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Benjamin P. Kleinstiver

University of Pennsylvania

41H-index
154Paper Count
1.4WCitation Count
Published Papers 60
Publication Date
Mechanistic machine learning for prediction of prime editing outcomes
err2026-08-12
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errOAAI
errAlvin Hsu; Peter J. Chen; Angus H. Li; Colin F. Hemez; Xin D. Gao; Markus Terrey; Charlie Nelson; Vijay Selvam; Ana Cristian; Amber N. McElroy; Benjamin J. Steinbeck; Gandhar K. Mahadeshwar; Smriti Pandey; Zachary Barsdale; Paul Z. Chen; Alexander A. Sousa; Holt A. Sakai; Rachel A. Silverstein; Ilias Morad; Ryan K. Krueger; Max W. Shen; Benjamin P. Kleinstiver; Cathleen M. Lutz; Jakub Tolar; Bruce R. Blazar; Mark J. Osborn; David R. Liu
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Towards precision medicine for brain arteriovenous malformations
err2026-05-15
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PREAI
errHale, Andrew T.; Kundishora, Adam J.; Kalailingam, Pazhanichamy; Barak, Tanyeri; Duy, Phan Q.; Ramundo, Christopher M.; Fan, Baojian; Li, Qiang; Brastianos, Priscilla K.; Shankar, Ganesh M.; Alper, Seth L.; Kleinstiver, Benjamin P.; Musolino, Patricia L.; Kahle, Kristopher T.
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Extracellular vesicles-mediated delivery of SpCas9 RNPs for therapeutic gene editing in Spinocerebellar Ataxia Type 3
err2026-03-09
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errOAAI
errKevin Leandro; David Rufino-Ramos; Sara M. Lopes; Francisca Santos Silva; Paulo Rodrigues-Santos; Ana Carolina Silva; Ana Rita Fernandes; Carina Henriques; Dina Pereira; Diana Lobo; Guilherme L. Gabriel; Rosário Faro; Rui Jorge Nobre; Pedro R.L. Perdigão; Benjamin P. Kleinstiver; Luís Pereira de Almeida
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Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing
err2026-03-03
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errOAAI
errBasheer Becerra; Sandra Wittibschlager; Zain M. Patel; Ana P. Kutschat; Justin Delano; Eric Che; Anzhelika Tauber; Ting Wu; Marlena Starrs; Christina S. Horstmann; Sophie Müller; Madelynn N. Whittaker; Elise Sylvander; Manfred Lehner; Michael I. Love; Benjamin P. Kleinstiver; Martin Jankowiak; Daniel E. Bauer; Davide Seruggia; Luca Pinello
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Customizing CRISPR–Cas PAM specificity with protein language models
err2026-02-02
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PREAI
errStephen Nayfach; Aadyot Bhatnagar; Andrey Novichkov; Nahye Kim; Alexander M. Hoffnagle; Riffat Hussain; Gabriella O. Estevam; Emily Hill; Jeffrey A. Ruffolo; Rachel A. Silverstein; Joseph Gallagher; Benjamin P. Kleinstiver; Alexander J. Meeske; Peter Cameron; Ali Madani
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An opportune time for targeted brain arteriovenous malformation therapy
err2025-12-01
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PREAI
errHale, Andrew T.; Kalailingam, Pazhanichamy; Kundishora, Adam J.; Reeves, Benjamin C.; Brastianos, Priscilla K.; Shih, Helen A.; Jain, Rakesh K.; Ning, Mingming; Stapleton, Christopher J.; Patel, Aman B.; Smith, Edward R.; Chapman, Paul H.; Rabinov, James D.; Kleinstiver, Benjamin P.; Musolino, Patricia L.; Kahle, Kristopher T.
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Treatment of a severe vascular disease using a bespoke CRISPR–Cas9 base editor in mice
err2025-09-11
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PREAI
errChristiano R. R. Alves; Sabyasachi Das; Vijai Krishnan; Leillani L. Ha; Lauren R. Fox; Hannah E. Stutzman; Claire E. Shamber; Pazhanichamy Kalailingam; Siobhan McCarthy; Christian L. Lino Cardenas; Claire E. Fong; Takahiko Imai; Sunayana Mitra; Shuqi Yun; Rachael K. Wood; Friederike M. C. Benning; Kangsan Roh; Joseph Lawton; Nahye Kim; Rachel A. Silverstein; Joana Ferreira da Silva; Demitri de la Cruz; Rashmi Richa; Jun Xie; Heather L. Gray-Edwards; Rajeev Malhotra; David Y. Chung; Luke H. Chao; Shengdar Q. Tsai; Casey A. Maguire; Mark E. Lindsay; Benjamin P. Kleinstiver; Patricia L. Musolino
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GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats
err2025-08-13
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errOAAI
errMiao Yu; Limei Ai; Bang Wang; Shifeng Lian; Lawrence Ip; James Liu; Linxian Li; Shengdar Q. Tsai; Benjamin P. Kleinstiver; Zongli Zheng
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Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model
err2025-01-01
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errOAAI
errMaalouf, Katia E.; Frederick, Dawn Madison; Sharma, Nutan; Abou Haidar, Edwina; Xiao, Tianhe; Han, Justin Seungkyu; Mahamdeh, Mohammed S.; Soberman, Roy J.; Rufino-Ramos, David; Kleinstiver, Benjamin P.; Jinnah, Hyder A.; Vaine, Christine A.; Bragg, D. Cristopher
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CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice
err2025-01-01
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errOAAI
errNieland, Lisa; Vrijmoet, Anne B.; Jetten, Isabelle W.; Rufino-Ramos, David; de Reus, Alexandra J. E. M.; Breyne, Koen; Kleinstiver, Benjamin P.; Maguire, Casey A.; Broekman, Marike L. D.; Breake, Xandra O.; Abels, Erik R.
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High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
err2024-10-16
err0
PREAI
errBzhilyanskaya, Vera; Ma, Linyuan; Liu, Siyuan; Fox, Lauren R.; Whittaker, Madelynn N.; Meis, Ronald J.; Choi, Uimook; Lawson, Amanda; Ma, Michelle; Theobald, Narda; Burkett, Sandra; Sweeney, Colin L.; Lazzarotto, Cicera R.; Tsai, Shengdar Q.; Lack, Justin B.; Wu, Xiaolin; Dahl, Gary A.; Malech, Harry L.; Kleinstiver, Benjamin P.; De Ravin, Suk See
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Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads
err2024-08-01
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errOAAI
errLeandro, Kevin; Rufino-Ramos, David; Breyne, Koen; Di Ianni, Emilio; Lopes, Sara M.; Nobre, Rui Jorge; Kleinstiver, Benjamin P.; Perdiga, Pedro R. L.; Breakefield, Xandra O.; de Almeida, Luis Pereira
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Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases
err2024-07-22
err10
PREAI
errda Silva, Joana Ferreira; Tou, Connor J.; King, Emily M.; Eller, Madeline L.; Rufino-Ramos, David; Ma, Linyuan; Cromwell, Christopher R.; Metovic, Jasna; Benning, Friederike M. C.; Chao, Luke H.; Eichler, Florian S.; Kleinstiver, Benjamin P.
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Splice modulators target PMS1 to reduce somatic expansion of the Huntington's disease-associated CAG repeat
err2024-04-12
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errOAAI
errMclean, Zachariah L.; Gao, Dadi; Correia, Kevin; Roy, Jennie C. L.; Shibata, Shota; Farnum, Iris N.; Valdepenas-Mellor, Zoe; Kovalenko, Marina; Rapuru, Manasa; Morini, Elisabetta; Ruliera, Jayla; Gillis, Tammy; Lucente, Diane; Kleinstiver, Benjamin P.; Lee, Jong-Min; Macdonald, Marcy E.; Wheeler, Vanessa C.; Mouro Pinto, Ricardo; Gusella, James F.
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In situ architecture of Opa1-dependent mitochondrial cristae remodeling
err2024-01-15
err9
errOAAI
errFry, Michelle Y.; Navarro, Paula P.; Hakim, Pusparanee; Ananda, Virly Y.; Qin, Xingping; Landoni, Juan C.; Rath, Sneha; Inde, Zintis; Lugo, Camila Makhlouta; Luce, Bridget E.; Ge, Yifan; Mcdonald, Julie L.; Ali, Ilzat; Ha, Leillani L.; Kleinstiver, Benjamin P.; Chan, David C.; Sarosiek, Kristopher A.; Chao, Luke H.
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Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy
err2023-12-06
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errOAAI
errAlves, Christiano R. R.; Ha, Leillani L.; Yaworski, Rebecca; Sutton, Emma R.; Lazzarotto, Cicera R.; Christie, Kathleen A.; Reilly, Aoife; Beauvais, Ariane; Doll, Roman M.; de la Cruz, Demitri; Maguire, Casey A.; Swoboda, Kathryn J.; Tsai, Shengdar Q.; Kothary, Rashmi; Kleinstiver, Benjamin P.
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PAM-flexible genome editing with an engineered chimeric Cas9
err2023-10-04
err11
errOAAI
errZhao, Lin; Koseki, Sabrina R. T.; Silverstein, Rachel A.; Amrani, Nadia; Peng, Christina; Kramme, Christian; Savic, Natasha; Pacesa, Martin; Rodriguez, Tomas C.; Stan, Teodora; Tysinger, Emma; Hong, Lauren; Yudistyra, Vivian; Ponnapati, Manvitha R.; Jacobson, Joseph M.; Church, George M.; Jakimo, Noah; Truant, Ray; Jinek, Martin; Kleinstiver, Benjamin P.; Sontheimer, Erik J.; Chatterjee, Pranam
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Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression
err2023-10-01
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errOAAI
errMesaki, Kumi; Juvet, Stephen; Yeung, Jonathan; Guan, Zehong; Wilson, Gavin W.; Hu, Jim; Davidson, Alan R.; Kleinstiver, Benjamin P.; Cypel, Marcelo; Liu, Mingyao; Keshavjee, Shaf
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Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F
err2023-08-01
err11
PREAI
errPeters, Cole W.; Hanlon, Killian S.; Ivanchenko, Maryna; Zinn, Eric; Linarte, Elizabeth F.; Li, Yaqiao; Levy, Jonathan M.; Liu, David R.; Kleinstiver, Benjamin P.; Indzhykulian, Artur A.; Corey, David P.
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Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis
errIMMUNITY
IF26.3
err2023-07-01
err20
PREAI
errKiss, Mate G.; Mindur, John E.; Yates, Abi G.; Lee, Donghoon; Fullard, John F.; Anzai, Atsushi; Poller, Wolfram C.; Christie, Kathleen A.; Iwamoto, Yoshiko; Roudko, Vladimir; Downey, Jeffrey; Chan, Christopher T.; Huynh, Pacific; Janssen, Henrike; Ntranos, Achilles; Hoffmann, Jan D.; Jacob, Walter; Goswami, Sukanya; Singh, Sumnima; Leppert, David; Kuhle, Jens; Kim-Schulze, Seunghee; Nahrendorf, Matthias; Kleinstiver, Benjamin P.; Probert, Fay; Roussos, Panos; Swirski, Filip K.; McAlpine, Cameron S.
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