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D

David D. Thomas

University of Minnesota

71H指数
804论文数
1.9W被引数
收录论文 316
发表时间
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Development of activators for SERCA2a for heart failure treatmentsSERCA2a激活剂的研发用于心力衰竭治疗
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-11-29
err0
PREAI
errMarzena Brinkmann; Tsung-Yun (Kent) Wong; Osha Roopnarine; Samantha L. Yuen; Kaja Berg; Razvan L. Cornea; Robyn T. Rebbeck; David D. Thomas; Courtney C. Aldrich
err分享
err收藏
Large-scale high-throughput screen for cardiac ryanodine receptor targeted therapeutics大规模高通量筛选针对心脏ryanodine受体靶向治疗药物
errJournal of Biological Chemistry
IF3.9
err2025-11-17
err0
errOAAI
errRoman Nikolaienko; Elisa Bovo; Jonathan C. Solberg; Marzena A. Brinkmann; Levy M. Treinen; Andrew R. Thompson; Kaja C.G. Berg; David D. Thomas; Jennifer J. Thomas; Donald M. Bers; Courtney C. Aldrich; Aleksey V. Zima; Razvan L. Cornea; Robyn T. Rebbeck
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Kinetics insight into the roles of the N- and C-lobes of calmodulin in RyR1 channel regulation
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-02-01
err0
errOAAI
errZhang, Jingyan; Treinen, Levy M.; Mast, Skylar J.; Mccarthy, Megan R.; Svensson, Bengt; Thomas, David D.; Cornea, Razvan L.
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Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors
errNATURE COMMUNICATIONS
IF15.7
err2024-06-15
err0
errOAAI
errRebbeck, Robyn T.; Svensson, Bengt; Zhang, Jingyan; Samso, Montserrat; Thomas, David D.; Bers, Donald M.; Cornea, Razvan L.
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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
errELIFE
IF0
err2024-05-14
err1
errOAAI
errRasmussen, Damien M.; Semonis, Manny M.; Greene, Joseph T.; Muretta, Joseph M.; Thompson, Andrew R.; Toledo Ramos, Silvia; Thomas, David D.; Pomerantz, William C. K.; Freedman, Tanya S.; Levinson, Nicholas M.
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Drug discovery for heart failure targeting myosin-binding protein C
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-12-01
err6
errOAAI
errBunch, Thomas A.; Guhathakurta, Piyali; Thompson, Andrew R.; Lepak, Victoria C.; Carter, Anna L.; Thomas, Jennifer J.; Thomas, David D.; Colson, Brett A.
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RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET
errACS CHEMICAL BIOLOGY
IF3.8
err2023-09-28
err5
errOAAI
errSeflova, Jaroslava; Schwarz, Jacob A.; Smith, Abigail N.; Svensson, Bengt; Blackwell, Daniel J.; Phillips, Taylor A.; Nikolaienko, Roman; Bovo, Elisa; Rebbeck, Robyn T.; Zima, Aleksey V.; Thomas, David D.; Van Petegem, Filip; Knollmann, Bjorn C.; Johnston, Jeffrey N.; Robia, Seth L.; Cornea, Razvan L.
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Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein
errASN NEURO
IF3.7
err2023-07-10
err3
errOAAI
errBraun, Anthony R.; Kochen, Noah Nathan; Yuen, Samantha L.; Liao, Elly E.; Cornea, Razvan L.; Thomas, David D.; Sachs, Jonathan N.
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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators
errSCIENTIFIC REPORTS
IF3.9
err2023-07-01
err10
errOAAI
errRoopnarine, Osha; Yuen, Samantha L.; Thompson, Andrew R.; Roelike, Lauren N.; Rebbeck, Robyn T.; Bidwell, Philip A.; Aldrich, Courtney C.; Cornea, Razvan L.; Thomas, David D.
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Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-03-01
err2
errOAAI
errGuhathakurta, Piyali; Rebbeck, Robyn T.; Denha, Sarah A.; Keller, Amanda R.; Carter, Anna L.; Atang, Alexandra E.; Svensson, Bengt; Thomas, David D.; Hays, Thomas S.; Avery, Adam W.
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Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †Nimesulide，一种COX-2抑制剂，通过促进DR5聚集 † 使胰腺癌细胞对TRAIL诱导的凋亡敏感
errCANCER BIOLOGY & THERAPY
IF4.6
err2023-02-12
err11
errOAAI
errVunnam, Nagamani; Young, Malaney C.; Liao, Elly E.; Lo, Chih Hung; Huber, Evan; Been, MaryJane; Thomas, David D.; Sachs, Jonathan N.
err分享
err收藏
New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+dynamics by increasing SERCA2a Ca2+pumping
errBIOPHYSICAL JOURNAL
IF3.1
err2023-01-01
err4
errOAAI
errNikolaienko, Roman; Bovo, Elisa; Yuen, Samantha L.; Treinen, Levy M.; Berg, Kaja; Aldrich, Courtney C.; Thomas, David D.; Cornea, Razvan L.; Zima, Aleksey V.
err分享
err收藏
Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-12-01
err1
errOAAI
errGuhathakurta, Piyali; Carter, Anna L.; Thompson, Andrew R.; Kurila, Dillon; LaFrence, Jeffrey; Zhang, Li; Trask, Jake R.; Vanderheyden, Bri; Muretta, Joseph M.; Ervasti, James M.; Thomas, David D.; Cruz, Enrique De La
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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
errEMBO JOURNAL
IF8.3
err2022-10-10
err24
errOAAI
errSimon, Matthew; Yang, Jiping; Gigas, Jonathan; Earley, Eric J.; Hillpot, Eric; Zhang, Lei; Zagorulya, Maria; Tombline, Greg; Gilbert, Michael; Yuen, Samantha L.; Pope, Alexis; Van Meter, Michael; Emmrich, Stephan; Firsanov, Denis; Athreya, Advait; Biashad, Seyed Ali; Han, Jeehae; Ryu, Seungjin; Tare, Archana; Zhu, Yizhou; Hudgins, Adam; Atzmon, Gil; Barzilai, Nir; Wolfe, Aaron; Moody, Kelsey; Garcia, Benjamin A.; Thomas, David D.; Robbins, Paul D.; Vijg, Jan; Seluanov, Andrei; Suh, Yousin; Gorbunova, Vera
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Synergistic FRET assays for drug discovery targeting RyR2 channels用于靶向RyR2通道的药物发现的协同FRET测定
errJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
err2022-07-01
err7
errOAAI
errRebbeck, RobynT; Ginsburg, Kenneth S.; Ko, Christopher Y.; Fasoli, Anna; Rusch, Katherine; Cai, George F.; Dong, Xiaoqiong; Thomas, David D.; Bers, Donald M.; Cornea, Razvan L.
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Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-01-01
err3
errOAAI
errZhang, Jingyan; Singh, Daniel P.; Ko, Christopher Y.; Nikolaienko, Roman; Yuen, Siobhan M. Wong King; Schwarz, Jacob A.; Treinen, Levy M.; Tung, Ching-Chieh; Rozman, Kaja; Svensson, Bengt; Aldrich, Courtney C.; Zima, Aleksey, V; Thomas, David D.; Bers, Donald M.; Launikonis, Bradley S.; Van Petegem, Filip; Cornea, Razvan L.
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Direct detection of the myosin super-relaxed state and interacting-heads motif in solution
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2021-10-01
err33
errOAAI
errChu, Sami; Muretta, Joseph M.; Thomas, David D.
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Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (PRKACA) and Its Oncogenic Mutant DNAJB1-PRKACA
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2021-08-26
err7
errOAAI
errKaramafrooz, Adak; Brennan, Jack; Thomas, David D.; Parker, Laurie L.
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Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2021-07-01
err11
errOAAI
errBunch, Thomas A.; Guhathakurta, Piyali; Lepak, Victoria C.; Thompson, Andrew R.; Kanassatega, Rhye-Samuel; Wilson, Anna; Thomas, David D.; Colson, Brett A.
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Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors
errNPJ PARKINSONS DISEASE
IF8.2
err2021-06-28
err24
errOAAI
errBraun, Anthony R.; Liao, Elly E.; Horvath, Mian; Kalra, Prakriti; Acosta, Karen; Young, Malaney C.; Kochen, Noah Nathan; Lo, Chih Hung; Brown, Roland; Evans, Michael D.; Pomerantz, William C. K.; Rhoades, Elizabeth; Luk, Kelvin; Cornea, Razvan L.; Thomas, David D.; Sachs, Jonathan N.
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研究方向

暂无研究方向
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