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Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers Vγ9vδ2t细胞识别嗜丁基蛋白2A1和3A1异聚体 Fulford, Thomas S.; Soliman, Caroline; Castle, Rebecca G.; Rigau, Marc; Ruan, Zheng; Dolezal, Olan; Seneviratna, Rebecca; Brown, Hamish G.; Hanssen, Eric; Hammet, Andrew; Li, Shihan; Redmond, Samuel J.; Chung, Amy; Gorman, Michael A.; Parker, Michael W.; Patel, Onisha; Peat, Thomas S.; Newman, Janet; Behren, Andreas; Gherardin, Nicholas A.; Godfrey, Dale I.; Uldrich, Adam P. 分享 收藏
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer 发现一种高效，选择性，口服生物利用度的KAT6A/B组蛋白乙酰转移酶抑制剂，对KAT6A-high ER乳腺癌有效 Sharma, Shikhar; Chung, Chi-Yeh; Uryu, Sean; Petrovic, Jelena; Cao, Joan; Rickard, Amanda; Nady, Nataliya; Greasley, Samantha; Johnson, Eric; Brodsky, Oleg; Khan, Showkhin; Wang, Hui; Wang, Zhenxiong; Zhang, Yong; Tsaparikos, Konstantinos; Chen, Lei; Mazurek, Anthony; Lapek, John; Kung, Pei-Pei; Sutton, Scott; Richardson, Paul F.; Greenwald, Eric C.; Yamazaki, Shinji; Jones, Rhys; Maegley, Karen A.; Bingham, Patrick; Lam, Hieu; Stupple, Alexandra E.; Kamal, Aileen; Chueh, Anderly; Cuzzupe, Anthony; Morrow, Benjamin J.; Ren, Bin; Carrasco-Pozo, Catalina; Tan, Chin Wee; Bhuva, Dharmesh D.; Allan, Elizabeth; Surgenor, Elliot; Vaillant, Francois; Pehlivanoglu, Havva; Falk, Hendrik; Whittle, James R.; Newman, Janet; Cursons, Joseph; Doherty, Judy P.; White, Karen L.; Macpherson, Laura; Devlin, Mark; Dennis, Matthew L.; Hattarki, Meghan K.; De Silva, Melanie; Camerino, Michelle A.; Butler, Miriam S.; Dolezal, Olan; Pilling, Patricia; Foitzik, Richard; Stupple, Paul A.; Lagiakos, H. Rachel; Walker, Scott R.; Hediyeh-Zadeh, Soroor; Nuttall, Stewart; Spall, Sukhdeep; Charman, Susan A.; Connor, Theresa; Peat, Thomas S.; Avery, Vicky M.; Bozikis, Ylva E.; Yang, Yuqing; Zhang, Ming; Monahan, Brendon J.; Voss, Anne K.; Street, Ian P.; Dawson, Sarah-Jane; Dawson, Mark A.; Lindeman, Geoffrey J.; Davis, Melissa J.; Visvader, Jane E.; Paul, Thomas A. 分享 收藏
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors 洞察药物再利用，以及基于哌啶的SARS-CoV-2 PLpro抑制剂的特异性和复合特性 Calleja, Dale J.; Kuchel, Nathan; Lu, Bernadine G. C.; Birkinshaw, Richard W.; Klemm, Theresa; Doerflinger, Marcel; Cooney, James P.; Mackiewicz, Liana; Au, Amanda E.; Yap, Yu Q.; Blackmore, Timothy R.; Katneni, Kasiram; Crighton, Elly; Newman, Janet; Jarman, Kate E.; Call, Melissa J.; Lechtenberg, Bernhard C.; Czabotar, Peter E.; Pellegrini, Marc; Charman, Susan A.; Lowes, Kym N.; Mitchell, Jeffrey P.; Nachbur, Ueli; Lessene, Guillaume; Komander, David 分享 收藏
Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices Guo, Zhong; Smutok, Oleh; Johnston, Wayne A.; Walden, Patricia; Ungerer, Jacobus P. J.; Peat, Thomas S.; Newman, Janet; Parker, Jake; Nebl, Tom; Hepburn, Caryn; Melman, Artem; Suderman, Richard J.; Katz, Evgeny; Alexandrov, Kirill 分享 收藏
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Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2 木瓜蛋白酶样蛋白酶PLpro的机制和抑制SARS-CoV-2 Klemm, Theresa; Ebert, Gregor; Calleja, Dale J.; Allison, Cody C.; Richardson, Lachlan W.; Bernardini, Jonathan P.; Lu, Bernadine G. C.; Kuchel, Nathan W.; Grohmann, Christoph; Shibata, Yuri; Gan, Zhong Yan; Cooney, James P.; Doerflinger, Marcel; Au, Amanda E.; Blackmore, Timothy R.; van der Heden van Noort, Gerbrand J.; Geurink, Paul P.; Ovaa, Huib; Newman, Janet; Riboldi-Tunnicliffe, Alan; Czabotar, Peter E.; Mitchell, Jeffrey P.; Feltham, Rebecca; Lechtenberg, Bernhard C.; Lowes, Kym N.; Dewson, Grant; Pellegrini, Marc; Lessene, Guillaume; Komander, David 分享 收藏
An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme Esquirol, Lygie; Peat, Thomas S.; Wilding, Matthew; Liu, Jian-Wei; French, Nigel G.; Hartley, Carol J.; Onagi, Hideki; Nebl, Thomas; Easton, Christopher J.; Newman, Janet; Scott, Colin 分享 收藏
Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis Zabara, Alexandru; Meikle, Thomas G.; Trenker, Raphael; Yao, Shenggen; Newman, Janet; Peat, Thomas S.; Separovic, Frances; Conn, Charlotte E.; Call, Melissa J.; Call, Matthew E.; Landau, Ehud M.; Drummond, Calum J. 分享 收藏
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Some of the most interesting CASP11 targets through the eyes of their authors Kryshtafovych, Andriy; Moult, John; Basle, Arnaud; Burgin, Alex; Craig, Timothy K.; Edwards, Robert A.; Fass, Deborah; Hartmann, Marcus D.; Korycinski, Mateusz; Lewis, Richard J.; Lorimer, Donald; Lupas, Andrei N.; Newman, Janet; Peat, Thomas S.; Piepenbrink, Kurt H.; Prahlad, Janani; van Raaij, Mark J.; Rohwer, Forest; Segall, Anca M.; Seguritan, Victor; Sundberg, Eric J.; Singh, Abhimanyu K.; Wilson, Mark A.; Schwede, Torsten 分享 收藏
Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly Knoblich, Konstantin; Park, Soohyung; Lutfi, Mariam; van 't Hag, Leonie; Conn, Charlotte E.; Seabrook, Shane A.; Newman, Janet; Czabotar, Peter E.; Im, Wonpil; Call, Matthew E.; Call, Melissa J. 分享 收藏
X-Ray Structure of the Amidase Domain of AtzF, the Allophanate Hydrolase from the Cyanuric Acid-Mineralizing Multienzyme Complex Balotra, Sahil; Newman, Janet; Cowieson, Nathan P.; French, Nigel G.; Campbell, Peter M.; Briggs, Lyndall J.; Warden, Andrew C.; Easton, Christopher J.; Peat, Thomas S.; Scott, Colin 分享 收藏
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