Not logged in A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma Goyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D. Share Save
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors Burr, Risa; Leshchiner, Ignaty; Costantino, Christina L.; Blohmer, Martin; Sundaresan, Tilak; Cha, Justin; Seeger, Karsen; Guay, Sara; Danysh, Brian P.; Gore, Ira; Jacobs, Raquel A.; Slowik, Kara; Utro, Filippo; Rhrissorrakrai, Kahn; Levovitz, Chaya; Barth, Jaimie L.; Dubash, Taronish; Chirn, Brian; Parida, Laxmi; Sequist, Lecia V.; Lennerz, Jochen K.; Mino-Kenudson, Mari; Maheswaran, Shyamala; Naxerova, Kamila; Getz, Gad; Haber, Daniel A. Share Save
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations Varkaris, Andreas; de la Cruz, Ferran Fece; Martin, Elizabeth; Nordern, Bryanna; Chevalier, Nicholas; Leshchiner, Ignaty; Stavridi, Anastasia; Kim, Janice; Papatheodoridi, Alkistis; Gunaydin, Hakan; Danysh, Brian; Parida, Laxmi; Sanidas, Ioannis; Ji, Yongli; Lau, Kayao; Wulf, Gerburg; Bardia, Aditya; Spring, Laura; Isakoff, Steven; Lennerz, Jochen; Pierce, Levi; Pazolli, Ermira; Getz, Gad; Corcoran, Ryan; Juric, Dejan Share Save
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations Varkaris, Andreas; de la Cruz, Ferran Fece; Martin, Elizabeth E.; Norden, Bryanna L.; Chevalier, Nicholas; Kehlmann, Allison M.; Leshchiner, Ignaty; Barnes, Haley; Ehnstrom, Sara; Stavridi, Anastasia-Maria; Yuan, Xin; Kim, Janice S.; Ellis, Haley; Papatheodoridi, Alkistis; Gunaydin, Hakan; Danysh, Brian P.; Parida, Laxmi; Sanidas, Ioannis; Ji, Yongli; Lau, Kayao; Wulf, Gerburg M.; Bardia, Aditya; Spring, Laura M.; Isakoff, Steven J.; Lennerz, Jochen K.; Del Vecchio, Kathryn; Pierce, Levi; Pazolli, Ermira; Getz, Gad; Corcoran, Ryan B.; Juric, Dejan Share Save
Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance Naeem, Aishath; Utro, Filippo; Wang, Qing; Cha, Justin; Vihinen, Mauno; Martindale, Stephen; Zhou, Yinglu; Ren, Yue; Tyekucheva, Svitlana; Kim, Annette S.; Fernandes, Stacey M.; Saksena, Gordon; Rhrissorrakrai, Kahn; Levovitz, Chaya; Danysh, Brian P.; Slowik, Kara; Jacobs, Raquel A.; Davids, Matthew S.; Lederer, James A.; Zain, Rula; Smith, C. I. Edvard; Leshchiner, Ignaty; Parida, Laxmi; Getz, Gad; Brown, Jennifer R. Share Save
Phylogenetic reconstruction across 303 metastatic tumor samples using Ultima whole-genome sequencing dramatically increases subclonal resolution Hess, Julian; Martin, Elizabeth; Soifer, Ilya; Benjamin, Hila; Miller, Mendy; Cibulskis, Carrie; Danysh, Brian P.; Coole, Matthew; Gabriel, Stacey; Juric, Dejan; Lipson, Doron; Getz, Gad Share Save
Share Save
Drug persistence pathways in ovarian cancer identified by single-cell analysis of patient samples and cell line models Leshchiner, Elizaveta; Panayiotou, Richard; Gupta, Anay; Zhang, Thomas; Neil, Kayli; Girnius, Nomeda; Henstridge, Aylin; Danysh, Brian P.; Leshchiner, Ignaty; Hill, Sarah J.; Parida, Laxmi; Matulonis, Ursula A.; Brugge, Joan S.; Getz, Gad Share Save
Mechanisms of genetic predisposition to multifocal lung cancer Burr, Risa; Leshchiner, Ignaty; Costantino, Christina L.; Blohmer, Martin; Sundaresan, Tilak; Cha, Justin; Seeger, Karsen; Guay, Sara; Danysh, Brian P.; Gore, Ira; Jacobs, Raquel A.; Slowik, Kara; Utro, Filippo; Rhrissorrakrai, Kahn; Levovitz, Chaya; Barth, Jaimie L.; Dubash, Taronish; Chirn, Brian; Parida, Laxmi; Sequist, Lecia V.; Mino-Kenudson, Mari; Naxerova, Kamila; Maheswaran, Shyamala; Getz, Gad; Haber, Daniel A. Share Save
A platform for deep evolutionary profiling of cancer resistance Ravi, Arvind; Sontha, Sainikhil; Chowdhury, Maisha; Smigiel, Jacob; Rees, Matthew; Danysh, Brian; Roth, Jennifer; Parida, Laxmi; Lander, Eric; Getz, Gad Share Save
Genomic mechanisms of resistance to tyrosine kinase inhibitors (TKIs) in HER2+metastatic breast cancer (HER2+MBC) Parsons, Heather A.; Messer, Conor; Santos, Katheryn; Danysh, Brian P.; Hughes, Melissa E.; Patel, Ashka; Jacobs, Raquel A.; Slowik, Kara; Hess, Julian; Stewart, Chip; Schlueter-Kuck, Kristy; Rhrissorrakrai, Kahn; Utro, Filippo; Levovitz, Chaya; Wagle, Nikhil; Leone, Jose Pablo; Freedman, Rachel; Parida, Laxmi; Krop, Ian E.; Getz, Gad; Lin, Nancy U. Share Save
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome Parry, Erin M.; Leshchiner, Ignaty; Guieze, Romain; Johnson, Connor; Tausch, Eugen; Parikh, Sameer A.; Lemvigh, Camilla; Broseus, Julien; Hergalant, Sebastien; Messer, Conor; Utro, Filippo; Levovitz, Chaya; Rhrissorrakrai, Kahn; Li, Liang; Rosebrock, Daniel; Yin, Shanye; Deng, Stephanie; Slowik, Kara; Jacobs, Raquel; Huang, Teddy; Li, Shuqiang; Fell, Geoff; Redd, Robert; Lin, Ziao; Knisbacher, Binyamin A.; Livitz, Dimitri; Schneider, Christof; Ruthen, Neil; Elagina, Liudmila; Taylor-Weiner, Amaro; Persaud, Bria; Martinez, Aina; Fernandes, Stacey M.; Purroy, Noelia; Anandappa, Annabelle J.; Ma, Jialin; Hess, Julian; Rassenti, Laura Z.; Kipps, Thomas J.; Jain, Nitin; Wierda, William; Cymbalista, Florence; Feugier, Pierre; Kay, Neil E.; Livak, Kenneth J.; Danysh, Brian P.; Stewart, Chip; Neuberg, Donna; Davids, Matthew S.; Brown, Jennifer R.; Parida, Laxmi; Stilgenbauer, Stephan; Getz, Gad; Wu, Catherine J. J. Share Save
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma Haradhvala, Nicholas J.; Leick, Mark B.; Maurer, Katie; Gohil, Satyen H.; Larson, Rebecca C.; Yao, Ning; Gallagher, Kathleen M. E.; Katsis, Katelin; Frigault, Matthew J.; Southard, Jackson; Li, Shuqiang; Kann, Michael C.; Silva, Harrison; Jan, Max; Rhrissorrakrai, Kahn; Utro, Filippo; Levovitz, Chaya; Jacobs, Raquel A.; Slowik, Kara; Danysh, Brian P.; Livak, Kenneth J.; Parida, Laxmi; Ferry, Judith; Jacobson, Caron; Wu, Catherine J.; Getz, Gad; Maus, Marcela, V Share Save
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer Noronha, Ashish; Nataraj, Nishanth Belugali; Lee, Joo Sang; Zhitomirsky, Benny; Oren, Yaara; Oster, Sara; Lindzen, Moshit; Mukherjee, Saptaparna; Will, Rainer; Ghosh, Soma; Simoni-Nieves, Arturo; Verma, Aakanksha; Chatterjee, Rishita; Borgoni, Simone; Robinson, Welles; Sinha, Sanju; Brandis, Alexander; Kerr, D. Lucas; Wu, Wei; Sekar, Arunachalam; Giri, Suvendu; Chung, Youngmin; Drago-Garcia, Diana; Danysh, Brian P.; Lauriola, Mattia; Fiorentino, Michelangelo; Ardizzoni, Andrea; Oren, Moshe; Blakely, Collin M.; Ezike, Jideofor; Wiemann, Stefan; Parida, Laxmi; Bivona, Trever G.; Aqeilan, Rami, I; Brugge, Joan S.; Regev, Aviv; Getz, Gad; Ruppin, Eytan; Yarden, Yosef Share Save
Proteogenomic characterization of CDK4/6 inhibitor-resistant ER plus breast cancer Chen, Christopher T.; Leshchiner, Ignaty; Martin, Liz; Kane, Harry; Rhrissorrakrai, Kahn; Utro, Filippo; Levovitz, Chaya; Gillette, Michael; Satpathy, Shankha; Pinto, Christopher; McLoughlin, Daniel; Allen, Read; Danysh, Brian P.; Slowik, Kara; Jacobs, Raquel A.; Carr, Steven; Parida, Laxmi; Getz, Gad; Juric, Dejan Share Save
Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer Coates, James T.; Sun, Sheng; Leshchiner, Ignaty; Thimmiah, Nayana; Martin, Elizabeth E.; McLoughlin, Daniel; Danysh, Brian P.; Slowik, Kara; Jacobs, Raquel A.; Rhrissorrakrai, Kahn; Utro, Filippo; Levovitz, Chaya; Denault, Elyssa; Walmsley, Charlotte S.; Kambadakone, Avinash; Stone, James R.; Isakoff, Steven J.; Parida, Laxmi; Juric, Dejan; Getz, Gad; Bardia, Aditya; Ellisen, Leif W. Share Save
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers (vol 25, pg 1415, 2019) Parikh, Aparna R.; Leshchiner, Ignaty; Elagina, Liudmila; Goyal, Lipika; Levovitz, Chaya; Siravegna, Giulia; Livitz, Dimitri; Rhrissorrakrai, Kahn; Martin, Elizabeth E.; Van Seventer, Emily E.; Hanna, Megan; Slowik, Kara; Utro, Filippo; Pinto, Christopher J.; Wong, Alicia; Danysh, Brian P.; de la Cruz, Ferran Fece; Fetter, Isobel J.; Nadres, Brandon; Shahzade, Heather A.; Allen, Jill N.; Blaszkowsky, Lawrence S.; Clark, Jeffrey W.; Giantonio, Bruce; Murphy, Janet E.; Nipp, Ryan D.; Roeland, Eric; Ryan, David P.; Weekes, Colin D.; Kwak, Eunice L.; Faris, Jason E.; Wo, Jennifer Y.; Aguet, Francois; Dey-Guha, Ipsita; Hazar-Rethinam, Mehlika; Dias-Santagata, Dora; Ting, David T.; Zhu, Andrew X.; Hong, Theodore S.; Golub, Todd R.; Iafrate, A. John; Adalsteinsson, Viktor A.; Bardelli, Alberto; Parida, Laxmi; Juric, Dejan; Getz, Gad; Corcoran, Ryan B. Share Save
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Not logged in.png){kind=icon}
