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RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer Singh, Harshabad; Sahgal, Pranshu; Kapner, Kevin; Corsello, Steven M.; Gupta, Hersh; Gujrathi, Rahul; Li, Yvonne Y.; Cherniack, Andrew D.; El Alam, Raquelle; Kerfoot, Joseph; Andrews, Elizabeth; Lee, Annette; Nambiar, Chetan; Hannigan, Alison M.; Remland, Joshua; Brais, Lauren; Leahy, Meghan E.; Rubinson, Douglas A.; Schlechter, Benjamin L.; Meyerson, Matthew; Kuang, Yanan; Paweletz, Cloud P.; Lee, Jessica K.; Quintanilha, Julia C. F.; Aguirre, Andrew J.; Perez, Kimberly J.; Huffman, Brandon M.; Rossi, Humberto; Abrams, Thomas A.; Kabraji, Sheheryar; Trusolino, Livio; Bertotti, Andrea; Sicinska, Ewa T.; Parikh, Aparna R.; Wolpin, Brian M.; Schrock, Alexa B.; Giannakis, Marios; Ng, Kimmie; Meyerhardt, Jeffrey A.; Hornick, Jason L.; Sethi, Nilay S.; Cleary, James M. Share Save
Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors Lu, Wenchao; Fan, Mengyang; Ji, Wenzhi; Tse, Jason; You, Inchul; Ficarro, Scott B.; Tavares, Isidoro; Che, Jianwei; Kim, Audrey Y.; Zhu, Xijun; Boghossian, Andrew; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Hinshaw, Stephen M.; Nabet, Behnam; Corsello, Steven M.; Kwiatkowski, Nicholas; Marto, Jarrod A.; Zhang, Tinghu; Gray, Nathanael S. Share Save
Virtual screening for small-molecule pathway regulators by image-profile matching Rohban, Mohammad H.; Fuller, Ashley M.; Tan, Ceryl; Goldstein, Jonathan T.; Syangtan, Deepsing; Gutnick, Amos; DeVine, Ann; Nijsure, Madhura P.; Rigby, Megan; Sacher, Joshua R.; Corsello, Steven M.; Peppler, Grace B.; Bogaczynska, Marta; Boghossian, Andrew; Ciotti, Gabrielle E.; Hands, Allison T.; Mekareeya, Aroonroj; Doan, Minh; Gale, Jennifer P.; Derynck, Rik; Turbyville, Thomas; Boerckel, Joel D.; Singh, Shantanu; Kiessling, Laura L.; Schwarz, Thomas L.; Varelas, Xaralabos; Wagner, Florence F.; Kafri, Ran; Eisinger-Mathason, T. S. Karin; Carpenter, Anne E. Share Save
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition Fang, Lishan; Ford-Roshon, Dane; Russo, Max; O'Brien, Casey; Xiong, Xiaozhe; Gurjao, Carino; Grandclaudon, Maximilien; Raghavan, Srivatsan; Corsello, Steven M.; Carr, Steven A.; Udeshi, Namrata D.; Berstler, James; Sicinska, Ewa; Ng, Kimmie; Giannakis, Marios Share Save
Adenosine receptor antagonists exhibit potent and selective off-target killing of FOXA1-high cancers Corsello, Steven M.; Spangler, Ryan D.; Humeidi, Ranad; Harrington, Caitlin N.; Nagari, Rohith T.; Singh, Ritu; Wang, Vickie; Kocak, Mustafa; Rossen, Jordan; Madec, Amael; Dumont, Nancy; Golub, Todd R. Share Save
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling Corsello, Steven M.; Nagari, Rohith T.; Spangler, Ryan D.; Rossen, Jordan; Kocak, Mustafa; Bryan, Jordan G.; Humeidi, Ranad; Peck, David; Wu, Xiaoyun; Tang, Andrew A.; Wang, Vickie M.; Bender, Samantha A.; Lemire, Evan; Narayan, Rajiv; Montgomery, Philip; Ben-David, Uri; Garvie, Colin W.; Chen, Yejia; Rees, Matthew G.; Lyons, Nicholas J.; McFarland, James M.; Wong, Bang T.; Wang, Li; Dumont, Nancy; O'Hearn, Patrick J.; Stefan, Eric; Doench, John G.; Harrington, Caitlin N.; Greulich, Heidi; Meyerson, Matthew; Vazquez, Francisca; Subramanian, Aravind; Roth, Jennifer A.; Bittker, Joshua A.; Boehm, Jesse S.; Mader, Christopher C.; Tsherniak, Aviad; Golub, Todd R. Share Save
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Novel cell line barcoding method reveals tepoxalin as a selective drug against MDR1-high tumor cells Corsello, Steven M.; Spangler, Ryan D.; Nagari, Rohith T.; Kocak, Mustafa; Rossen, Jordan; O'Hearn, Patrick; Roth, Jennifer; Gonzalez, Alfredo; Dumont, Nancy; Doench, John; Boehm, Jesse S.; Vazquez, Francisca; Tsherniak, Aviad; Golub, Todd R. Share Save
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Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models Tseng, Yuen-Yi; Hong, Andrew; Keskula, Paula; Gill, Shubhroz; Cheah, Jaime; Kryukov, Grigoriy; Tsherniak, Aviad; Vazquez, Francisca; Cowley, Glenn; Alkhairy, Sahar; Oh, Coyin; Peng, Anson; Deasy, Rebecca; Sayeed, Abeer; Ronning, Peter; Ng, Samuel; Corsello, Steven; Painter, Corrie; Sandak, David; Garraway, Levi; Rubin, Mark; Kuo, Calvin; Puram, Sidharth; Weinstock, David; Bass, Adam; Wagle, Nikhil; Ligon, Keith; Janeway, Katherine; Root, David; Schreiber, Stuart; Clemons, Paul; Shamji, Aly; Shamji, Aly; Hahn, William; Golub, Todd; Boehm, Jesse Share Save
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study Ghazani, Arezou A.; Oliver, Nelly M.; Pierre, Joseph P. St.; Garofalo, Andrea; Rainville, Irene R.; Hiller, Elaine; Treacy, Daniel J.; Rojas-Rudilla, Vanesa; Wood, Sam; Bair, Elizabeth; Parello, Michael; Huang, Franklin; Giannakis, Marios; Wilson, Frederick H.; Stover, Elizabeth H.; Corsello, Steven M.; Nguyen, Tom; Rana, Huma Q.; Church, Alanna J.; Lowenstein, Carol; Cibulskis, Carrie; Amin-Mansour, Ali; Heng, Jennifer; Brais, Lauren; Santos, Abigail; Bauer, Patrick; Waldron, Amanda; Lo, Peter; Gorman, Megan; Lydon, Christine A.; Welch, Marisa; McNamara, Philip; Gabriel, Stacey; Sholl, Lynette M.; Lindeman, Neal I.; Garber, Judy E.; Joffe, Steven; Van Allen, Eliezer M.; Gray, Stacy W.; Janne, Pasi A.; Garraway, Levi A.; Wagle, Nikhil Share Save
Accelerating drug repurposing for cancer therapy using multiplexed viability assays Corsello, Steven M.; Mader, Christopher C.; Bryan, Jordan; Roth, Jennifer; Peck, David; Davis, John; Bender, Samantha; Wang, Li; Wang, Alice; Bittker, Joshua; Vazquez, Francisca; Subramanian, Aravind; Tsherniak, Aviad; Golub, Todd R. Share Save
PDE3A modulation for cancer therapy Wu, Xiaoyun; Lewis, Timothy; de Waal, Luc; Gao, Galen; Zhang, Jian; Schenone, Monica; Garvie, Colin; Diamond, Brett; Lorrey, Selena; Cherniack, Andrew; Corsello, Steven; Burgin, Alex; Golub, Todd; Schreiber, Stuart; Meyerson, Matthew; Greulich, Heidi Share Save
The Drug Repurposing Hub: a next-generation drug library and information resource Corsello, Steven M.; Bittker, Joshua A.; Liu, Zihan; Gould, Joshua; McCarren, Patrick; Hirschman, Jodi E.; Johnston, Stephen E.; Vrcic, Anita; Wong, Bang; Khan, Mariya; Asiedu, Jacob; Narayan, Rajiv; Mader, Christopher C.; Subramanian, Aravind; Golub, Todd R. Share Save
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles Kim, Eejung; Ilic, Nina; Shrestha, Yashaswi; Zou, Lihua; Kamburov, Atanas; Zhu, Cong; Yang, Xiaoping; Lubonja, Rakela; Tran, Nancy; Nguyen, Cindy; Lawrence, Michael S.; Piccioni, Federica; Bagul, Mukta; Doench, John G.; Chouinard, Candace R.; Wu, Xiaoyun; Hogstrom, Larson; Natoli, Ted; Tamayo, Pablo; Horn, Heiko; Corsello, Steven M.; Lage, Kasper; Root, David E.; Subramanian, Aravind; Golub, Todd R.; Getz, Gad; Boehm, Jesse S.; Hahn, William C. Share Save
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