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W

William D. Tolbert

uniformed services university of the health sciences - usa
H指数:32
被引数:2,801

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The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

HIV-1 Env的对称性开启由一种强效的CD4模拟物实现，这使抗共受体结合位点抗体能够介导ADCC。

Nature Communications
IF15.7
2025-12-010
OAAI
Jonathan Richard; Michael W. Grunst; Ling Niu; Marco A. Díaz-Salinas; Li Zhu; William D. Tolbert; Lorie Marchitto; Fei Zhou; Catherine Bourassa; Hongil Kim; Sri Lakshmi Tejaswi Boodapati; Derek Yang; Ta Jung Chiu; Hung-Ching Chen; Mehdi Benlarbi; Guillaume Beaudoin-Bussières; Suneetha Gottumukkala; Wenwei Li; Katrina Dionne; Étienne Bélanger; Debashree Chatterjee; Halima Medjahed; Wayne A. Hendrickson; Joseph Sodroski; Zabrina C. Lang; Abraham J. Morton; Rick K. Huang; Doreen Matthies; Amos B. Smith; Priti Kumar; Walther Mothes; James B. Munro; Marzena Pazgier; Andrés Finzi
Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants

VE607优化以生成对SARS-CoV-2变体具有增强中和活性的类似物

JOURNAL OF VIROLOGY
IF3.8
2025-10-010
PRE
Ding, Shilei; Yang, Derek; Ullah, Irfan; Niu, Ling; Unger, Matthew; Diaz-Salinas, Marco A.; Chandravanshi, Monika; Zhou, Fei; Beaudoin-Bussieres, Guillaume; Benlarbi, Mehdi; Tolbert, William D.; Yoon, Keon-Woong; Xu, Ruixue; Laroche, Genevieve; Gaudette, Fleur; Morton, Abraham J.; Lang, Zabrina C.; Son, Anna; Abrams, Cameron; Cote, Marceline; Smith III, Amos B.; Huang, Rick K.; Matthies, Doreen; Munro, James B.; Pazgier, Marzena; Uchil, Pradeep D.; Finzi, Andres
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV

一项全面的工程策略提高了针对HIV的近全中和抗体的效力和可制造性。

Structure
IF4.3
2025-05-140
OA
Mohammad M. Sajadi; Abdolrahim Abbasi; Zahra Rikhtegaran Tehrani; Christine Siska; Rutilio Clark; Woo Chi; Michael S. Seaman; Dieter Mielke; Kshitij Wagh; Qingbo Liu; Taylor Jumpa; Randal R. Ketchem; Dung N. Nguyen; William D. Tolbert; Brian G. Pierce; Ben Atkinson; Derrick Deming; Megan Sprague; Andrew Asakawa; David Ferrer; Yasmin Dunn; Sarah Calvillo; Rui Yin; Johnathan D. Guest; Bette Korber; Bryan T. Mayer; Alicia H. Sato; Xin Ouyang; Scott Foulke; Parham Habibzadeh; Maryam Karimi; Arash Aslanabadi; Mahsa Hojabri; Saman Saadat; Roza Zareidoodeji; Mateusz Kędzior; Edwin Pozharski; Alonso Heredia; Hegang Chen; David Montefiori; Guido Ferrari; Marzena Pazgier; George K. Lewis; Joseph G. Jardine; Paolo Lusso; Anthony DeVico
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
JOURNAL OF VIROLOGY
IF3.8
2024-10-220
PRE
Marchitto, Lorie; Richard, Jonathan; Prevost, Jeremie; Tauzin, Alexandra; Yang, Derek; Chiu, Ta-Jung; Chen, Hung-Ching; Diaz-Salinas, Marco A.; Nayrac, Manon; Benlarbi, Mehdi; Beaudoin-Bussieres, Guillaume; Anand, Sai Priya; Dionne, Katrina; Belanger, Etienne; Chatterjee, Debashree; Medjahed, Halima; Bourassa, Catherine; Tolbert, William D.; Hahn, Beatrice H.; Munro, James B.; Pazgier, Marzena; Smith III, Amos B.; Finzi, Andres
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics

CD4-induced抗体的三个家族与HIV感染者血浆在存在CD4-mimetics的情况下介导ADCC的能力有关。

JOURNAL OF VIROLOGY
IF3.8
2024-10-222
OA
Tauzin, Alexandra; Marchitto, Lorie; Belanger, Etienne; Benlarbi, Mehdi; Beaudoin-Bussieres, Guillaume; Prevost, Jeremie; Yang, Derek; Chiu, Ta-Jung; Chen, Hung-Ching; Bourassa, Catherine; Medjahed, Halima; Korzeniowski, Marek K.; Gottumukkala, Suneetha; Tolbert, William D.; Richard, Jonathan; Smith III, Amos B.; Pazgier, Marzena; Finzi, Andres
Immune response profiles from humans experimentally exposed to Phlebotomus duboscqi bites

实验暴露于Phlebotomus duboscqi叮咬的人类的免疫反应概况

FRONTIERS IN IMMUNOLOGY
IF5.9
2024-04-031
OAAI
de Araujo, Fernanda Fortes; Abdeladhim, Maha; Teixeira, Clarissa; Hummer, Kelly; Wilkerson, Matthew D.; Ressner, Roseanne; Lakhal-Naouar, Ines; Ellis, Michael W.; Meneses, Claudio; Nurmukhambetova, Saule; Gomes, Regis; Tolbert, W. David; Turiansky, George W.; Pazgier, Marzena; Oliveira, Fabiano; Valenzuela, Jesus G.; Kamhawi, Shaden; Aronson, Naomi
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia
JOURNAL OF INFECTIOUS DISEASES
IF4.5
2023-11-306
OAAI
Benlarbi, Mehdi; Richard, Jonathan; Bourassa, Catherine; Tolbert, William D.; Chartrand-Lefebvre, Carl; Gendron-Lepage, Gabrielle; Sylla, Mohamed; El-Far, Mohamed; Messier-Peet, Marc; Guertin, Camille; Turcotte, Isabelle; Fromentin, Remi; Verly, Myriam Maude; Prevost, Jeremie; Clark, Andrew; Mothes, Walther; Kaufmann, Daniel E.; Maldarelli, Frank; Chomont, Nicolas; Begin, Philippe; Tremblay, Cecile; Baril, Jean-Guy; Trottier, Benoit; Trottier, Sylvie; Duerr, Ralf; Pazgier, Marzena; Durand, Madeleine; Finzi, Andres
Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC

哌啶CD4-Mimetic化合物暴露脆弱的Env表位，使HIV-1-Infected细胞对ADCC敏感

VIRUSES-BASEL
IF3.5
2023-05-176
OAAI
Ding, Shilei; Tolbert, William D.; Zhu, Huile; Lee, Daniel; Marchitto, Lorie; Higgins, Tyler; Zhao, Xuchen; Nguyen, Dung; Sherburn, Rebekah; Richard, Jonathan; Gendron-Lepage, Gabrielle; Medjahed, Halima; Mohammadi, Mohammadjavad; Abrams, Cameron; Pazgier, Marzena; Smith, Amos B., III; Finzi, Andres
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120
CELL CHEMICAL BIOLOGY
IF7.2
2023-05-0112
OAAI
Richard, Jonathan; Prevost, Jeremie; Bourassa, Catherine; Brassard, Nathalie; Boutin, Marianne; Benlarbi, Mehdi; Goyette, Guillaume; Medjahed, Halima; Gendron-Lepage, Gabrielle; Gaudette, Fleur; Chen, Hung-Ching; Tolbert, William D.; Smith, Amos B., III; Pazgier, Marzena; Dube, Mathieu; Clark, Andrew; Mothes, Walther; Kaufmann, Daniel E.; Finzi, Andres
Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

抗HIV-1临床分离株的新型CD4模拟化合物YIR-821的表征

JOURNAL OF VIROLOGY
IF3.8
2023-01-312
OA
Matsumoto, Kaho; Kuwata, Takeo; Tolbert, William D.; Richard, Jonathan; Ding, Shilei; Prevost, Jeremie; Takahama, Shokichi; Judicate, George P.; Ueno, Takamasa; Nakata, Hirotomo; Kobayakawa, Takuya; Tsuji, Kohei; Tamamura, Hirokazu; Smith, Amos B., III; Pazgier, Marzena; Finzi, Andres; Matsushita, Shuzo
Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques

解码人猕猴种间Fc效应子功能的差异: 恒河猴CD16-dependent效应子功能的结构基础

FRONTIERS IN IMMUNOLOGY
IF5.9
2022-09-059
OAAI
Tolbert, William D. D.; Gohain, Neelakshi; Kremer, Paul G. G.; Hederman, Andrew P. P.; Nguyen, Dung N. N.; Van, Verna; Sherburn, Rebekah; Lewis, George K. K.; Finzi, Andres; Pollara, Justin; Ackerman, Margaret E. E.; Barb, Adam W. W.; Pazgier, Marzena
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

工程ACE2-Fc通过直接中和和Fc效应子活性对抗小鼠致死性SARS-CoV-2感染

SCIENCE ADVANCES
IF12.5
2022-07-1525
OAAI
Chen, Yaozong; Sun, Lulu; Ullah, Irfan; Beaudoin-Bussieres, Guillaume; Anand, Sai Priya; Hederman, Andrew P.; Tolbert, William D.; Sherburn, Rebekah; Nguyen, Dung N.; Marchitto, Lorie; Ding, Shilei; Wu, Di; Luo, Yuhong; Gottumukkala, Suneetha; Moran, Sean; Kumar, Priti; Piszczek, Grzegorz; Mothes, Walther; Ackerman, Margaret E.; Finzi, Andres; Uchil, Pradeep D.; Gonzalez, Frank J.; Pazgier, Marzena

研究方向

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M
Marzena Pazgier
H 指数:44论文数:245被引数:6,630
A
Andrés Finzi
H 指数:60论文数:317被引数:1.3万
J
Jonathan Richard
H 指数:46论文数:179被引数:6,511
S
Shilei Ding
H 指数:39论文数:128被引数:4,868
J
Jérémie Prévost
H 指数:40论文数:138被引数:5,506
H
Halima Medjahed
H 指数:34论文数:185被引数:4,356
A
Amos B. Smith
H 指数:95论文数:1,150被引数:4.0万
D
Dung N. Nguyen
H 指数:12论文数:43被引数:494
M
Mehdi Benlarbi
H 指数:22论文数:83被引数:2,485
G
George K. Lewis
H 指数:48论文数:331被引数:1.3万