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I

Ian Pike

proteome sciences plc
H指数:36
被引数:4,535

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A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease (Vol 32, pg 3372, 2024)

一种小分子TAT-TrkB多肽可防止BDNF受体裂解，并恢复阿尔茨海默病中的突触生理学（卷32，页3372，2024）

MOLECULAR THERAPY
IF12
2025-01-011
OAAI
Fonseca-Gomes, Joao; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Aleman-Serrano, Nuno; Atalaia-Barbacena, Henrique; Ribeiro-Rodrigues, Leonor; Ramalho, Rita M.; Pinto, Rui; Miranda, Hugo Vicente; Tanqueiro, Sara R.; de Almeida-Borlido, Carolina; Ramalho, Maria Joao; Miranda-Lourenco, Catarina; Belo, Rita F.; Ferreira, Catarina B.; Neves, Vera; Rombo, Diogo M.; Viais, Ricardo; Umemori, Juzoh; Martins, Ivo C.; Jeronimo-Santos, Andre; Caetano, Antonio; Manso, Nuno; Makinen, Petra; Marttinen, Mikael; Takalo, Mari; Bremang, Michael; Pike, Ian; Haapasalo, Annakaisa; Loureiro, Joana A.; Pereira, Maria Carmo; Santos, Nuno C.; Outeiro, Tiago F.; Castanho, Miguel A. R. B.; Fernandes, Adelaide; Hiltunen, Mikko; Duarte, Carlos B.; Castren, Eero; de Mendonca, Alexandre; Sebastiao, Ana M.; Rodrigues, Tiago M.; Diogenes, Maria Jose
Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
NEUROBIOLOGY OF DISEASE
IF5.6
2023-06-017
OAAI
Wittrahm, Rebekka; Takalo, Mari; Kuulasmaa, Teemu; Maekinen, Petra M.; Maekinen, Petri; Koncarevic, Sasa; Fartzdinov, Vadim; Selzer, Stefan; Kokkola, Tarja; Antikainen, Leila; Martiskainen, Henna; Kemppainen, Susanna; Marttinen, Mikael; Jeskanen, Heli; Rostalski, Hannah; Rahunen, Eija; Kivipelto, Miia; Ngandu, Tiia; Natunen, Teemu; Lambert, Jean-Charles; Tanzi, Rudolph E.; Kim, Doo Yeon; Rauramaa, Tuomas; Herukka, Sanna-Kaisa; Soininen, Hilkka; Laakso, Markku; Pike, Ian; Leinonen, Ville; Haapasalo, Annakaisa; Hiltunen, Mikko
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5
NEUROBIOLOGY OF DISEASE
IF5.6
2022-02-0110
OAAI
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M. A.; Takalo, Mari; Makinen, Petra; Leppanen, Luukas; Miranda-Lourenco, Catarina; Fonseca-Gomes, Joao; Tanqueiro, Sara R.; Vaz, Sandra H.; Belo, Rita F.; Sebastiao, Ana Maria; Leinonen, Ville; Soininen, Hilkka; Pike, Ian; Haapasalo, Annakaisa; Lopes, Luisa V.; de Mendonca, Alexandre; Diogenes, Maria Jose; Hiltunen, Mikko
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification
ALZHEIMERS & DEMENTIA
IF11.1
2021-02-0857
OA
Izzo, Nicholas J.; Yuede, Carla M.; LaBarbera, Kelsie M.; Limegrover, Colleen S.; Rehak, Courtney; Yurko, Raymond; Waybright, Lora; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Hamby, Mary E.; Williams, Claire; Sadlek, Kelsey; Edwards, Hannah M.; Davis, Charles S.; Grundman, Michael; Schneider, Lon S.; DeKosky, Steven T.; Chelsky, Daniel; Pike, Ian; Henstridge, Christopher; Blennow, Kaj; Zetterberg, Henrik; LeVine, Harry, III; Spires-Jones, Tara L.; Cirrito, John R.; Catalano, Susan M.
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner (Nov, 10.1038/s41380-020-00926-w, 2020)
MOLECULAR PSYCHIATRY
IF10.1
2021-01-042
OAAI
Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anais-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Checler, Frederic; Farinelli, Melissa; Delay, Charlotte; Malmanche, Nicolas; Hebert, Sebastien S.; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien
Tryptophan metabolism is inversely regulated in the tumor and blood of with

色氨酸代谢在肿瘤和血液中是反向调节的

THERANOSTICS
IF13.3
2021-01-0126
OAAI
Panitz, Verena; Koncarevic, Saga; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Juergenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflueger, Irada; Sharma, Suraj; Wick, Antje; Pfaender, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von Deimling, Andreas; Heiland, Ines; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A.
Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

阿尔茨海默氏症的遗传危险因子FERMT2 (Kindlin-2) 以APP依赖性方式控制轴突生长和突触可塑性

MOLECULAR PSYCHIATRY
IF10.1
2020-11-0330
OAAI
Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Checler, Frederic; Farinelli, Melissa; Delay, Charlotte; Malmanche, Nicolas; Hebert, Sebastien S.; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien

研究方向

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