未登录Degrading SMARCA2/4 Relieves the Differentiation Block in AML Via Chromatin Alterations Affecting S100A8/9通过影响S100A8/9的染色质改变，降解SMARCA2/4可解除急性髓系白血病（AML）的分化阻滞
Aminov, Sarah; Zhao, Rongbao; Pradhan, Kith; Sahu, Srabani; Sanawar, Rahul; Mitchell, Shanisha Gordon; Rabinovich, Emma; Fromowitz, Ariel; Chakraborty, Joyeeta; Aluri, Srinivas; Haque, Nayem; Carbajal, Milagros; Shastri, Aditi; Steidl, Ulrich; Samajdar, Susanta; Kumar, Akhil; Ramachandra, Murali; Stengel, Kristy; Coleman, Robert; Verma, Amit .png)
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收藏Combining OP-3136, a KAT6 inhibitor, with endocrine therapy and CDK4/6 inhibitor enhances anti-tumor activity in ER+/HER2-breast cancer modelsPalanisamy, G.; Barratt, S.; Hope, C.; Robello, B.; Pena, G.; Goyal, M.; Venkateshappa, C.; Ng, R.; Ramachandra, M.; Myles, D. 分享 收藏 Paralogue selective p300 degraders induce synthetic lethality in pre-clinical models of CBP-deficient and p300-dependent malignanciesThiyagarajan, Saravanan; Abbineni, Chandrasekhar; Chaitanya, Krishna T.; Apte, Achala; Iqbal, Iram Khan; Kumar, Naveen R.; Aravind, A. B.; Kumar, Avinash; Babu, Dabbeeru Madhu; Shwetha, Shwetha; Manna, Ankita; Mandal, Monalisha; Panigrahi, Rituparna; Marappan, Sivapriya; Gore, Suraj T.; Fairus, Mohamad; Jin, Lim Yang; Mukherjee, Subhendu; Daginakatte, Girish; Chelur, Shekar; Nellore, Kavitha; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 A novel CCR4 antagonist induces potent anti-tumor response through inhibition of Treg migration into the tumor microenvironmentNair, Rashmi; Abbineni, Chandrasekhar; Talluri, Krishna Chaitanya; Dhudashiya, Amit A.; Aravind, A. B.; Kumar, Naveen R.; Ramya, R.; Balasubramanyam, D.; Obanna, Pathur; Madhaiyan, Rabin; Samiulla, D. S.; Daginakatte, Girish; Narayanan, Kishore; Nellore, Kavitha; Chelur, Shekar; Samajdar, Susanta; Ramachandra, Murali 分享 收藏 SMARCA2/4 degraders relieve the differentiation block in AML via changes in chromatin looping and accessibilityAminov, Sarah; Pradhan, Kith; Sahu, Srabani; Gordon-Mitchell, Shanisha; Rabinovich, Emma; Fromowitz, Ariel; Chakraborty, Joyeeta; Aluri, Srinivas; Zhao, Rongbao; Haque, Nayem; Carbajal, Milagros; Shastri, Aditi; Steidl, Ulrich; Samajdarr, Susanta; Kumar, Akhil; Ramachandra, Murali; Coleman, Robert A.; Stengel, Kristy; Verma, Amit K. 分享 收藏 Targeting the SWI/SNF complex in POU2F-POU2AF transcription factor-driven malignanciesXiao, Lanbo; He, Tongchen; Klingbeil, Olaf; Eleanor, Young; Wu, Xiaoli; Qiao, Yuanyuan; Parolia, Abhijit; Eyunni, Sanjana; Mannan, Rahul; Mahapatra, Somnath; Kim, NamHoon; Zheng, Heng; Su, Fengyun; Cao, Xuhong; Samajdar, Susanta; Ramachandra, Murali; Vakoc, Christopher R.; Chinnaiyan, Arul M. 分享 收藏 Development of novel anti-SIRPa/ß dual antibody with single-agent phagocytosis activityChakrabarty, Subhra Prakash; Patil, Sandeep Sadashiv; Rajput, Sunaina Singh; Mukerji, Amrita; Aurumugam, Sandhya; Gade, Pooja Balu; Sidhesha, S.; Patra, Anup Kumar; Shivaranjini, C.; Khamkar, Vaishnavi Shivaji; Lavanya, P.; Lakshmeesha, K. N.; Kapoor, Ujjwal; Jagadeesh, R.; Nagaraj, Jwala; Nataraj, Vijaya Shankar; Nellore, Kavitha; Antony, Thomas; Samajdar, Susanta; Ramachandra, Murali 分享 收藏 Identification and characterization of paralogue selective CBP degraders for potential use in cancer therapyThiyagarajan, Saravanan; Abbineni, Chandrasekhar; Chaitanya, Krishna T.; Apte, Achala; Iqbal, Iram Khan; Kumar, Naveen R.; Aravind, A. B.; Kumar, Avinash; Girish, A. R.; Kamath, Aishwarya B.; Mane, Deepak Dattatray; Raj, Gouri A.; Reghu, Reshma; Mohapatra, Subhasmita; Marappan, Sivapriya; Gore, Suraj T.; Mukherjee, Subhendu; Daginakatte, Girish; Nellore, Kavitha; Chelur, Shekar; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 Discovery of AUR-112, a novel MALT1 protease inhibitor for the treatment of B cell lymphomasBalasubramanian, Wesley Roy; Raju, Sammeta Srinivasa; Vasantha, K. Y.; Reddy, Archana Bhumi; Maben, Janith Mary; Patil, Sandeep Sadashiv; Raghavendra, N. R.; Aithal, Kiran B.; Charamanna, K. B.; Chikkanna, Dinesh; Nellore, Kavitha; Samiulla, D. S.; Daginakatte, Girish; Chelur, Shekar; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 Discovery of potent and paralog selective PROTAC degraders of CBP or p300 proteins for the treatment of various cancersAbbineni, Chandrasekhar; Thiyagarajan, Saravanan; Chaitanya, Krishna T.; Apte, Achala; Kumar, Naveen R.; Kumar, Avinash; Babu, Dabbeeru Madhu; Shwetha, S.; Kamath, Aishwarya B.; Mandel, Monalisha; Panigrahi, Rituparna; Marappan, Sivapriya; Mukherjee, Subhendu; Nellore, Kavitha; Chelur, Shekar; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 Potent anti-tumor activity of a selective and orally bioavailable reversible covalent CDK12 inhibitorKhare, Leena; Poddutoori, Ramulu; Mukherjee, Subhendu; Samiulla, D. S.; Devaraja, T. S.; Marappan, Sivapriya; Nayak, Shilpa; Sivakumar, Sasirekha; Kaza, Lakshmi; Tgore, Suraj; Dhudashiya, Amit; Raghavendra, N. R.; Gunnepalli, Bhargav; Aravind, A. B.; Amith, A.; Charamanna, K. B.; Antony, Thomas; Nellore, Kavitha; Daginakatte, Girish; Chelur, Shekar; Giri, Sanjeev; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 The discovery of potent KAT6 inhibitors that demonstrate anti-tumor activity in preclinical models of ER plus breast cancerPalanisamy, Gopinath S.; Venkateshappa, Chandregowda; Goyal, Megha; Barrett, Susanna A.; Heam, Brian R.; Daginakatte, Girish; Aravind, A. B.; Samiulla, D. S.; Bera, Kalisankar; Sangeetha, S.; Khare, Leena; Parisian, Alison D.; Heerding, Dirk A.; Ng, Raymond A.; Harmon, Cyrus L.; Samajdar, Susanta; Ramachandra, Murali; Myles, David C. 分享 收藏 Identification of paralog selective degraders of SMARCA2 and SMARCA4 for treatment of various cancersAbbineni, Chandrasekhar; Aithal, Kiran; Khare, Leena; Dukare, Sandeep, V; Kuila, Bilash; Goyal, Megha; Rawoof, Khaji Abdul; Mahadeo, Dhaytadak Bhagwan; Kumar, Bhagya M. S.; Premkumar, M.; Sahu, Swetangini; Gore, Suraj T.; Krishna, Lavanya N.; Charamanna, K. B.; Gopinath, C. H.; Samiulla, D. S.; Mukherjee, Subhendu; Antony, Thomas; Gin, Sanjeev; Chelur, Shekar; Nellore, Kavitha; Daginakatte, Girish; Ramachandra, Murali; Samajdar, Susanta 分享 收藏 A highly differentiated A2AR inhibitor for potential use in cancer therapyVenkateshappa, Chandregowda; Narayanan, Kishore; Nair, Rashmi; Ab, Aravind; Putta, Ramakishore Vp; Nagaraj, Jwala; Goyal, Megha; Ahuja, Vijay Kamal; Dhudashiya, Amith A.; Ds, Samiulla; Daginakatte, Girish; Antony, Thomas; Nellore, Kavitha; Samajdar, Susanta; Ramachandra, Murali 分享 收藏 Generation of profound anti-tumor immunity by AUR-109, a spectrum-selective tyrosine kinase inhibitor, either as a single agent or in combination with immune checkpoint inhibitorsDaginakatte, Girish; Thiyagarajan, Saravanan; Aithal, Kiran; Dey, Mamon; Reghu, Reshma; Mandal, Monalisha; Nellore, Kavitha; Samajdar, Susanta; Ramachandra, Murali 分享 收藏 Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutationsChoudhary, Gaurav S.; Pellagatti, Andrea; Agianian, Bogos; Smith, Molly A.; Bhagat, Tushar D.; Gordon-Mitchell, Shanisha; Sahu, Srabani; Pandey, Sanjay; Shah, Nishi; Aluri, Srinivas; Aggarwal, Ritesh; Aminov, Sarah; Schwartz, Leya; Steeples, Violetta; Booher, Robert N.; Ramachandra, Murali; Samson, Maria; Carbajal, Milagros; Pradhan, Kith; Bowman, Teresa, V; Pillai, Manoj M.; Will, Britta; Wickrema, Amittha; Shastri, Aditi; Bradley, Robert K.; Martell, Robert E.; Steidl, Ulrich G.; Gavathiotis, Evripidis; Boultwood, Jacqueline; Starczynowski, Daniel T.; Verma, Amit 分享 收藏 分享 收藏 Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of ActionPoddutoori, Ramulu; Aardalen, Kimberly; Aithal, Kiran; Barahagar, Sanjeev Surendranath; Belliappa, Charamanna; Bock, Mark; Chelur, Shekar; Gerken, Andrea; Gopinath, Sreevalsam; Gruenenfelder, Bjoern; Kiffe, Michael; Krishnaswami, Maithreyi; Langowski, John; Madapa, Sudharshan; Narayanan, Kishore; Pandit, Chetan; Panigrahi, Sunil Kumar; Perrone, Mark; Potakamuri, Ravi Kumar; Ramachandra, Murali; Ramanathan, Anuradha; Ramos, Rita; Sager, Emine; Samajdar, Susanta; Subramanya, Hosahalli S.; Thimmasandra, Devaraja Seethappa; Venetsanakos, Eleni; Mobitz, Henrik 分享 收藏 Structural and binding studies of cyclin-dependent kinase 2 with NU6140 inhibitor细胞周期蛋白依赖性激酶2与NU6140抑制剂的结构和结合研究Talapati, Sumalatha Rani; Goyal, Megha; Nataraj, Vijayashankar; Pothuganti, Manoj; Sreevidya, M. R.; Gore, Suraj; Ramachandra, Murali; Antony, Thomas; More, Sunil S.; Rao, Narasimha K. 分享 收藏 PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacySasikumar, Pottayil G.; Sudarshan, Naremaddepalli S.; Adurthi, Srinivas; Ramachandra, Raghuveer K.; Samiulla, Dodderi S.; Lakshminarasimhan, Anirudha; Ramanathan, Anuradha; Chandrasekhar, Talapaneni; Dhudashiya, Amit A.; Talapati, Sumalatha R.; Gowda, Nagesh; Palakolanu, Sreenivasulareddy; Mani, Jiju; Srinivasrao, Bandi; Joseph, David; Kumar, Nigam; Nair, Rashmi; Atreya, Hanudatta S.; Gowda, Nagaraj; Ramachandra, Murali 分享 收藏 
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