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J

Jos H. Beijnen

the netherlands cancer institute

129H-index
1.8KPaper Count
7.5WCitation Count
Published Papers 575
Publication Date
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
err2026-02-16
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errMark C. de Gooijer; Daria M. Fedorushkova; Ping Zhang; Levi C. M. Buil; Ceren H. Çitirikkaya; Hilal Çolakoğlu; Ana Rita R. Maia; Irena Bočkaj; Margarita Espitia-Ballestas; Laura E. Kuil; Jos H. Beijnen; Olaf van Tellingen
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Development of a multi-target drug combination targeting three major proliferation pathways in glioblastoma
err2025-11-01
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errTheir, Anna; Elens, Robert; Baltira, Chrysiida; Szewczyk, Aldona; Rozing, Kicky; Beijnen, Jos; De Gooijer, Mark; Van Tellingen, Olaf
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Reducing the Burden of Interaction Studies in Cancer Patients Using a Stable Isotopically Labeled Microtracer: A Proof-of-Concept Study with Alectinib
err2025-11-01
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errMohmaed Ali, Ma Ida; van der Heijden, Lisa T.; Tibben, Matthijs; Rosing, Hilde; Kalicharan, Raween; Ruiter, Gerrina; Beijnen, Jos H.; Huisman-siebinga, Hinke; Huitema, Alwin D. R.; Steeghs, Neeltje
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Phase I Study of Sorafenib Combined with Gemcitabine and Carboplatin in Patients with Advanced Solid Tumors
err2025-05-14
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errDaphne W. M. Voogd; Merel J. J. Lucassen; Ruud van der Noll; Sybrand W. J. Zielhuis; David Boss; Jos H. Beijnen; Hilde Rosing; Matthijs Tibben; Alwin D. R. Huitema; Jan H. M. Schellens; Neeltje Steeghs
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Defining the Quality Attributes for Tumor-Infiltrating Lymphocyte Medicinal Products
err2025-03-01
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PREAI
errLievense, Justin J.; Nijenhuis, Cynthia; Jedema, Inge; Jonker-Hoogerkamp, Arendien; Moyers, Justin T.; Hamid, Omid; Beijnen, Jos H.; Haanen, John B. A. G.; Nuijen, Bastiaan
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Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
err2024-11-04
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errWang, Yao-geng; Gan, Chang-pei; Beukers-Korver, Joke; Rosing, Hilde; Li, Wen-long; Wagenaar, Els; Lebre, Maria C.; Song, Ji-ying; Pritchard, Colin; Bin Ali, Rahmen; Huijbers, Ivo; Beijnen, Jos H.; Schinkel, Alfred H.
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Dose-individualisation of fluoropyrimidines in DPYD wild-type patients: Final results from the Alpe2U study
err2024-09-01
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PREAI
errHeersche, N.; Knikman, J. E.; De With, M.; Lopez-Yurda, M.; Baars, A.; Creemers, G-J.; Droogendijk, H.; Fiets, E.; Deenen, M.; Van Schaik, R.; van den Bosch, B.; Oomen-de Hoop, E.; Rosing, H.; Swen, J.; Gelderblom, H.; Schellens, J. H. M.; Beijnen, J. H.; Mathijssen, R. H.; Guchelaar, H-J.; Cats, A.
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The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites
err2024-09-01
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PREAI
errMartins, Margarida L. F.; Heydari, Paniz; Li, Wenlong; Martinez-Chavez, Alejandra; el Yattouti, Malika; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain
err2024-08-05
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errLentzas, Aristeidis; de Gooijer, Mark C.; Zuidema, Stefanie; Meurs, Amber; Citirikkaya, Ceren H.; Venekamp, Nikkie; Beijnen, Jos H.; van Tellingen, Olaf
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ELISA assay for the quantification of ipilimumab in human serum, plasma, milk, and cerebrospinal fluid
err2024-08-01
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PREAI
errPluim, Dick; Buitelaar, Pauline; de Jong, Karen A. M.; Rosing, Hilde; Brandsma, Dieta; Huitema, Alwin D. R.; Beijnen, Jos H.
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Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood
err2024-08-01
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errSchouten, Wietse M.; Roseboom, Ignace C.; Lucas, Luc; Tshiongo, Japhet Kabalu; Mavoko, Hypolite Muhindo; Kayentao, Kassoum; Rosing, Hilde; Huitema, Alwin D. R.; Beijnen, Jos H.; Dorlo, Thomas P. C.
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A multiplex UPLC-MS/MS method for the quantification of three PD-L1 checkpoint inhibitors, atezolizumab, avelumab, and durvalumab, in human serum
err2024-06-01
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PREAI
errBuitelaar, Pauline L. M.; de Jong, Karen A. M.; Aardenburg, Leon; van der Heijden, Michiel S.; Huitema, Alwin D. R.; Beijnen, Jos H.; Rosing, Hilde
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ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
err2024-06-01
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errRijmers, Jamie; Retmana, Irene A.; Bui, Viet; Arguedas, Davinia; Lebre, Maria C.; Sparidans, Rolf W.; Beijnen, Jos H.; Schinkel, Alfred H.
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Skin pharmacokinetics of miltefosine in the treatment of post-kala-azar dermal leishmaniasis in South Asia
err2024-05-10
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errPalic, Semra; Chu, Wan-Yu; Sundar, Shyam; Mondal, Dinesh; Das, Pradeep; Pandey, Krishna; Raja, Sheeraz; Rijal, Suman; Roseboom, Ignace C.; Hamadeh, Abdullah; Malik, Paul R. V.; Beijnen, Jos H.; Huitema, Alwin D. R.; Sjogren, Erik; Alves, Fabiana; Dorlo, Thomas P. C.
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The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib
err2024-04-01
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errLoos, Nancy H. C.; Sparidans, Rolf W.; Heydari, Paniz; Bui, Viet; Lebre, Maria C.; Beijnen, Jos H.; Schinkel, Alfred H.
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Coadministration of ABCB1/P-glycoprotein inhibitor elacridar improves tissue distribution of ritonavir-boosted oral cabazitaxel in mice
err2024-01-01
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PREAI
errLoos, Nancy H. C.; Martins, Margarida L. F.; de Jong, Danielle; Lebre, Maria C.; Tibben, Matthijs; Beijnen, Jos H.; Schinkel, Alfred H.
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Predictability of human exposure by human-CYP3A4-transgenic mouse models: A meta-analysis
err2023-12-01
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errDamoiseaux, David; Schinkel, Alfred H.; Beijnen, Jos H.; Huitema, Alwin D. R.; Dorlo, Thomas P. C.
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