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E

Emily Han-Chung Hsiue

Howard Hughes Medical Institute
H指数:19
被引数:1,924

个人简介

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Bispecific antibodies and CAR T cells targeting a TP53 mutation-associated neoantigen show discordant affinity requirements

双特异性抗体和靶向TP53突变相关新抗原的CAR T细胞显示出不同的亲和力需求

Journal of Clinical Investigation
IF13.6
2026-01-160
OA
Dinapoli, Sarah R.; Wright, Katharine M.; Mog, Brian J.; Pearlman, Alexander H.; Nichakawade, Tushar D.; Marcou, Nikita; Hsiue, Emily Han-Chung; Hwang, Michael S.; Douglass, Jacqueline; Liu, Qiang; Watson, Evangeline; Dal Molin, Marco; Cohen, Joshua D.; Popoli, Maria; Paul, Suman; Konig, Maximilian F.; Wyhs, Nicolas; Azurmendi, P. Aitana; Glavaris, Stephanie; Ge, Jiaxin; Awosika, Tolulope O.; Liu, Jin; Gabrielson, Kathleen L.; Gabelli, Sandra B.; Pardoll, Drew M.; Bettegowda, Chetan; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Zhou, Shibin; Vogelstein, Bert
Preclinical studies show that Co-STARs combine the advantages of chimeric antigen and T cell receptors for the treatment of tumors with low antigen densities
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-07-101
PRE
Mog, Brian J.; Marcou, Nikita; Dinapoli, Sarah R.; Pearlman, Alexander H.; Nichakawade, Tushar D.; Hwang, Michael S.; Douglass, Jacqueline; Hsiue, Emily Han-Chung; Glavaris, Stephanie; Wright, Katharine M.; Konig, Maximilian F.; Paul, Suman; Wyhs, Nicolas; Ge, Jiaxin; Miller, Michelle S.; Azurmendi, Aitana; Watson, Evangeline; Pardoll, Drew M.; Gabelli, Sandra B.; Bettegowda, Chetan; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin
Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen

疏水相互作用主导了KRAS G12V新抗原的识别

NATURE COMMUNICATIONS
IF15.7
2023-08-218
OAAI
Wright, Katharine M.; DiNapoli, Sarah R.; Miller, Michelle S.; Azurmendi, P. Aitana; Zhao, Xiaowei; Yu, Zhiheng; Chakrabarti, Mayukh; Shi, WuXian; Douglass, Jacqueline; Hwang, Michael S.; Hsiue, Emily Han-Chung; Mog, Brian J.; Pearlman, Alexander H.; Paul, Suman; Konig, Maximilian F.; Pardoll, Drew M.; Bettegowda, Chetan; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin; Gabelli, Sandra B.
Hybrid TCR-CAR design surpasses conventional CARs and patient-derived TCRs in targeting an ultra-low-density neoantigen
CANCER RESEARCH
IF16.6
2023-04-140
PRE
Mog, Brian J.; DiNapoli, Sarah R.; Hwang, Michael S.; Nichakawade, Tushar D.; Douglass, Jacqueline; Hsiue, Emily Han-Chung; Wright, Katharine M.; Pearlman, Alexander H.; Konig, Maximilian F.; Paul, Suman; Wyhs, Nicolas; Marcou, Nikita; Glavaris, Stephanie; Ge, Jiaxin; Miller, Michelle S.; Azurmendi, P. Aitana; Watson, Evangeline; Pardoll, Drew M.; Gabelli, Sandra B.; Bettegowda, Chetan; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin
TCR-mimic bispecific antibodies to target the HIV-1 reservoir

TCR模拟双特异性抗体靶向HIV-1库

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2022-04-0816
OAAI
Sengupta, Srona; Board, Nathan L.; Wu, Fengting; Moskovljevic, Milica; Douglass, Jacqueline; Zhang, Josephine; Reinhold, Bruce R.; Duke-Cohan, Jonathan; Yu, Jeanna; Reed, Madison C.; Tabdili, Yasmine; Azurmendi, Aitana; Fray, Emily J.; Zhang, Hao; Hsiue, Emily Han-Chung; Jenike, Katharine; Ho, Ya-Chi; Gabelli, Sandra B.; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin; Siliciano, Janet D.; Sadegh-Nasseri, Scheherazade; L.Reinherz, Ellis; Siliciano, Robert F.
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

靶向HLA限制性新抗原的嵌合抗原受体的结构工程

NATURE COMMUNICATIONS
IF15.7
2021-09-0625
OAAI
Hwang, Michael S.; Miller, Michelle S.; Thirawatananond, Puchong; Douglass, Jacqueline; Wright, Katharine M.; Hsiue, Emily Han-Chung; Mog, Brian J.; Aytenfisu, Tihitina Y.; Murphy, Michael B.; Azurmendi, P. Aitana; Skora, Andrew D.; Pearlman, Alexander H.; Paul, Suman; DiNapoli, Sarah R.; Konig, Maximilian F.; Bettegowda, Chetan; Pardoll, Drew M.; Papadopoulos, Nickolas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin; Gabelli, Sandra B.
Targeting public neoantigens for cancer immunotherapy
NATURE CANCER
IF28.5
2021-05-1793
OAAI
Pearlman, Alexander H.; Hwang, Michael S.; Konig, Maximilian F.; Hsiue, Emily Han-Chung; Douglass, Jacqueline; DiNapoli, Sarah R.; Mog, Brian J.; Bettegowda, Chetan; Pardoll, Drew M.; Gabelli, Sandra B.; Papadopoulos, Nicholas; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin
Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2021-05-1761
OA
Dykema, Arbor G.; Zhang, Boyang; Woldemeskel, Bezawit A.; Garliss, Caroline C.; Cheung, Laurene S.; Choudhury, Dilshad; Zhang, Jiajia; Aparicio, Luis; Bom, Sadhana; Rashid, Rufiaat; Caushi, Justina X.; Hsiue, Emily Han-Chung; Cascino, Katherine; Thompson, Elizabeth A.; Kwaa, Abena K.; Singh, Dipika; Thapa, Sampriti; Ordonez, Alvaro A.; Pekosz, Andrew; D'Alessio, Franco R.; Powell, Jonathan D.; Yegnasubramanian, Srinivasan; Zhou, Shibin; Pardoll, Drew M.; Ji, Hongkai; Cox, Andrea L.; Blankson, Joel N.; Smith, Kellie N.
Targeting loss of heterozygosity for cancer-specific immunotherapy

靶向杂合性缺失的癌症特异性免疫治疗

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2021-03-1751
OAAI
Hwang, Michael S.; Mog, Brian J.; Douglass, Jacqueline; Pearlman, Alexander H.; Hsiue, Emily Han-Chung; Paul, Suman; DiNapoli, Sarah R.; Konig, Maximilian F.; Pardoll, Drew M.; Gabelli, Sandra B.; Bettegowda, Chetan; Papadopoulos, Nickolas; Vogelstein, Bert; Zhou, Shibin; Kinzler, Kenneth W.
TCR β chain-directed bispecific antibodies for the treatment of T cell cancers
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-03-1040
OA
Paul, Suman; Pearlman, Alexander H.; Douglass, Jacqueline; Mog, Brian J.; Hsiue, Emily Han-Chung; Hwang, Michael S.; DiNapoli, Sarah R.; Konig, Maximilian F.; Brown, Patrick A.; Wright, Katharine M.; Sur, Surojit; Gabelli, Sandra B.; Li, Yana; Ghiaur, Gabriel; Pardoll, Drew M.; Papadopoulos, Nickolas; Bettegowda, Chetan; Kinzler, Kenneth W.; Zhou, Shibin; Vogelstein, Bert
Bispecific antibodies targeting mutant RAS neoantigens
SCIENCE IMMUNOLOGY
IF16.3
2021-03-04122
OAAI
Douglass, Jacqueline; Hsiue, Emily Han-Chung; Mog, Brian J.; Hwang, Michael S.; DiNapoli, Sarah R.; Pearlman, Alexander H.; Miller, Michelle S.; Wright, Katharine M.; Azurmendi, P. Aitana; Wang, Qing; Paul, Suman; Schaefer, Annika; Skora, Andrew D.; Dal Molin, Marco; Konig, Maximilian F.; Liu, Qiang; Watson, Evangeline; Li, Yana; Murphy, Michael B.; Pardoll, Drew M.; Bettegowda, Chetan; Papadopoulos, Nickolas; Gabelli, Sandra B.; Kinzler, Kenneth W.; Vogelstein, Bert; Zhou, Shibin
Targeting a neoantigen derived from a common TP53 mutation
Science
IF45.8
2021-01-010
OA
Emily Han-Chung Hsiue; Katharine M. Wright; Jacqueline Douglass; Michael S. Hwang; Brian J. Mog; Alexander H. Pearlman; Suman Paul; Sarah R. DiNapoli; Maximilian F. Konig; Qing Wang; Annika Schaefer; Michelle S. Miller; Andrew D. Skora; P. Aitana Azurmendi; Michael B. Murphy; Qiang Liu; Evangeline Watson; Yana Li; Drew M. Pardoll; Chetan Bettegowda; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Sandra B. Gabelli; Shibin Zhou

研究方向

暂未获取到该数据
K
Kenneth W. Kinzler
H 指数:213论文数:791被引数:24.8万
S
Shibin Zhou
H 指数:49论文数:162被引数:4.0万
S
Sandra B. Gabelli
H 指数:40论文数:235被引数:7,767
B
Bert Vogelstein
H 指数:255论文数:1,049被引数:36.8万
J
Jacqueline Douglass
H 指数:16论文数:70被引数:1,796
C
Chetan Bettegowda
H 指数:69论文数:752被引数:3.1万
D
Drew M. Pardoll
H 指数:164论文数:895被引数:16.5万
S
Sarah R. DiNapoli
H 指数:18论文数:35被引数:1,450
B
Brian J. Mog
H 指数:13论文数:69被引数:1,634
A
Alexander H. Pearlman
H 指数:12论文数:97被引数:1,438