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K

Karolien De Bosscher

vib ugent center for medical biotechnology
H指数:61
被引数:1.6万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Optimizing efficacy to safety ratio of glucocorticoids in rheumatoid arthritis models by leveraging PPARα agonism

通过利用PPARα激动作用优化类风湿关节炎模型中糖皮质激素的疗效与安全性比值

Arthritis & Rheumatology
IF10.9
2026-09-070
OAAI
Lisa L. Koorneef PhD; Elisabeth Gilis PhD; Dorien Clarisse PhD; Daria Fijalkowska PhD; Sara Dufour BSc; Julie Coudeneys BSc; Bert Luyckx PhD; Annick Verhee BSc; Jonathan Thommis BSc; Candice Vanden Bussche BSc; Ulf Müller-Ladner MD; Elena Neumann PhD; Matthias Kerkhofs MSc; Guillaume Planckaert MSc; Simon Devos PhD; Leander Meuris PhD; Dirk Elewaut; Karolien De Bosscher
Development of 2-and 3-prenylated quinolines and tetrahydroquinolines with PPAR activity: From hit to lead and a novel pan-PPAR agonist as a potential candidate for metabolic syndrome

具有PPAR活性的2-和3-聚戊烯喹啉及四氢喹啉的开发：从先导到候选化合物及一种新型泛PPAR激动剂作为代谢综合征的潜在候选药物

BIOORGANIC CHEMISTRY
IF4.7
2025-06-010
PRE
Villarroel-Vicente, Carlos; Martinez-Solsona, Maria; Garcia, Ainhoa; Vila, Laura; Zibar, Khamis; Schiel, Maria Ayelen; Hennuyer, Nathalie; Clarisse, Dorien; Enriz, Ricardo D.; Staels, Bart; De Bosscher, Karolien; Gonzalez-Navarro, Herminia; Cortes, Diego; Cabedo, Nuria
Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain

靶向HDAC6锌指泛素结合域的新型抑制剂的合成及功能筛选

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2025-03-010
PRE
Geurs, Silke; Staessens, Eleni; Bredael, Kato; Borghgraef, Stefaan; De Ridder, Jordy; Persoons, Leentje; De Jonghe, Steven; Schols, Dominique; Mann, Mandeep K.; Harding, Rachel J.; Franceus, Jorick; Desmet, Tom; Van Hecke, Kristof; Clarisse, Dorien; De Bosscher, Karolien; D'hooghe, Matthias
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

HNF4α 在多微生物败血症相关的代谢重编程和死亡中的关键作用

EMBO MOLECULAR MEDICINE
IF8.3
2024-09-111
OAAI
Van Dender, Celine; Timmermans, Steven; Paakinaho, Ville; Vanderhaeghen, Tineke; Vandewalle, Jolien; Claes, Maarten; Garcia, Bruno; Roman, Bart; De Waele, Jan; Croubels, Siska; De Bosscher, Karolien; Meuleman, Philip; Herpain, Antoine; Palvimo, Jorma J.; Libert, Claude
Crosstalk interactions between transcription factors ERR a and PPAR a assist PPAR a-mediated gene expression

转录因子ERR a和PPAR a之间的串扰相互作用有助于PPAR a介导的基因表达

MOLECULAR METABOLISM
IF6.6
2024-06-014
OAAI
Desmet, Sofie J.; Thommis, Jonathan; Vanderhaeghen, Tineke; Vandenboorn, Edmee M. F.; Clarisse, Dorien; Li, Yunkun; Timmermans, Steven; Fijalkowska, Daria; Ratman, Dariusz; Van Hamme, Evelien; De Cauwer, Lode; Staels, Bart; Brunsveld, Luc; Peelman, Frank; Libert, Claude; Tavernier, Jan; De Bosscher, Karolien
Crosstalk between glucocorticoid and mineralocorticoid receptors boosts glucocorticoid-induced killing of multiple myeloma cells

糖皮质激素和盐皮质激素受体之间的串扰促进糖皮质激素诱导的多发性骨髓瘤细胞杀伤

CELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
2023-08-149
OAAI
Clarisse, Dorien; Prekovic, Stefan; Vlummens, Philip; Staessens, Eleni; Van Wesemael, Karlien; Thommis, Jonathan; Fijalkowska, Daria; Acke, Guillaume; Zwart, Wilbert; Beck, Ilse M.; Offner, Fritz; De Bosscher, Karolien

研究方向

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G
Guy Haegeman
H 指数:73论文数:344被引数:2.0万
C
Claude Libert
H 指数:85论文数:390被引数:2.4万
W
Wim Vanden Berghe
H 指数:67论文数:403被引数:1.7万
J
Jan Tavernier
H 指数:85论文数:551被引数:2.7万
D
Dorien Clarisse
H 指数:13论文数:46被引数:703
I
Ilse M. Beck
H 指数:22论文数:59被引数:3,181
J
Jonathan Thommis
H 指数:10论文数:25被引数:319
N
Nadia Bougarne
H 指数:15论文数:47被引数:1,689
L
Lode De Cauwer
H 指数:12论文数:23被引数:632
J
Jolien Vandewalle
H 指数:19论文数:57被引数:1,791