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P

Pilar Álvarez Jerez

national institute on aging
H指数:12
被引数:714

个人简介

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教育背景

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工作经历

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荣誉奖项

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APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

APOE分层的全基因组关联分析为阿尔茨海默病的遗传病因提供了见解

Nature Genetics
IF29
2026-09-140
OAAI
Jesper Qvist Thomassen; Hampton Leonard; Brittany Ulms; Benjamin Grenier-Boley; Sami Heikkinen; Pablo Garcia-González; Atahualapa Castillo-Morales; Masataka Kikuchi; Jungsoo Gim; Han Cao; Fahri Küçükali; Najaf Amin; Dabin Yoon; Itziar de Rojas; Pilar Alvarez Jerez; Victoria Alvarez; Beatrice Arosio; Céline Bellenguez; Sverre Bergh; Kimberley Billingsley; Cornelis Blauwendraat; Merce Boada; Barbara Borroni; Paola Bossù; María J. Bullido; Antonio Daniele; Ángel Carracedo; Alexandre de Mendonça; Mark Cookson; Jürgen Deckert; Martin Dichgans; Srdjan Djurovic; Oriol Dols-Icardo; Carole Dufouil; Emrah Düzel; Valentina Escott-Price; Tormod Fladby; Laura Fratiglioni; Amy K. Y. Fu; Daniela Galimberti; Jose Maria García-Alberca; Vilmantas Giedraitis; Guillermo Garcia-Ribas; Caroline Graff; Timo Grimmer; Edna Grünblatt; Olivier Hanon; Lucrezia Hausner; Stefanie Heilmann-Heimbach; Jakub Hort; Frank Jessen; Kendall Jensen; Caroline Jonson; Yoontae Kim; Nicole Kuznetsov; Ville Leinonen; Anssi Lipponen; Jiao Luo; Mary Makarious; Henna Martiskainen; Carlo Masullo; Patrizia Mecocci; Shima Mehrabian; Pablo Mir; Akinori Miyashita; Susanne Moebus; Kin Y. Mok; Laura Molina Porcel; Fermin Moreno; Benedetta Nacmias; Lucilla Parnetti; Pau Pastor; Jordi Pérez-Tur; Oliver Peters; Yolande A. L. Pijnenburg; Gerard Piñol-Ripoll; Julius Popp; Innocenzo Rainero; Luis M. Real; Steffi Riedel-Heller; Eloy Rodriguez-Rodriguez; Arvid Rongve; Giacomina Rossi; Jose Luis Royo; Dan Rujescu; Ingvild Saltvedt; María Eugenia Sáez; Raquel Sánchez-Valle; Florentino Sanchez-Garcia; Nicolai Sandau; Nikolaos Scarmeas; Katja Scheffler; Norbert Scherbaum; Anja Schneider; Geir Selbæk; Davide Seripa; Vincenzo Solfrizzi; Marco Spallazzi; Alessio Squassina; Eystein Stordal; Niccoló Tesi; Lucio Tremolizzo; Kumar P. Tripathi; Wiesje M. van der Flier; Julie Williams; Jens Wiltfang; Dag Aarsland; Andrew B. Singleton; Philippe Amouyel; Stéphanie Debette; Magda Tsolaki; Gael Nicolas; Sven van der Lee; Henne Holstege; Maria Victoria Fernandez; Patrick Gavin Kehoe; Kristel Sleegers; Martin Ingelsson; Roberta Ghidoni; Ole A. Andreassen; Peter A. Holmans; Pascual Sánchez-Juan; Rebecca Sims; Nancy Y. Ip; Kun Ho Lee; Takeshi Ikeuchi; Alfredo Ramirez; Agustin Ruiz; Mikko Hiltunen; Jean-Charles Lambert; Cornelia van Duijn; Mike Nalls; Ruth Frikke-Schmidt
iSCORE-PD: an isogenic stem cell collection to research Parkinson’s disease

iSCORE-PD：用于帕金森病研究的同基因干细胞库

Nature Communications
IF15.7
2026-06-170
OAAI
Oriol Busquets; Hanqin Li; Khaja Mohieddin Syed; Pilar Alvarez Jerez; Jesse Dunnack; Riana Lo Bu; Yogendra Verma; Gabriella R. Pangilinan; Annika Martin; Jannes Straub; YuXin Du; Vivien M. Simon; Steven Poser; Zipporiah Bush; Jessica Diaz; Atehsa Sahagun; Jianpu Gao; Samantha Hong; Dena G. Hernandez; Kristin S. Levine; Nathalie Pochet; Ezgi O. Booth; Marco Blanchette; Helen S. Bateup; Donald C. Rio; Cornelis Blauwendraat; Dirk Hockemeyer; Frank Soldner
Long-read sequencing identifies FGF14 repeat expansions in Parkinson’s disease

长读测序鉴定帕金森病中的FGF14重复扩展

Brain
IF11.7
2025-12-020
OAAI
Fulya Akçimen; Kensuke Daida; Lara M Lange; Abraham Moller; Abigail Miano-Burkhardt; Laksh Malik; Kimberly Paquette; Pilar Alvarez Jerez; Jackson Mingle; Breeana Baker; Melissa Meredith; Cedric Kouam; Paige Jarreau; Androo Markham; Jessica Anderson; Miten Jain; Mark Chaisson; Mark Cookson; Bradford Casey; Hirotaka Iwaki; Sara Bandres-Ciga; Paula Saffie-Awad; Mike A Nalls; Zih-Hua Fang; Andrew B Singleton; Cornelis Blauwendraat; Kimberley J Billingsley; null
Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations

大规模帕金森病在非洲和非洲混血人群中的遗传特征研究

Brain
IF11.7
2025-10-080
OAAI
Fulya Akçimen; Kimberly Paquette; Peter Wild Crea; Kathryn Step; Emily Waldo; Mathew J Koretsky; Paula Saffie-Awad; Charles Achoru; Funmilola Taiwo; Simon Ozomma; Gerald Onwuegbuzie; Marzieh Khani; Spencer Grant; Lukman Owolabi; Chiamaka Okereke; Olajumoke Oshinaike; Emmanuel Iwuozo; Suleyman Can Akerman; Paul Suhwan Lee; Shyngle Oyakhire; Nosakhare Osemwegie; Kensuke Daida; Sani Abubakar; Adedunni Olusanya; Mariam Isayan; Christiane Alvarez; Rami Traurig; Adebimpe Ogunmodede; Sarah Samuel; Mary B Makarious; Fadimatu Sa’ad; Rashidat Olanigan; Kristin Levine; Ewere Marie Ogbimi; Dan Vitale; Francis Odiase; Francis Ojini; Olanike Odeniyi; Zih-Hua Fang; Nkechi Obianozie; Deborah A Hall; Ernest Nwazor; Tao Xie; Francesca Nwaokorie; Mahesh Padmanaban; Paul Nwani; Ejaz A Shamim; Alero Nnama; David Standaert; Morenikeji Komolafe; Marissa Dean; Godwin Osaigbovo; Elizabeth Disbrow; Ismaila Ishola; Ashley Rawls; Frank Imarhiagbe; Shivika Chandra; Cyril Erameh; Vanessa Hinson; Naomi Louie; Ahmed Idowu; J Solle; Scott A Norris; Abdullahi Ibrahim; Camilla Kilbane; Gauthaman Sukumar; Lisa M Shulman; Daniel Ezuduemoih; Julia Staisch; Sarah Breaux; Clifton Dalgard; Erin R Foster; Abiodun Bello; Andrew Ameri; Raquel Real; Erica Ikwenu; Huw R Morris; Roosevelt Anyanwu; Erin Furr Stimming; Kimberley Billingsley; Wemimo Alaofin; Pilar Alvarez Jerez; Osigwe Agabi; Dena G Hernandez; Rufus Akinyemi; Sampath Arepalli; Laksh Malik; Raymond Owolabi; Yakub Nyandaiti; Hampton L Leonard; Kolawole Wahab; Oladunni Abiodun; Carlos F Hernandez; Fatima Abdulai; Hirotaka Iwaki; Soraya Bardien; Christine Klein; John Hardy; Henry Houlden; Kamalini Ghosh Galvelis; Mike A Nalls; Nabila Dahodwala; Whitley Aamodt; Emily Hill; Alberto Espay; Stewart Factor; Chantale Branson; Cornelis Blauwendraat; Andrew B Singleton; Oluwadamilola Ojo; Lana M Chahine; Njideka Okubadejo; Sara Bandres-Ciga; null
A CGG Repeat Expansion in CSNK1E Associated with Progressive Myoclonic Epilepsy with Incomplete Penetrance

CSNK1E基因中的CGG串联重复序列扩展与不完全外显的进行性肌阵挛癫痫相关

Movement Disorders
IF7.6
2025-08-010
OAAI
Fulya Akçimen PhD; Pilar Alvarez Jerez BSc; Ulviyya Guliyeva MD; Jasmine Lee BSc; Laksh Malik; Breeana Baker; Kamran Salayev MD, PhD; Sughra Guliyeva MD; Kimberley J. Billingsley; Henry Houlden MD, PhD; Andrew B. Singleton PhD; Cornelis Blauwendraat PhD; Sara Bandres-Ciga PhD; Rauan Kaiyrzhanov MD, PhD
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1

非洲血统神经变性风险变异破坏了GBA1的内含子分支

NATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
2024-12-120
OAAI
Jerez, Pilar Alvarez; Crea, Peter Wild; Ramos, Daniel M.; Gustavsson, Emil K.; Radefeldt, Mandy; Damianov, Andrey; Makarious, Mary B.; Ojo, Oluwadamilola O.; Billingsley, Kimberley J.; Malik, Laksh; Daida, Kensuke; Bromberek, Sarah; Hu, Fangle; Schneider, Zachary; Surapaneni, Aditya L.; Stadler, Julia; Rizig, Mie; Morris, Huw R.; Pantazis, Caroline B.; Leonard, Hampton L.; Screven, Laurel; Qi, Yue A.; Nalls, Mike A.; Bandres-Ciga, Sara; Hardy, John; Houlden, Henry; Eng, Celeste; Burchard, Esteban Gonzalez; Kachuri, Linda; Lin, Chia-Ho; Black, Douglas L.; Singleton, Andrew B.; Fischer, Steffen; Bauer, Peter; Reed, Xylena; Ryten, Mina; Beetz, Christian; Ward, Michael; Okubadejo, Njideka U.; Blauwendraat, Cornelis
The ZFHX3 GGC Repeat Expansion Underlying Spinocerebellar Ataxia Type 4 has a Common Ancestral Founder

脊髓小脑性共济失调4型的ZFHX3 GGC重复扩增具有共同的祖先创始人

MOVEMENT DISORDERS
IF7.6
2024-12-050
OA
Chen, Zhongbo; Alvarez Jerez, Pilar; Anderson, Claire; Paucar, Martin; Lee, Jasmaine; Nilsson, Daniel; Macpherson, Hannah; Scardamaglia, Annarita; Montgomery, Kylie; Hardy, John; Singleton, Andrew B.; Tucci, Arianna; Mathews, Katherine D.; Fu, Ying-Hui; Engvall, Martin; Laffita-Mesa, Jose; Nennesmo, Inger; Wedell, Anna; Ptacek, Louis J.; Blauwendraat, Cornelis; Gustavsson, Emil K.; Svenningsson, Per; Ryten, Mina; Houlden, Henry
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

使用大规模靶向扩增子长读测序表征SNCA内含子4中复杂的富含CT的单倍型

NPJ PARKINSONS DISEASE
IF8.2
2024-07-260
OAAI
Jerez, Pilar Alvarez; Daida, Kensuke; Grenn, Francis P.; Malik, Laksh; Miano-Burkhardt, Abigail; Makarious, Mary B.; Ding, Jinhui; Gibbs, J. Raphael; Moore, Anni; Reed, Xylena; Nalls, Mike A.; Shah, Syed; Mahmoud, Medhat; Sedlazeck, Fritz J.; Dolzhenko, Egor; Park, Morgan; Iwaki, Hirotaka; Casey, Bradford; Ryten, Mina; Blauwendraat, Cornelis; Singleton, Andrew B.; Billingsley, Kimberley J.
Profiling complex repeat expansions in RFC1 in Parkinson's disease
NPJ PARKINSONS DISEASE
IF8.2
2024-05-240
OAAI
Jerez, Pilar Alvarez; Daida, Kensuke; Miano-Burkhardt, Abigail; Iwaki, Hirotaka; Malik, Laksh; Cogan, Guillaume; Makarious, Mary B.; Sullivan, Roisin; Vandrovcova, Jana; Ding, Jinhui; Gibbs, J. Raphael; Markham, Androo; Nalls, Mike A.; Kesharwani, Rupesh K.; Sedlazeck, Fritz J.; Casey, Bradford; Hardy, John; Houlden, Henry; Blauwendraat, Cornelis; Singleton, Andrew B.; Billingsley, Kimberley J.
Adaptive Long-Read Sequencing Reveals GGC Repeat Expansion in ZFHX3 Associated with Spinocerebellar Ataxia Type 4
MOVEMENT DISORDERS
IF7.6
2024-01-1016
OA
Chen, Zhongbo; Gustavsson, Emil K.; Macpherson, Hannah; Anderson, Claire; Clarkson, Chris; Rocca, Clarissa; Self, Eleanor; Jerez, Pilar Alvarez; Scardamaglia, Annarita; Pellerin, David; Montgomery, Kylie; Lee, Jasmaine; Gagliardi, Delia; Luo, Huihui; Hardy, John; Polke, James; Singleton, Andrew B.; Blauwendraat, Cornelis; Mathews, Katherine D.; Tucci, Arianna; Fu, Ying-Hui; Houlden, Henry; Ryten, Mina; Ptacek, Louis J.
Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation
NATURE METHODS
IF32.1
2023-09-1428
OA
Kolmogorov, Mikhail; Billingsley, Kimberley J.; Mastoras, Mira; Meredith, Melissa; Monlong, Jean; Lorig-Roach, Ryan; Asri, Mobin; Alvarez Jerez, Pilar; Malik, Laksh; Dewan, Ramita; Reed, Xylena; Genner, Rylee M.; Daida, Kensuke; Behera, Sairam; Shafin, Kishwar; Pesout, Trevor; Prabakaran, Jeshuwin; Carnevali, Paolo; Yang, Jianzhi; Rhie, Arang; Scholz, Sonja W.; Traynor, Bryan J.; Miga, Karen H.; Jain, Miten; Timp, Winston; Phillippy, Adam M.; Chaisson, Mark; Sedlazeck, Fritz J.; Blauwendraat, Cornelis; Paten, Benedict
Large-scale rare variant burden testing in Parkinson's disease
BRAIN
IF11.7
2023-06-228
OA
Makarious, Mary B.; Lake, Julie; Pitz, Vanessa; Fu, Allen Ye; Guidubaldi, Joseph L.; Solsberg, Caroline Warly; Bandres-Ciga, Sara; Leonard, Hampton L.; Kim, Jonggeol Jeffrey; Billingsley, Kimberley J.; Grenn, Francis P.; Jerez, Pilar Alvarez; Alvarado, Chelsea X.; Iwaki, Hirotaka; Ta, Michael; Vitale, Dan; Hernandez, Dena; Torkamani, Ali; Ryten, Mina; Hardy, John; Scholz, Sonja W.; Traynor, Bryan J.; Dalgard, Clifton L.; Ehrlich, Debra J.; Tanaka, Toshiko; Ferrucci, Luigi; Beach, Thomas G.; Serrano, Geidy E.; Real, Raquel; Morris, Huw R.; Ding, Jinhui; Gibbs, J. Raphael; Singleton, Andrew B.; Nalls, Mike A.; Bhangale, Tushar; Blauwendraat, Cornelis
Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias
CELL GENOMICS
IF9
2023-06-018
OAAI
Kaivola, Karri; Chia, Ruth; Ding, Jinhui; Rasheed, Memoona; Fujita, Masashi; Menon, Vilas; Walton, Ronald L.; Collins, Ryan L.; Billingsley, Kimberley; Brand, Harrison; Talkowski, Michael; Zhao, Xuefang; Dewan, Ramita; Stark, Ali; Ray, Anindita; Solaiman, Sultana; Jerez, Pilar Alvarez; Malik, Laksh; Dawson, Ted M.; Rosenthal, Liana S.; Albert, Marilyn S.; Pletnikova, Olga; Troncoso, Juan C.; Maselis, Mario; Keith, Julia; Black, Sandra E.; Ferrucci, Luigi; Resnick, Susan M.; Tanaka, Toshiko; Topol, Eric; Torkamani, Ali; Tienari, Pentti; Foroud, Tatiana M.; Ghetti, Bernardino; Landers, John E.; Rtyen, Mina; Morris, Huw R.; Hardy, John A.; Mazzini, Letizia; D'Alfonso, Sandra; Moglia, Cristina; Calvo, Andrea; Serrano, Geidy E.; Beach, Thomas G.; Ferman, Tanis; Graff-Radford, Neill R.; Boeve, Bradley F.; Wszolek, Zbigniew K.; Dickson, Dennis W.; Chio, Adriano; Bennett, David A.; De Jager, Philip L.; Ross, Owen A.; Dalgard, Clifton L.; Gibbs, J. Raphael; Traynor, Bryan J.; Scholz, Sonja W.
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data (vol 9, 33, 2023)
NPJ PARKINSONS DISEASE
IF8.2
2023-05-240
OAAI
Leonard, Hampton. L.; Murtadha, Ruqaya; Martinez-Carrasco, Alejandro; Jama, Alina; Mueller-Nedebock, Amica Corda; Gil-Martinez, Ana-Luisa; Illarionova, Anastasia; Moore, Anni; Bustos, Bernabe., I; Jadhav, Bharati; Huxford, Brook; Storm, Catherine; Towns, Clodagh; Vitale, Dan; Chetty, Devina; Yu, Eric; Grenn, Francis. P.; Salazar, Gabriela; Rateau, Geoffrey; Iwaki, Hirotaka; Elsayed, Inas; Foote, Isabelle Francesca; van Rensburg, Zune Jansen; Kim, Jonggeol Jeff; Yuan, Jie; Lake, Julie; Brolin, Kajsa; Senkevich, Konstantin; Wu, Lesley; Tan, Manuela M. X.; Perinan, Maria Teresa; Makarious, Mary. B.; Ta, Michael; Pillay, Nikita Simone; Betancor, Oswaldo Lorenzo; Reyes-Perez, Paula R.; Alvarez Jerez, Pilar; Saini, Prabhjyot; al-Ouran, Rami; Sivakumar, Ramiya; Real, Raquel; Reynolds, Regina. H.; Hu, Ruifneg; Abrahams, Shameemah; Rao, Shilpa. L.; Antar, Tarek; Leal, Thiago Peixoto; Iankova, Vassilena; Scotton, William J.; Song, Yeajin; Singleton, Andrew; Nalls, Mike. A.; Dey, Sumit; Bandres-Ciga, Sara; Blauwendraat, Cornelis; Noyce, Alastair. J.
Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease
NPJ PARKINSONS DISEASE
IF8.2
2023-04-064
OAAI
Jerez, Pilar Alvarez; Alcantud, Jose Luis; de los Reyes-Ramirez, Lucia; Moore, Anni; Ruz, Clara; Montero, Francisco Vives; Rodriguez-Losada, Noela; Saini, Prabhjyot; Gan-Or, Ziv; Alvarado, Chelsea X.; Makarious, Mary B.; Billingsley, Kimberley J.; Blauwendraat, Cornelis; Noyce, Alastair J.; Singleton, Andrew B.; Duran, Raquel; Bandres-Ciga, Sara
The IPDGC/GP2 Hackathon-an open science event for training in data science, genomics, and collaboration using Parkinson's disease data
NPJ PARKINSONS DISEASE
IF8.2
2023-03-043
OAAI
Leonard, Hampton L.; Murtadha, Ruqaya; Martinez-Carrasco, Alejandro; Jama, Alina; Mueller-Nedebock, Amica Corda; Gil-Martinez, Ana-Luisa; Illarionova, Anastasia; Moore, Anni; Bustos, Bernabe I.; Jadhav, Bharati; Huxford, Brook; Storm, Catherine; Towns, Clodagh; Vitale, Dan; Chetty, Devina; Yu, Eric; Grenn, Francis P.; Salazar, Gabriela; Rateau, Geoffrey; Iwaki, Hirotaka; Elsayed, Inas; Foote, Isabelle Francesca; van Rensburg, Zune Jansen; Kim, Jonggeol Jeff; Yuan, Jie; Lake, Julie; Brolin, Kajsa; Senkevich, Konstantin; Wu, Lesley; Tan, Manuela M. X.; Perinan, Maria Teresa; Makarious, Mary B.; Ta, Michael; Pillay, Nikita Simone; Betancor, Oswaldo Lorenzo; Reyes-Perez, Paula R.; Alvarez Jerez, Pilar; Saini, Prabhjyot; al-Ouran, Rami; Sivakumar, Ramiya; Real, Raquel; Reynolds, Regina H.; Hu, Ruifneg; Abrahams, Shameemah; Rao, Shilpa C.; Antar, Tarek; Leal, Thiago Peixoto; Iankova, Vassilena; Scotton, William J.; Song, Yeajin; Singleton, Andrew; Nalls, Mike A.; Dey, Sumit; Bandres-Ciga, Sara; Blauwendraat, Cornelis; Noyce, Alastair J.
Genome-Wide Analysis of Structural Variants in Parkinson Disease
ANNALS OF NEUROLOGY
IF7.7
2023-02-0319
OA
Billingsley, Kimberley J.; Ding, Jinhui; Jerez, Pilar Alvarez; Illarionova, Anastasia; Levine, Kristin; Grenn, Francis P.; Makarious, Mary B.; Moore, Anni; Vitale, Daniel; Reed, Xylena; Hernandez, Dena; Torkamani, Ali; Ryten, Mina; Hardy, John; Chia, Ruth W.; Scholz, Sonja J.; Traynor, Bryan L.; Dalgard, Clifton J.; Ehrlich, Debra; Tanaka, Toshiko; Ferrucci, Luigi G.; Beach, Thomas E.; Serrano, Geidy P.; Quinn, John J.; Bubb, Vivien; Collins, Ryan L.; Zhao, Xuefang; Walker, Mark; Pierce-Hoffman, Emma; Brand, Harrison E.; Talkowski, Michael; Casey, Bradford; Cookson, Mark R.; Markham, Androo A.; Nalls, Mike; Mahmoud, Medhat; Sedlazeck, Fritz J.; Blauwendraat, Cornelis; Gibbs, J. Raphael B.; Singleton, Andrew
Profiling the NOTCH2NLC GGC Repeat Expansion in Parkinson's Disease in the European Population
MOVEMENT DISORDERS
IF7.6
2022-07-223
PRE
Billingsley, Kimberley J.; Alvarez Jerez, Pilar; Grenn, Francis P.; Bandres-Ciga, Sara; Malik, Laksh; Hernandez, Dena; Torkamani, Ali; Ryten, Mina; Hardy, John; Scholz, Sonja W.; Traynor, Bryan J.; Dalgard, Clifton L.; Ehrlich, Debra J.; Tanaka, Toshiko; Ferrucci, Luigi; Beach, Thomas G.; Serrano, Geidy E.; Ding, Jinhui; Gibbs, J. Raphael; Blauwendraat, Cornelis; Singleton, Andrew B.

研究方向

暂未获取到该数据
C
Cornelis Blauwendraat
H 指数:61论文数:377被引数:1.5万
J
John Hardy
H 指数:207论文数:1,883被引数:23.9万
L
Laksh Malik
H 指数:9论文数:46被引数:504
K
Kimberley J. Billingsley
H 指数:23论文数:94被引数:4,546
A
Andrew Singleton
H 指数:131论文数:800被引数:8.7万
S
Sara Bandrés‐Ciga
H 指数:43论文数:272被引数:1.2万
M
Mike A. Nalls
H 指数:85论文数:590被引数:3.2万
K
Kensuke Daida
H 指数:18论文数:64被引数:1,026
M
Mary B. Makarious
H 指数:16论文数:89被引数:1,192
H
Hirotaka Iwaki
H 指数:33论文数:205被引数:4,896