China Pharmaceutical University

学者数2.3W

论文数1.2W

被引数1.7W

关联论文 (2921)

发表时间

Discovery of an Orally Bioavailable Selenium-Containing Polθ Inhibitor with a Dual Mechanism of DNA Damage and Immune Activation for HR-Deficient Cancers 发现一种具有口服生物利用度的含硒聚合酶θ抑制剂，其通过DNA损伤和免疫激活双重机制用于同源重组缺陷型癌症

European Journal of Medicinal Chemistry

IF5.9

2026-04-28

PREAI

Luyu Ma; Mingjin Luo; Xiangchi Liu; Jinyue Yang; Jianyu Li; Mingzhe Zhong; Xinyan Liu; Maoxu Xiao; Hua Xiang; Guoshun Luo

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis TGM2介导的GPX4色氨酰化赋予抗铁死亡能力以促进胃癌发生

Cell Discovery

IF12.5

2026-04-28

OAAI

Junping Bai; Dandan Geng; Xinwen Chen; Wanting Li; Xiaowei Wang; Luyang Tian; Yi Han; Zhao Jin; Meihang Du; Yang Tang; Weisheng Hu; Chunxiao Zhu; Shan Zhang; Zhangting Zhao; Run Zhang; Xinru Zhang; Wei Kang; KaFai To; Sachiyo Nomura; Fenghua Guo; Shi Jiao; Yixuan Xie; Zhaocai Zhou; Chao Dong; Hui Li; Liwei An

Copper-catalyzed three-component radical relay alkenylation of sulfenamides 铜催化三组分自由基接力烯基化硫酰胺

chem. commun.

IF0

2026-04-27

PREAI

Renkang Wei †; Jing Zhong †; Qian Wang; Yixin Wang; Hequan Yao; Aijun Lin

Mining of natural diversity enables efficient and expressible peptide asparaginyl ligases 挖掘天然多样性能够实现高效且可表达的肽天冬酰胺酰基连接酶

Nature Communications

IF15.7

2026-04-27

OAAI

Wenyu Du; Shi Qi; Mingming Zhen; Miao Liao; Yang Zhao; Jiahui Ma; Yining Hao; Hui Jiang; Gengyu Lu; Chong Wai Liew; Niying Chua; Huachao Chen; Guangwan Hu; Xinya Hemu

DrugGPS: Attention-guided multimodal fusion for intelligent exploration of drug-target and drug-disease interactions DrugGPS：注意力引导的多模态融合用于智能探索药物-靶点和药物-疾病相互作用

British Journal of Pharmacology

IF7.7

2026-04-27

PREAI

Huifeng Yao; Xinyi Yang; Yu Wang; Chenxiao Wang; Yiming Sun; Yunya Jiang; Li Liang; Qing Zhang; Haichun Liu; Hongmei Li; Xian Wei; Yadong Chen; Mengyi Lu; Yanmin Zhang

Spatiotemporally controlled systemic delivery reshapes the in vivo fate of a cationic antimicrobial peptide for lung-selective exposure and an improved therapeutic index 时空可控的系统递送重塑了阳离子抗菌肽在体内的命运，以实现肺选择性暴露和改善的治疗指数

European Journal of Pharmaceutics and Biopharmaceutics

IF4.3

2026-04-25

OAAI

Weiyan Tao; Mingzhen Li; Yunlin Zhou; Kexin Liu; Guoqiu Wu; Jingru Guo; Bin Di

Engineered commensal Bacteroides thetaiotaomicron enables tumor-targeted delivery and dual-mode regulation in colitis-associated colorectal cancer 工程化共生脆弱拟杆菌能够实现肿瘤靶向递送和双模式调控在结直肠炎相关结直肠癌中的作用

Journal of Controlled Release

IF11.5

2026-04-24

PREAI

Xiaoyu Jia; Yuna Xu; Xinyu Liu; Meng Ye; Feng Wang; Xiaobing Yang; Xiangdong Gao; Juping Yu; Wei Liu

Unsymmetrical N; C; Se-Pincer Palladium(II) Complexes Bearing Pyrimidine-Selenoether-Functionalized N-Heterocyclic Carbenes: Synthesis; Characterization; and Photocatalytic Amidation 不对称N;C;Se-钳形钯(II)配合物：含嘧啶-硒醚官能化N-杂环卡宾的合成、表征及光催化酰胺化

Organometallics

IF2.9

2026-04-23

PREAI

Nannan Han; Ziheng Yu; Duo Yu; Ping Liao; Xiaoqiong Diao; Jinwei Yuan; Yongmei Xiao; Liangru Yang; Lingbo Qu

Precision nose-to-brain therapeutics: Advances in drug delivery systems and emerging preclinical models 精准鼻脑靶向治疗：药物递送系统进展及新兴的预临床模型

Journal of Controlled Release

IF11.5

2026-04-23

PREAI

Yinglan Lu; Guang Wei; Zhengle Zhou; Xiyuan Xu; Jun Huang; Jianping Zhou; Xiaochen Gu; Guochen Han; Yang Ding

Structure-Based Discovery of the First Inhibitor Targeting the Talin2-β-integrin Interaction with Potent In Vivo Antitumor Activity in Breast Cancer Models 基于结构的首次发现靶向Talin2-β-整合素相互作用且在乳腺癌模型中具有强效体内抗肿瘤活性的抑制剂

Journal of Medicinal Chemistry

IF6.8

2026-04-22

PREAI

Xiaobo Zhang; Lixia Guan; Shuting Li; Shutong Chen; Miao-Miao Niu; Mengting Lou; Yang Zhou; Yunjiang Zhou; Weiwei Hu

Antibiotic Stress Response in a Medicinal Plant: Sulfamethoxazole–Mediated Regulation of Growth and Bioactive Compound Biosynthesis in Isatis indigotica 药用植物中的抗生素胁迫响应：甲氧苄氨嘧啶介导的生长和生物活性化合物生物合成的调控在Isatis indigotica中

Plant Physiology and Biochemistry

IF5.7

2026-04-22

PREAI

Yunfeng Ma; Yanhua Liu; Shuhan Li; Yiqi Su; Wuyue Wang; Qianjiahua Liao; Rong Ji; Jianqiu Chen

May 2026 issue first authors 2026年5月刊首作者

Trends in Pharmacological Sciences

IF19.9

2026-04-22

PREAI

Yue Zhang; Md. Asaduzzaman Rakib; Min Zhang; Kwang-Su Park

An Experimental Design for Pharmacy Undergraduates: Applying Conductometric Methods to Study the Kinetics of Aspirin Alkaline Hydrolysis 药学本科生实验设计：应用电导率法研究阿司匹林碱性水解动力学

Journal of Chemical Education

IF2.9

2026-04-22

PREAI

Junting Xi; Chenhui Zhang; Yuting Yang; Kaijie Zhang; Hai Qian; Ying Hu

Modulation of Intrabone Distribution of Anionic Polypeptide Nanocarriers through Hydrophobic Modification for the Treatment of Acute Myeloid Leukemia 通过疏水修饰调节阴离子多肽纳米载体的骨内分布以治疗急性髓系白血病

Acta Biomaterialia

IF9.6

2026-04-21

PREAI

Wanying Wang; Jing Zhao; Yuqian Liu; Xiaoxiong Jin; Xingliang Liu; Guangbao Yang; Jianglong Xia; Ziyuan Song

Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice 工程化BCG选择性触发肿瘤相关巨噬细胞的训练性免疫并使小鼠胶质母细胞瘤对放射治疗敏感

Nature Communications

IF15.7

2026-04-20

OAAI

Ke Ren; Ziyang Yuan; Lei Lei; Ziyuan Xiao; Ningyi Ma; Guodong Wang; Ningyi Sun; Tai Yang; Zhiyong Chang; Liang Qin; Ying Xu; Dahai Yu; Lizhou Jia; Haishi Qiao

VAP1 promotes cardiac fibrosis by enabling PDGFR signaling in myofibroblasts VAP1通过在肌成纤维细胞中激活PDGFR信号通路促进心肌纤维化

experimental & molecular medicine

IF0

2026-04-20

OAAI

Shan Huang; Qianwen Zhao; Tinghui Shao; Chenghao Zhu; Yujia Xue; Naxia Chen; Yue Zhang; Huihui Xu; Ming Kong; Rui Wang

Targeting of MARK2, but not other MARKs, suppresses TNBC progression by inhibition of the mutant p53-driven signaling pathway 靶向MARK2而非其他MARKs，通过抑制突变p53驱动的信号通路抑制TNBC进展

Chinese Journal of Natural Medicines

IF4.9

2026-04-20

PREAI

Min Zhang; Xilong Zhu; Mengqian Cui; Yinan Guan; Yong Zhang; Stephen J Weiss; Jun Chen; Yongzhong Yao; Rong Fu; Zhaoqiu Wu