未登录 Targeting the SHOC2-RAS interaction in RAS-mutant cancers 靶向RAS突变癌症中的SHOC2-RAS相互作用 Hauseman, Zachary J.; Stauffer, Frederic; Beyer, Kim S.; Molle, Sandra; Cavicchioli, Elena; Marchand, Jean-Remy; Fodor, Michelle; Viscomi, Jessica; Dhembi, Anxhela; Katz, Stephanie; Faggion, Beatrice; Lanter, Mylene; Kerr, Grainne; Schildknecht, Daniela; Handl, Cornelia; Maddalo, Danilo; Soldermann, Carole Pissot; Brady, Jacob; Shrestha, Om; Nguyen, Zachary; Leder, Lukas; Cremosnik, Gregor; Romero, Sandra Lopez; Hassiepen, Ulrich; Stams, Travis; Linder, Markus; Galli, Giorgio G.; Guthy, Daniel A.; King, Daniel A.; Maira, Sauveur-Michel; Thoma, Claudio R.; Ehmke, Veronika 分享 收藏
CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer Prahallad, Anirudh; Weiss, Andreas; Voshol, Hans; Kerr, Grainne; Sprouffske, Kathleen; Yuan, Tina; Ruddy, David; Meistertzheim, Morgane; Kazic-Legueux, Malika; Kottarathil, Tina; Piquet, Michelle; Cao, Yichen; Martinuzzi-Duboc, Laetitia; Buhles, Alexandra; Adler, Flavia; Mannino, Salvatore; Tordella, Luca; Sansregret, Laurent; Maira, Sauveur-Michel; Graus Porta, Diana; Fedele, Carmine; Brachmann, Saskia M. 分享 收藏
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors Tiedt, Ralph; King, Frederick J.; Stamm, Christelle; Niederst, Matthew J.; Delach, Scott; Zumstein-Mecker, Sabine; Meltzer, Jodi; Mulford, Iain J.; Labrot, Emma; Engstler, Barbara Schacher; Baltschukat, Sabrina; Kerr, Grainne; Golji, Javad; Wyss, Daniel; Schnell, Christian; Ainscow, Edward; Engelman, Jeffrey A.; Sellers, William R.; Barretina, Jordi; Caponigro, Giordano; Porta, Diana Graus 分享 收藏
RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancer RNF43突变预测BRAFV600E转移性结直肠癌对抗BRAF/EGFR联合治疗的反应 Elez, Elena; Ros, Javier; Fernandez, Jose; Villacampa, Guillermo; Moreno-Cardenas, Ana Belen; Arenillas, Carlota; Bernatowicz, Kinga; Comas, Raquel; Li, Shanshan; Kodack, David Philip; Fasani, Roberta; Garcia, Ariadna; Gonzalo-Ruiz, Javier; Piris-Gimenez, Alejandro; Nuciforo, Paolo; Kerr, Grainne; Intini, Rossana; Montagna, Aldo; Germani, Marco Maria; Randon, Giovanni; Vivancos, Ana; Smits, Ron; Graus, Diana; Perez-Lopez, Raquel; Cremolini, Chiara; Lonardi, Sara; Pietrantonio, Filippo; Dienstmann, Rodrigo; Tabernero, Josep; Toledo, Rodrigo A. 分享 收藏
JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic properties in preclinical models Brachmann, Saskia M.; Weiss, Andreas; Guthy, Daniel A.; Beyer, Kim; Voshol, Johannes; Maira, Michel; Prahallad, Anirudh; Porta, Diana Graus; Schnell, Christian; Ostermann, Nils; Vaupel, Andrea; Gerspacher, Marc; Leblanc, Catherine; Erdmann, Dirk; Sterker, Dario; Kerr, Grainne; Jerome, Giovannoni; Head, Victoria; Stringer, Rowan; De Kanter, Ruben; Jeff, Kearns; Roman, Danielle; Widmer, Toni; Wessels, Peter; Nunez, Eloisa Jimenez; Sedrani, Richard; Zecri, Frederic; Hofmann, Francesco; Engleman, Jeff; Lorthiois, Edwige; Cotesta, Simona 分享 收藏
Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen Schukur, Lina; Zimmermann, Tamara; Niewoehner, Ole; Kerr, Grainne; Gleim, Scott; Bauer-Probst, Beatrice; Knapp, Britta; Galli, Giorgio G.; Liang, Xiaoyou; Mendiola, Angelica; Reece-Hoyes, John; Rapti, Melivoia; Barbosa, Ines; Reschke, Markus; Radimerski, Thomas; Thoma, Claudio R. 分享 收藏
The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma Rago, Florencia; Elliott, GiNell; Li, Ailing; Sprouffske, Kathleen; Kerr, Grainne; Desplat, Aurore; Abramowski, Dorothee; Chen, Julie T.; Farsidjani, Ali; Xiang, Kay X.; Bushold, Geoffrey; Feng, Yun; Shirley, Matthew D.; Bric, Anka; Vattay, Anthony; Moebitz, Henrik; Nakajima, Katsumasa; Adair, Christopher D.; Mathieu, Simon; Ntaganda, Rukundo; Smith, Troy; Papillon, Julien P. N.; Kauffmann, Audrey; Ruddy, David A.; Bhang, Hyo-eun C.; Castelletti, Deborah; Jagani, Zainab 分享 收藏
In vivo shRNA screens under treatment pressure by BRAF and MEK inhibitors to identify novel combination treatment strategies for BRAF-mutant colorectal cancer Bhang, Hyo-eun C.; DiMare, Matthew T.; Kodack, David P.; Tan, Lujian; Kerr, Grainne; Radhakrishna, Viveksagar Krishnamurthy; Golji, Javad; Ruddy, David A.; Yuan, Tina; Niederst, Matthew J.; Korn, Joshua M.; Porta, Diana Graus; Hammerman, Peter S.; Engelman, Jeffrey A.; Abrams, Tinya; Williams, Juliet 分享 收藏
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss 肿瘤衍生的IFN触发慢性途径激动和对ADAR丢失的敏感性 Liu, Huayang; Golji, Javad; Brodeur, Lauren K.; Chung, Franklin S.; Chen, Julie T.; deBeaumont, Rosalie S.; Bullock, Caroline P.; Jones, Michael D.; Kerr, Grainne; Li, Li; Rakiec, Daniel P.; Schlabach, Michael R.; Sovath, Sosathya; Growney, Joseph D.; Pagliarini, Raymond A.; Ruddy, David A.; MacIsaac, Kenzie D.; Korn, Joshua M.; McDonald, E. Robert, III 分享 收藏
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201 Jeay, Sebastien; Ferretti, Stephane; Holzer, Philipp; Fuchs, Jeanette; Chapeau, Emilie A.; Wartmann, Markus; Sterker, Dario; Romanet, Vincent; Murakami, Masato; Kerr, Grainne; Durand, Eric Y.; Gaulis, Swann; Cortes-Cros, Marta; Ruetz, Stephan; Stachyra, Therese-Marie; Kallen, Joerg; Furet, Pascal; Wurthner, Jens; Guerreiro, Nelson; Halilovic, Ensar; Jullion, Astrid; Kauffmann, Audrey; Kuriakose, Emil; Wiesmann, Marion; Jensen, Michael R.; Hofmann, Francesco; Sellers, William R. 分享 收藏
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SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors Dardaei, Leila; Wang, Hui Qin; Singh, Manrose; Fordjour, Paul; Shaw, Katherine X.; Yoda, Satoshi; Kerr, Grainne; Yu, Kristine; Liang, Jinsheng; Cao, Yichen; Chen, Yan; Lawrence, Michael S.; Langenbucher, Adam; Gainor, Justin F.; Friboulet, Luc; Dagogo-Jack, Ibiayi; Myers, David T.; Labrot, Emma; Ruddy, David; Parks, Melissa; Lee, Dana; DiCecca, Richard H.; Moody, Susan; Hao, Huaixiang; Mohseni, Morvarid; LaMarche, Matthew; Williams, Juliet; Hoffmaster, Keith; Caponigro, Giordano; Shaw, Alice T.; Hata, Aaron N.; Benes, Cyril H.; Li, Fang; Engelman, Jeffrey A. 分享 收藏
SHP2 inhibition restores sensitivity to ALK inhibitors in resistant ALK-rearranged NSCLC Dardaei, Leila; Wang, Hui Qin; Singh, Manrose; Fordjour, Paul; Yoda, Satoshi; Kerr, Grainne; Liang, Jinsheng; Cao, Yichen; Chen, Yan; Gainor, Justin; Friboulet, Luc; Dagogo-Jack, Ibiayi; Myers, David; Labrot, Emma; Ruddy, David; Parks, Melissa; Lee, Dana; DiCecca, Richard; Moody, Susan; Hao, Huaixiang; Mohseni, Morvarid; LaMarche, Matthew; Williams, Juliet; Hoffmaster, Keith; Caponigro, Giordano; Shaw, Alice; Hata, Aaron; Benes, Cyril; Li, Fang; Engelman, Jeffrey 分享 收藏
SHP2 inhibition restores sensitivity to ALK inhibition in resistant ALK-rearranged non-small cell lung cancer (NSCLC) Dardaei, Leila; Wang, Hui Qin; Fordjour, Paul; Singh, Manrose; Kerr, Grainne; Yoda, Satoshi; Liang, Jinsheng; Cao, Yichen; Chen, Yan; Gainor, Justin F.; Friboulet, Luc; Dagogo-Jack, Ibiayi; Myers, David T.; Labrot, Emma; Ruddy, David; Parks, Melissa; Lee, Dana; DiCecca, Richard H.; Moody, Susan; Hao, Huaixiang; Mohseni, Morvarid; LaMarche, Matthew; Williams, Juliet; Hoffmaster, Keith; Caponigro, Giordano; Benes, Cyril H.; Shaw, Alice T.; Hata, Aaron N.; Li, Fang; Engelman, Jeffrey A. 分享 收藏
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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells Voloshanenko, Oksana; Erdmann, Gerrit; Dubash, Taronish D.; Augustin, Iris; Metzig, Marie; Moffa, Giusi; Hundsrucker, Christian; Kerr, Grainne; Sandmann, Thomas; Anchang, Benedikt; Demir, Kubilay; Boehm, Christina; Leible, Svenja; Ball, Claudia R.; Glimm, Hanno; Spang, Rainer; Boutros, Michael 分享 收藏
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