Chunlong Xu

yancheng hospital of chinese medicine affiliated to nanjing university of chinese medicine

H指数:20

被引数:1,816

个人简介

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教育背景

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工作经历

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荣誉奖项

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Tetrandrine attenuates hypoxia-induced microglial M1 polarization and microglia-mediated photoreceptor cell injury through modulation of NF-κB/p65 signaling

粉防己碱通过调节NF-κB/p65信号通路减轻缺氧诱导的小胶质细胞M1极化和小胶质细胞介导的光感受器细胞损伤

Experimental Eye Research

IF2.7

2026-08-070

OAAI

Engineered IscB-WRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice

具有改进的碱基编辑效率的工程iscb-wrna系统，用于通过小鼠单次AAV递送进行疾病校正

CELL REPORTS

IF6.9

2024-11-010

OAAI

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation (vol 15, 8090, 2024)

NATURE COMMUNICATIONS

IF15.7

2024-10-180

OAAI

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation

NATURE COMMUNICATIONS

IF15.7

2024-09-161

OAAI

Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

腺嘌呤碱基编辑介导的外显子跳跃恢复人源化Duchenne小鼠模型中的肌营养不良蛋白

NATURE COMMUNICATIONS

IF15.7

2024-07-151

OAAI

Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

COMMUNICATIONS BIOLOGY

IF5.1

2024-07-131

OAAI

Correction of human nonsense mutation via adenine base editing for Duchenne muscular dystrophy treatment in mouse

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2024-06-015

OAAI

Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

设计转座子相关的tnpb-ωrna系统，用于酪氨酸血症小鼠模型的有效基因编辑和表型校正

NATURE COMMUNICATIONS

IF15.7

2024-01-277

OAAI

Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED

用工程DdCBE和tale增强线粒体DNA中的c-to-t和a-to-g碱基编辑

ADVANCED SCIENCE

IF14.1

2023-11-204

Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-09-0111

OAAI

In vivo treatment of tyrosinaemia with hypercompact Cas12f1

用高致密Cas12f1体内治疗酪氨酸血症

CELL DISCOVERY

IF12.5

2023-07-184

OAAI

Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model

ACTA PHARMACOLOGICA SINICA

IF8.4

2023-07-042

PRE

Mitochondrial genome editing: Get aCcess to modeling broad disease mutations with engineered base editors

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2023-06-010

OAAI

Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-02-0119

OAAI

Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

NATURE BIOTECHNOLOGY

IF41.7

2023-01-09107

PRE

Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor

PROTEIN & CELL

IF12.8

2022-11-031

OAAI

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

NATURE BIOTECHNOLOGY

IF41.7

2022-08-11103

Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2022-07-2048

PRE

Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

CELL DISCOVERY

IF12.5

2022-03-1854

OAAI

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

CELL DISCOVERY

IF12.5

2022-02-0130

OAAI

Chunlong Xu

个人简介

教育背景

工作经历

荣誉奖项

研究方向