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M

Mari Takalo

Institute of Biomedicine
H指数:19
被引数:4,111

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Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

额颞叶痴呆患者来源的iPSC神经元表现出细胞病理学特征以及突触功能障碍和DNA损伤的证据

Molecular Psychiatry
IF10.1
2025-09-260
OAAI
Nadine Huber; Tomi Hietanen; Sami Heikkinen; Anastasia Shakirzyanova; Dorit Hoffmann; Hannah Rostalski; Ashutosh Dhingra; Salvador Rodriguez-Nieto; Sari Kärkkäinen; Marja Koskuvi; Eila Korhonen; Päivi Hartikainen; Katri Pylkäs; Johanna Krüger; Tarja Malm; Mari Takalo; Mikko Hiltunen; Jari Koistinaho; Anne M. Portaankorva; Eino Solje; Annakaisa Haapasalo
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease

单等位基因TYROBP缺失是阿尔茨海默病的一种新型风险因素。

MOLECULAR NEURODEGENERATION
IF17.5
2025-04-290
OA
Martiskainen, Henna; Willman, Roosa-Maria; Harju, Paivi; Heikkinen, Sami; Heiskanen, Mette; Mueller, Stephan A.; Sinisalo, Rosa; Takalo, Mari; Makinen, Petra; Kuulasmaa, Teemu; Pekkala, Viivi; del Rey, Ana Galvan; Juopperi, Sini-Pauliina; Jeskanen, Heli; Kervinen, Inka; Saastamoinen, Kirsi; Niiranen, Marja; Heikkinen, Sami V.; Kurki, Mitja I.; Marttila, Jarkko; Makinen, Petri I.; Hietanen, Tomi; Bellenguez, Celine; Lambert, Jean-Charles; Haass, Christian; Rinne, Juha; Hakumaki, Juhana; Rauramaa, Tuomas; Kruger, Johanna; Soininen, Hilkka; Haapasalo, Annakaisa; Lichtenthaler, Stefan F.; Leinonen, Ville; Solje, Eino; Hiltunen, Mikko
The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions

保护性PLCγ2-P522R变异体通过增强有益的小胶质细胞功能来减轻与阿尔茨海默病相关的病理学改变

JOURNAL OF NEUROINFLAMMATION
IF10.1
2025-03-051
OA
Takalo, Mari; Jeskanen, Heli; Kervinen, Inka; Hellen, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Mueller, Stephan A.; Koivumaki, Esa-Mikko; Makinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jaentti, Henna; Peitz, Michael; Fliessbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtenthaler, Stefan F.; Tanila, Heikki; Haass, Christian; Rinne, Juha; Hiltunen, Mikko
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease (Vol 32, pg 3372, 2024)

一种小分子TAT-TrkB多肽可防止BDNF受体裂解，并恢复阿尔茨海默病中的突触生理学（卷32，页3372，2024）

MOLECULAR THERAPY
IF12
2025-01-011
OAAI
Fonseca-Gomes, Joao; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Aleman-Serrano, Nuno; Atalaia-Barbacena, Henrique; Ribeiro-Rodrigues, Leonor; Ramalho, Rita M.; Pinto, Rui; Miranda, Hugo Vicente; Tanqueiro, Sara R.; de Almeida-Borlido, Carolina; Ramalho, Maria Joao; Miranda-Lourenco, Catarina; Belo, Rita F.; Ferreira, Catarina B.; Neves, Vera; Rombo, Diogo M.; Viais, Ricardo; Umemori, Juzoh; Martins, Ivo C.; Jeronimo-Santos, Andre; Caetano, Antonio; Manso, Nuno; Makinen, Petra; Marttinen, Mikael; Takalo, Mari; Bremang, Michael; Pike, Ian; Haapasalo, Annakaisa; Loureiro, Joana A.; Pereira, Maria Carmo; Santos, Nuno C.; Outeiro, Tiago F.; Castanho, Miguel A. R. B.; Fernandes, Adelaide; Hiltunen, Mikko; Duarte, Carlos B.; Castren, Eero; de Mendonca, Alexandre; Sebastiao, Ana M.; Rodrigues, Tiago M.; Diogenes, Maria Jose
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
NEUROBIOLOGY OF DISEASE
IF5.6
2023-06-017
OAAI
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Maekinen, Petra M.; Maekinen, Petri; Koncarevic, Sasa; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E.; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, Annakaisa; Hiltunen, Mikko
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates

成年TAU病小鼠的器官型海马切片培养物和纳米材料磷酸-TAU抗体缀合物的治疗评估

CELLS
IF5.2
2023-05-180
OAAI
Kemppainen, Susanna; Huber, Nadine; Willman, Roosa-Maria; Zamora, Ana; Makinen, Petra; Martiskainen, Henna; Takalo, Mari; Haapasalo, Annakaisa; Sobrino, Tomas; Gomez, Manuel Antonio Gonzalez; Pineiro, Yolanda; Rivas, Jose; Himmelreich, Uwe; Hiltunen, Mikko
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
NEUROBIOLOGY OF DISEASE
IF5.6
2022-02-0110
OAAI
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M. A.; Takalo, Mari; Makinen, Petra; Leppanen, Luukas; Miranda-Lourenco, Catarina; Fonseca-Gomes, Joao; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastiao, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luisa V.; de Mendonca, Alexandre; Diogenes, Maria Jose; Hiltunen, Mikko
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner (Nov, 10.1038/s41380-020-00926-w, 2020)
MOLECULAR PSYCHIATRY
IF10.1
2021-01-042
OAAI
Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anais-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Checler, Frederic; Farinelli, Melissa; Delay, Charlotte; Malmanche, Nicolas; Hebert, Sebastien S.; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
MOLECULAR NEURODEGENERATION
IF17.5
2020-11-1026
OAAI
Natunen, Teemu; Martiskainen, Henna; Marttinen, Mikael; Gabbouj, Sami; Koivisto, Hennariikka; Kemppainen, Susanna; Kaipainen, Satu; Takalo, Mari; Svobodova, Helena; Leppanen, Luukas; Kemilainen, Benjam; Ryhanen, Simo; Kuulasmaa, Teemu; Rahunen, Eija; Juutinen, Sisko; Makinen, Petra; Miettinen, Pasi; Rauramaa, Tuomas; Pihlajamaki, Jussi; Haapasalo, Annakaisa; Leinonen, Ville; Tanila, Heikki; Hiltunen, Mikko
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

阿尔茨海默氏症的遗传危险因子FERMT2 (Kindlin-2) 以APP依赖性方式控制轴突生长和突触可塑性

MOLECULAR PSYCHIATRY
IF10.1
2020-11-0330
OAAI
Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Checler, Frederic; Farinelli, Melissa; Delay, Charlotte; Malmanche, Nicolas; Hebert, Sebastien S.; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien
Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice
NEUROBIOLOGY OF AGING
IF3.5
2019-03-0127
OAAI
Gabbouj, Sami; Natunen, Teemu; Koivisto, Hennariikka; Jokivarsi, Kimmo; Takalo, Mari; Marttinen, Mikael; Wittrahm, Rebekka; Kemppainen, Susanna; Naderi, Reyhaneh; Posado-Fernandez, Adrian; Ryhanen, Simo; Makinen, Petra; Paldanius, Kaisa M. A.; Doria, Goncalo; Poutiainen, Pekka; Flores, Orfeu; Haapasalo, Annakaisa; Tanila, Heikki; Hiltunen, Mikko

研究方向

暂未获取到该数据
A
Annakaisa Haapasalo
H 指数:48论文数:184被引数:1.7万
M
Mikael Marttinen
H 指数:19论文数:62被引数:1,397
P
Petra Mäkinen
H 指数:21论文数:88被引数:1,304
M
Mikko Hiltunen
H 指数:59论文数:294被引数:3.2万
T
Teemu Natunen
H 指数:21论文数:69被引数:1,642
V
Ville Leinonen
H 指数:47论文数:277被引数:7,900
S
Susanna Kemppainen
H 指数:16论文数:45被引数:1,188
H
Hilkka Soininen
H 指数:144论文数:1,229被引数:10.9万
I
Ian Pike
H 指数:36论文数:124被引数:4,522
M
Mikko Hiltunen
H 指数:46论文数:154被引数:1.4万