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Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling Zhang, Ruirui; Huetzen, Maxim A.; Binici, Aylin; Martin-Gago, Pablo; Gasper, Raphael; Rudashevskaya, Elena; Liu, Jie; Nagaraju, Chinta; Reckzeh, Elena S.; Stuedle, Alana S. T.; Hopff, Ann-Sophie; Mesaros, Andrea; Unger, Anke; Thelen, Melanie; Janning, Petra; Reinhardt, H. Christian; Ziegler, Slava; Jachimowicz, Ron D.; Waldmann, Herbert 分享 收藏
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Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation Giuranna, Johanna; Zheng, Yiran; Brandt, Matthaeus; Jall, Sigrid; Mukherjee, Amrita; Shankhwar, Soni; Renner, Simone; Kurapati, Nirup Kumar; May, Caroline; Peters, Triinu; Herpertz-Dahlmann, Beate; Seitz, Jochen; de Zwaan, Martina; Herzog, Wolfgang; Ehrlich, Stefan; Zipfel, Stephan; Giel, Katrin; Egberts, Karin; Burghardt, Roland; Foecker, Manuel; Marcus, Katrin; Keyvani, Kathy; Mueller, Timo D.; Schmitz, Frank; Rajcsanyi, Luisa Sophie; Hinney, Anke 分享 收藏
TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia TRPC5控制肾上腺素介导的低血糖反调节 Broeker-Lai, Jenny; Terol, Jose Rego; Richter, Christin; Mathar, Ilka; Wirth, Angela; Kopf, Stefan; Moreno-Perez, Ana; Buettner, Michael; Tan, Linette Liqi; Makke, Mazen; Poschet, Gernot; Hermann, Julia; Tsvilovskyy, Volodymyr; Haberkorn, Uwe; Wartenberg, Philipp; Susperreguy, Sebastian; Berlin, Michael; Ottenheijm, Roger; Philippaert, Koenraad; Wu, Moya; Wiedemann, Tobias; Herzig, Stephan; Belkacemi, Anouar; Levinson, Rebecca T.; Agarwal, Nitin; Londono, Juan E. Camacho; Klebl, Bert; Dinkel, Klaus; Zufall, Frank; Nussbaumer, Peter; Boehm, Ulrich; Hell, Ruediger; Nawroth, Peter; Birnbaumer, Lutz; Leinders-Zufall, Trese; Kuner, Rohini; Zorn, Markus; Bruns, Dieter; Schwarz, Yvonne; Freichel, Marc 分享 收藏
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland Bjornstad, Frithjof; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik; Hoff, Bard Helge 分享 收藏
An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity Yu, DongHoon; Wagner, Sabrina; Schuetz, Martin; Jeon, Yeejin; Seo, Mooyoung; Kim, Jaeseung; Brueckner, Nadine; Kicuntod, Jintawee; Tillmanns, Julia; Wangen, Christina; Hahn, Friedrich; Kaufer, Benedikt B.; Neipel, Frank; Eickhoff, Jan; Klebl, Bert; Nam, Kiyean; Marschall, Manfred 分享 收藏
Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA Teuber, A.; Schulz, T.; Fletcher, B. S.; Gontla, R.; Muehlenberg, T.; Zischinsky, M. -L.; Niggenaber, J.; Weisner, J.; Kleinboelting, S. B.; Lategahn, J.; Sievers, S.; Mueller, M. P.; Bauer, S.; Rauh, D. 分享 收藏
Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers Wild, Markus; Karner, Dubravka; Eickhoff, Jan; Wagner, Sabrina; Kicuntod, Jintawee; Chang, William; Barry, Peter; Jonjic, Stipan; Rovis, Tihana Lenac; Marschall, Manfred 分享 收藏
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation 高选择性嘌呤基CSF1R抑制剂有效抑制破骨细胞分化 Aarhus, Thomas Ihle; Eickhoff, Jan; Klebl, Bert; Unger, Anke; Boros, Joanna; Choidas, Axel; Zischinsky, Mia -Lisa; Wolowczyk, Camilla; Bjorkoy, Geir; Sundby, Eirik; Hoff, Bard Helge 分享 收藏
Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate 表征源自链霉菌分离物的Alnumycin生物合成基因簇的醌基化合物的抗菌活性 Sagurna, Leonie; Heinrich, Sascha; Kaufmann, Lara-Sophie; Rueckert-Reed, Christian; Busche, Tobias; Wolf, Alexander; Eickhoff, Jan; Klebl, Bert; Kalinowski, Joern; Bandow, Julia E. 分享 收藏
IFNa primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization Andlovic, Blaz; Heilmann, Geronimo; Ninck, Sabrina; Andrei, Sebastian A.; Centorrino, Federica; Higuchi, Yusuke; Kato, Nobuo; Brunsveld, Luc; Arkin, Michelle; Menninger, Sascha; Choidas, Axel; Wolf, Alexander; Klebl, Bert; Kaschani, Farnusch; Kaiser, Markus; Eickhoff, Jan; Ottmann, Christian 分享 收藏
Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form Aarhus, Thomas Ihle; Bjornstad, Frithjof; Wolowczyk, Camilla; Larsen, Kristin Uhlving; Rognstad, Line; Leithaug, Trygve; Unger, Anke; Habenberger, Peter; Wolf, Alexander; Bjorkoy, Geir; Pridans, Clare; Eickhoff, Jan; Klebl, Bert; Hoff, Bard H.; Sundby, Eirik 分享 收藏
A Reinvestigation of the Role of the Sorbic Acid Tail on the Antibacterial and Anti-Tuberculosis Properties of Moiramide B Kollmorgen, Irina; Bachmann, Nathalie; Dal Molin, Michael; Degenhart, Carsten; Zent, Eldar; Pareek, Vikram; Koch, Uwe; Rybniker, Jan; Metzler-Nolte, Nils; Stoll, Raphael; Klebl, Bert; Bandow, Julia Elisabeth; Scherkenbeck, Jurgen 分享 收藏
Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target Tillmanns, Julia; Haege, Sigrun; Borst, Eva Maria; Wardin, Julia; Eickhoff, Jan; Klebl, Bert; Wagner, Sabrina; Wangen, Christina; Hahn, Friedrich; Socher, Eileen; Marschall, Manfred 分享 收藏
Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells Kelso, Timothy W. R.; Baumgart, Karen; Eickhoff, Jan; Albert, Thomas; Antrecht, Claudia; Lemcke, Sarah; Klebl, Bert; Meisterernst, Michael 分享 收藏
A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling Brueggenthies, Johanna B.; Fiore, Alessandra; Russier, Marion; Bitsina, Christina; Broetzmann, Julian; Kordes, Susanne; Menninger, Sascha; Wolf, Alexander; Conti, Elena; Eickhoff, Jan E.; Murray, Peter J. 分享 收藏
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening Kaufmann, Johanna; Blum, Nina Kathleen; Nagel, Falko; Schuler, Anna; Drube, Julia; Degenhart, Carsten; Engel, Julian; Eickhoff, Jan Eicke; Dasgupta, Pooja; Fritzwanker, Sebastian; Guastadisegni, Maria; Schulte, Clemens; Miess-Tanneberg, Elke; Maric, Hans Michael; Spetea, Mariana; Kliewer, Andrea; Baumann, Matthias; Klebl, Bert; Reinscheid, Rainer K.; Hoffmann, Carsten; Schulz, Stefan 分享 收藏
Synthesis, Biological Evaluation, and Binding Mode of a New Class of Oncogenic K-Ras4b Inhibitors Jeuken, Stephan; Shkura, Oleksandr; Roeger, Marc; Brickau, Victoria; Choidas, Axel; Degenhart, Carsten; Guelden, Daniel; Klebl, Bert; Koch, Uwe; Stoll, Raphael; Scherkenbeck, Juergen 分享 收藏
OCT4 interprets and enhances nucleosome flexibility MacCarthy, Caitlin M.; Huertas, Jan; Ortmeier, Claudia; vom Bruch, Hermann; Tana, Daisylyn Senna; Reinke, Deike; Sander, Astrid; Bergbrede, Tim; Jauch, Ralf; Schoeler, Hans R.; Cojocaru, Vlad 分享 收藏
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