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M

Marc van de Wetering

oncode institute
H指数:68
被引数:4.8万

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Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features

单细胞多组学分析表征了结直肠肿瘤、相邻健康组织及匹配的（肿瘤）类器官，并识别了CRC（结直肠癌）特有的特征。

International Journal of Cancer
IF4.7
2025-08-230
OAAI
Zhijun Yu; Merel Derksen; Brigit M. te Pas; Sabrina Ladstätter; Rene Overmeer; Peter Brazda; Marc van de Wetering; Farzin Pourfarzad; Robert G. J. Vries; Wout Megchelenbrink; Christoph Bock; Lucia Altucci; Hendrik G. Stunnenberg
Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

小型圆形细胞肉瘤类器官生物库揭示了CIC::DUX4肉瘤对MCL-1抑制的易感性

Nature Communications
IF15.7
2025-08-210
OAAI
Femke C. A. S. Ringnalda; Gijs J. F. van Son; Laurens H. G. Verweij; Seok-Young Kim; Vicky Amo-Addae; Uta E. Flucke; Laura S. Hiemcke–Jiwa; Karin P. S. Langenberg; Jos A. M. Bramer; Lotte Heimans; Michiel A. J. van de Sande; Winan J. van Houdt; Max M. van Noesel; Hinri H. D. Kerstens; Marcel Santoso; Georg Seifert; Olivier Delattre; Katia Scotlandi; Birgit Geoerger; Johannes H. M. Merks; Jan J. Molenaar; Ruben van Boxtel; Marc van de Wetering; Karin Sanders; Hans Clevers
Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities
ONCOGENE
IF7.3
2023-04-0510
OAAI
Paassen, Irene; Williams, Justin; Arceo, Carla Rios; Ringnalda, Femke; Mercer, Kimberly Shea; Buhl, Juliane L.; Moreno, Natalia; Federico, Aniello; Franke, Niels E.; Kranendonk, Mariette; Upadhyaya, Santhosh A.; Kerl, Kornelius; van de Wetering, Marc; Clevers, Hans; Kool, Marcel; Hoving, Eelco W.; Roussel, Martine F.; Drost, Jarno
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

无偏转录因子CRISPR筛选确定ZNF800为肠内分泌分化的主要阻遏物

Science
IF45.8
2023-01-010
OA
Lin Lin; Jeff DeMartino; Daisong Wang; Gijs J. F. van Son; Reinier van der Linden; Harry Begthel; Jeroen Korving; Amanda Andersson-Rolf; Stieneke van den Brink; Carmen López‐Iglesias; Willine J. van de Wetering; Aleksandra Balwierz; Thanasis Margaritis; Marc van de Wetering; Peter J. Peters; Jarno Drost; Johan H. van Es; Hans C. Clevers
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
EMBO MOLECULAR MEDICINE
IF8.3
2022-08-0224
OAAI
Meister, Michael T.; Groot Koerkamp, Marian J. A.; de Souza, Terezinha; Breunis, Willemijn B.; Frazer-Mendelewska, Ewa; Brok, Mariel; DeMartino, Jeff; Manders, Freek; Calandrini, Camilla; Kerstens, Hinri H. D.; Janse, Alex; Dolman, M. Emmy M.; Eising, Selma; Langenberg, Karin P. S.; van Tuil, Marc; Knops, Rutger R. G.; van Scheltinga, Sheila Terwisscha; Hiemcke-Jiwa, Laura S.; Flucke, Uta; Merks, Johannes H. M.; van Noesel, Max M.; Tops, Bastiaan B. J.; Hehir-Kwa, Jayne Y.; Kemmeren, Patrick; Molenaar, Jan J.; van de Wetering, Marc; van Boxtel, Ruben; Drost, Jarno; Holstege, Frank C. P.
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR x LGR5 bispecific antibody with efficacy in epithelial tumors
NATURE CANCER
IF28.5
2022-04-2570
OA
Herpers, Bram; Eppink, Berina; James, Mark, I; Cortina, Carme; Canellas-Socias, Adria; Boj, Sylvia F.; Hernando-Momblona, Xavier; Glodzik, Dominik; Roovers, Rob C.; van de Wetering, Marc; Bartelink-Clements, Carina; Zondag-van der Zande, Vanessa; Mateos, Jara Garcia; Yan, Kuan; Salinaro, Lucia; Basmeleh, Abdul; Fatrai, Szabolcs; Maussang, David; van Bueren, Jeroen J. Lammerts; Chicote, Irene; Serna, Garazi; Cabellos, Laia; Ramirez, Lorena; Nuciforo, Paolo; Salazar, Ramon; Santos, Cristina; Villanueva, Alberto; Attolini, Camille Stephan-Otto; Sancho, Elena; Palmer, Hector G.; Tabernero, Josep; Stratton, Michael R.; de Kruif, John; Logtenberg, Ton; Clevers, Hans; Price, Leo S.; Vries, Robert G. J.; Batlle, Eduard; Throsby, Mark
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
NATURE GENETICS
IF31.8
2019-04-29161
PREAI
Bolhaqueiro, Ana C. F.; Ponsioen, Bas; Bakker, Bjorn; Klaasen, Sjoerd J.; Kucukkose, Emre; van Jaarsveld, Richard H.; Vivie, Judith; Verlaan-Klink, Ingrid; Hami, Nizar; Spierings, Diana C. J.; Sasaki, Nobuo; Dutta, Devanjali; Boj, Sylvia F.; Vries, Robert G. J.; Lansdorp, Peter M.; van de Wetering, Marc; van Oudenaarden, Alexander; Clevers, Hans; Kranenburg, Onno; Foijer, Floris; Snippert, Hugo J. G.; Kops, Geert J. P. L.

研究方向

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H
Hans Clevers
H 指数:236论文数:1,340被引数:25.0万
J
Johan H. van Es
H 指数:77论文数:197被引数:5.6万
A
Alexander van Oudenaarden
H 指数:116论文数:460被引数:6.2万
D
Daniel E. Stange
H 指数:40论文数:141被引数:2.6万
F
Femke Ringnalda
H 指数:15论文数:35被引数:2,943
H
Harry Begthel
H 指数:52论文数:107被引数:3.0万
R
Robert G. Vries
H 指数:20论文数:57被引数:1.1万
M
Meritxell Huch
H 指数:49论文数:125被引数:1.9万
T
Toshiro Sato
H 指数:75论文数:540被引数:4.3万
J
Jarno Drost
H 指数:34论文数:187被引数:1.1万