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Alfred S.L. Cheng

The Chinese University of Hong Kong

64H-index
473Paper Count
1.3WCitation Count
Published Papers 149
Publication Date
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Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma
errNature Communications
IF15.7
err2025-11-11
err0
errOAAI
errMartina Mang Leng Lei; Carmen Oi Ning Leung; Rainbow Wing Hei Leung; Xue Qian Wu; Katherine Po Sin Chung; Catherine Yu Jia Gu; Mandy Sze Man Chan; Wing Ki Chau; Quan Hua Mu; Kai Yu Ng; Man Tong; Jing Ping Yun; Jia Ming Nickolas Teo; Guang Sheng Ling; Patrick Pak Chun Wong; Stephen Lam Chan; Zhe Wen Xiong; Alfred Sze Lok Cheng; Jin Ding; Stephanie Ma; Terence Kin Wah Lee
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errSave
Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator
errSignal Transduction and Targeted Therapy
IF52.7
err2025-10-14
err0
errOAAI
errXiaoyu Liu; Weiqin Yang; Alfred Sze-Lok Cheng
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errSave
Correction: PPARγ is essential for protection against nonalcoholic steatohepatitis
errGene Therapy
IF4.5
err2025-09-26
err0
PREAI
errC. W. Wu; E. S. H. Chu; C. N. Y. Lam; A. S. L. Cheng; C. W. Lee; V. W. S. Wong; J. J. Y. Sung; J. Yu
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errSave
Epigenetic therapeutics to overcome resistance against immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC): a proof-of-concept clinical trial
errLANCET REGIONAL HEALTH-WESTERN PACIFIC
IF8.1
err2025-02-01
err0
errOAAI
errChan, Stephen; Cheng, Alfred; La Thangue, Nick; Kerr, David
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errSave
Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non-Small Cell Lung Cancer With High Programmed Death-Ligand 1 Expression
errJTO CLINICAL AND RESEARCH REPORTS
IF3.5
err2025-01-01
err0
errOAAI
errCheung, Alvin H. K.; Mui, Zeta; Yeung, Walter W.; Chow, Chit; Yu, Mandy F.; Chen, Olivia H.; Wong, Kit-Yee; Xie, Fuda; Lau, Yat Ming; Cheng, Alfred S. -L.; Kang, Wei; To, Ka-Fai; Mok, Tony S.; Li, Molly S. C.
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errSave
PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosisassociated hepatocellular carcinoma
errJHEP REPORTS
IF7.5
err2024-07-01
err0
errOAAI
errLiu, Xiaoyu; Liu, Man; Wu, Haoran; Tang, Wenshu; Yang, Weiqin; Chan, Thomas T. H.; Zhang, Lingyun; Chen, Shufen; Xiong, Zhewen; Liang, Jianxin; Si-Tou, Willis Wai-Yiu; Shu, Ting; Li, Jingqing; Cao, Jianquan; Zhong, Chengpeng; Sun, Hanyong; Kwong, Tsz Tung; Leung, Howard H. W.; Wong, John; Lai, Paul Bo-San; To, Ka-Fai; Xiang, Tingxiu; Sung, Joseph Jao-Yiu; Chan, Stephen Lam; Zhou, Jingying; Cheng, Alfred Sze-Lok
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Integrative analysis reveals associations between oral microbiota dysbiosis and host genetic and epigenetic aberrations in oral cavity squamous cell carcinoma
errNPJ BIOFILMS AND MICROBIOMES
IF9.2
err2024-04-08
err11
errOAAI
errCai, Liuyang; Zhu, Hengyan; Mou, Qianqian; Wong, Po Yee; Lan, Linlin; Ng, Cherrie W. K.; Lei, Pu; Cheung, Man Kit; Wang, Daijuanru; Wong, Eddy W. Y.; Lau, Eric H. L.; Yeung, Zenon W. C.; Lai, Ronald; Meehan, Katie; Fung, Sherwood; Chan, Kwan Chee A.; Lui, Vivian W. Y.; Cheng, Alfred S. L.; Yu, Jun; Chan, Paul K. S.; Chan, Jason Y. K.; Chen, Zigui
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errSave
Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-04-01
err6
errOAAI
errMa, Bowen; Khan, Khadija Shahed; Xu, Tongyang; Amada, Josefina Xeque; Guo, Zhihao; Huang, Yunpeng; Yan, Yu; Lam, Henry; Cheng, Alfred Sze-Lok; Ng, Billy Wai-Lung
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errSave
Deciphering the cellular and molecular determinants of immunotherapy resistance in NASH-associated hepatocellular carcinoma by single-cell analysis
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errZhang, Lingyun; Zhang, Yiling; Tang, Wenshu; Xiong, Zhewen; Liu, Xiaoyu; Liang, Zhixian; Tsang, Yuk Wah; Yang, Weiqin; Long, Xiaohang; Cheng, Alfred Sze Lok
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errSave
HDAC9 as a potential regulator of lenvatinib resistance in hepatocellular carcinoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errXie, Yunong; Zhang, Minghe; Liu, Yan; Liu, Linglin; Cheng, Alfred Sze-Lok; Ma, Stephanie; Tong, Man
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errSave
Accurate identification of structural variations from cancer samples
errBRIEFINGS IN BIOINFORMATICS
IF7.7
err2024-01-16
err1
errOAAI
errLi, Le; Hong, Chenyang; Xu, Jie; Chung, Claire Yik-Lok; Leung, Alden King-Yung; Boncan, Delbert Almerick T.; Cheng, Lixin; Lo, Kwok-Wai; Lai, Paul B. S.; Wong, John; Zhou, Jingying; Cheng, Alfred Sze-Lok; Chan, Ting-Fung; Yue, Feng; Yip, Kevin Y.
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errSave
The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas
errCLINICAL AND TRANSLATIONAL MEDICINE
IF6.8
err2023-12-26
err11
errOAAI
errChen, Bonan; Chan, Wai Nok; Xie, Fuda; Mui, Chun Wai; Liu, Xiaoli; Cheung, Alvin H. K.; Lung, Raymond W. M.; Chow, Chit; Zhang, Zhenhua; Fang, Canbin; Yu, Peiyao; Shi, Shihua; Zhou, Shikun; Chen, Guoming; Wang, Zhangding; Wang, Shouyu; Ding, Xiaofan; Huang, Bing; Liang, Li; Dong, Yujuan; Wong, Chi Chun; Wu, William K. K.; Cheng, Alfred S. L.; Wong, Nathalie; Yu, Jun; Lo, Kwok Wai; Tse, Gary M. K.; Kang, Wei; To, Ka Fai
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errSave
The E2F1-HOXB9/PBX2-CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer
errJOURNAL OF PATHOLOGY
IF5.2
err2023-06-05
err5
errOAAI
errZhang, Jinglin; Chen, Bonan; Wang, Yifei; Liu, Xiaoli; Yan, Huan; Wong, Kit Yee; Chan, Aden K. Y.; Cheung, Alvin H. K.; Chow, Chit; Xu, Dazhi; Wang, Shouyu; Huang, Bing; Liang, Li; Ke, Huixing; Wong, Chi Chun; Wu, William K. K.; Cheng, Alfred S. L.; Yu, Jun; Lo, Kwok Wai; To, Ka Fai; Kang, Wei
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errSave
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
errSCIENTIFIC REPORTS
IF3.9
err2023-04-25
err1
errOAAI
errCheung, Stanley K. K.; Kwok, Jacinda; Or, Penelope M. Y.; Wong, Chi Wai; Feng, Bo; Choy, Kwong Wai; Chang, Raymond C. C.; Burbach, J. Peter H.; Cheng, Alfred S. L.; Chan, Andrew M.
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errSave
Targeting SMARCAL1 as a therapeutic strategy to enhance cGAS/STING signaling in gastric cancer
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errHsu, Po-Yen; Chuang, Yu-Ming; Lin, Shu-Hui; Lee, Yu-Ting; Chen, Yin-Chen; Ng, Enders K. W.; Yeh, Kun-Tu; Cheng, Alfred S. L.; Chan, Michael W. Y.
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errSave
Compromised browning in white adipose tissue of ageing people
errEUROPEAN JOURNAL OF ENDOCRINOLOGY
IF5.2
err2023-02-08
err1
PREAI
errGu, Ping; Ding, Kai; Lu, Lei; Zhang, Yu; Wang, Wei; Guo, Qingyu; Liao, Yannian; Yang, Bingjie; Wang, Tiantian; Zhou, Changsheng; Lu, Bin; Kong, Alice P. S.; Cheng, Alfred S.; Hui, Hannah Xiaoyan; Shao, Jiaqing
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errSave
Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing
errRESEARCH
IF10.7
err2023-01-01
err16
errOAAI
errLiu, Qing; Long, Qiaoyun; Zhao, Jiayu; Wu, Wenjie; Lin, Zexin; Sun, Wei; Gu, Ping; Deng, Tuo; Loomes, Kerry Martin; Wu, Donghai; Kong, Alice P. S.; Zhou, Jingying; Cheng, Alfred S.; Hui, Hannah Xiaoyan
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errSave
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
errMOLECULAR THERAPY
IF12
err2023-01-01
err16
errOAAI
errLiu, Xiaoyu; Zhou, Jingying; Wu, Haoran; Chen, Shufen; Zhang, Lingyun; Tang, Wenshu; Duan, Liang; Wang, Ying; McCabe, Eleanor; Hu, Mengying; Yu, Zhuo; Liu, Hanzhuang; Choi, Chung Hang Jonathan; Sung, Joseph Jao-yiu; Huang, Leaf; Liu, Rihe; Cheng, Alfred Sze-lok
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errSave
Cancer-associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2-IGF1R and Hippo-YAP1 signaling pathways
errJOURNAL OF PATHOLOGY
IF5.2
err2022-12-17
err27
PREAI
errZhang, Jinglin; Chen, Bonan; Li, Hui; Wang, Yifei; Liu, Xiaoli; Wong, Kit Yee; Chan, Wai Nok; Chan, Aden K. Y.; Cheung, Alvin H. k; Leung, Kam Tong; Dong, Yujuan; Pan, Yi; Ke, Huixing; Liang, Li; Zhou, Zhaocai; Xiao, Jianyong; Wong, Chi Chun; Wu, William K. K.; Cheng, Alfred S. L.; Ma, Brigette B. Y.; Yu, Jun; Lo, Kwok Wai; Kang, Wei; To, Ka Fai
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Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-11-30
err16
errOAAI
errSun, Ping; Wang, Jing; Khan, Khadija S.; Yang, Weiqin; Ng, Billy Wai-Lung; Ilment, Nikita; Zessin, Matthes; Buelbuel, Emre F.; Robaa, Dina; Erdmann, Frank; Schmidt, Matthias; Romier, Christophe; Schutkowski, Mike; Cheng, Alfred Sze-Lok; Sippl, Wolfgang
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Research Directions

No research directions
Co-authors
Cooperation Journals
J
Joseph J.�Y. Sung
H-index: 171 · Papers: 2.2K
R
Richard L. Gallo
H-index: 148 · Papers: 884
V
Vincent Wai‐Sun Wong
H-index: 142 · Papers: 1.2K
余君 cover
余君 (Jun Yu)
H-index: 133 · Papers: 1.8K
J
Jean‐Pierre J. Issa
H-index: 130 · Papers: 984
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