Malcolm J. Low - Publications, H-index & Citations

Malcolm J. Low

Department of Molecular and Integrative Physiology

80H指数

520论文数

3.0W被引数

收录论文 99

发表时间

Highly Conserved STAT3 Motifs Present in the Neuronal Pomc Enhancer nPE1 are Critical for Maximal Hypothalamic Pomc Expression 高度保守的STAT3基序存在于神经元POMC增强子nPE1中，对最大化的下丘脑POMC表达至关重要。

Molecular Neurobiology

IF4.3

2025-11-15

PREAI

Clara E. Hael; Malcolm J. Low; Lucía F. Franchini; Marcelo Rubinstein

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice

MOLECULAR METABOLISM

IF6.6

2024-09-01

OAAI

Yu, Hui; Chiang, Angelika; Rubinstein, Marcelo; Low, Malcolm J.

A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-04-23

PREAI

Rojo, Daniela; Hael, Clara E.; Soria, Agustina; de Souza, Flavio S. J.; Low, Malcolm J.; Franchini, Lucia F.; Rubinstein, Marcelo

Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

de Souza, FSJ; Santangelo, AM; Bumaschny, V; Avale, ME; Smart, JL; Low, MJ; Rubinstein, M

The G209R Mutant Mouse as a Model for Human PCSK1 Polyendocrinopathy

ENDOCRINOLOGY

IF3.3

2022-03-04

OAAI

Shakya, Manita; Gahlot, Surbhi; Martin, Nicolle K.; Arunagiri, Anoop; Martin, Martin G.; Arvan, Peter; Low, Malcolm J.; Lindberg, Iris

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

ELIFE

IF0

2022-01-19

OAAI

Yu, Hui; Rubinstein, Marcelo; Low, Malcolm J.

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

MOLECULAR METABOLISM

IF6.6

2021-11-01

OAAI

Surbhi; Wittmann, Gabor; Low, Malcolm J.; Lechan, Ronald M.

Mice Lacking PC1/3 Expression in POMC-expressing Cells Do Not Develop Obesity

ENDOCRINOLOGY

IF3.3

2021-03-10

OAAI

Shakya, Manita; Surbhi; White, Anne; Verchere, C. Bruce; Low, Malcolm J.; Lindberg, Iris

Regulation of Opioid Receptors by Their Endogenous Opioid Peptides

CELLULAR AND MOLECULAR NEUROBIOLOGY

IF4.8

2021-01-02

OAAI

Gupta, Achla; Gullapalli, Srinivas; Pan, Hui; Ramos-Ortolaza, Dinah L.; Hayward, Michael D.; Low, Malcom J.; Pintar, John E.; Devi, Lakshmi A.; Gomes, Ivone

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity

MOLECULAR METABOLISM

IF6.6

2020-05-01

OAAI

Yu, Hui; Chhabra, Kavaljit H.; Thompson, Zoe; Jones, Graham L.; Kiran, Sylee; Shangguan, Gary; Low, Malcolm J.

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

MOLECULAR METABOLISM

IF6.6

2020-04-01

OAAI

Hael, Clara E.; Rojo, Daniela; Orquera, Daniela P.; Low, Malcolm J.; Rubinstein, Marcelo

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy

JOURNAL OF ENDOCRINOLOGY

IF3.9

2020-04-01

OAAI

Yu, Hui; Thompson, Zoe; Kiran, Sylee; Jones, Graham L.; Mundada, Lakshmi; Surbhi; Rubinstein, Marcelo; Low, Malcolm J.

Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D

ENDOCRINOLOGY

IF3.3

2019-09-02

OAAI

Jarvela, Timothy S.; Surbhi; Shakya, Manita; Bachor, Tomas; White, Anne; Low, Malcolm J.; Lindberg, Iris

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2019-06-01

OAAI

Zhou, Yan; Leri, Francesco; Low, Malcolm J.; Kreek, Mary Jeanne

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

MOLECULAR METABOLISM

IF6.6

2019-02-01

OAAI

Tooke, Benjamin P.; Yu, Hui; Adams, Jessica M.; Jones, Graham L.; Sutton-Kennedy, Talisha; Mundada, Lakshmi; Qi, Nathan R.; Low, Malcolm J.; Chhabra, Kavaljit H.

Ruboxistaurin Reduces Cocaine-Stimulated Increases in Extracellular Dopamine by Modifying Dopamine-Autoreceptor Activity

ACS CHEMICAL NEUROSCIENCE

IF3.9

2018-11-01

OAAI

Zestos, Alexander G.; Carpenter, Colleen; Kim, Youngsoo; Low, Malcolm J.; Kennedy, Robert T.; Gnegy, Margaret E.

Hypothalamic ER associated degradation regulates POMC maturation, feeding, and age-associated obesity

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2018-02-19

OAAI

Kim, Geun Hyang; Shi, Guojun; Somlo, Diane R. M.; Haataja, Leena; Song, Soobin; Long, Qiaoming; Nillni, Eduardo A.; Low, Malcolm J.; Arvan, Peter; Myers, Martin G., Jr.; Qi, Ling

Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells 胃泌素诱导肠神经胶质细胞中核输出和Menin的蛋白酶体降解

GASTROENTEROLOGY

IF25.1

2017-12-01

OAAI

Sundaresan, Sinju; Meininger, Cameron A.; Kang, Anthony J.; Photenhauer, Amanda L.; Hayes, Michael M.; Sahoo, Nirakar; Grembecka, Jolanta; Cierpicki, Tomasz; Ding, Lin; Giordano, Thomas J.; Else, Tobias; Madrigal, David J.; Low, Malcolm J.; Campbell, Fiona; Baker, Ann-Marie; Xu, Haoxing; Wright, Nicholas A.; Merchant, Juanita L.

17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

AGING CELL

IF7.1

2017-11-23

OAAI

Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey-Downs, Lora C.; Xie, Teresa Y.; Ghadami, Martin; Brimijoin, Stephen; Freeman, Willard M.; Rubinstein, Marcelo; Low, Malcolm J.; Stout, Michael B.

Lorcaserin improves glycemic control via a melanocortin neurocircuit

MOLECULAR METABOLISM

IF6.6

2017-10-01

OAAI

Burke, Luke K.; Ogunnowo-Bada, Emmanuel; Georgescu, Teodora; Cristiano, Claudia; de Morentin, Pablo B. Martinez; Torres, Lourdes Valencia; D'Agostino, Giuseppe; Riches, Christine; Heeley, Nicholas; Ruan, Yue; Rubinstein, Marcelo; Lows, Malcolm J.; Myers, Martin G.; Rochford, Justin J.; Evans, Mark L.; Heisler, Lora K.

研究方向