Blair R. Leavitt - Publications, H-index & Citations

Blair R. Leavitt

University of British Columbia

86H指数

394论文数

3.1W被引数

收录论文 166

发表时间

A novel minimally humanized mouse model of aniridia for preclinical evaluation of CRISPR gene editing strategies 一种新型最小程度人源化无虹膜小鼠模型，用于CRISPR基因编辑策略的临床前评估

Frontiers in Genome Editing

IF4.4

2026-09-19

OAAI

SZ Seyedeh Zeinab Mirjalili Mohanna †; AJ Andrea J. Korecki †; PK Pardis Kazemian †; TC Tess C. Lengyell †; BA Bethany A. Adair †; BR Blair R. Leavitt †; EM Elizabeth M. Simpson †

Design and development of lipid nanoparticle formulations for brain gene therapy 脑基因治疗的脂质纳米粒制剂的设计与开发

Molecular Therapy Nucleic Acids

IF6.1

2026-07-20

OAAI

Sarah B. Thomson; Alissandra de Moura Gomes; Pardis Kazemian; Daniel Z. Kurek; Jayesh A. Kulkarni; Fariba Sadaati; Pamela K. Wagner; Terri L. Petkau; Marco A. Ciufolini; Pieter R. Cullis; Blair R. Leavitt

Preface to special issue on neurodevelopment in Huntington's disease 亨廷顿病神经发育特刊序言

Journal of Huntingtons Disease

IF3.1

2026-05-01

PREAI

Leavitt, Blair R.; Thompson, Leslie M.

Wild-type huntingtin in neurodevelopment 野生型亨廷蛋白在神经发育中的作用

Journal of Huntingtons Disease

IF3.1

2026-05-01

PREAI

Chan, Laura Lynn; Leavitt, Blair R.

Humanized mice carrying a pathogenic GRN deletion as a pre-clinical platform for targeted gene therapies in frontotemporal dementia 携带致病性GRN缺失的人类化小鼠作为额颞叶痴呆靶向基因疗法的临床前平台

Neurobiology of Disease

IF5.6

2026-04-26

OAAI

Benjamin E. Life; Pardis Kazemian; Terri L. Petkau; Alissandra de Moura Gomes; Sarah B. Thomson; Ning Shen; Junia Myung; Farah Jayousi; Tess C. Lengyell; Philipp F. Lange; Elizabeth M. Simpson; Keegan Korthauer; Blair R. Leavitt

Progranulin genetic variant rs5848 displays ancestry-specific associations with Alzheimer’s disease Progranulin遗传变异rs5848显示出与阿尔茨海默病的谱系特异性关联

Human Genomics

IF4.3

2026-04-13

OAAI

Benjamin E. Life; Erick I. Navarro-Delgado; Oriol Fornes; Jan M. Friedman; Wyeth W. Wasserman; Keegan Korthauer; Blair R. Leavitt

Classical and Emerging Biomarkers in Pyridoxine-Dependent Epilepsy (PDE-ALDH7A1): Implications for Early Diagnosis and Therapeutic Development 经典和新出现的生物标志物在吡哆醇依赖性癫痫（PDE-ALDH7A1）中的研究：早期诊断和治疗开发的启示

Biomolecules

IF4.8

2026-03-30

OAAI

Muna Abedrabbo; Safiya Al Yazeedi; Blair R. Leavitt; Hilal Al-Shekaili

Quantitative relationship between tominersen concentrations in cerebrospinal fluid and biomarker changes in Huntington's disease patients 脑脊液中tominersen浓度的定量关系与亨廷顿病患者的生物标志物变化

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2025-11-01

OAAI

Yamamoto, Yumi; Silber Baumann, Hanna E.; Bjornsson, Marcus; Grimsey, Paul; Hawellek, David J.; Anderson, Karen; Leavitt, Blair R.; Landwehrmeyer, Bernhard G.; Tabrizi, Sarah; Mccolgan, Peter; Wild, Edward J.; Sanwald Ducray, Patricia

Targeting AASS alleviates neurotoxicity and improves mitochondrial function in astrocyte models for pyridoxine dependent epilepsy 靶向AASS可缓解神经毒性并改善吡哆醇依赖性癫痫星形胶质细胞模型的线粒体功能

Molecular Therapy Nucleic Acids

IF6.1

2025-09-30

OAAI

Imke M.E. Schuurmans; Udo Engelke; Muna Abedrabbo; Sofía Puvogel; Rachel Mijdam; Gijs-Jan Scholten; Sara B. van Katwijk; Astrid Oudakker; Hilal H. Al-Shekaili; Dirk J. Lefeber; Blair R. Leavitt; Clara D.M. van Karnebeek; Nael Nadif Kasri; Alejandro Garanto

Progranulin function and regulation in the CNS Progranulin功能与调节在中枢神经系统(CNS)

Trends in Neurosciences

IF15.1

2025-06-16

PREAI

Benjamin E. Life; Blair R. Leavitt

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification 脑脊液中亨廷蛋白检测的挑战与进展：支持相对定量

BIOMARKER RESEARCH

IF11.5

2025-04-21

OAAI

Harding, Rachel J.; Xie, Yuanyun; Caron, Nicholas S.; Findlay-Black, Hailey; Lyu, Caroline; Potluri, Nalini; Chandrasekaran, Renu; Hayden, Michael R.; Leavitt, Blair R.; Langbehn, Douglas R.; Southwell, Amber L.

Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice

CELL REPORTS

IF6.9

2024-12-01

PREAI

Johal, Amritpal S.; Al-Shekaili, Hilal H.; Abedrabbo, Muna; Kehinde, Abisola Z.; Towriss, Morgan; Koe, Jessica C.; Hewton, Keeley G.; Thomson, Sarah B.; Ciernia, Annie, V; Leavitt, Blair; Parker, Seth J.

New MiniPromoter Ple389 (ADORA2A) drives selective expression in medium spiny neurons in mice and non-human primates

SCIENTIFIC REPORTS

IF3.9

2024-11-15

OAAI

Gomes, Alissandra de Moura; Petkau, Terri L.; Korecki, Andrea J.; Fornes, Oriol; Galvan, Adriana; Lu, Ge; Hill, Austin M.; Lam, Siu Ling; Yao, Anqi; Farkas, Rachelle A.; Wasserman, Wyeth W.; Smith, Yoland; Simpson, Elizabeth M.; Leavitt, Blair R.

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice

TRANSLATIONAL NEURODEGENERATION

IF15.2

2024-10-08

OAAI

Caron, Nicholas S.; Byrne, Lauren M.; Lemarie, Fanny L.; Bone, Jeffrey N.; Aly, Amirah E. -E.; Ko, Seunghyun; Anderson, Christine; Casal, Lorenzo L.; Hill, Austin M.; Hawellek, David J.; McColgan, Peter; Wild, Edward J.; Leavitt, Blair R.; Hayden, Michael R.

Tominersen in Adults with Manifest Huntington's Disease

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2023-12-07

OAAI

McColgan, Peter; Thobhani, Alpa; Boak, Lauren; Schobel, Scott A.; Nicotra, Alessia; Palermo, Giuseppe; Trundell, Dylan; Zhou, Julian; Schlegel, Valerie; Ducray, Patricia Sanwald; Hawellek, David J.; Dorn, Jonas; Simillion, Cedric; Lindemann, Michael; Wheelock, Vicki; Durr, Alexandra; Anderson, Karen E.; Long, Jeffrey D.; Wild, Edward J.; Landwehrmeyer, G. Bernhard; Leavitt, Blair R.; Tabrizi, Sarah J.; Doody, Rachelle

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-12-01

OAAI

Aggarwal, Geetika; Banerjee, Subhashis; Jones, Spencer A.; Benchaar, Yousri; Belanger, Jasmine; Sevigny, Myriam; Smith, Denise M.; Niehoff, Michael L.; Pavlack, Monica; Vera, Ian Mitchelle S. de; Petkau, Terri L.; Leavitt, Blair R.; Ling, Karen; Jafar-Nejad, Paymaan; Rigo, Frank; Morley, John E.; Farr, Susan A.; Dutchak, Paul A.; Sephton, Chantelle F.; Nguyen, Andrew D.

Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration 亨廷顿氏病的遗传地形和皮质细胞丢失与发育和神经变性有关

BRAIN

IF11.7

2023-08-17

OAAI

Estevez-Fraga, Carlos; Altmann, Andre; Parker, Christopher S.; Scahill, Rachael, I; Costa, Beatrice; Chen, Zhongbo; Manzoni, Claudia; Zarkali, Angeliki; Durr, Alexandra; Roos, Raymund A. C.; Landwehrmeyer, Bernhard; Leavitt, Blair R.; Rees, Geraint; Tabrizi, Sarah J.; McColgan, Peter

FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD

NEUROBIOLOGY OF DISEASE

IF5.6

2023-06-01

OAAI

Life, Benjamin; Petkau, Terri L.; Cruz, Giuliano N. F.; Navarro-Delgado, Erick I.; Shen, Ning; Korthauer, Keegan; Leavitt, Blair R.

Antisense oligonucleotides targeting microRNA binding sites in the GRN mRNA increase progranulin translation: potential therapeutic strategy for frontotemporal dementia

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-06-01

OAAI

Jones, Spencer; Aggarwal, Geetika; Benchaar, Yousri; Belanger, Jasmine; Sevigny, Myriam; Smith, Denise; Niehoff, Michael; de Vera, Ian Mitchelle; Petkau, Terri; Leavitt, Blair; Ling, Karen; Jafar-Nejad, Paymaan; Rigo, Frank; Morley, John; Nguyen, Andrew

Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice 亨廷顿降低FVN/B小鼠对自发性癫痫发作的易感性

AGING AND DISEASE

IF6.9

2023-01-01

OAAI

Van Raamsdonk, Jeremy M.; Al-Shekaili, Hilal H.; Wagner, Laura; Bredy, Tim W.; Chan, Laura; Pearson, Jacqueline; Schwab, Claudia; Murphy, Zoe; Devon, Rebecca S.; Lu, Ge; Kobor, Michael S.; Hayden, Michael R.; Leavitt, Blair R.

研究方向