Audrey; Li De Hoyos, Cheryl; Yu, Jinghua; Prakash, Thazha P.; Ostergaard, Michael E.; Liang, Xue-hai; Crooke, Stanley T.; Swayze, Eric E.; Migawa, Michael T.; Seth, Punit P. Share Save
The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration Jafar-nejad, Paymaan; Powers, Berit; Soriano, Armand; Zhao, Hien; Norris, Daniel A.; Matson, John; DeBrosse-Serra, Beatrice; Watson, Jamie; Narayanan, Padmakumar; Chun, Seung J.; Mazur, Curt; Kordasiewicz, Holly; Swayze, Eric E.; Rigo, Frank Share Save
Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system Sullivan, Jenna M.; Mazur, Curt; Wolf, Daniel A.; Horky, Laura; Currier, Nicolas; Fitzsimmons, Bethany; Hesterman, Jacob; Pauplis, Rachel; Haller, Scott; Powers, Berit; Tayefeh, Leighla; DeBrosse-Serra, Bea; Hoppin, Jack; Kordasiewicz, Holly; Swayze, Eric E.; Verma, Ajay Share Save
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