未登录 Analysis of infection rates in neuromyelitis optica spectrum disorder: Comparing satralizumab treatment in SAkuraMoon, post-marketing, and US-based health claims data 视神经脊髓炎谱系障碍感染率分析：比较SAkuraMoon研究、上市后研究和基于美国医疗索赔数据的satralizumab治疗。 Greenberg, Benjamin M.; Fujihara, Kazuo; Weinshenker, Brian; Patti, Francesco; Kleiter, Ingo; Bennett, Jeffrey L.; Palace, Jacqueline; Blondeau, Kathleen; Burdeska, Alexander; Ngwa, Innocent; Klingelschmitt, Gaelle; Triyatni, Miriam; Yamamura, Takashi 分享 收藏
Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor [3H]AZ12464237作为高亲和力、非核苷拮抗剂放射性配体对P2Y12受体的表征 Steen, E. Johanna L.; Tousiaki, Efthalia-Natalia; Kingston, Lee; van der Wildt, Berend; Lenart, Nikolett; Beaino, Wissam; Verlaan, Mariska; Zarzycka, Barbara; Zinnhardt, Bastian; Denes, Adam; Gobbi, Luca; de Esch, Iwan J. P.; Elmore, Charles S.; Windhorst, Albert D.; Honer, Michael; Leurs, Rob 分享 收藏
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A microfluidic bone marrow chip for the safety profiling of biologics in pre-clinical drug development 一种用于临床前药物开发中生物制剂安全性评定的微流控骨髓芯片 Koenig, Leopold; Juglair, Laurent; Tao, Thi Phuong; Fischer, Susanne; Clausen, Inga; Imhof-Jung, Sabine; Janssen, Niels; Mader, Robert; Marbach, Daniel; Niewoehner, Jens; Winter, Annika; Schubert, Desiree 分享 收藏
NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesis NRF2支持非小细胞肺癌的生长，且该作用独立于CBP/p300增强的谷胱甘肽合成。 Conrad, Ryan J.; Mondo, James A.; Wang, Mike Lingjue; Liu, Peter S.; Lai, Zijuan; Choudhury, Feroza K.; Li, Qingling; Wong, Weng Ruh; Lee, James; Shanahan, Frances; Lin, Eva; Martin, Scott; Rudolph, Joachim; Moffat, John G.; Sangaraju, Dewakar; Sandoval, Wendy; Sterne-Weiler, Timothy; Foster, Scott A. 分享 收藏
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Quantitative Muscle Magnetic Resonance Outcomes in Patients With Duchenne Muscular Dystrophy An Exploratory Analysis From the EMBARK Randomized Clinical Trial 杜氏肌营养不良症患者定量肌肉磁共振结局：EMBARK随机临床试验的探索性分析 Vandenborne, Krista; Walter, Glenn A.; Straub, Volker; Willcocks, Rebecca J.; Forbes, Sean C.; Mercuri, Eugenio M.; Muntoni, Francesco; Ding, Kai; Ennamuri, Sravya; Reid, Carol; Murphy, Alexander P.; Manfrini, Marianna; Mendell, Jerry R.; Elkins, Jacob S.; Rodino-Klapac, Louise R. 分享 收藏
Green Chemistry Articles of Interest to the Pharmaceutical Industry 制药行业感兴趣的绿色化学文章 Ashley, Melissa A.; Aukland, Miles H.; Bryan, Marian C.; Cismesia, Megan A.; Dutschei, Theresa; Engl, Oliver D.; Engl, Pascal S.; Garcia, Alvaro Enriquez; Molina, Alejandro Gimenez; Harawa, Vanessa; Karageorgis, George; Keily, Shazia; Kelly, Christopher B.; Leclair, Alexandre; Lee, Johnny W.; Li, Wei; Osborne, Matthew; Pawlas, Jan; Richardson, Paul F.; Scott, Samuel C.; Steven, Alan; Takale, Balaram S.; Zeng, Mingshuo 分享 收藏
Real-world characteristics and survival outcomes of patients with metastatic ALK fusion-positive solid tumors treated with standard-of-care therapies 真实世界中接受标准护理治疗的患者，其ALK融合阳性转移性实体瘤的临床特征和生存结局 Gadgeel, Shirish M.; Fajardo, Otto; Barlesi, Fabrice; Kim, Jeong Eun; Kurzrock, Razelle; Thomas, David M.; Jagtiani, Ritika; Noe, Johannes; Schwemmers, Sven; Nikolaidis, Christos 分享 收藏
Development of a Broadly Applicable Enzymatic Ligation Process for the Production of Single Guide RNAs 开发一种广泛适用的酶促连接过程用于单链引导RNA的生产 Bigatti, Martina; Moser, Andre; Dierssen, Bas; Frrokaj, Shtjefen; Covato, Elena; Pfleger, Christophe; Lill, Joerg; Leiser, Yael; Zuber, Joel; Staempfli, Andreas; Sladojevich, Filippo; Koenig, Stefan G. 分享 收藏
Application of new approach methodologies for nonclinical safety assessment of drug candidates 新方法学在药物候选物非临床安全性评估中的应用 Beilmann, Mario; Adkins, Karissa; Boonen, Harrie C. M.; Hewitt, Philip; Hu, Wenyue; Mader, Robert; Moore, Susanne; Rana, Payal; Steger-Hartmann, Thomas; Villenave, Remi; van Vleet, Terry 分享 收藏
Japanese participant data from three gantenerumab trials in early Alzheimer's disease 日本参与者数据来自三项早期阿尔茨海默病中的gantenerumab试验 Asada, T; Thanasopoulou, A; Delmar, P; Wojtowicz, J; Smith, J; Yoshiyama, Y; Yokoi, K; Watanabe, C; Isozaki, M; Ozaki, R; Ishida, T; Tatsuda, H; Tamaoka, A 分享 收藏
Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction 帕金森病的特点是维生素B6依赖性的炎症犬尿氨酸通路功能障碍。 Wilson, Edward N.; Umans, Jacob; Swarovski, Michelle S.; Minhas, Paras S.; Mendiola, Justin H.; Midttun, Oivind; Ulvik, Arve; Shahid-Besanti, Marian; Linortner, Patricia; Mhatre, Siddhita D.; Wang, Qian; Channappa, Divya; Corso, Nicole K.; Tian, Lu; Fredericks, Carolyn A.; Kerchner, Geoffrey A.; Plowey, Edward D.; Cholerton, Brenna; Ueland, Per M.; Zabetian, Cyrus P.; Gray, Nora E.; Quinn, Joseph F.; Montine, Thomas J.; Sha, Sharon J.; Longo, Frank M.; Wolk, David A.; Chen-Plotkin, Alice; Henderson, Victor W.; Wyss-Coray, Tony; Wagner, Anthony D.; Mormino, Elizabeth C.; Aghaeepour, Nima; Poston, Kathleen L.; Andreasson, Katrin I. 分享 收藏
Optimization of a DNA encoded library derived autotaxin inhibitor hit to a potent in vivo LPA lowering quinazolinone compound with a non-zinc binding mode 基于DNA编码库筛选的自主生长因子抑制剂先导化合物的优化，获得了一种具有非锌结合模式的强效体内溶血磷脂酸降低的喹唑啉酮类化合物。 Martin, Rainer E.; Satz, Alexander L.; Kuratli, Christoph; Hunziker, Daniel; Mattei, Patrizio; Hert, Jerome; Ullmer, Christoph; Rudolph, Markus G.; Alker, Andre M.; Hochstrasser, Remo; Marx, Andreas; Binder, Martin; Muller, Stephan 分享 收藏
Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors 实体瘤患者接受免疫检查点抑制剂治疗后，年龄相关的循环免疫反应差异 Kao, Chester; Charmsaz, Soren; Tsai, Hua-Ling; Aziz, Khaled; Shu, Daniel H.; Munjal, Kabeer; Griffin, Ervin; Leatherman, James M.; Lipson, Evan J.; Ged, Yasser; Hoffman-Censits, Jeannie; Li, Howard L.; Hallab, Elsa; Brancati, Madelena; Nakazawa, Mari; Alden, Stephanie; Thoburn, Christopher; Gross, Nicole E.; Hernandez, Alexei G.; Coyne, Erin M.; Kartalia, Emma; Baretti, Marina; Jaffee, Elizabeth M.; Bansal, Sanjay; Tang, Laura; Chandler, G. Scott; Mohindra, Rajat; Ho, Won Jin; Yarchoan, Mark; Zabransky, Daniel J. 分享 收藏
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Exploring the neuromagnetic signatures of cognitive decline from mild cognitive impairment to Alzheimer's disease dementia 探索从轻度认知障碍到阿尔茨海默病痴呆的认知衰退的神经磁学特征 Gaubert, Sinead; Garces, Pilar; Hipp, Jorg; Bruna, Ricardo; Lopez, Maria Eugenia; Maestu, Fernando; Vaghari, Delshad; Henson, Richard; Paquet, Claire; Engemann, Denis-Alexander 分享 收藏
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Port Delivery System With Ranibizumab vs Monitoring in Nonproliferative Diabetic Retinopathy Without Macular Edema: The Pavilion Randomized Clinical Trial Pieramici, Dante J.; Awh, Carl C.; Chang, Margaret; Emanuelli, Andres; Holekamp, Nancy M.; Hu, Allen Y.; Suner, Ivan J.; Wykoff, Charles C.; Brittain, Christopher; Howard, Dena; Quezada-Ruiz, Carlos; Santhanakrishnan, Anjana; Latkany, Paul 分享 收藏
Chemical Process Development in the Pharmaceutical Industry in Europe-Insights and Perspectives from Industry Scientists 欧洲制药工业中的化学工艺开发——来自行业科学家的见解与展望 Krueger, Joachim; Dieskau, Andre P.; Hassfeld, Jorma; Gries, Joerg; Block, Oliver; Weinmann, Hilmar; Kaufmann, Daniel; Hildbrand, Stefan; Kraft, Volker; Moeckel, Robert; Dehli, Juan R.; Scholz, Ulrich; Nising, Carl Friedrich 分享 收藏
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